Deubiquitinating enzyme USP2 regulates brown adipose tissue thermogenesis via controlling EBF2 stabilization by Yuejie Xu, Ying Chen, Ningning Bai, Yingying Su, Yafen Ye, Rong Zhang, Ying Yang, Caizhi Liu, Cheng Hu, Jiemin Pan

“…Conversely, overexpression of Usp2 in BAT conferred protection against high-fat diet-induced obesity and associated metabolic disorders. Proteome-wide analysis identified EBF2 as the substrate of USP2 that mediates the thermogenic function of USP2 in BAT. …”
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Case report: Duplication of the GCK gene is a novel cause of nesidioblastosis: evidence from a case with Silver-Russell syndrome-like phenotype related to chromosome 7 by Takashi Shoji, Ichiro Yamauchi, Hidenori Kawasaki, Kogoro Iwanaga, Takuro Hakata, Daisuke Tanaka, Junji Fujikura, Toshihiko Masui, Hisato Suzuki, Mamiko Yamada, Kenjiro Kosaki, Yosuke Kasai, Etsuro Hatano, Akira Inaba, Takahito Wada, Shinji Kosugi, Yohei Ueda, Toshihito Fujii, Daisuke Taura, Nobuya Inagaki

“…Whole-exome sequencing (WES) identified the heterozygous NR0B2 Ala195Ser variant, which alone was unlikely to cause nesidioblastosis because this variant is sometimes detected in the Japanese population. Copy number analysis using WES data suggested duplication in chromosome 7, and subsequent G-banding chromosome analysis confirmed mos dup(7)(p11.2p14). …”
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Codifying Deliberative Democracy within the EU in the Digital Era by MarÍa Jesus GarcÍa GarcÍa

“…Data analysis is based on legal reasoning, mainly. …”
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Prospectively assessed hypothalamic-pituitary dysfunction after proton therapy in adults with head and neck, skull base and brain tumors by Jordan Bouter, Nathan Azemar, Anthony Vela, Pauline Dutheil, Paul Lesueur, Dinu Stefan, Yves Reznik, Juliette Thariat

“…Pituitary hormones govern many vital functions but data of standardized monitoring for deficiencies after irradiation are lacking. …”
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Theoretical Insights into the Chemical Bonding, Electronic Structure, and Spectroscopic Properties of the Lanarkite Pb₂SO₅ Structure by Guilherme S. L. Fabris, Mateus M. Ferrer, Claudio R. R. Almeida, Carlos A. Paskocimas, Julio R. Sambrano, Felipe A. La Porta

“…All DFT calculations were performed using a triple-zeta valence plus polarization basis set. Among all the DFT functionals, PBE0 showed the best agreement with the experimental and theoretical data available in the literature. …”
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NH4 Modelling with ARIMA and LSTM by Hanna Arini Parhusip, Suryasatriya Trihandaru, Johanes Dian Kurniawan

“…The study investigates the effectiveness of AI-Mining in detecting and predicting gas levels, focusing on data collection and analysis. Initial data analysis employed the Autoregressive Moving Average (ARIMA) model, specifically ARIMA (1,1,1), described by the equation yt = 0.0311 - 0.0750yt-1 + 0.3842εt-1. …”
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iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Contro... by Christy Au-Yeung, Helen Thai, Michael Best, Christopher R Bowie, Synthia Guimond, Katie M Lavigne, Mahesh Menon, Steffen Moritz, Myra Piat, Geneviève Sauvé, Ana Elisa Sousa, Elisabeth Thibaudeau, Todd S Woodward, Martin Lepage, Delphine Raucher-Chéné

“…Implementation strategy evaluation will consider the digital platform’s efficacy for mental health care practitioners’ training, contextual factors influencing implementation, and sustainability, using descriptive statistics for quantitative data and thematic analysis for qualitative data. …”
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Trade-offs and synergies for urban Production-Living-Ecological spatial Patterns-Comparison study between Fuzhou, China, and Saskatoon, Canada by Xi Wang, Xiaomei Li, Jinming Sha, Hao Zhang, Eshetu Shifaw, Xulin Guo, Shuhui Lai, Jinliang Wang

“…First, the paper identified the PLE spaces by integrating multi-source data, then analyzed the PLE spatial agglomeration characteristics by using the average nearest neighbor and kernel density analysis, finally detected the trade-offs and synergies between functional spaces by Spearman correlation and bivariate spatial autocorrelation. …”
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Being An Wholistic and Developmental Healthcare Leader: Insights from a grounded theory research study by Shannon Richards-Green, Suzanne Gough, Mickan Sharon

“…Memo writing throughout the data collection and analysis process afforded additional valuable data. …”
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Characteristics of cardiopulmonary exercise capacity in adults with different degrees of obesity by Shukun Deng, Shengrui Mei, Qunyan Zhou, Wenjun Zhi, Wenjun Wu, Junyan Cai, Peng Yuan

“…In terms of static pulmonary function, there were significant differences among the five groups in FVC%Pred (F = 4.577, P = 0.001), FEV1%Pred (F = 3.681, P = 0.006) and FEV1/FVC (F = 3.344, P = 0.011). …”
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Exploring district implementation of national guidelines and maintenance of essential health services during the COVID-19 pandemic in Uganda by Fredrick E Makumbi, Freddie Ssengooba, Charles Olaro, Dorit Talia Stein, Adrian Ssessanga, Jesca Nsungwa Sabiiti, Betty Kyaddondo, Catherine Mbabazi

“…This study examines whether variation in implementation of national guidelines across districts and health system functions explains differences in local health system performance in maintaining continuity of essential maternal health, family planning and child vaccination services during the COVID-19 pandemic in Uganda.Methods We used routine health data and an interrupted time-series analysis to estimate district-specific relative declines in service outputs during COVID-19 compared with expected volumes if prepandemic trends continued for maternal health, family planning and child vaccination services. …”
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Guiding Principles for Transformation Towards Integrated Acute Care for Older Adults Close to Home: Lessons from Nine Dutch Regional Partnerships. A Realist Evaluation by Eline D. Kroeze, Gercora Hoitinga, Susanne M. Smorenburg, Janet L. MacNeil Vroomen, Anneke J. A. H. van Vught, Bianca M. Buurman

“…Methods: The Rainbow Model, RE-theory, Coleman’s boat and ripple effects functioned as theoretical basis. We conducted a document analysis (n = 19), semi-structured interviews (n = 11) and two focus groups (n = 8). …”
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Three-Dimensional Real-Scene-Enhanced GNSS/Intelligent Vision Surface Deformation Monitoring System by Yuanrong He, Weijie Yang, Qun Su, Qiuhua He, Hongxin Li, Shuhang Lin, Shaochang Zhu

“…To enhance the functionality of the system, the visual sensor data are fused with 3D models through streaming media technology, enabling 3D real-scene augmented reality to support dynamic deformation monitoring and visual analysis. …”
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Determination of Trace Elements in Corydalis conspersa and Corydalis linarioides by ICP-AES by Qing Du, Yanguo Cai, Zhi Chen, Dongliang Wei, Yande Cao, Ying Chen, Shulin Yu, Qianqian Zhao, Jiang Wu, Mingdi Liu

“…A 3-factor model was obtained by principal component analysis which could clarify 82.46% of the total experimental data; the factors of Al, Fe, Mg, Na, P, Ca, Cu, Si, and Zn had great influence on the efficacy of 21 kinds of medicinal materials. …”
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PSMD11 and PSMD14 may serve as novel biomarkers for the prognosis of pancreatic ductal adenocarcinoma by Yan-Hui Yang, Zhe-Hua Xing, Hao Wang, Chi Zhang, Yu-Bo Liu, Qian-Qian Bai, Fang-Fei Liu, Wei-Feng Liu, Jun-Chuan Yang, Da-Huan Li, Hua Fan

“…BackgroundThe ubiquitin proteasome system is involved in the regulation of cellular gene transcription and cellular receptor function through the degradation of proteins, thus affecting tumorigenesis and development. …”
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Evaluasi Aplikasi Raileo Melalui Analisis Sentimen Ulasan Playstore Dengan Metode Naive Bayes by Haris Junianto, Primandani Arsi, Bagus Adhi Kusuma, Dhanar Intan Surya Saputra

“… Abstrak The Raileo application is a staffing platform owned by PT. KAI, functions as a personnel data management system. Effective application development requires data as a basis, and one source of data that can be utilized is user reviews. …”
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Population dynamics and monitoring applied to decision-making by M. J. Conroy, D. C. Lee

“…Ring–recovery and harvest data are used to estimate fall age ratios under alternative reproductive models. …”
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Four cardiomyopathy patients with a heterozygous DSG2 p.Arg119Ter variant by Takuya Sumida, Shou Ogawa, Shuichiro Higo, Yuki Kuramoto, Ryo Eto, Yoshihiko Ikeda, Congcong Sun, Junjun Li, Li Liu, Tomoka Tabata, Yoshihiro Asano, Mikio Shiba, Yasuhiro Akazawa, Daisuke Nakamura, Takafumi Oka, Tomohito Ohtani, Yasushi Sakata

“…The patients also exhibited reduced left ventricular contractile function and varying clinical courses. Genetic analysis identified additional possible causative variants, DSG2 p.Arg292Cys in Pt-1 and BAG3 p.His166SerfsTer6 in Pt-3. …”
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A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages by Nils Schmerer, Harshavardhan Janga, Michelle Aillaud, Janina Hoffmann, Marina Aznaourova, Sarah Wende, Henrike Steding, Luke D. Halder, Michael Uhl, Fabian Boldt, Thorsten Stiewe, Andrea Nist, Lukas Jerrentrup, Andreas Kirschbaum, Clemens Ruppert, Oliver Rossbach, Evgenia Ntini, Annalisa Marsico, Chanil Valasarajan, Rolf Backofen, Uwe Linne, Soni S. Pullamsetti, Bernd Schmeck, Leon N. Schulte

“…Lastly, all data are consolidated in the SMyLR web interface, a searchable reference catalog for exploring lncRNA functions and pathway-dependencies in immune cells. …”
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Le fromage en Gaule à l’âge du Fer et à l’époque romaine : état des lieux pour sa production et analyse de sa place dans le monde antique by Alain Ferdière, Jean-Marc Séguier

“…It also meant examining the data published or recorded in excavation reports and eliminating the numerous parasitic elements that constitute various other “potsherds pierced with small holes” which have the most diverse functions –and are not always well identified– certainly far removed from the straining of curdled milk. …”
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