Developmental regulators in promoting genetic transformation efficiency in maize and other plants by Yilin Jiang, Xun Wei, Meirui Zhu, Xiaoyan Zhang, Qingping Jiang, ZiXiao Wang, Yanyong Cao, Xueli An, Xiangyuan Wan

“…Through multi-omics data analysis, we identified 12 homologous DRs from various species that are potentially applicable to maize. …”
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Climate and anthropogenic activities control the concentrations of copper, zinc, cadmium and chromium in global inland waters by Xia Jin, Qiqian Wu, Josep Peñuelas, Jordi Sardan, Yan Peng, Zimin Li, Xin Peng, Petr Heděnec, Qiao Yang, Chaoxiang Yuan, Ji Yuan, Zihao Chen, Zemin Zhao, Fuzhong Wu, Kai Yue

“…Abstract Pollution by heavy metals (Cu, Zn, Cd, Cr) in global inland waters poses significant threats to freshwater biodiversity and ecosystem function, yet the global patterns and drivers of heavy metals remain poorly explored. …”
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Reevaluating the role of Pou3f1 in striatal development: Evidence from transgenic mouse models by Xiaolei Song, Fengzhu Zhang, Danyu Han, Jingzhe Yu, Qian Ren, Xiaoming Xin, Rongliang Guo, Weidong Le

“…Recently, a comprehensive analysis of the human embryonic scRNA-seq dataset predicted and emphasized the bridging function of POU3F1 between striatal progenitor cells and immature neurons, though this finding lacked genetic validation. …”
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Huppke–Brendel syndrome: Novel cases and a therapeutic trial with ketogenic diet and N‐acetylcysteine by Katarina Šikić, Tessa M. A. Peters, Udo Engelke, Danijela Petković Ramadža, Tamara Žigman, Ksenija Fumić, Maša Davidović, Sanda Huljev Frković, Tibor Körmendy, Diego Martinelli, Antonio Novelli, Francesca Romana Lepri, Ron A. Wevers, Ivo Barić

“…Although there are some assumptions, the function of AT‐1 is still not clear and further studies are needed to better understand mechanisms underlying this complex disorder.…”
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Machine learning-driven integration of time-series InSAR and multiple surface factors for landslide identification and susceptibility assessment by Qianyu Wang, Wen Zhang, Jinglin Li, Ziyang Li, Zhi Luo, Qiang Zhao, Jianbo Jian, Fang Shangguan, Yuanxing Yang, Yangyang Ma, Zhen Zhang, Shuangming Zhao, Linyi Li, Lingkui Meng

“…This model operates independently of historical landslide inventory data. Based on the delineated landslide areas, we enhanced the information value model using the inverse tangent function, which was then integrated with Random Forest and Extreme Gradient Boosting methods for landslide susceptibility assessment. …”
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Protocol and research program of the European registry and biobank for interstitial lung diseases (eurILDreg) by Ekaterina Krauss, Silke Tello, Jennifer Naumann, Sandra Wobisch, Clemens Ruppert, Stefan Kuhn, Poornima Mahavadi, Raphael W. Majeed, Philippe Bonniaud, Maria Molina-Molina, Athol Wells, Nik Hirani, Carlo Vancheri, Simon Walsh, Matthias Griese, Bruno Crestani, Andreas Guenther, on behalf of further eurILDreg investigators, RARE-ILD investigators

“…Collaborating with the RARE-ILD consortium, the eurILDreg aims to comprehensively describe different ILDs, analyze genetically defined forms across age groups, create innovative diagnostic and therapeutic biomarkers, and employ artificial intelligence for data analysis. Methods The foundation of eurILDreg is built on a comprehensive parameter list developed and adopted by clinical experts, encompassing over 1,800 distinct parameters related to patient history, clinical examinations, diagnosis, lung function and biospecimen collection. …”
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Research on the GST gene family in Salix lindleyana reveals Trp162 and Pro202 as key amino acids controlling the release rate of GS-X by Nan Xu, Yu-Wen Wang, Chang Qu, Zhao-Qun Wu, Xiu-Xing Zhang, Shi-Yi Wang, Ye-Bo Yang, Jing Xue, Hai-Ling Yang

“…Abstract The adaptive evolution of the glutathione S-transferase (GST) gene family in Salix lindleyana provides insights into the relationship between enzyme structure and function. In this study, 37 genes encoding the GST protein were cloned from S. lindleyana with no genomic data available, and their expression levels and enzyme activity were determined in vitro. …”
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Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma by Fanjie Meng, Hao Li, Ruoyi Jin, Airong Yang, Hao Luo, Xiao Li, Peiyu Wang, Yaxing Zhao, Olga Chervova, Kaicheng Tang, Sida Cheng, Bin Hu, Yun Li, Jianpeng Sheng, Fan Yang, David Carbone, Kezhong Chen, Jun Wang

“…Additionally, we used multiplex immunohistochemistry (mIHC) on a propensity score-matched cohort, which enabled us to profile the immune microenvironment of primary tumors in detail while preserving cellular metaclusters, interactions, and neighborhood functional units. By integrating data from NGS and mIHC, we successfully identified spatial immunogenomic patterns and developed a predictive model for LN metastasis, which was subsequently validated independently. …”
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New susceptibility loci associated with kidney disease in type 1 diabetes. by Niina Sandholm, Rany M Salem, Amy Jayne McKnight, Eoin P Brennan, Carol Forsblom, Tamara Isakova, Gareth J McKay, Winfred W Williams, Denise M Sadlier, Ville-Petteri Mäkinen, Elizabeth J Swan, Cameron Palmer, Andrew P Boright, Emma Ahlqvist, Harshal A Deshmukh, Benjamin J Keller, Huateng Huang, Aila J Ahola, Emma Fagerholm, Daniel Gordin, Valma Harjutsalo, Bing He, Outi Heikkilä, Kustaa Hietala, Janne Kytö, Päivi Lahermo, Markku Lehto, Raija Lithovius, Anne-May Osterholm, Maija Parkkonen, Janne Pitkäniemi, Milla Rosengård-Bärlund, Markku Saraheimo, Cinzia Sarti, Jenny Söderlund, Aino Soro-Paavonen, Anna Syreeni, Lena M Thorn, Heikki Tikkanen, Nina Tolonen, Karl Tryggvason, Jaakko Tuomilehto, Johan Wadén, Geoffrey V Gill, Sarah Prior, Candace Guiducci, Daniel B Mirel, Andrew Taylor, S Mohsen Hosseini, DCCT/EDIC Research Group, Hans-Henrik Parving, Peter Rossing, Lise Tarnow, Claes Ladenvall, François Alhenc-Gelas, Pierre Lefebvre, Vincent Rigalleau, Ronan Roussel, David-Alexandre Tregouet, Anna Maestroni, Silvia Maestroni, Henrik Falhammar, Tianwei Gu, Anna Möllsten, Danut Cimponeriu, Mihai Ioana, Maria Mota, Eugen Mota, Cristian Serafinceanu, Monica Stavarachi, Robert L Hanson, Robert G Nelson, Matthias Kretzler, Helen M Colhoun, Nicolae Mircea Panduru, Harvest F Gu, Kerstin Brismar, Gianpaolo Zerbini, Samy Hadjadj, Michel Marre, Leif Groop, Maria Lajer, Shelley B Bull, Daryl Waggott, Andrew D Paterson, David A Savage, Stephen C Bain, Finian Martin, Joel N Hirschhorn, Catherine Godson, Jose C Florez, Per-Henrik Groop, Alexander P Maxwell

“…Functional data suggest that AFF3 influences renal tubule fibrosis via the transforming growth factor-beta (TGF-β1) pathway. …”
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The impact of METTL3 on bladder cancer through m6A modification: a potential therapeutic target and prognostic biomarker by Dong Wen, Pengcheng Fu, Geliu Shuai, Yuebin Wang, Shengxin Yu, Huiquan Liu, Wei Wan, Junrong Zou, Junrong Zou, Xiaofeng Zou, Xiaofeng Zou, Xiaofeng Zou

“…This review aims to systematically explore the role of METTL3 in BCa, including its biological function, expression characteristics, potential therapeutic targets, and prognosis related research progress. …”
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Downregulation of AKT-mediated p27Kip1 phosphorylation with shift to sphingomyelin synthesis in CLN3 disease by Fatima Bilal, Jihane Soueid, Sara Saab, Nadine Makhoul, Zeinab Hamze, Lara El-Bazzal, Joelle Makoukji, Rose-Mary Boustany

“…AKT, a serine/threonine protein kinase, is at the core of a complex signaling pathway regulating apoptosis and cell proliferation and is neuroprotective. AKT fulfils this function via cyclin-dependent kinase inhibitor p27Kip1 phosphorylation at residue T198 resulting in its cytoplasmic localization and promotion of cell survival. …”
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Rescuing ACE2‐Deficiency‐Mediated Nucleus Pulposus Senescence and Intervertebral Disc Degeneration by a Nanotopology‐Enhanced RNAi System by Kaiqiang Sun, Zijian Kang, Chen Yan, Yan Yu, Linhui Han, Yangyang Shi, Liang Chen, Jiangang Shi, Yu Chen, Jingchuan Sun

“…Using both loss‐ and gain‐of‐function mouse models, it is revealed that ACE2 deficiency increased the senescence of NPCs and exacerbated injury‐ or instability‐induced IVDD, whereas ACE2 overexpression counteracted these detrimental effects. …”
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Use of ICT to Confront COVID-19 by Yousry Saber El Gamal

“…The risk of getting infected is a function of numerous factors where mathematical modeling would not yield fruitful results. …”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

“…Functional experiments demonstrate the requirement of PLAC8 in SARS-CoV-2 pancreatic productive infection by pseudovirus and full SARS-CoV-2 infectious virus inoculum from Wuhan-1 and BA.1 strains. …”
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Population prevalence and correlates of prolonged and shortened QTc intervals in a nationwide survey of adults in China: a report from Chinese arrhythmia epidemiology cross-section... by Li-Guo Tan, Li-Guo Tan, Jing-Xuan Liu, Fei Guo, Jing Lin, Ran Xiong, Hao Fu, Hao-Ming You, Liu He, Shi-Jun Xia, Xin Du, Jian-Zeng Dong

“…Individuals with QTc < 320 ms were not observed in this study. Abnormal renal function (eGFR (estimated glomerular filtration rate) <90 ml/min/m2) was independently linked to an elevated risk of short QTc intervals; hypertension was strongly associated with reduced short QTc intervals.ConclusionThis study provides epidemiological data on the distribution of QT intervals in Chinese adults. …”
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Factors contributing to persistent shoulder pain after arthroscopic rotator cuff repair: Protocol for a scoping review [version 2; peer review: 2 approved] by G Arun Maiya, Mira Meeus, James Elliott M, Prabu Raja G, Vivek Pandey, Kiran K V Acharya, Anupama Prabhu B

“…Although most individuals show improvement in function and pain following arthroscopic rotator cuff repair (ARCR), a subgroup of patients continue to suffer from persistent shoulder pain following the surgical procedure. …”
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XV-AMD: An Explainable Vision Transformer Detection Framework for Age-Related Macular Degeneration Using Fundus Imaging by Aya A. Abd El-Khalek, Hossam Magdy Balaha, Mohamed T. Azam, Ashraf Sewelam, Mohammed Ghazal, Abeer T. Khalil, Mohy Eldin A. Abo-Elsoud, Ayman El-Baz

“…Through a systematic preprocessing pipeline, including average cumulative distribution function (CDF) calculation and contrast limited adaptive histogram equalization (CLAHE), our approach enhances image quality and prepares data for analysis. …”
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Image Quality and Information Parameters of Electronic Portal Imaging Devices by Marios K. Tzomakas, Vasiliki Peppa, Antigoni Alexiou, Georgios Karakatsanis, Anastasios Episkopakis, Christos Michail, Ioannis Valais, George Fountos, Nektarios Kalyvas, Ioannis S. Kandarakis

“…In this study, the imaging performance of electronic portal imaging devices (EPIDs) is evaluated, comparing measurements collected from EPID images captured at 115 cm, with a field size of 15 × 15 cm², monitor units (MUs) in the range of 2 MU-100 MU and dose rates (DRs) of 200 MU/min, 400 MU/min and 600 MU/min, using a 6 MV LINAC system and the QC-3V image quality phantom. The analysis includes the normalized contrast transfer function (CTFnorm), the noise power spectrum (NPS) and the information capacity (IC), as well as the signal-to-noise frequency response (SNFR), which can be used as a comprehensive quality index. …”
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SFD-YOLO: A novel framework for subsidence funnels detection in China based on large-scale SAR interferograms by Jing Guo, Zhengjia Zhang, Peifeng Ma, Mengmeng Wang, Xuefei Zhang, Dongdong Li, Bing Sui

“…Overall, subsidence funnels are predominantly distributed in northern and northwestern China. Further analysis and experimental evaluation reveal that the SFD-YOLO model exhibits strong generalization capabilities across complex surface environments nationwide and multi-source satellite data.…”
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Association of Cardiovascular Disease Mortality and Ambient Temperature Variation in Shanghai, China: Beyond Air Quality Index PM_2.5 by Qi Li, Shizhen Li, Ting Zhai, Shan Jin, Chunfang Wang, Bo Fang, Tian Xia

“…The daily PM_2.5 concentration was transformed using a natural spline (ns) function and integrated into the model for adjustment. …”
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