Profiling of innate and adaptive immune cells during influenza virus infection reveals sex bias in invariant natural killer T (iNKT) cells by Piotr Humeniuk, Aidan Barrett, Hannes Axelsson, Carmen Corciulo, Christina Drevinge, Alicia Del Carpio Pons, Davide Angeletti, Julia M. Scheffler, Ulrika Islander

“…Invariant natural killer T (iNKT) cells are fast‐reacting forces and modulators of immune responses that are important to IAV immunity, but it is not known if the presence and function of iNKT cells differ between females and males. …”
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Genomic insights into the plasmidome of non-tuberculous mycobacteria by Margo Diricks, Florian P. Maurer, Viola Dreyer, Ivan Barilar, Christian Utpatel, Matthias Merker, Nils Wetzstein, Stefan Niemann

“…The annotated plasmids varied widely in length (most between 10 and 400 kbp) and gene content, with many genes having an unknown function. Predicted gene functions primarily involved plasmid replication, segregation, maintenance, and mobility. …”
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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…The study objectives are to: (1) map the patient pathway and identify the characteristics of adult patients presenting to NHS ENT and hearing services with SSNHL, (2) develop a prognostic model to predict recovery for patients with idiopathic SSNHL and (3) establish the impact of idiopathic SSNHL on patients’ quality of life (QoL).Methods and analysis Study design: national multicentre prospective cohort study across 97 NHS trusts.Inclusion criteria: adult patients presenting to NHS ENT and hearing services with SSNHL.Outcomes: change in auditory function; change in QoL score.Analysis: multivariable prognostic model, using prespecified candidate predictors. …”
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Stereotactic body radiotherapy with carbon ions as local ablative treatment in patients with primary liver cancer by Paula Hoffmeister-Wittmann, Philipp Hoegen-Saßmannshausen, Livia Wicklein, Fabian Weykamp, Katharina Seidensaal, Christoph Springfeld, Michael T. Dill, Thomas Longerich, Peter Schirmacher, Arianeb Mehrabi, René Michael Mathy, Bruno C. Köhler, Jürgen Debus, Klaus Herfarth, Jakob Liermann

“…No significant impairment of liver function was observed in either cohort. Conclusion In this retrospective analysis, patients who received CIRT presented excellent local tumor control and had better oncologic outcomes than patients who received photon-based SBRT. …”
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An Equilibrium Model of the Galaxy Determined by Element Abundance Gradients by Lawrence M. Widrow, David W. Hogg, Danny Horta, Haochaun Li, Adrian M. Price-Whelan

“…We also use N -body simulations to test the extent by which secular evolution in the disk introduces statistical and systematic errors into the analysis. We apply our method to a sample of stars from Gaia Data Release 3 and the APOGEE survey and infer the vertical force profile at the position of the Sun and the rotation curve in the midplane and find good agreement with previously published results. …”
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Construction and validation of a prognostic model based on cuproptosis-related genes in patients with multiple myeloma by KANG Zhongmin, KANG Zhongmin, LI Licheng

“…The differences between the high- and low-risk cohorts were explored using Kaplan-Meier survival curve analysis and immune microenvironment correlation analysis. ② RT-qPCR and Western blotting were used to verify the expression of prognostic model genes in MM cell lines and normal bone marrow single-nucleated cells, and CCK-8 assay, flow cytometry, and Western blotting were applied to verify the biological function of UBE2D1 in MM cells. …”
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Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acidA receptors by Anika Fuhr, Robin Roediger, Mariana Simelitidis, Jutta Gamper-Tsigaras, Markus Templin, Michael Kormann, Bernd Antkowiak, Uwe Rudolph, David Köhler, Peter Rosenberger, Kristian-Christos Ngamsri, Franziska M. Konrad

“…Only Muscimol lowered protein extravasation, improved blood gas analysis and lung function. A multiplex assay ascribed these anti-inflammatory effects to the influence of the IL-6 and phosphoinositide 3-kinase signaling pathways. …”
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Pretransplant NT‐proBNP levels are associated with mortality among lung transplant recipients by Shimon Izhakian, Assaf Frajman, Ariel D. Hayat, Alon Gorenshtein, Osnat Shtraichman, Lev Freidkin, Dror Rosengarten, Mordechai R. Kramer

“…Correlations of NT‐proBNP values with lung function and RHC parameters and all‐cause mortality were analyzed. …”
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Effects of angiotensin receptor–neprilysin inhibition on myocardial energy metabolism and prognosis in patients with acute myocardial infarction complicated by heart failure by Caiming Cheng, Caiming Cheng, Caiming Cheng, Yu Nie, Yu Nie, Di Chen, Di Chen, Yan Yang, Yan Yang, Shunji Liang, Qin Yu

“…ObjectiveThis study aims to evaluate the effects of angiotensin receptor–neprilysin inhibitor (ARNI) on myocardial energy metabolism and prognosis in patients with acute myocardial infarction (AMI) complicated by heart failure (HF).MethodsA retrospective analysis was conducted on data from 244 inpatients admitted to our center, who were diagnosed with AMI complicated by HF. …”
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Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci. by Samuel E Jones, Jessica Tyrrell, Andrew R Wood, Robin N Beaumont, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Youna Hu, Maris Teder-Laving, Caroline Hayward, Till Roenneberg, James F Wilson, Fabiola Del Greco, Andrew A Hicks, Chol Shin, Chang-Ho Yun, Seung Ku Lee, Andres Metspalu, Enda M Byrne, Philip R Gehrman, Henning Tiemeier, Karla V Allebrandt, Rachel M Freathy, Anna Murray, David A Hinds, Timothy M Frayling, Michael N Weedon

“…The PER2 signal has previously been associated with iris function. We sought replication using self-reported data from 89,283 23andMe participants; thirteen of the chronotype signals remained associated at P<5x10-8 on meta-analysis and eleven of these reached P<0.05 in the same direction in the 23andMe study. …”
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Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients by Luo Jie-yu, Ding Zi-jun, Zhang Chun-jiang, Jin Xin, Hao Wen-juan, Zhao Dan

“…The general and laboratory data of the patients were collected. Cognitive function was evaluated with the Chinese version of Montreal Cognitive Assessment Scale （C-MoCA）. …”
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Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing by Lijuan Li, Mi Tao, Xueyun Gao, Quan Cao, Zejing Liao, Feng Chen, Ayinigaer Yusufu, Haihang Nie, Ziyue Zeng, Kai Huang, Xuan Deng, Ping Gao, Xiaoyan Wu

“…In the STZ mouse model, PROM1 correlated with fibrosis and diminished renal function, whereas THY1 exhibited protective effects. …”
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Global characterization of mouse testis O-glycoproteome landscape during spermatogenesis by Qiannan Liu, Xiaoyan Lu, Yao Deng, Han Zhang, Rumeng Wei, Hongrui Li, Ying Feng, Juan Wei, Fang Ma, Yan Zhang, Xia Zou

“…Notably, the importance of O-glycosylation was supported by its effects on the stability, cleavage, and interaction of acrosomal proteins. Collectively, these data illustrate the global properties of O-glycosylation in testis, providing insights and resources for future functional studies targeting O-glycosylation dysregulation in male infertility.…”
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<i>AtPADRE13</i> Negatively Regulates Salt Stress Tolerance in <i>Arabidopsis thaliana</i> by Ziru Chang, Xiaona Tian, Xiaocui Niu, Meiting Bai, Wei Bai, Ruigang Wang, Guojing Li, Qi Yang

“…After salt treatment, the overexpression lines presented a significantly lower survival rate, increased MDA (Malondialdehyde) content, and reduced antioxidant enzyme activities compared with the wild-type, and were more sensitive to salt stress. Transcriptome data analysis further revealed that <i>AtPADRE13</i> overexpression resulted in different degrees of down-regulation for a series of positive regulators related to ABA catabolism, transport, and their mediated plant responses to salt stress. …”
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Sentry 'towers' of Isfijab in archaeological cartography by B.A. Baitanayev, M.A. Antonov, A.A. Yergeshbayev, A.Kh. Shayakhmetov

“…A digital map with data on the visibility of the chains of monuments and their functioning in the settlements of the region was created. …”
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Radial Symmetry and Monotonicity of Solutions to a System Involving Fractional p-Laplacian in a Ball by Linfen Cao, Xiaoshan Wang, Zhaohui Dai

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Transcriptomics‐Based Liquid Biopsy for Early Detection of Recurrence in Locally Advanced Gastric Cancer by Ping'an Ding, Jiaxiang Wu, Haotian Wu, Tongkun Li, Xiaoman Niu, Peigang Yang, Honghai Guo, Yuan Tian, Jinchen He, Jiaxuan Yang, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Lingjiao Meng, Qun Zhao

“…Four mRNA biomarkers (AGTR1, DNER, EPHA7, and SUSD5) linked to recurrence are identified through transcriptomic data analysis. A Risk Stratification Assessment (RSA) model combining these biomarkers with clinical features showed superior predictive accuracy for postoperative recurrence, with AUCs of 0.919 and 0.935 in surgical and liquid biopsy validation cohorts, respectively. …”
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Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies by Pekka Kallunki, Florence Sotty, Katarina Willén, Michal Lubas, Laurent David, Malene Ambjørn, Ann-Louise Bergström, Louise Buur, Ibrahim Malik, Steffen Nyegaard, Thomas Thiilmark Eriksen, Berit O. Krogh, Jeffrey B. Stavenhagen, Kathrine J. Andersen, Lars Ø. Pedersen, Ersoy Cholak, Edward N. van den Brink, Rik Rademaker, Tom Vink, David Satijn, Paul W.H.I. Parren, Søren Christensen, Line R. Olsen, Josefine N. Søderberg, Sandra Vergo, Allan Jensen, Jan Egebjerg, Pernille Gry Wulff-Larsen, Mikkel N. Harndahl, Dina S. M. Damlund, Kaare Bjerregaard-Andersen, Karina Fog

“…The epitope of amlenetug was mapped to amino acids 112-117 and further characterized by crystallographic structure analysis. Based on our data, we hypothesize that targeting α-synuclein will potentially slow further disease progression by inhibiting further pathology development but be without impact on established pathology and symptoms.…”
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Effect of sodium promotion on zinc-ferrite catalysts for CO and CO2 co-conversion: Insights from in situ and theoretical studies by Mansurbek Urol ugli Abdullaev, Gyungah Park, Nam Sun Kim, Jin-Ju Lee, Yang Sik Yun, Jung Ho Shin, Hee-Joon Chun, Yong Tae Kim

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Models, systems, networks in economics, engineering, nature and society by M.I. Krevskiy, A.S. Bozhday

“…The methods of assessing the quality of stochastic process models, alignment of business process paths, predictive analysis, event data analysis and methods of advisory support of business processes are considered. …”