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Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis
Published 2019-05-01“…Objectives This multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease—ILD, emphysema or neither).Methods Chest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. …”
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16383
Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity
Published 2025-01-01“…Mechanically, ex vivo human and mouse Treg cell data and in vivo mouse tumor models suggest that SOAT2 overexpression in Treg cells promotes cholesterol metabolism by activating the SREBP2-HMGCR-GGPP pathway, leading to enhanced Treg suppresser functions but reduced CD8+ T cell proliferation, migration, homeostasis and anti-tumor immunity. …”
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16384
Automation of the complex ecological monitoring of the territory of the airport using the method of machine learning
Published 2017-08-01“…The structure of such system, the sources of its data and the functionality have been described. The system of the environmental forecasts formation with machine learning elements has been presented. …”
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16385
A Mobile App for Promoting Breastfeeding-Friendly Communities in Hong Kong: Design and Development Study
Published 2025-01-01“…For the usability evaluation, semistructured, in-depth, one-to-one interviews were conducted with breastfeeding individuals (n=30) to understand their experiences of using bfGPS. Content analysis was used to analyze the data. …”
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16386
Effects of exopolysaccharides from Rhizobium tropici on transformation and aggregate sizes of iron oxides
Published 2024-12-01“…The characterization of the EPS-iron oxide composites was carried out using X-ray Powder Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM)/Energy Dispersive X-ray Analysis (EDX). The EPS adsorption kinetics revealed chemisorption and diffusion as controlling processes for EPS adsorption on Fe3O4, while isotherm data with releasing proton indicated possible ion exchange and heterogeneous layered adsorption. …”
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16387
Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway
Published 2025-05-01“…Functional enrichment analyses were performed to compare molecular features between low and high TLR3 expression groups using gene set variation analysis (GSVA). …”
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16388
Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors
Published 2022-02-01“…We used inhibitors of mitochondrial functions and Seahorse Flux Analyzer to investigate the mechanism underlying the effect of PQDN on T cells. …”
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16389
Genome-wide analyses reveal intricate genetic mechanisms underlying egg production efficiency in chickens
Published 2025-08-01“…By combining the signals of Singleton Density Score (SDS), which is a population-genetic statistic designed to detect recent selection by leveraging the distribution of singletons, and association analyses, multiple egg-laying traits related to egg production efficiency were found to have experienced polygenic selection. Consistently, functional analysis of associated genes demonstrates that egg production efficiency benefits from multiple physiological functions. …”
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16390
Adipocytes reprogram the proteome of breast cancer cells in organotypic three-dimensional cell cultures
Published 2024-11-01“…Of these, 605 showed no significant changes in abundance, whereas 87 proteins were significantly upregulated and 224 downregulated after interaction with fat cells (p < 0.05, FC > 2.0). Bioinformatic analysis of upregulated proteins indicated that the most enriched GO terms and molecular functions were related to lipids transport, cell differentiation, hypoxia response, and cell junctions. …”
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16391
DETERMINATION OF THE QUALITY OF LIFE OF PATIENTS WITH CONGENITAL CLEFT OF THE UPPER LIP AND PALATE BEFORE AND AFTER THEIR ORTHOPEDIC REHABILITATION
Published 2020-12-01“…Inadequate aesthetic condition of the oral cavity, which is formed after a comprehensive treatment, along with the functions of chewing and speech, most significantly affects the life quality. …”
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Optimization of medium components for the production of exopolysaccharide by Lycoperdon pyriforme Schaeff.: Pers. using response surface methodology
Published 2013-09-01“…A total of 15 experimental runs (with three factors at three levels) were conducted to determine the optimum combination of these medium components by ANOVA analysis of experimental data. A second-order polynomial models with EPS yield as response variable was then obtained and confirmed to adequately represent the actual relationship between the independent variables and responses through validation tests. …”
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16393
Determining the Bioavailability Percentage of Bone Ash Phosphorus Compared to Monocalcium Phosphate and Its Effect on Performance, Bone Quality and Phosphorus Digestibility in Broi...
Published 2024-06-01“…Also, the percentage of P digestibility increased numerically with the increase in diet P and the use of BA. Also, factorial analysis of the data related to the production of antibody titer against sheep red blood cells, we observed that the only significant difference in the main effects was for the total antibody titer and IgG in the secondary response; So that the antibody titer produced in the secondary response was significantly higher in chickens fed with monocalcium phosphate than in chickens fed with bone ash (P<0.05). …”
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Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers
Published 2025-03-01“…Here, we conducted a pan-cancer analysis integrating multi-omics data from cell lines, single-cell RNA sequencing, and pan-cancer and immunotherapy datasets to explore the dynamic interplay between m6A modification and TEX. …”
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Cardiac power output ratio: Novel survival predictor after percutaneous ventricular assist device in cardiogenic shock
Published 2024-12-01“…Abstract Aims Currently, there is limited data on prognostic indicators after insertion of percutaneous ventricular assist device (PVAD) in the treatment of cardiogenic shock (CS). …”
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16396
Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators
Published 2021-01-01“…We previously demonstrated that Lactobacillus brevis-derived long-chain polyphosphate (poly P) improved the intestinal barrier function by the upregulation of cell adhesion and relieved intestinal inflammation, thereby exerting a curing effect on colitis in vitro, in vivo, and in an investigator-initiated clinical study of UC. …”
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16397
EFFECTS OF SMOKING IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS RECEIVING TUMOR NECROSIS FACTOR INHIBITORS THERAPY
Published 2022-07-01“…Mann-Whitney U and Spearman correlation analysis tests were used for data analysis Results: Comparison of the smoker (n=121) and non-smoker groups (n=90) revealed BASMI was lower in the non-smoker group (p=0.04). …”
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CHARACTERISTIC FEATURES OF PARATEXTS IN UKRAINIAN TRANSLATIONS OF THE HOLY SCRIPTURES
Published 2024-06-01“…The comparative translation analysis provides a historically based translation quality assessment. …”
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Peptide Toxin Diversity and a Novel Antimicrobial Peptide from the Spider <i>Oxyopes forcipiformis</i>
Published 2024-10-01“…This study presents a transcriptome analysis of venom glands from an undescribed <i>Oxyopes forcipiformis</i> species, revealing 339 putative protein and peptide toxin sequences categorized into seven functional groups. …”
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SPATIAL PECULIARITIES OF LOCAL TOURISM SUPPLY CHAINS IN HIGH-MOUNTAINOUS GEORGIA: CHALLENGES AND PERSPECTIVES
Published 2019-01-01“…The empirical data was analyzed on the basis of a seven-step thematic analysis method processed hrough qualitative data analysis software (MAXQDA). …”
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