Hybrid immunity and host factors: implications on serostatus induced by COVID-19 vaccines by Franklin E. Torres-Jiménez, Evelyn Mendoza-Torres, Adalgisa E. Alcocer-Olaciregui, María F. Torres-Ferias, Daniel A. Mendoza-Zapata, Mariangel Cantillo-Barrios, David J. Echeverría-Bernal, Valentina Varón-Toscano, Giselle P. Pineda-Awadalla

“…Sociodemographic, clinical, and vaccination data were collected via survey. Statistical comparisons were performed using t-tests, Mann–Whitney U tests, and linear regression analysis. …”
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Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma by Akihiko Kawahara, Jun Akiba, Hirohisa Yano, Ambrogio Fassina, Rocco Cappellesso, Yoshiki Naito, Maria Guido, Paolo Simioni, Giuliana Cortese, Lorenzo Nicolè, Tiziana Sanavia, Valeria Maffeis, Claudia Maria Radu, Davide Serafin, Giacomo Zanus

“…However, in HCC, the relationship between the necroptotic machinery and the tumor-infiltrating lymphocytes has not been fully investigated so far.Methods We investigated the association between the main necroptosis-related genes, that is, RIPK1, RIPK3, MLKL-p, and CD3+/CD8+ tumor-infiltrating T cell by RNA-seq data analysis in 371 patients with primary HCC from The Cancer Genome Atlas and then by immunohistochemistry in two independent cohorts of HCC patients from Italy (82) and Japan (86).Results Our findings highlighted the immunogenetic role of necroptosis and its potential prognostic role in HCC: RIPK1, RIPK3 and MLKL-p were found significantly associated with intratumoral CD3+ and CD8+ T cells. …”
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Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias by Venkata K. Yellepeddi, Mohamed Ismail, T. Jared Bunch, Thomas F. Deering, Richard Holubkov, Robert Kennedy, Suneet Mittal, Marco Perez, Jonathan P. Piccini, Parash Pokharel, Salvatore Savona, Nishant Verma, Benjamin Steinberg, Kevin Watt

“…This study evaluates the population pharmacokinetics (PK) and pharmacodynamics (PD) of sotalol using data from the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry, which includes patients with atrial arrhythmias undergoing IV sotalol loading. …”
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Breaking down the recovery of O2 pathway: Peripheral extraction recovery pattern defines exercise capacity and clinical outcomes by Ahmed El Shaer, Mariana Garcia‐Arango, Anas Abed, Shannon Heffernan, Yuning Wang, Tashfeen Javed, Amirhossein Esmaeeli, Abdul Wahab Arif, Ran Tao, Naga Dharmavaram, James Runo, Jill N. Barnes, Farhan Raza

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Viterbi-Viterbi Carrier Phase Estimation for Multi-Ring <inline-formula><tex-math notation="LaTeX">$M$</tex-math></inline-formula>-APSK With Wiener Carrier Phase Noise and Its Perf... by Qian Wang, Wenqiang Ma, Li Ping Qian, Xinwei Du, Changyuan Yu, Pooi-Yuen Kam

“…High-order modulations are currently widely used in optical communications to increase the data rate. However, due to the existence of laser phase noise, the performance of high-order modulated systems will be greatly degraded. …”
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Identification of stemness subtypes and prognostic modeling in thyroid cancer: the critical role of DPYSL3 in tumor progression and immune microenvironment by Jialong Yu, Wei Luo, Guangwei Xu, Mei Tao, Yuqi Wang, Qiman Dong, Linfei Hu, Xiukun Hou, Jingzhu Zhao, Dapeng Li, Songfeng Wei, Xianhui Ruan, Xiangqian Zheng

“…This model revealed that patients in the high-risk group had lower progression-free survival (PFS) but may benefit more from immune checkpoint blockade therapy, as indicated by TIME analysis. Functional experiments demonstrated that the stemness signature gene DPYSL3 promotes the proliferation, migration, and invasion of thyroid cancer cells and is associated with cancer stem cell properties. …”
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TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer by Yue Jia, Jiaqian Liao, Xiangqun Yang, Hongyan Hu, Wentao Zhao, Liufang Zhao, Conghui Ai, Yuanbo Xue, Shufen Tan, Yi Zhang

“…In this study, we investigated the functional significance of the gene TIMM8B, which is differentially expressed in ovarian cancer to better understand the molecular processes involved in the development of this disease. …”
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Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation by Erik P. Hughes, Erik P. Hughes, Asit K. Manna, Asit K. Manna, Wenxiang Sun, Sandra M. Osburn-Staker, Samuel Aamodt, Kristi J. Warren, James E. Cox, Dean Tantin, Dean Tantin

“…DNA binding data using recombinant proteins and reporter data using T cell lines are consistent with a model in which OCA-B restricts transcription at the Th2 locus control region and subsequent IL-4 and IL-13 secretion. …”
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THE ROLE OF DIET DURING HEALTH EDUCATION PROGRAMS FOR THE IMPROVEMENT OF CLINICAL OUTCOMES IN COPD PATIENTS: LITERATURE REVIEW by Rita Citarella, Adriano Brenca, Myriam Palomba, Maria Guarnaccia, Giuseppina Gargiulo, Diodato Ferrante, Jessica Marano, Aniello Lanzuise, Serena Pannetta

“…Materials and methods: For this scope, a review process was conducted following these five steps: 1) identification of the research problem, 2) literature research, 3) data evaluation, 4) data analysis and 5) presentation of the synthesis of the results. …”
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Effects of Saharan Dust Advection on Atmospheric Aerosol Properties in the West-Mediterranean Area by G. Pavese, M. Calvello, F. Esposito, L. Leone, R. Restieri

“…Daily averaged volume size distributions can be unimodal or bimodal functions and one three-modal distribution, with a coarse mode generally prevailing. …”
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Genome-wide identification and expression of the HB gene family during overwintering in Korla pear (Pyrus sinkiangensis) by LIU Xiaoyan, WANG Lijuan, YANG Shenghui, LUO Guanghong, ZHU Jianbo

“…Additionally, 41.94% and 54.84% of the PsHB genes contained low-temperature responsive elements (LTR) and drought-responsive elements (MBS), respectively. Transcriptome data analysis during three stages of the overwintering process in P. sinkiangensis revealed that 39 out of the 93 PsHB genes were differentially expressed. …”
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Socioeconomic status and lifestyle as factors of multimorbidity among older adults in China: results from the China Health and Retirement Longitudinal Survey by Wei Gong, Wei Gong, Wei Gong, Xiaoxiao Hu, Huimin Cui, Huimin Cui, Yuxin Zhao, Yuxin Zhao, Hong Lin, Hong Lin, Hong Lin, Peng Sun, Peng Sun, Jianjun Yang, Jianjun Yang

“…Subgroup analyses showed variated associations by age and sex, with psychological and geographic factors playing a larger role among those aged ≥80.ConclusionThis study demonstrated the feasibility and interpretability of using machine learning to model complex risk patterns of multimorbidity. Socioeconomic and functional variables were dominant factors associated with multimorbidity, suggesting structural roots of health inequality. …”
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Decoding the hypoxic tumor microenvironment in colorectal cancer for prognostic modeling and therapeutic target discovery by Xiao-Cui Duan, Yan Zhou, Fan Feng, Hai-Bo Jiang, Mei-Lin Wang, Zhe Han, Hong-Fei Pang, Yu-Hang Liu, Heng-Zhe Jia, Meng- He, Hong-Pan Xu, Yuan-Yuan Wang

“…Finally, in vitro assays assessed the functional role of GIPC2, a model gene, in CRC cell lines.ResultsSingle-cell profiling uncovered eight distinct hypoxic clusters, with H3 exhibiting the highest hypoxia scores and enrichment in glycoprotein metabolic and angiogenesis pathways. …”
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Predicting 30-Day Venous Thromboembolism Following Total Joint Arthroplasty: Adjusting for Trends in Annual Length of Stay by Johnathan R. Lex, MBChB, MASc, Robert Koucheki, MD, MEng, Aazad Abbas, MD, Jesse I. Wolfstadt, MD, MSc, FRCSC, FAAOS, Alexander S. McLawhorn, MD, MBA, Bheeshma Ravi, MD, PhD, FRCSC

“…The logistic regression model trained on all data with a balanced loss scoring function performed the best (area under the curve = 0.600). …”
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Prediction Equations for Calculating Maximal Inspiratory Pressure from Spirometry and Thoracic Ultrasound After COVID-19 with Gastroesophageal Reflux Disease in Indonesian Adults... by Siti Chandra Widjanantie, Ari Fahrial Syam, Nury Nusdwinuringtyas, Agus Dwi Susanto, Rudy Hidayat, Aria Kekalih, Maria Regina Rachmawati, Maryastuti Maryastuti, Triya Damayanti, Putri Prathiwi, Won Ah Choi, Seong Woong Kang

“…The following tests were used: spirometry (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1); thoracic USG (left diaphragm excursion (LDE) and right diaphragm excursion (RDE); and respirometry (maximal inspiratory pressure (MIP). The data were analyzed using Pearson correlational analysis and multiple linear regression. …”
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Counselling for physical activity, life-space mobility and falls prevention in old age (COSMOS): protocol of a randomised controlled trial by Pekka Kannus, Ari Heinonen, Harri Sievänen, Lasse Kannas, Timo Rantalainen, Johanna Edgren, Saija Karinkanta, Taina Rantanen, Robin Daly, Timo Törmäkangas, Sarianna Sipilä, Outi Teittinen, R Nikander

“…Maintaining lower extremity muscle function with good balance has been associated with fewer falls and the need of help from others. …”
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Uncovering Subclinical Cardiac Involvement in VEDOSS: An Echocardiographic Driven Study by Eugenio Capparelli, Eleonora Zaccara, Ilaria Suardi, Antonella Laria, Laura Castelnovo, Eleonora Mauric, Daniela Bompane, Antonio Tamburello, Maria Iacovantuono, Maria Sole Chimenti, Antonino Mazzone, Paola Faggioli

“…<b>Conclusions:</b> Careful monitoring of cardiac function in VEDOSS patients is crucial as subclinical alterations may occur even in the absence of symptoms. …”
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Regression-based leaf nitrogen concentration estimation of young Cephalotaxus hainanensis in small and imbalanced samples by Mengmeng Shi, Tian Wang, Ling Lin, Qingxue Li, Zhulin Chen, Xingjing Chen, Peng Wang, Xuefeng Wang

“…The research employed an image processing workflow to extract color and texture features, combined with data preprocessing techniques such as natural logarithmic transformation, feature selection based on Least Absolute Shrinkage and Selection Operator (LASSO), and resampling methods, especially the application of the Synthetic Minority Over-Sampling Technique for Regression with Gaussian Noise (SMOGN) and Adaptive Synthetic combined with a relevance function for regression (ADASYNR) to address critical challenges associated with small and imbalanced samples in regression. …”
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基于DSP和FPGA的锥齿轮传动噪声测试分析系统设计 by 刘甜, 吴小平, 陈洪芳, 石照耀

“…To remedy the defects of hearing determine methods which over-reliance on the experience of works andcan not accurately judge the bevel gear mesh quality,a design of bevel gear mesh noise measurement and analysis system based on DSP and FPGA is proposed.DSP used as the controlling and data processing core in the system,collecting noise signal,after filtering,analog-digital conversion,spectrum analysis,bevel gear meshquality is comprehensive judged,By field programmable gate array（FPGA） logic control to coordinate DSP,the entire system functions are achieved.Using keyboard and LCD hardware design,humanmachine interface is implemented.In addition,by serial communication,this system can communicate with PC and implement signal data storage.Generally,the system is favorable for its integrated functions,simple structures and provide a powerful measurement and analysis tool for controlling bevel gear mesh quality.…”
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Trade-off between resistance and persistence in high cell density cultures by F. Beulig, J. Bafna-Rührer, P. E. Jensen, S. H. Kim, A. Patel, V. Kandasamy, C. Steffen, K. Decker, D. Zielinski, L. Yang, E. Özdemir, S. Sudarsan, B. Palsson

“…Knowledge-enriched, machine-learning-based analysis of the >470 transcriptomic samples reveals distinct stress-related gene expression patterns that allow the first functional and quantitative description of associated stimulons. …”
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