TMCO1, as a potential biomarker of prognosis and immunotherapy response, regulates head and neck squamous cell carcinoma proliferation and migration by Ting Li, Lu Chen, Guangkai Zhou, Yuhan Deng, Meng Zhou, Mingze Yan, Shuyan Dong, Kaixun Xing, Shan Yu, Hongjiang He

“…In addition, nomogram and receiver operating characteristic (ROC) curve, gene ontology, gene concentration and gene network analysis were used to reveal the function and regulatory mechanism of TMCO1. …”
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Association between sleep quality and mild cognitive impairment in Chinese patients with type 2 diabetes mellitus: a cross-sectional study by Rehanguli Maimaitituerxun, Hengxue Wang, Wenhang Chen, Jingsha Xiang, Yu Xie, Fang Xiao, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, Songning Ding, Wenjie Dai

“…Sleep quality is thought to be a modifiable factor that may contribute to MCI, as previous studies have linked it to cognitive function in older adults. However, evidence concerning the association between sleep quality and MCI among patients with T2DM in China is limited. …”
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Cardiometabolic index predicts cardiovascular events in aging population: a machine learning-based risk prediction framework from a large-scale longitudinal study by Yuanxi Luo, Yuanxi Luo, Zhiyang Yin, Xin Li, Xin Li, Chong Sheng, Ping Zhang, Dongjin Wang, Dongjin Wang, Yunxing Xue

“…BackgroundWhile the Cardiometabolic Index (CMI) serves as a novel marker for assessing adipose tissue distribution and metabolic function, its prognostic utility for cardiovascular disease (CVD) events remains incompletely understood. …”
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Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein by Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov

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RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes by Shruti Chopra, Janine Siegl, Verena Kopfnagel, Sylvia Dreyer, Franziska Rademacher, Juliane Lokau, Christoph Garbers, Jürgen Harder, Thomas Werfel, Katinka Döhner

“…R7 increased the release of the cytokines IL-6 and IL-24 by keratinocytes. Using a function-blocking antibody against IL-6 we showed that the R7-induced IL-24 secretion was triggered by IL-6. …”
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Presence of symptoms after COVID-19 infection may explain the onset of female urinary incontinence: a cross-sectional study by Ana Jéssica dos Santos Sousa, Ana Paula Rodrigues Rocha, Jordana Barbosa-Silva, Patrícia Driusso

“… Introduction: Coronavirus 2019 (COVID-19) is a multisystem disease that may affect lower urinary tract function. Objective: To determine if symptoms after COVID-19 infection may explain the onset of urinary incontinence (UI) in female survivors; to investigate the impacts of symptoms on the quality of life of incontinent women. …”
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Research on the fatigue of construction workers by heart rate monitoring by XU Ming-wei, JIN Long-zhe, ZHANG Lin, YU Lu, LIU Jian-guo, TIAN Xing-hua

“…Analysis of variance, one-sample t-test, and nonlinear curve fitting were adopted in this study. …”
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Anti-fibrosis effect of astragaloside IV in animal models of cardiovascular diseases and its mechanisms: a systematic review by Shiyu Zhang, Shijie Li, Xue Li, Chen Wan, Lin Cui, Youping Wang

“…The underlying mechanisms of the anti-fibrosis effects of AS-IV may include collagen metabolism, anti-apoptosis, anti-inflammation and, pyroptosis, antioxidants, improving mitochondrial function, regulating senescence, etc. Current evidence remains preclinical, with critical gaps in toxicological profiles, human safety thresholds, and clinical adverse reaction data. …”
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A Design Framework for Scalable and Adaptive Multi-Agent Coordination in Dynamic Environments: Addressing Concurrent Agent and Environment Interactions by Raza Muhammad Kazim, Guoxin Wang, Zhenjun Ming, Jinhui Cao, Janet K. Allen, Farrokh Mistree

“…Through systematic experimentation across five scenarios, SRSM is employed to uncover key trends in MAS performance and identify configurations that improve scalability and adaptability. From the analysis of simulation data, it has been observed that SGD struggles significantly in dynamic environments, while ADAM demonstrates moderate improvements. …”
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The Role of Pulmonary Genetic Variations in the Pathogenesis of Pediatric Postinfectious Bronchiolitis Obliterans by Sedef Narin Tongal, Gülsüm Kayhan, Özge Yılmaz, Merve Öçalan, Hasan Yüksel

“…In all but one, a wide range of variations genes related to both pulmonary structure and function were identified. The genes identified included those related to primary ciliary dyskinesia (DNAH genes), surfactant metabolism disorder (ABCA3, CSF2RB), pulmonary fibrosis (MUC5B, SFTP), and bronchiectasis (SCNN1B). …”
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Effectiveness of electrical stimulation with conservative treatment for lower urinary tract symptoms in Parkinson's disease: A three-armed randomized controlled trial protocol by Dorien Bennink, Rob A. de Bie, Henk W. Elzevier, Dagmar H. Hepp, Gommert A. van Koeveringe, Anton A. van der Plas, Hein Putter, Maxime T.M. Kummeling, Heidi F.A. Moossdorff-Steinhauser

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Research on the microstructure influence mechanism of hydraulic asphalt concrete based on fuzzy sets by Fang Jianyin, Bian Junhua, Constantinos Soutis, Dang Faning, Qin Yuan, Ren Jie, Gao Jun

“…The study further establishes that both power-law and exponential function models effectively characterize peak strength and modulus patterns under extreme λ conditions (λ₁→0 and λ₂→1). …”
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Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion by Marizela Delic, Alexandra B. Graf, Gunda Koellensperger, Christina Haberhauer-Troyer, Stephan Hann, Diethard Mattanovich, Brigitte Gasser

“…Constitutive co-overexpression of PpYAP1 leads to increased levels of secreted recombinant protein, while a lowered Yap1 function leads to accumulation of ROS and strong flocculation. …”
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Flaws in Estrus Synchronization Protocols Increase Vaginal Prolapse and Hydrometra Risk in Sheep by Nikolaos Tsekouras, Ioannis Tsakmakidis, Dimitrios Gougoulis, Mathis A. B. Christodoulopoulos, Christos Kousoulis, Georgios I. Papakonstantinou, Vasileios G. Papatsiros, Georgios Christodoulopoulos

“…This study examines the reproductive outcomes of Lacaune-crossbred ewes and hoggets in intensive production systems, focusing on vaginal prolapse and hydrometra associated with flaws in estrus synchronization (E.S.) protocols. Data from multiple farms were combined for analysis due to the absence of significant variation at the farm level. …”
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Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma by Beichen Cai, Beichen Cai, Beichen Cai, Qian Lin, Qian Lin, Qian Lin, Ruonan Ke, Ruonan Ke, Ruonan Ke, Jiaqi Yu, Jiaqi Yu, Jiaqi Yu, Lu Chen, Lu Chen, Xuejun Ni, Xuejun Ni, Hekun Liu, Xiuying Shan, Xiuying Shan, Biao Wang, Biao Wang, Biao Wang

“…Experimental validation of gene expression was performed via immunohistochemistry (IHC) and functional assays in gene-modified melanoma cell lines.ResultsTwenty-two genes involved in KRAS signaling were identified as critical for patient survival. …”
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Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses. by Anya Topiwala, Chaoyue Wang, Klaus P Ebmeier, Stephen Burgess, Steven Bell, Daniel F Levey, Hang Zhou, Celeste McCracken, Adriana Roca-Fernández, Steffen E Petersen, Betty Raman, Masud Husain, Joel Gelernter, Karla L Miller, Stephen M Smith, Thomas E Nichols

“…Executive function was assessed with the trail-making test, fluid intelligence with puzzle tasks, and reaction time by a task based on the "Snap" card game. …”
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Pathogen Distribution, Drug Resistance, and Postoperative High-Quality Nursing Intervention Effectiveness in Knee Osteoarthritis Patients After Knee Arthroplasty With Postoperative... by Tang Y, Fu B, Tong Q

“…Yuanyuan Tang,1 Baihui Fu,2 Qun Tong3 1Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China; 2Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China; 3Bachelor of Neurosurgery, Spine Research Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Baihui Fu, Email f18846812513@163.comObjective: To analyze the distribution and drug resistance of pathogens in patients with postoperative infection following knee arthroplasty (TKA) for knee osteoarthritis (KOA) and to explore the effectiveness of high-quality nursing interventions postoperatively.Methods: A retrospective analysis was conducted on clinical data from 87 KOA patients who underwent TKA and developed postoperative wound infections (infection group) at the first Affiliated Hospital of Harbin Medical University from July 2022 to September 2024. …”
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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility by Careen A. Schroeter, Anna Gorlova, Michael Sicker, Aleksei Umriukhin, Alisa Burova, Boris Shulgin, Sergey Morozov, Joao P. Costa-Nunes, Tatyana Strekalova

“…Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing their function. Little is known about how altered palmitoylation affects function at the systemic level and contributes to CNS pathology. …”
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Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review by Bashir MBA, Milani GP, De Cosmi V, Mazzocchi A, Zhang G, Basna R, Hedman L, Lindberg A, Ekerljung L, Axelsson M, Vanfleteren LEGW, Rönmark E, Backman H, Kankaanranta H, Nwaru BI

“…ACO and rhinitis phenotypes were mostly defined by symptoms, lung function, and sensitization, respectively. Most studies used hierarchical clustering, with some employing latent class modeling, mixture models, and factor analysis. …”
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The Influence of Right Ventricular Pacing Location, Pacing Burden and Paced QRS Duration to Subclinical Left Ventricular Systolic Dysfunction as Shown by Global Longitudinal Strain... by Mohammad Iqbal, Gadih Ranti Endamatriza, Irene Lampita, Sindy Hendrawansyah, Sidhi Laksono, Melawati Hasan, Chaerul Achmad, Giky Karwiky, Hanna Goenawan, Mohammad Rizki Akbar, Arief Sjamsulaksan Kartasasmita

“…Methods: A single-center, prospective cohort study was conducted, and all patients indicated for PPM implantation with preserved LV systolic function were included. Data of RV pacing location (RV apical vs right ventricular outflow tract (RVOT), pacing burden (percentage) (≤40% vs >40%), and paced QRS duration (≤150 ms and >150 ms) were obtained. …”
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