Interpretable and generalizable deep learning model for preoperative assessment of microvascular invasion and outcome in hepatocellular carcinoma based on MRI: a multicenter study by Xue Dong, Xibin Jia, Wei Zhang, Jingxuan Zhang, Hui Xu, Lixue Xu, Caili Ma, Hongjie Hu, Jiawen Luo, Jingfeng Zhang, Zhenchang Wang, Wenbin Ji, Dawei Yang, Zhenghan Yang

“…The adversarial network-based model's performance surpassed clinical radiology and squeeze-and-excitation network-based models. Biological function analysis was employed to enhance the interpretability and clinical translatability of the adversarial network-based model. …”
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Novel non-coding FOXP3 transcript isoform associated to potential transcriptional interference in human regulatory T cells by Marcos Cases, Niclas Ritter, Hector Rincon-Arevalo, Sandy Kroh, Aysegül Adam, Marieluise Kirchner, Hanieh Moradian, Manfred Gossen, Maria Dzamukova, Artür Manukyan, Markus Landthaler, Christopher Kressler, Anja E. Hauser, Daniel P. Depledge, Julia K. Polansky, Hyun-Dong Chang

“…By direct RNA sequencing we identified multiple novel FOXP3 transcriptional products, including one relatively abundant isoform with an extended 5’ UTR that we named ‘longFOXP3’. Western blotting, analysis of public mass spectrometry data, and transfection of in vitro transcribed RNA suggested that longFOXP3 is not coding. …”
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Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells by Haruka Kumabe, Takeshi Masuda, Shingo Ito, Tomomi Furihata, Akiko Toda, Masayuki Mogi, Norie Araki, Sumio Ohtsuki

“…The differences in the expression of these proteins in the BBB among different species and cultured BBB model cells should be clarified to interpret the BBB function in model animals and cells. This study aimed to elucidate species differences among humans, monkeys, and mice and in vitro–in vivo differences in the BBB proteome using deep proteomic analysis. …”
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Impact of Surgical Margin Status and Tumor Volume on Mortality After Robotic Radical Prostatectomy by Zaki Zeidan, Joshua Tran, Yeagyeong Hwang, Linda My Huynh, Mai Xuan Nguyen, Erica Huang, Whitney Zhang, Thomas Ahlering

“…In addition to high stage and grade, MPSM predicted PCSM in multivariate analysis, but lost predictive significance when PTV was included. …”
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Identification of Factors Affecting Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…Variables were identified using the content analysis method, which involved utilizing MAXQDA software for theoretical and qualitative data analysis.   …”
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Association between oxidative balance scores and peripheral artery disease in US adults: a cross-sectional study by Min Zhou, Min Zhou, Peng-Fei He, Peng-Fei He, Keren Zhang, Li-Juan Deng, Ning Wang, Gang Wang, Guang-Yao Yang, Shang Ju

“…Mediation analyses investigated the roles of glucolipid metabolism and renal function in the OBS-PAD association. Sensitivity and stratification analyses were conducted to ensure robustness.ResultsThis study included 2,437 eligible adult participants. …”
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Adaptive zero velocity correction method for fiber optic inertial navigation system in coal mining roadheader by Qinghua MAO, Qing ZHOU, Jianquan CHAI, Yanzhang CHEN, Wenjuan YANG, Xusheng XUE

“…Secondly, the time-frequency domain features of IMF components are extracted, and the principal component analysis method is used to reduce the dimension to reduce the complexity of the diagnostic model and the difficulty of data analysis. …”
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Mendelian randomization reveals probucol’s preventive role in Behçet’s disease via circulating metabolites by Zhang Hongchen, Zhang Yijia, Xu Yubo, Zhong Jianguang, Sun Mouyuan, Li Jian, Li Jin

“…To ensure the robustness and validity of our findings, we employed several MR methods, including the Inverse Variance Weighted (IVW) approach, heterogeneity tests, and pleiotropy analysis. This study identified a total of 30 SNPs associated with BD, 7502 SNPs linked to circulating metabolites, and 1,049 SNPs associated with BD from circulating metabolites, all derived from ABCA1 expression quantitative trait loci (eQTL) data. …”
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The Duration of Prophylactic Antibiotic Use for Esophageal Cancer Patients with Postoperative Infection and Nutritional Status by Ning D, Zhou L, Shi G, Fu M

“…Dong Ning,1,* Lin Zhou,2,* Guidong Shi,1 Maoyong Fu1 1Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 2Department of Ultrasound, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Ning, Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, No. 1, Maoyuan South Road, Shunqing District, Nanchong, Sichuan, 63000, People’s Republic of China, Email dongningcb@21cn.comObjective: To verify the hypothesis that “the prophylaxis use time of antibiotics after esophageal cancer (EC) surgery ≤ 24 hours is associated with a lower postoperative infection rate and improvement of nutritional indicators”, a retrospective cohort analysis was conducted to compare the infection incidence and differences in serum nutritional indicators among patients with different medication durations (< 24 hours, 24– 48 hours, > 48 hours), and to identify independent risk factors for postoperative infection.Methods: A retrospective analysis was conducted on the data of 566 patients who underwent EC surgery in Affiliated Hospital of North Sichuan Medical College from January 2020 to October 2022. …”
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The mechanisms of Brucea javanica in the treatment of oral squamous cell carcinoma: a network pharmacology, molecular docking, and experimental study by MingKang Li, Juan Zhan, YiHan Lai, YuJie Ma, HongCheng Wei, Lin Jiang, JuanJuan Zha, YiSen Shao, Wei Wang

“…The protein–protein interaction (PPI) network was constructed using the STRING database and Cytoscape 3.7.2 to identify core targets. Gene ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the intersection targets were conducted using the Metascape database. …”
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Does Valve-Sparing Repair Improve Outcomes in Tetralogy of Fallot? A Systematic Review by Jabez David John, Tirath Patel, Monica Kharat, Jeet HansalKumar Patel, Jubran Al Hooti, Zoya Riyaz Syeda, Rohit Anil Khare, Sonya Bhatia, Amin Ibrahim, Arjun Bellamkonda, Nikhilesh Anand, Bharathi S. Gadad

“…The search strategy initially revealed seventy articles; these were further screened by title and abstract and refined to fifteen articles for full-text analysis. For further full-paper analysis, eight articles were refined and formed the basis of our analysis. …”
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A review of periostin in orthopedics by Mark D. Wishman, William M. Sgrignoli, Brendan M. Patterson, James V. Nepola, Brian R. Wolf, Maria Bozoghlian, Carter M. Lane, Mitchell C. Coleman, Joseph W. Galvin

“…Objective: This review explores periostin (POSTN), a matricellular protein integral to developmental physiological, and pathological processes, by examining its structure, function, and emerging roles in orthopedic and non-musculoskeletal pathologies. …”
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Biological variation in serum thyroid, iron metabolism, and plasma bone metabolism biomarkers in patients with type 2 diabetes mellitus by Xia Wang, Mei Zhang, Zhi Liu, Chuan Li, Yujue Li, Hengjian Huang, He He, Xijie Yu

“…The biological variation (BV) of biomarkers associated with thyroid function, iron metabolism, and bone metabolism may show population-specific differences. …”
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Causal association between modifiable risk factors and esophageal cancer: A Mendelian randomization study by Xiaoqing Wang, Weiguang Zhang, Tianxin Lin, Renyan Mao, Ye Lin, Jingchuan Yu, Limin Ruan, Jihong Lin, Lei Gao, Peipei Zhang, Zhimin Shen, Mingqiang Kang

“…Conclusions Our findings suggest that coffee intake, smoking, and BMI potentially contribute as risk factors in the pathogenesis of EC, whereas type 2 diabetes, duration of education, and LDL-C may function as protective elements against the development of this malignancy.…”
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Efficacy of high-volume injections with and without corticosteroid compared with sham for Achilles tendinopathy: a protocol for a randomised controlled trial by Martin Underwood, Hylton B Menz, Dylan Morrissey, Anders Ploug Boesen, Shannon E Munteanu, Terry P Haines, David Connell, Rebecca S Kearney, Karin G Silbernagel

“…The primary outcome measure will be the Victorian Institute of Sport Assessment – Achilles (VISA-A) at 12 months post-randomisation, a validated, reliable and disease-specific measure of pain and function. Choice of secondary outcomes was informed by core outcome domains for tendinopathy. …”
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Associations of renal sinus fat with metabolic parameters, abdominal visceral adipose tissue, metabolic syndrome, fructose intake, and blood pressure control in obese individuals w... by Paniz Anvarifard, Maryam Anbari, Mohammad Naemi Kermanshahi, Alireza Ostadrahimi, Soghra Aliasgharzadeh, Mohammadreza Ardalan

“…Basic and clinical information were collected through interviews. Data included anthropometrics, blood pressure, number of antihypertensive medications, body composition (bioelectrical impedance analysis), dietary intake (semi-quantitative 147-item food frequency questionnaire), and blood samples. …”
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Artificial intelligence for screening and early diagnosis of pancreatic neoplasms in the context of centralization of the laboratory service in the region by S. I. Panin, V. A. Suvorov, A. V. Zubkov, S. A. Bezborodov, A. A. Panina, N. V. Kovalenko, A. R. Donsckaia, I. G. Shushkova, A. V. Bykov, Ya. A. Marenkov

“…Statistical processing of the data was carried out using the Python programming language. …”
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Improved Black-Winged Kite Algorithm with Multi-Strategy Optimization for Identifying <i>Dendrobium huoshanense</i> by Chaochuan Jia, Ting Yang, Maosheng Fu, Yu Liu, Xiancun Zhou, Zhendong Huang, Fang Wang, Wenxia Li

“…Comprehensive testing was conducted on four benchmark function sets (CEC2017, CEC2019, CEC2021, and CEC2022) to validate the effectiveness of the improved algorithm. …”
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Integration of single cell and bulk transcriptomes identifies T cell stress subtypes in LUAD by Shengping Min, Linfeng Pan, Xinyu Zhang, Huili Chen, Lixuan Qiu, Xinyu Wang, Yiluo Xie, Kai Zhang, Qiang Zhang, Chaoqun Lian, Jing Zhang

“…The exploration delved into the bio-function of CREG2 in the progression of LUAD.…”
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Molting of laying hens can activate AMPK- lipophagy - lipid metabolism pathway and improve intestinal digestion and absorption by Meiwei Lv, Chenxin Liu, Xiaowen Jiang, Ming Ge, Haibin Wang, Wenhui Yu

“…Poultry molting is a natural phenomenon, and process that improves the physiological function of laying hens. In this study, artificial intervention was used to induced molting (IM) in aged hens and improve their egg- laying performance. …”
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