Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease by Naybí Prendes Rivero, Levis Verde Corvo, Belkis López González, Iris Dany Carmenate Rodríguez, Nibaldo B Mesa Hernández, María A Robinson Agramonte

“…A neuropsychological test battery, and the immunoenzymatic method (ELISA), Promega Emax Kit were applied to determine the serum brain-derived neurotrophic factor levels. The statistical analysis of data was performed using the one-way ANOVA test, the post-hoc Dunnett´s test and the Pearson’s correlation coefficient (p<0.05). …”
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The role of triglycerides in predicting new-onset arthritis in the general population over 45 years old: evidence from the China health and retirement longitudinal study by Weiwei Ma, Honggu Chen, Jing Deng, Qipeng Yuan, Huanan Li, Huanan Li

“…The findings suggest that interventions targeting reduced TG levels and enhanced HDL function may have potential value in arthritis prevention. …”
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Risk factors and predictive model for mild cognitive impairment in elderly patients with rheumatoid arthritis by Jun Yan, Hua Guo, Lin-Xin Zhang, Pei Chen, Yong-Ku Du, Juan Li, Ya-Ya Gao, Nan Ye

“…Methods We enrolled 378 elderly RA patients, aged 60 to 80 years, from Xi’an Fifth Hospital between December 2023 and December 2024. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), with scores ranging from 20 to 26 indicating MCI. …”
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Design of a randomised, placebo-controlled, double-blind multicentre study assessing the effect of colchicine on the incidence of knee or hip replacements in symptomatic knee or hi... by Wietske Kievit, Cornelia H M van den Ende, Calin D Popa, Bart J F van den Bemt, Henk J Schers, Jan H Cornel, Sander Koeter, Michelle W J Heijman, José M H Smolders

“…Harm-related endpoints include the number of (serious) adverse events, the number of withdrawals due to (serious) adverse events and changes in laboratory data (ie, serum creatinine, estimated glomerular filtration rate and alanine transferase) throughout the study. …”
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Epigenetic targeting of MECOM/KRAS axis by JIB-04 impairs tumorigenesis and cisplatin resistance in MECOM-amplified ovarian cancer by Ibha Singh, Amarnath Karna, Anita Prajapati, Ujjawal Solanki, Archana Mukherjee, Sheetal Uppal, Pawan Malhotra, Manoj Kumar, Pallavi Agarwal

“…MDS1 and EVI1 Complex locus (MECOM) gene is copy number amplified and overexpressed in aggressive epithelial ovarian cancers. The biological function and precise molecular mechanism of MECOM in the progression and drug resistance of ovarian cancer remain unclear. …”
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Effect of different hemodialysis modalities on resistin and nutritional status by HUANG Jing-jing, ZHANG Jin-ping, WANG Jia, WANG Xin, WANG Wei-wei, YANG Xiao-ping

“…Objective To investigate the level of resistin in the patients with different hemodialysis modalities and its influence on nutritional status.Methods A total of 55 hemodialysis patients were randomly divided into low flux hemodialysis group(LFHD,n=27)and high flux hemodialysis group(HFHD,n=28),and compared with 30 healthy volunteers(normal control group).All of them were selected as the study objects in the First Affiliated Hospital of Shihezi University.The levels of serum resistin before and after dialysis were determined by enzymelinked immunosorbent assay(ELISA).Fasting samples of venous blood were obtained in 55 hemodialysis patients before dialysis and the following biochemical indexes were measured:for nutrition index,total protein(TP),albumin(Alb),prealbumin(PA),hemoglobin(Hb);for inflammation indicators,C reactive protein(CRP),ferritin(Fer);for blood lipids,serum total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL);for renal function and electrolyte,renal urea nitrogen(BUN),serum creatinine(SCr),uric acid(UA),kalium(K),calcium(Ca),phosphorus(P),magnesium(Mg).The differences in resistin levels and biochemical indexes were compared between the two groups.All of the patients underwent subjective comprehensive nutritional assessment by specially-assigned person and according to the guidelines,at the same time the clinical data of the subjects were collected.The changes of resistin levels in each dialysis group were analyzed and their relationships with the above biochemical indexes were analyzed.Results(1)As compared with the normal control group,the resistin level in LFHD group and HFHD group was significantly increased.There was no statistically significant difference between LFHD group and HFHD group in the level of pre-dialysis resistance and the level of resistin.There was no significant difference in resistin level between LFHD group and HFHD group before and after dialysis.There were statistically significant differences in the level of resistin before and after dialysis in HFHD group.(2)The differences in Alb,PA and SGA in patients undergoing different hemodialysis methods were statistically significant.As compared with LFHD group,HFHD group had higher Alb and PA but lower SGA scores;(3)Single factor analysis revealed that serum resistin was positively correlated with SCr and CRP(r=0.768,and r=0.473,P<0.05),and negatively correlated with glomerular filtration rate(eGFR)(r=-0.813,P<0.05).Serum resistin was positively correlated with TC,TG,LDL and SGA(r=0.408,r=0.294,r=0.397,and r=0.286 respectively,P<0.05).(4)Multiple linear regression analysis demonstrated that eGFR and CRP had influence on the level of resistin,and the dialysis mode had no significant effect on it.Conclusions High flux dialysis may eliminate some of the resistin.Resistin in hemodialysis patients is closely related to their nutritional status.…”
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Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis by Lu L, Zhou X, Zheng J, Li D

“…The relationship between COIL expression and clinical outcomes was assessed, and COIL’s biological function in HCC was investigated through cellular assays.Results: Analysis of cell lines and HCC tissue samples revealed that COIL mRNA or protein expression levels were significantly higher in HCC cell lines/tissues compared to normal liver cells/tissues. …”
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Exploring the Causes of Severe Fluctuations in Water Surface Area Using Water Index and Structural Equation Modeling: Evidence from Ebinur Lake, China by Mengfan Li, Changjiang Liu, Fei Zhang, Ngai Weng Chan, Elhadi Adam, Weiwei Wang, Yingxiu Wu

“…Arid zone lakes function as indicators of watershed ecology and environment, significantly influencing regional social development. …”
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Nutritional Status and Associated Factors among Primary Schoolchildren from Pastoral Communities, Mieso-Mulu District, Sitti Zone, Somali Regional State, Eastern Ethiopia: Institut... by Alayou Geletaw, Gudina Egata, Fitsum Weldegebreal, Gesessew Kibr, Mohammed Semaw

“…Child undernourishment is the disturbance of body function arising from a dietary imbalance between body demand and supply, which is the most serious public health problem in developing countries. …”
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Understanding the evolution of trust in a participatory health research partnership: A qualitative study by Meghan Gilfoyle, Anne MacFarlane, Zoe Hughes, Jon Salsberg

“…Setting and Participants Participants from the PPI network (n = 15/21) completed a semistructured interview discussing the evolution of trust by reviewing four social network maps derived from a previous longitudinal study. Analysis Following Braun and Clarke, we used reflexive thematic analysis, to iteratively develop, analyse and interpret our mediated reflection of the data. …”
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From Clinical Presentation to Genetic Confirmation: A Case of L2HGDH-Related Leukodystrophy in an 11-Year-Old by Negareh Poursalehi, Mojtaba Movahedinia, Mohammad Hossein Mohammadi, Mohamammad Ebrahim Ghanei, Mohammad Yahya Vahidi Mehrjerdi, Seyed Mehdi Kalantar

“…Leukodystrophies cause a progressive loss of neurological function in infants, children, and sometimes adults. …”
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Association between GRIN2B polymorphism and Parkinson’s disease risk, age at onset, and progression in Southern China by Can Cui, Hongxia Li, Yiwen Bao, Yingying Han, Hongxiang Yu, Huan Song, Bei Zhang

“…Notably, the GG genotype carriers exhibited a more rapid decline in recall function.ConclusionThe GRIN2B rs219882 G allele is associated with increased PD susceptibility, particularly in LOPD. …”
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Spatiotemporal Agglomeration, Response Mode, and Interpretation Model of Daily Activities of Residents in Large Public Housing Areas in Nanjing Based on Household Labor Division by He Yan, Wu Xiao

“…Based on the perspective of "family division of labor" and the activity log data of the residents in the large-scale affordable residential area, we initially applied a spatial autocorrelation model to construct a spatiotemporal autocorrelation function, and depicted the overall characteristics of the spatiotemporal agglomeration of the daily activities of the residents in this area from the dual scales of "main urban area–residential area." …”
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Reading the Visual Aspects of the Grotesque Body in the Iranian Cinema and Theater Posters (1390s) by Amir Hossein Pormehr Yabandeh, Mohsen Marasy

“…The data analysis method has been qualitative and sampling has been goal-oriented. …”
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Association between the number of pregnancies and hearing loss: NHANES 1999–2018 by Haohong Lai, Juntao Wu, ZhuoYi Chen, Minqian Gao, Haidi Yang

“…Reproductive health data, including the number of pregnancies, were obtained via self-reported questionnaires. …”
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Profile of a patient with non-ST segment elevation myocardial infarction in actual clinical practice by V. V. Ryabov, A. E. Gombozhapova, S. V. Demyanov

“…To describe profile of a modern portrait with non-ST-segment elevation myocardial infarction (non-STEMI) through a comprehensive analysis of the Emergency Cardiology Unit (ECU) practice, which discharge a function of a regional vascular centre.Material and methods. …”
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Seropositivity of Brucella spp. and Leptospira spp. antibodies among abattoir workers and meat vendors in the city of Mwanza, Tanzania: A call for one health approach control strat... by Mariam M Mirambo, Georgies F Mgode, Zakaria O Malima, Matata John, Elifuraha B Mngumi, Ginethon G Mhamphi, Stephen E Mshana

“…<h4>Conclusion</h4>Seropositivity of B.abortus antibodies among abattoir workers and meat vendors is high and seem to be a function of being abattoir worker, having worked for long duration in the abattoir and having primary education. …”
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Post-Stroke PTSD: The Protective Role of CCR5-Δ32 Polymorphism by Hen Hallevi, Oren Tene, Jeremy Molad, Aviva Alpernas, Dana Niry, Saly Usher, Lital Feldinger, Estelle Seyman, Einor Ben Assayag

“…The C-C-Chemokine receptor-5 gene (CCR5) loss-of-function mutation (LOFM, CCR5-Δ32) has been identified as a protective factor against post-stroke depression. …”
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Association between perfluoroalkyl and polyfluoroalkyl substances and adolescents' sleep disorders: NHANES 2005–2018 by Bocheng Gao, Yanju Gong, Yan Lu, Shuhua Gou, Xingyue Lai, Gan Luo, Hong Yang

“…BackgroundPrevious research indicates that per- and polyfluoroalkyl substances (PFAS) can disrupt metabolism and neurological function via endocrine pathway interference and neuroinflammation. …”
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Test and treat—impact of microbiological testing on antibiotic prescribing for Legionnaires’ disease in Switzerland: results of the multicentre SwissLEGIO study by Melina Bigler, Florian Zacher, Sarah Dräger, Werner C. Albrich, Daniel Mäusezahl, the SwissLEGIO Hospital Network

“…Prolonged treatment was associated with CALD severity and antibiotic use > 2 days postdischarge (proxy for clinical stability reached). 38.5% of patients with impaired renal function received a suboptimal loading dose of levofloxacin. …”
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