Severe clinical forms of Mediterranean spotted fever: A case series from an endemic area in Bulgaria by Baymakova Magdalena, Pekova Liliya, Parousheva Pavlina, Andonova Radina, Plochev Kamen

“…During the analyzed period, 58 cases had clinical and laboratory data for MSF. Serological tests were applied for the etiological diagnosis. …”
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Gait-based Parkinson’s disease diagnosis and severity classification using force sensors and machine learning by Navita, Pooja Mittal, Yogesh Kumar Sharma, Anjani Kumar Rai, Sarita Simaiya, Umesh Kumar Lilhore, Vimal Kumar

“…Parkinson’s disease is the primary neurodegenerative disorder that results in a gradual reduction in motor function. Early detection and monitoring of the disease progression is highly challenging due to the gradual progression of symptoms and the inadequacy of conventional methods in identifying subtle changes in mobility. …”
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Post occupancy evaluation of architectural design studio facilities by Mohamed Salah Ezz, Mohamed Salah Ezz, Mohamed Ahmed F. Mahdy, Mohamed Ahmed F. Mahdy, Saleh Baharetha, Mohammad A. Hassanain, Mohammad A. Hassanain, Mohammed M. Gomaa, Mohammed M. Gomaa

“…A structured categorization of performance criteria included ten groups that evaluated functional and technical operations with behavioral capabilities across environmental comfort and spatial organization and technological implementation and user satisfaction. …”
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Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review by Mohamed E. Abd El-Hack, Hassan A. Rudayni, Ahmed K Aldhalmi, Abdullah S. Alawam, Ahmed A. Allam, Mohammad M.H. Khan, Asmaa F. Khafaga

“…Furthermore, PSPs hold potential for applications in the pharmaceutical, nutraceutical, and functional food industries due to their biocompatibility and therapeutic value. …”
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Unveiling the Microbial Symphony of Amasi: A Targeted Metagenomic 16S rRNA, ITS, and Metabolites Insights Using Bovine and Caprine Milk by Betty Olusola Ajibade, Titilayo Adenike Ajayeoba, Saheed Sabiu, Konstantin V. Moiseenko, Sizwe Vincent Mbona, Errol D. Cason, Tatyana V. Fedorova, Oluwatosin Ademola Ijabadeniyi

“…This study investigated the microbial diversity in Amasi (produced from cow’s and goat’s milk) through targeted metagenomic bacterial 16S rRNA and fungal ITS sequencing, the metabolic functional prediction of Amasi samples using the Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) and profiled amino acids constituents using Liquid Chromatographic-Mass Spectrophotometry (LC-MS). …”
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Vaccine-induced T cell responses correlate with reduced risk of severe COVID-19 in a placebo-controlled efficacy trialResearch in context by Nina Hertoghs, Sanne Roels, Matthias Brückner, Jerald Sadoff, Barbara L. Banbury, Nicholas K. Akers, Bryan Howie, Harlan S. Robins, Griet A. van Roey, Jeroen T.B.M. Tolboom, Veronica V. Rezelj, Jenny Hendriks, Hanneke Schuitemaker, Daniel J. Stieh, Mathieu Le Gars

“…Furthermore, vaccine-elicited T cell responses correlated inversely with the risk of developing severe COVID-19, while no strong relation was observed with overall symptomatic COVID-19 risk. A multivariable analysis including neutralizing antibody data and TCR scores indicated that, in addition to humoural responses, T cell responses contribute to protection against severe COVID-19. …”
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Missense variants in PRKCD: elucidating their potential association with breast cancer by Sameen Zafar, Yasmin Badshah, Maria Shabbir, Uzma Mussarat, Asma Latif, Janeen H. Trembley, Tayyaba Afsar, Fohad Mabood Husain, Suhail Razak

“…Missense variants were analysed through various computational tools, and four variants of PRKCD rs1703806197 (T/C), rs782555227 (G/A), rs1703449438 (T/C), and rs1575535582 (T/G) were selected from the data. The genotype analysis for these variants was performed for 360 breast cancer patients and 363 healthy controls. …”
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Nitrogen cycling during an Arctic bloom: from chemolithotrophy to nitrogen assimilation by Rafael Laso-Pérez, Juan Rivas-Santisteban, Nuria Fernandez-Gonzalez, Christopher J. Mundy, Javier Tamames, Carlos Pedrós-Alió

“…In contrast, during summer, the chemolithotrophic organisms thriving during winter reduced their relative abundance and the expression of their catabolic genes. Based on our functional analysis, we see a transition from a community where nitrogen-based chemolitotrophy plays a relevant role to a chemoorganotrophic community based on the carbohydrates released during the phytoplankton bloom, where different groups seem to specialize in different nitrogen sources.IMPORTANCEThe Arctic is one of the environments most affected by anthropogenic climate change. …”
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Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression by Li-Hong Wu, Liu Yang, Xiang-Xu Wang, Shuang Bai, Xi Yan, Jing Wei, Jun Wang, Fei Tian

“…The CIBERSORT algorithm was utilized to analyze immune cell infiltration. Functional validation of the lactylation-related gene CCL20 in HCC was conducted through in vitro experiments using HCC cell lines.ResultsWe identified three distinct lactylation modification patterns, with higher lactylation modification levels correlating with worse prognosis in HCC. …”
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Vulvovaginal atrophy: modern approaches to diagnostics and management by V. H. Siusiuka, N. V. Avramenko, M. I. Pavliuchenko, M. Yu. Serhiienko, A. O. Kniazieva

“…The aim of the review is to analyze the latest data on the current state of diagnosis and management of a common benign vulvar and vaginal disease in postmenopausal women – atrophic vulvovaginitis. …”
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Incidence and Risk Factors of Postoperative Neuropsychiatric Dysfunctions After Deep Brain Stimulation Surgery in Patients with Parkinson's Disease: A Prospective Cohort Study by XIE Sining, JIANG Chenguan, LI Xiangjiahui, HAN Ruquan, YANG Zhou, LI Bingxin, SHI Lin

“…ObjectiveTo investigate the incidence of postoperative neuropsychic dysfunction (PND) in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) and to analyze its influencing factors.MethodsA prospective study was conducted between January 2020 and December 2022, recruiting PD patients from the Functional Neurosurgery Outpatient Clinic of Beijing Tiantan Hospital, Capital Medical University. …”
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Characteristics of Land Use Change and Evaluation of Ecological Sensitivity in Chongqing by XIE Xianjian, GOU Qiantao, WU Han

“…[Objective] Chongqing, as the economic center of the upper reaches of the Yangtze River in China and a barrier to ensure ecological security in the middle and lower reaches of the Yangtze River, is a typical ecological functional and fragile area in China. Studying the spatiotemporal evolution characteristics and ecological sensitivity of its land use is of great significance for the reconstruction of land use and ecological protection in the research area. …”
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Feature extraction and classification of digital rock images via pre-trained convolutional neural network and unsupervised machine learning by Masashige Shiga, Masao Sorai, Tetsuya Morishita, Masaatsu Aichi, Naoki Nishiyama, Takashi Fujii

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Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods by Ankita Lawarde, Ankita Lawarde, Masuma Khatun, Prakash Lingasamy, Prakash Lingasamy, Andres Salumets, Andres Salumets, Andres Salumets, Vijayachitra Modhukur, Vijayachitra Modhukur

“…Furthermore, in silico validation revealed that many of the top miRNAs, including miR-21-5p, miR-93-5p, and miR-10b-5p, were not only highly central in the network but also correlated with patient survival and drug response. In addition, functional enrichment analyses indicated significant involvement of miRNAs in pathways such as TGF-beta signaling, epithelial-mesenchymal transition, and immune modulation. …”
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Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator by L. Hilman, M. Ondičová, A. Caffrey, M. Clements, C. Conway, M. Ward, K. Pentieva, R. E. Irwin, H. McNulty, C. P. Walsh

“…Functional consequences of altered methylation were examined in cultured cells with mutations or by inhibition of the main DNA methyltransferases. …”
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Evaluating the value of machine learning models for predicting hematoma expansion in acute spontaneous intracerebral hemorrhage based on CT imaging features of hematomas and surrou... by Tianyu Yang, Tianyu Yang, Zhen Zhao, Yan Gu, Shengkai Yang, Yonggang Zhang, Lei Li, Ting Wang, Zhongchang Miao

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LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5 by Shu‐Jun Li, Zhuo‐Ran Liang, Zhi‐Chao Liu, Xue‐Ping Luo, Jun‐Yi Li, Xiao‐Mei Yu, Xuan‐Zhang Huang, Yan He, Tao‐Yang Xu, Jiao‐Jiao Xu, Shao‐Cong Peng, Yu‐Xiang Song, Yan He, Xiao‐Wan Zhuang, Can‐Can Zheng, Fan Zhang, Alfred King‐Yin Lam, Wei Dai, Ming‐Liang He, Bo Liu, Qi Zhao, Guo‐Liang Lu, Jin‐Bao Liu, Zhen‐Ning Wang, Zhi‐Gang Li, Ze‐Xian Liu, Wen‐Wen Xu, Bin Li

“…By further consolidating data with CRISPR/Cas9 functional screening, LIM domain kinase 1 (LIMK1) is identified as a novel kinase of β‐catenin. …”
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Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…Key genes were selected based on integration with rank-sum test results. Functional enrichment analysis was performed for these key genes. …”
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Identification of optimal Sentinel-1 SAR polarimetric parameters for forest monitoring in Czechia by Daniel Paluba, Bertrand Le Saux, Francesco Sarti, Přemysl Štych

“…Time series analysis of synthetic aperture radar data (SAR) offers a systematic, dynamic and comprehensive way to monitor forests. …”
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Association between daily living activities and quality of life in post-COVID-19 patients: a cross-sectional study by Shameem Ahammad, Ruksana Akter, Md. Abdul Koddus, Md. Kabir Hossain, Ehsanur Rahman, Tofajjal Hossain, Mohammad Mohinul Islam, Khin Nyein Yin, Md. Feroz Kabir, Md. Iqbal Kabir Jahid

“…After the acute period of COVID-19, many people still face considerable difficulties in carrying out activities of daily living (ADLs), which are essential for independent functioning and overall quality of life (QoL). Objective This study aimed to prompt how these persistent symptoms affect individuals’ ability to perform ADLs-basic tasks essential for self-care and daily functioning and how these limitations, in turn, influence overall QoL. …”
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