Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting... by Bo Yang, Bo Yang, Ruiji Chen, Ruiji Chen, Mali Zu, Jie Yao, Hong Ren, Hong Ren, Yingxue Lin, Yingxue Lin, Bo Zhang, Tianjiao Ji, Yang Liu

“…Cell-cell communication analysis, Meta-Programs (MPs) via non-negative matrix factorization, and functional enrichment were performed. …”
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Chemical Pollutant Exposure in Neurodevelopmental Disorders: Integrating Toxicogenomic and Transcriptomic Evidence to Elucidate Shared Biological Mechanisms and Developmental Signa... by Xuping Gao, Xinyue Wang, Xiangyu Zheng, Yilu Zhao, Ning Wang, Suhua Chang, Li Yang

“…Time trajectory analysis of developmental transcriptomic data from the BrainSpan database for ASD (275 genes) and ID (93 genes) revealed three distinct expression patterns of chemical-pollutant-associated genes—higher prenatal, postnatal, and perinatal expression—indicating common and divergent underlying mechanisms across critical windows of chemical pollutant exposure.…”
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Prevalence of hitherto unknown brain meningioma detected on 68Ga-DOTATATE positron-emission tomography/computed tomography in patients with metastatic neuroendocrine tumor and expl... by Rahul V. Parghane, Sanjay Talole, Sandip Basu

“…Two patients (40%) died of advanced NET at the time of analysis of these data. The observed mean PFS of the meningioma lesions following PRRT was 26.25 months (95% confidence interval, 16.65–35.84 months).No major hematological and renal toxicity were documented in any of these patients. …”
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Prevalence of hitherto unknown brain meningioma detected on 68Ga-DOTATATE positron-emission tomography/computed tomography in patients with metastatic neuroendocrine tumor and expl... by Rahul V Parghane, Sanjay Talole, Sandip Basu

“…Two patients (40%) died of advanced NET at the time of analysis of these data. The observed mean PFS of the meningioma lesions following PRRT was 26.25 months (95% confidence interval, 16.65–35.84 months).No major hematological and renal toxicity were documented in any of these patients. …”
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Transcriptome analyses reveal common immune system dysregulation in PAH patients and Kcnk3‐deficient rats by Grégoire Ruffenach, Hélène Le Ribeuz, Mary Dutheil, Kristell El Jekmek, Florent Dumont, Anaïs Saint‐Martin Willer, Marc Humbert, Véronique Capuano, Lejla Medzikovic, Mansoureh Eghbali, David Montani, Fabrice Antigny

“…Taking advantage of unique Kcnk3‐deficient rats, we analyzed the transcriptomic changes in the lungs from homozygous Kcnk3‐deficient rats and wild‐type (WT) littermates and compared them to PAH patient transcriptomic data. Transcriptome analysis of lung tissue obtained from WT and Kcnk3‐deficient rats identified 1915 down‐ or upregulated genes. …”
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Biopsychosocial factors and falls among older adults during the COVID-19 pandemic: a longitudinal study by Renata Zacharias Grando, Letícia Pophal Cutisque, Alyssa Cristine de Oliveira Elias, André Luiz Felix Rodacki, Natália Boneti Moreira

“…Cohen’s effect size (d) was used in data analysis. Comparing the timeline changes (baseline vs. final assessment) the biopsychosocial factors were worst in Activities (SB, d = 0.70) and Personal Factors (Fear of falling, d = 4.06). …”
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TempO-seq and RNA-seq gene expression levels are highly correlated for most genes: A comparison using 39 human cell lines. by Laura J Word, Clinton M Willis, Richard S Judson, Logan J Everett, Sarah E Davidson-Fritz, Derik E Haggard, Bryant A Chambers, Jesse D Rogers, Joseph L Bundy, Imran Shah, Nisha S Sipes, Joshua A Harrill

“…Recent advances in transcriptomics technologies allow for whole transcriptome gene expression profiling using targeted sequencing techniques, which is becoming increasingly popular due to logistical ease of data acquisition and analysis. As data from these targeted sequencing platforms accumulates, it is important to evaluate their similarity to traditional whole transcriptome RNA-seq. …”
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Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT by F D Richard Hobbs, Richard McManus, Clare Taylor, Nicholas Jones, Joy Rahman, Jane Wolstenholme, Louise Jones, Jennifer Hirst, Sam Mort, Ly-Mee Yu

“…Secondary outcome measures included changes in blood pressure, renal function, B-type natriuretic peptide, incidence of hyperkalaemia and treatment costs and benefits. …”
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“Eculizumab First” in the Management of Posttransplant Thrombotic Microangiopathy by Federica Maritati, Valeria Corradetti, Claudia Bini, Michele Provenzano, Vania Cuna, Marco Busutti, Francesco Tondolo, Fulvia Zappulo, Gisella Vischini, Francesca Iacovella, Chiara Abenavoli, Greta Borelli, Marcello Demetri, Benedetta Fabbrizio, Giorgia Radi, Matteo Ravaioli, Caterina Mele, Gaetano La Manna, Giorgia Comai

“…Conclusion: This is, to our knowledge, the largest series of KT patients with PT-TMA treated with eculizumab. These data suggest that eculizumab is associated with a normalization of hemolysis indices and an important and progressive improvement of graft function.…”
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Child developmental delay and its associated factors among children aged 12–59 months in Dembecha district, Northwest Ethiopia: a community-based cross-sectional study by Adugna Kerebh, Melese Linger Endalifer, Molla Yigzaw Birhanu, Animut Takele Telayneh, Lake Kumlachew Abate, Zemene Adissie, Ayenew Negesse, Alehegn Aderaw Alamneh

“…Data were entered into Epi Data version 4.2 software and exported into Statistical Package for Social Science (SPSS) version 25 software for analysis. …”
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Representation of Iran among Iraqi social media users (A case study of Facebook users after the defeat of ISIS until the martyrdom of Hajj Qassem Soleimani) by mohsen finizadeh bidgoli

“…However, in today's world—and likely in the future—soft power and public diplomacy offer some of the most relevant frameworks for understanding power’s current form and function. At the same time, the growing importance of social networks has become an undeniable reality. …”
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Impact of COVID-19 on mobility and participation of older adults living in Hamilton, Ontario, Canada: a multimethod cohort design protocol by Luciana G Macedo, Marla K Beauchamp, Heather Keller, Nazmul Sohel, Renata Kirkwood, Brenda Vrkljan, Elisabeth Vesnaver, Janie Astephen-Wilson, Tara Noble, Nicholas Dietrich, Paula Gardner, K Bruce Newbold, Darren Scott

“…The Late-Life Function and Disability Instrument and global rating of change anchors are the primary outcomes of interest. …”
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Increases in Temperature and Precipitation in the Different Regions of the Tarim River Basin Between 1961 and 2021 Show Spatial and Temporal Heterogeneity by Siqi Wang, Ailiyaer Aihaiti, Ali Mamtimin, Hajigul Sayit, Jian Peng, Yongqiang Liu, Yu Wang, Jiacheng Gao, Meiqi Song, Cong Wen, Fan Yang, Chenglong Zhou, Wen Huo, Yisilamu Wulayin

“…Moreover, precipitation trends varied significantly among the sub-basins, with that in the Aksu River Basin increasing the most (12.9 mm/10a) and that in the Cherchen River Basin increasing the least (1.9 mm/10a). Moreover, ERA5_Land data accurately reproduced the spatiotemporal patterns of temperature (correlation 0.92) and precipitation (correlation 0.72) in the TRB. (2) Empirical Orthogonal Function analysis identified the northern sections of the Kaidu, Weigan, and Yerqiang river basins as centers of temperature sensitivity and the western part of the Kaidu and Cherchen River Basin as the center of precipitation sensitivity. (3) Global warming is closely correlated with sub-basin temperature (correlation above 0.5) but weakly correlated with precipitation (correlation 0.2~0.5). …”
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The influence of genetics on the endocannabinoid system gene expression and relevance for targeting reproductive conditions by Keisuke Tanaka, Akwasi A. Amoako, Sally Mortlock, Peter A. W. Rogers, Sarah J. Holdsworth-Carson, Jacqueline F. Donoghue, Wan Tinn Teh, Grant W. Montgomery, Brett McKinnon

“…Analysis of the eQTLGen data identified 22,020 eQTLs that influenced 43 of the selected 70 ECS genes. …”
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Wearable sensors for measuring spontaneous upper limb use in children with unilateral cerebral palsy and typical development by Elena Beani, Mattia Franchi de ’Cavalieri, Silvia Filogna, Veronica Barzacchi, Matteo Cianchetti, Martina Maselli, Giada Martini, Valentina Menici, Giuseppe Prencipe, Elisa Sicola, Giovanni Cioni, Giuseppina Sgandurra

“…Through wearable sensor data analysis, we demonstrate a linear correlation between asymmetry measured during smi-structured assessments and daily life. …”
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Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation by Yuchen Cai, Tianyi Zhou, Xueyao Cai, Wenjun Shi, Hao Sun, Yao Fu

“…Based on transcriptomics datasets of KC, mitochondria-related differentially expressed genes (mDEGs) were identified and analyzed for potential functional pathways, protein-protein interaction (PPI), and gene regulatory networks. …”
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Development of CSOARG: a single-cell and multi-omics-based machine learning model for ovarian cancer prognosis and drug response prediction by Junyu Chen, Junyu Chen, Bin Guan, Bin Guan, Jihong Zhang, Xin Li, Xin Li, Jingyi Fang, Jingyi Fang, Wencai Guan, Qi Lu, Qi Lu, Qi Lu, Guoxiong Xu, Guoxiong Xu

“…This study aims to generate a predictive model for prognosis and therapeutic responses in ovarian cancer using defined specific genes.MethodsThe cellular senescence-associated gene sets and the ovarian aging-associated gene sets from the TCGA and GEO databases were analyzed using Cox regression with LASSO approach and employed to construct a prognostic model of Cellular Senescence and Ovarian Aging-Related Genes (CSOARG). Immunology analysis, functional enrichment, single-cell analysis, and therapeutic responses of ovarian cancer were conducted using the data from public databases. …”
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Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD by Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, Claudio Grassi

“…Methods Nup153-regulated mechanisms contributing to NSC function were investigated: (1) in cultured NSCs isolated from AD and wild type (WT) mice by proteomics; (2) in vivo by lentiviral-mediated delivery of Nup153 or GFP in the hippocampus of AD and control mice analyzing neurogenesis and cognitive function; (3) in human iPSC-derived brain organoids obtained from AD patients and control subjects as a model of neurodevelopment. …”
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Cisplatin-based chemotherapy-induced nephrotoxicity and its impact on the survival status of patients with gynecological cancer in Ethiopia: A multicenter retrospective cohort stud... by Samuel Agegnew Wondm, Samuel Berihun Dagnew, Fisseha Nigussie Dagnew, Getachew Yitayew Tarekegn, Tilaye Arega Moges, Rahel Belete Abebe, Tirsit Ketsela Zeleke, Wubetu Yihunie Belay, Fasil Bayafers Tamene

“…Background: Cisplatin-based chemotherapy regimen associated nephrotoxicity is a significant adverse effect that restricts the standard dose of cisplatin by impairing renal function. There is a lack of data on cisplatin-based chemotherapy-induced nephrotoxicity (CIN) in Ethiopian patients with gynecological cancer. …”
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Non-Cognitive Behavioral Therapy Psychological Interventions May Not Make the Difference in Children and Adolescents With Chronic Pain by Perlman L, Malka N, Terry O, Nguyen A, Guimarães Ferreira Fonseca L, Ingelmo JI, Ingelmo P

“…We found no meaningful difference between the use of non-CBT psychological intervention and no treatment in the incidence of PGIC 6– 7 points, pain intensity, school attendance, physical function, suicidality, and cause of end of treatment. …”
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