WORK EXPERIENCE INTERNSHIP THROUGH THE EYES OF TECHNICAL UNIVERSITY STUDENTS (ON THE MATERIALS OF SOCIOLOGICAL RESEARCH) by Alexandr Yu. Myagkov, Maria V. Grigorieva, Irina V. Zhuravleva, Svetlana L. Zhuravleva

“…As a result, there is a commonplace opinion that internship is a waste of time. These data show that universities today have a reserve of unused potential to increase internship efficiency.Practical significance. …”
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Comparison of New‐Onset Peripheral Artery Disease in Patients With Type 2 Diabetes Exposed to Sodium–Glucose Cotransporter‐2 Inhibitors, Dipeptidyl Peptidase‐4 Inhibitors, or Gluca... by Oscar Hou‐In Chou, Zhiyao Luo, Cheuk To Skylar Chung, Jeffrey Chan, Huixian Li, Ishan Lakhani, Sharen Lee, Dawnie Ho Hei Lau, Qingpeng Zhang, Tong Liu, Wing Tak Wong, Bernard Man Yung Cheung, Gregory Y. H. Lip, Fung Ping Leung, Gary Tse, Jiandong Zhou

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Impact of Growing Rod Surgery for Early-Onset Scoliosis on Cervical Sagittal Alignment by Shuhei Ito, Satoshi Suzuki, Yohei Takahashi, Masahiro Ozaki, Osahiko Tsuji, Narihito Nagoshi, Mitsuru Yagi, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

“…Summary of Background Data: Cervical sagittal malalignment is associated with neck and cervical spine dysfunction. …”
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Automated ejection fraction and risk stratification in cardiomyopathy patients with diverse LV geometry using 2D echocardiography by Ziwei Zhu, Ke Fan, Shuyuan Zhang, Tingting Hu, Jingyi Li, Ze Zhao, Ye Jin, Shuyang Zhang

“…Abstract Cardiomyopathy often alters left ventricular geometry (LVG), impairing cardiac function. We developed a deep learning (DL) model to estimate left ventricular ejection fraction (LVEF) from echocardiographic images while accounting for LVG variability and assessed prognostic factors across LVG subtypes. …”
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Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia by Shanshan Guo, Ekaterina Bourova-Flin, Sophie Rousseaux, Florent Chuffart, Lijun Peng, Duohui Jing, Jian-Qing Mi, Saadi Khochbin, Jin Wang

“…Computational analyses and a series of functional assays were performed to investigate the molecular links between altered mitochondrial activity and drug resistance. …”
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Machine learning-based integration of DCE-MRI radiomics for STAT3 expression prediction and survival stratification in breast cancer by Dong Pan, Dong Pan, Dong Pan, Cheng-Yan Zhang, Cheng-Yan Zhang, Cheng-Yan Zhang, Ya-Fei Wang, Ya-Fei Wang, Shuang Liu, Shuang Liu, Shuang Liu, Xiong-Zhi Wu, Xiong-Zhi Wu, Xiong-Zhi Wu, Xiong-Zhi Wu, Xiong-Zhi Wu

“…ObjectiveTo explore the association between signal transducer and activator of transcription 3 (STAT3) expression, tumor immune microenvironment, and overall survival (OS) in breast cancer, and to develop a non-invasive radiomics model for early risk stratification using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).MethodsData from 1,008 patients with breast cancer in The Cancer Genome Atlas were analyzed to evaluate the prognostic significance of STAT3 expression using Kaplan-Meier survival analysis and Cox regression models. …”
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Association between Life's Crucial 9 and Cardiorenal syndrome: the mediating role of weight-adjusted-waist index by Huanjie Fu, Zhichao Liu, Hao Yu, Yisheng Zhao, Yongkang Gan, Jinhong Chen, Eryue Liu

“…The findings emphasize the intricate interactions between LC9 and CRS, illustrating the essential function of WWI as a mediator in future research endeavors.…”
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CXCL12/CXCR4 axis governs Treg spatial dominance over CD8+ T cells via IL-2 sequestration: a dual therapeutic target in prostate cancer by Junyi Li, Long Zhang, Ruoyang Liu, Changwen Xu, HuiHui Tang, Yunfei Zou, Qingfei Cao, Weichao Huang

“…A spatial proximity relationship was established between CD8+ effector T cells and Tregs, suggesting Tregs directly influence CD8+ T cell function. Immune cell state analysis revealed interleukin-2 (IL-2) as a critical cytokine in reshaping the immune microenvironment, with Tregs competitively depleting IL-2 and mediating IL-2/STAT5 signaling to induce CD8+ effector T cell exhaustion. …”
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A novel PAK1/TCF1 regulatory axis promotes non-small cell lung cancer progression by Chuangang Lu, Yuncong Su, Youzhong Xu, Siyuan Sheng, Taiting Chen, Juan Li

“…Immunoprecipitation analysis confirmed PAK1 and TCF1 interaction in NSCLC. …”
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Mitochondria-associated programmed cell death: elucidating prognostic biomarkers, immune checkpoints, and therapeutic avenues in multiple myeloma by Gongzhizi Gao, Jiyu Miao, Yachun Jia, Aili He, Aili He, Aili He

“…However, the precise roles of mitochondria-related genes (MRGs) and PCD-related genes (PCDRGs) in MM prognosis remain unclear.MethodsTranscriptomic data from MM patients and healthy controls were analyzed to identify differentially expressed genes (DEGs). …”
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Lipid metabolism disturbance and immune dysfunction in HBV-related acute-on-chronic liver failure: a retrospective cohort study by Neng Wang, Yu Zheng, Shuai Tao, Liang Chen

“…Abstract Objective This study aimed to elucidate the correlations among dyslipidemia, immune function, and clinical outcomes in patients with acute-on-chronic liver failure (ACLF), with particular emphasis on the clinical significance of lipid metabolism and cellular immune parameters in hepatitis B virus-associated ACLF (HBV-ACLF). …”
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Prevalence and Correlates of Neurocognitive Disorders among HIV Patients on Antiretroviral Therapy at a Kenyan Hospital by A. G. Mugendi, M. N. Kubo, D. G. Nyamu, L. M. Mwaniki, S. K. Wahome, J. E. Haberer

“…HIV-associated neurocognitive disorders (HAND) represent a spectrum of cognitive abnormalities affecting attention, concentration, learning, memory, executive function, psychomotor speed, and/or dexterity. Our objectives in this analysis are to determine the prevalence of HAND and the covariates in a Kenyan population. …”
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Prediction of basal glycaemia dynamics during treatment with 6-month lipid-lowering therapy in patients at high risk of cardiovascular disease by Olga A. Koshelskaya, Anastasiya S. Sushkova, Olga A. Zhuravleva, Irina V. Vinnizkaya, Nataliya G. Brazovskaya, Elena S. Kravchenko, Tatyana E. Suslova, Rostislav S. Karpov

“…Multivariate discriminant analysis across all patient groups revealed a canonical linear discriminant function that included the following factors: baseline basal glucose levels, total cholesterol levels, triglycerides and ratio of LDL/HDL cholesterol. …”
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Hypertension and cognitive impairment among older persons in rural Northern Uganda: a cross-sectional study by Joel Oyugi, Jonathan Izudi, Francis Bajunirwe

“…Abstract Background Hypertension is common among older adults and negatively affects cognitive function. Available data on this association is mostly from resource-rich settings and has been understudied in resource-limited settings especially rural areas where the majority of older persons live. …”
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Association between the Endothelial Activation and Stress Index (EASIX) and all-cause and cardiovascular mortality in patients with diabetes and prediabetes by Enfa Zhao, Yiqing Chen, Hang Xie, Ruimeng Wang, Yuan Gao, Bingtian Dong, Chaoxue Zhang

“…Abstract Background Vascular endothelial impairment is crucial in diabetes and its cardiovascular complications, but clinically applicable endothelial function markers remain limited. We investigated the Endothelial Activation and Stress Index (EASIX), a novel biomarker calculated from lactate dehydrogenase, creatinine, and platelet count, for predicting mortality in diabetes and prediabetes populations. …”
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Identification of multiomics and immune infiltration-associated biomarkers for early gastric cancer: a machine learning-based diagnostic model development study by Kewei Du, Wenfei Hu, Shan Gao, Jianxin Gan, Chongge You, Shangdi Zhang

“…Single-cell RNA sequencing (ScRNA-seq) and immune infiltration analysis were performed to evaluate the relationship between gene expression and immune cell function. …”
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Subcellular localization and tissue expression pattern of SlMAPK7 gene in tomato by Guan Xiaoyan, Chen Lifei, He Yanjun, Wang Jie, Lu Gang

“…However, the most extensively studied MAPKs are MAPK3, MAPK4 and MAPK6 in Arabidopsis and rice. The function of other MAPK family members is not clear yet. …”
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Structural characteristics and antioxidant activity of a low-molecular-weight jujube polysaccharide by ultrasound assisted metal-free Fenton reaction by Yingying Liu, Yan Meng, Haozhen Ji, Jianhang Guo, Miaomiao Shi, Feiliao Lai, Xiaolong Ji

“…Monosaccharide compositional analysis of DPZMP3 revealed the presence of Rha, Ara, Gal, and GalA at a molar ratio of 1.00:1.49:1.60:7.68, and the HPGPC data demonstrated the average Mw of 34.3 kDa. …”
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Cardiac Sympathetic Denervation Mitigated Ischemic Cardiomyopathy Progression in a Rat Model of Sleep Apnea by Maximin Détrait, Jonathan Gaucher, Emma Billoir, Sophie Bouyon, Emeline Lemarié, Stéphanie Paradis, Guillaume Vial, Florent Chuffart, Côme Pasqualin, Fabien Hubert, Francesca Rochais, Stéphane Doutreleau, Jean‐Louis Pépin, Diane Godin‐Ribuot, Elise Belaidi, Claire Arnaud

“…Immunohistochemistry further supported these findings, demonstrating increased cardiomyocyte proliferation in the hypoxic group, as indicated by elevated Ki67 expression colocalized with MF20 markers. Conclusions Our data demonstrate that CSD prevents IH‐induced sympathetic hyperactivity, depletion of cardiac adrenergic reserve, and deterioration of cardiac function in a rat model of ischemic cardiomyopathy. …”
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Structural variants linked to Alzheimer’s disease and other common age-related clinical and neuropathologic traits by Ricardo A. Vialle, Katia de Paiva Lopes, Yan Li, Bernard Ng, Julie A. Schneider, Aron S. Buchman, Yanling Wang, Jose M. Farfel, Lisa L. Barnes, Aliza P. Wingo, Thomas S. Wingo, Nicholas T. Seyfried, Philip L. De Jager, Chris Gaiteri, Shinya Tasaki, David A. Bennett

“…Methods By leveraging data from two ongoing cohort studies of aging and dementia, the Religious Orders Study and Rush Memory and Aging Project (ROS/MAP), we performed genome-wide association analysis testing 20,205 common SVs from 1088 participants with whole genome sequencing (WGS) data. …”
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