Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis by Yi-Ming Li, Chen‑Xi Li, Reyila Jureti, Gulinuer Awuti

“…In addition, biomarker-associated immune cells and functional pathways were analysed to predict the upstream regulatory molecules. …”
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Harnessing single-cell and multi-omics insights: STING pathway-based predictive signature for immunotherapy response in lung adenocarcinoma by Yang Ding, Dingli Wang, Dali Yan, Jun Fan, Zongli Ding, Lei Xue

“…The STING signaling pathway plays a pivotal role in the immunotherapy of lung adenocarcinoma; therefore, further investigation into the relationship between the STING pathway and lung adenocarcinoma is warranted.MethodsWe conducted a comprehensive analysis integrating single-cell RNA sequencing (scRNA-seq) data with bulk transcriptomic profiles from public databases (GEO, TCGA). …”
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Iron Deficiency in Depressive Disorders: A Review of Mechanisms, Clinical Relevance, and Treatment Perspectives by Michał Wycik, Gabriela Kondratiuk, Agnieszka Kruk, Marta Łupińska, Kamila Stępień, Julia Kucińska, Hubert Chmielewski, Artur Wądołowski, Joanna Przeniosło, Julia Komar

“…Studies included observational data, clinical trials, and systematic reviews. The analysis focused on populations with iron deficiency (with or without anemia) and assessed the effects of iron status and supplementation on mood and psychiatric symptoms. …”
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Long-term grape powder feed attenuates experimental ischemic stroke by altering gut microbiota and metabolome by Haojie Jin, Decao Yang, Jia Guo, Baohui Xu, Yu Fu, Lixiang Xue, Yan Wang

“…As an antioxidant food, grape powder (GP) has been shown to have a neuroprotective function after ischemic injury. In the current research, we aimed to determine whether regular GP feeding before brain damage plays a protective role against ischemic damage and its potential mechanism. …”
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Differential Responses of Net Ecosystem Exchange of Carbon Dioxide to Light and Temperature between Spring and Neap Tides in Subtropical Mangrove Forests by Qing Li, Weizhi Lu, Hui Chen, Yiqi Luo, Guanghui Lin

“…The eddy flux data with field records of tidal water inundation depths of the year 2010 from two mangroves forests in southern China were analyzed to investigate the tidal effect on mangrove carbon cycle. …”
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Follow-up of phenotype and metabolic changes in adult males living with HIV on combination antiretroviral therapy (CART) for a decade by Samantha Satyakumar, Prasanna Kumar, Priscilla Rupali, Shajith Anoop, Debashree Banerjee, Felix K. Jebasingh, Asha Hesarghatta Shyamasunder, Grace Rebekah, Nihal Thomas

“…However, long-term CART causes fat redistribution, insulin resistance, and dyslipidaemia in patients living with HIV (PLWH). There is limited data from India that have studied these features exclusively in males. …”
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The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice by Katarina Bojkovic, Jennifer Leigh Rodgers, Riddhi Vichare, Asmita Nandi, Noah Mansour, Faizan Saleem, Zain Ul Abidin, Sahit Vanthenapalli, Feng Cheng, Siva Kumar Panguluri

“…Abstract Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. …”
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DBDB: de-bimodal defocus blur in joint infrared-visible imaging by Zhe Cao, Lixin Xu, Jin Zhang, Biwen Yang, Kaizheng Chen, Ruiheng Zhang

“…LSH is designed to ensure that the low-frequency information captured by the infrared modality does not contain any misleading data, while CCFI facilitates the acquisition of accurate information by means of adaptive adjustment and the loss function. …”
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Continuous beta-2 microglobulin–based clearance highlights superiority of high-Dose HDF over high-flux HD in predicting outcomes by Bernard Canaud, Andrew Davenport, Marion Morena-Carrere, Mailis Amico, Nicolas Molinari, Jean-Paul Cristol

“…By better reflecting the continuous function of the native kidney, this approach may improve patient stratification and outcome prediction across all forms of kidney replacement treatment schedule. …”
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Novel Heterozygous Sequence Variant in the HOXD13 Gene Underlie Non-syndromic Syndactyly by Safdar Abbas, Farooq Ahmad, Misbah Kanwal, Annum Sultan, Gulab Said, Muhammad Umair

“…Methodology: Whole exome sequencing coupled with Sanger sequencing was carried out to uncover the disease associated variant/s followed by 3D protein modeling to check variant related effect on protein level. Results: WES data analysis revealed a novel-HOXD13 gene missense variant (c.969G>T; p.Trp323Cys) that might explain the disease phenogenesis. 3D protein modeling of the normal and mutant protein predicated high level changes that might compromise the ultimate function of the protein. …”
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Current trends in the pharmacotherapy of uterine myoma, associated with heavy menstrual bleeding and anemia: a literature review by Z. V. Revazova, L. V. Adamyan, O. N. Loginova, L. M. Manukyan, K. N. Arslanyan

“…Aim: to summarize up-to-date world data on current opportunities of drug therapy in treatment of symptomatic myoma accompanied with heavy menstrual bleeding and anemia.Materials and Methods. …”
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Impact of multimorbidity and cognitive impairment on depressive symptoms in community-dwelling older adults and their interaction effects by Pengxin Dong, Haichen Wu, Yidan Chai, Ping Huang, Dongmei Huang, Lichong Lai, Jie Peng, Xiaoying Cao, Xiaoling Feng, Huiqiao Huang

“…Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), cognitive function was evaluated with the Alzheimer’s Disease-8 (AD-8) scale, and chronic disease conditions were recorded. …”
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Enhancing access to specialist appointments in tertiary healthcare in Shanghai, China: a structured reservation pathway using digital health technologies by Li Li, Tao Zheng, Enhong Dong, Minjie Chen, Xiaojing Zhao, Binyuan Zhang, Xuji Zhao, Weijun Shao, Yiling Fan

“…Objective The aim of this study is to develop, implement the precise reservation path (PRP) and investigate its prediction function for scheduling shunting patients for specialist appointment registration in Shanghai, China.Design The PRP system was built on the hospital’s existing information system, integrated with WeChat (WeCom) for user convenience. …”
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48-Hour and 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms in Arabidopsis by Yuwei Qin, Zhijian Liu, Shiqi Gao, Carlos Martínez-Vasallo, Yanping Long, Xinlong Zhu, Bin Liu, Ya Gao, Xiaodong Xu, Maria A. Nohales, Qiguang Xie, Jixian Zhai

“…Here, we find that four cell clusters in the shoot share a coherent rhythm, while around 3000 genes display cell-type specific rhythmic expression. Our analysis indicates that genes encoding circadian regulators oscillate in multiple cell types, and the majority of them are well-documented core clock genes, suggesting the snRNA-seq circadian data could be used to identify more clock components oscillating in a cell-autonomous way. …”
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Objectively measured activity behaviours using the ActivPAL accelerometer following robotic and manually performed total knee arthroplasty: a feasibility study from a randomized co... by Nick D. Clement, Bola Ajekigbe, Jayasree Ramaskandhan, Steven Galloway, Karen Smith, David J. Weir, David J. Deehan

“…There were no significant (p ≥ 0.144) correlations between changes in measures of physical activity functional assessments. Conclusion: Objectively assessed physical activity was logistically difficult due to patient and data loss. …”
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Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…We also performed differential analysis of SH3BP1 gene expression. We verified its expression level and function by protein blotting, immunohistochemistry, and cell scratch and cell viability assays. …”
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Mannan-Modified PLGA Nanoparticles for Targeted Gene Delivery by Fansheng Kong, Linfu Ge, Ximin Liu, Ning Huang, Fang Zhou

“…When compared with non-modified DNA-NPs and Lipofectamine 2000-DNA, MAN-DNA-NPs produced the highest gene expressions, especially in vivo. The in vivo data from flow cytometry analysis showed that MAN-DNA-NPs displayed a remarkably higher transfection efficiency (39%) than non-modified DNA-NPs (25%) and Lipofectamine 2000-DNA (23%) in KCs. …”
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Exploring factors influencing the consistent adoption of a post-stroke upper extremity outcome measure using Normalisation Process Theory by Silvana X. Choo, Joshua Yong, Shaikh Abdullah Bin Mohamed Rafi, Chen Ju Lo, Jun Bin Tong, Elaine Lum, Julian Thumboo

“…Methods Employing a mixed-method sequential exploratory study design rooted in Normalisation Process Theory (NPT), we gathered quantitative data through a validated survey followed by qualitative insights analysed with directed content analysis from focus group discussions involving occupational therapists from four hospitals. …”
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TFE3 regulates whole‐body energy metabolism in cooperation with TFEB by Nunzia Pastore, Anna Vainshtein, Tiemo J Klisch, Andrea Armani, Tuong Huynh, Niculin J Herz, Elena V Polishchuk, Marco Sandri, Andrea Ballabio

“…TFE3 deficiency resulted in altered mitochondrial morphology and function both in vitro and in vivo due to compromised mitochondrial dynamics. …”
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Point Cloud Registration for Lava Tube Surface Reconstruction Using Curvature-Optimized Projection by Jiaqi Yao, Yanqiu Wang, Wen Li, Yuan Han, Hognxu Ai, Zhenchen Ji, Fu Zheng, Zhibin Sun

“…First, the normal vectors were estimated and normalized on an unstructured point cloud using Principal Component Analysis. Subsequently, the point cloud was projected using the Moving Least Squares method based on an anisotropic weighting function to obtain curvature-optimized point cloud data. …”
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