A new association between Kleefstra syndrome and Panayiotopoulos epilepsy by Alessandra Giliberti, Stefania Giustiniano, Ylenia Carbonaro, Adele Maria Frisina, Michele Roccella, Gregorio Serra, Rosaria Nardello

“…Abstract Background Kleefstra syndrome is a rare genetic disorder attributed to loss of function of EHMT1, either due to a point mutation or a microdeletion in the chromosome region 9q34.3. …”
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Volumetric 3D Reconstruction of Large Osteochondral Lesions of the Talus Being Reconstructed with Viable Osteochondral Allograft Combined with Autograft by Nathaniel Zona BA, Daniel Moon MD, MS, MBA

“…Patient Reported Outcome (PRO) measures included PROMIS-physical function (PROMIS-PF), PROMIS-pain interference (PROMIS-PI), and single assessment numeric evaluation (SANE). …”
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Clinical application of preoperative autologous blood donation under anesthesia monitoring by DU Chunhong, SHI Yongjiu, SUI Weijia, ZHOU Lingyi, ZHANG Xinge

“…Autologous blood transfusion was performed in 443 patients (38.1%) during or after operation, with no adverse reaction during blood transfusion. 2) The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of patients after blood collection were lower than before blood collection, and the SpO2 was higher than before blood collection, with statistically significant differences (P<0.05); There was no significant difference in heart rate before and after blood collection (P>0.05); Our analysis found that age, gender, blood collection volume, department, or mild-to-moderate circulatory system complications didn’t significantly affect BP, HR and SpO2 fluctuations (P>0.05). 3) The experimental group had shorter hospital stays and lower transfusion costs than the control group (P<0.05). 4) No significant differences were observed in Hb, Hct, Plt levels or coagulation function (PT, APTT) between the two groups after operation (P>0.05). …”
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Application characteristics and clinical effectiveness of clinical finding staging in guiding non-surgical treatment of knee osteoarthritis involving 92 medical institutions by Yan Yan, Baohong Mi, Jiawen Zhang, Yanqiong Zhang, Na Lin, Changhai Ding, Ling Qin, Weiheng Chen

“…Methods A total of 14,985 KOA patients were included in the study. Data from 13,983 patients were used to analyze the characteristics of CMS application, while 1465 patients were used to evaluate CMS-guided clinical effectiveness, and 152 patients were included in a comparative analysis of clinical effectiveness without CMS guidance. …”
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Systematic review of the impact of ginger extract and alpinetin on pregnancy outcomes in animal models by Jonquile T. Williams, Kendra A. Tiani, Margaret J. Foster, Amanda J. MacFarlane, Regan L. Bailey, Patrick J. Stover, Martha S. Field

“…., liver and kidney), improved gestational weight gain, and improved placental function; fetal benefits included prevention of organ damage (e.g., liver, kidney, cardiac), improved fetal growth, reduced oxidative stress, and reduced death. …”
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Do Patients with Prior Distraction Arthroplasty Fare Worse after Total Ankle Replacement? by Allison Boden MD, Kira Lu, Emily Teehan MS, Jensen Henry MD, Constantine Demetracopoulos MD

“…Patients experienced clinical and statistical improvement in PROMIS domains for Physical Function (P=0.002), Pain Interference (P=0.007), and Pain Intensity (P=0.010). …”
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Predictors of Cognitive Defects and Its Prevention Capabilities in Premature Infants by Irina A. Belyaeva, Alexander A. Baranov, Leyla S. Namazova-Baranova, Kamilla E. Efendieva, Polina S. Arimova, Alexey I. Molodchenkov, Elena P. Bombardirova, Georgiy A. Karkashadze, Tatiana V. Turti, Elena A. Vishnyova

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MicroRNA–target cross-talks: Key players in glioblastoma multiforme by Eman Ali Toraih, Nagwa Mahmoud Aly, Hoda Y Abdallah, Saeed Awad Al-Qahtani, Aly AM Shaalan, Mohammad Hosny Hussein, Manal Said Fawzy

“…Immunohistochemistry staining for three proteins (VEGFA, BAX, and BCL2) was performed. Gene enrichment analysis identified the biological regulatory functions of the gene panel in glioma pathway. …”
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AURKB affects the proliferation of clear cell renal cell carcinoma by regulating fatty acid metabolism by Yang Yang, Dan Li, Zhigang Liu, Kai Zhou, Wenxing Li, Yanqi Yang, Ruifang Sun, Yulong Li

“…Methods We performed bioinformatics analysis, CCK-8 assay, RNA sequencing, RT-PCR and Western blot to analyze the function and mechanism of AURKB in ccRCC. …”
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Characterization of a new mutation of mitochondrial ND6 gene in hepatocellular carcinoma and its effects on respiratory complex I by Veronica Bazzani, Deepali L Kundnani, Mara Equisoain Redin, Francesca Agostini, Kirti Chhatlani, Angelo Corso Faini, Jakub Poziemski, Umberto Baccarani, Pawel Siedlecki, Silvia Deaglio, Francesca Storici, Carlo Vascotto

“…Through biochemical analyses, we characterized this new mutation and showed that the expression of ΔND6 negatively affects the stability and functionality of Complex I. Data were confirmed by molecular dynamics simulations suggesting conformational rearrangements, overall revealing a leading role of ND6 in the assembly of Complex I.…”
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Changes in heart rate variability induced by E-sports activities by Ti Wu, Po-Yao Lee, Jie-An Tu, Hsin-Huan Wang, Hsin-Huan Wang, Hsueh-Chin Chao, Chia-Hsiang Chen, Jui-Hung Tu

“…First, a normality test was conducted to determine the data distribution. Since the data did not meet the assumption of normality, the Friedman test was used to compare pre-, during-, and post-gaming heart rate data. …”
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Approximating the Proportion of Individuals With Kidney Failure Who Die Without Kidney Replacement Therapy in Ontario, Canada by Andrea C. Cowan, Nivethika Jeyakumar, Amit X Garg, Stephanie Dixon, Bin Luo, Peter G Blake

“…In this last cohort, patients whose kidney function improved (evidence of an eGFR > 10 mL/min/1.73 m 2 ) or who received a transplant during follow-up were excluded from the analysis. …”
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Early rehabilitation of cancer patients after endoprosthetic reconstruction following resection of the lower extremity long bones by A. V. Bukharov, E. V. Filonenko, D. A. Erin, V. A. Derzhavin, A. V. Yadrina, A. M. Shatalov, D. O. Elkhov, M. D. Aliev

“…Aim of the study: to conduct a systematic analysis of the data available in the modern literature, prognostic factors, and modern methods of rehabilitation of cancer patients after endoprosthetic reconstruction following resection of the lower extremity long bones. …”
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Comparing Raman and NanoSIMS for heavy water labeling of single cells by George A. Schaible, John B. Cliff, Jennifer A. Crandall, Jeremy J. Bougoure, Michael N. Mathuri, Alex L. Sessions, Joseph Atwood, Roland Hatzenpichler

“…These findings provide a robust framework for leveraging both techniques, enabling informed experimental design and data interpretation. By enhancing cross-technique comparability, this work advances SIP methodologies for investigating microbial metabolism and interactions in diverse systems.IMPORTANCEAccurate and reliable measurements of cellular properties are fundamental to understand the function and activity of microbes. …”
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Protocol of the pilot study to test and evaluate the iCARE tool: a machine learning-based e-platform tool to make health prognoses and support decision-making for the care of older... by John P Hirdes, Hao Luo, Davide L Vetrano, Graziano Onder, Jonathan Chen, Violetta Kijowska, Katarzyna Szczerbińska, Johanna Edgren, Amaia Calderón-Larrañaga, George Heckman, Ron MC Herings, Johanna de Almeida Mello, Anja Declercq, Mark Hoogendoorn, Caitlin McArthur, Mari Aaltonen, Yi Chai, Karlijn J Joling, Micaela Jantzi, Rosa Liperoti, Melissa Northwood, Ilona Barańska, Agata Stodolska, Hein P J van Hout, Margaret Saari, Luca Mariotti, Emiel O Hoogendijk, Luke Turcotte, Louk Smalbil, Elizabeth P Howard, John N Morris, Daniela Fialová, Eline CM Kooijmans, Riikka-Leena Leskelä, Jokke Häsä, Georg Ruppe, Carmen Angioletti, Olena Antonenko, Shireen Aziz, Gustavo Betini, Jovana Brkič, Roberto Da Cas, Daniel Da Cunha Leme, Lu Dai, Cecilia Damiano, Natalia Drapała, Bonaventure Egbujie, Collin JC Exmann, Harriet Finne-Soveri, Charlene France, Tiziana Grisetti, Ira Haavisto, Sophie Hogeveen, Paweł Jagielski, Laurian Jongejan, Jet E Klunder, Ingrid Kummer, Anna Lukačišinová, Matti Mäkelä, Krista Mathias, Amanda Mofina, Reem Mulla, Mikko Nuutinen, Sandra Ochwat, Paula Pennanen, Jitka Pokladníková, Bregtje Proost, Ahmer Raza, Emanuele Rocco Villani, Jindra Reissigová, Erez Schachter, Katarzyna Sekulak, Chi-Ling Joanna Sinn, Andrea Vokálová, Adrianna Ziuziakowska, Mari Lahelma, Anna-Maria Hiltunen, Anna Salminen, Mor Alon, Collin Exmann, Wiebe Boorsma, Johanna de Almeida Mello, Hein PJ van Hout

“…Descriptive statistics and bivariate and multivariate analysis will be conducted. All notes and text field data will be translated into English, and a thematic analysis will be performed. …”
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Uncommon but intriguing: A pediatric primary histiocytic sarcoma case—Clinical insights and literature review by Sofia Elouaouch, MD, Soufiane Berhili, MD, Hanane Mansouri, MD, Zahira El Youssi, MD, Ahmed Bensghier, MD, Mohammed Moukhlissi, MD, Karim Bahhous, PhD, Loubna Mezouar, MD

“…Pediatric soft tissue involvement is exceptionally rare, with limited data to guide management. We present the case of a 5-year-old girl with a painless mass on the right thigh. …”
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Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages by Isaac A. Babarinde, Xiuling Fu, Gang Ma, Yuhao Li, Zhangting Liang, Jianfei Xu, Zhen Xiao, Yu Qiao, Zheng Lin, Katerina Oleynikova, Mobolaji T. Akinwole, Xuemeng Zhou, Alexey Ruzov, Andrew P. Hutchins

“…TEs were thought to have little functional relevance but recent studies report roles in biological processes, including embryonic development. …”
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New State Identification Method for Rotating Machinery under Variable Load Conditions Based on Hybrid Entropy Features and Joint Distribution Adaptation by Xiaoming Xue, Nan Zhang, Suqun Cao, Wei Jiang, Jianzhong Zhou, Liyan Liu

“…Then, hybrid entropy features that can characterize the dynamic and complexity of time series in the local space, global space, and frequency domain were extracted from each intrinsic mode function. As for the training and testing set under different load conditions, all data was mapped into a reproducing space by joint distribution adaptation to reduce the distribution discrepancies between datasets, where the pseudolabels of the testing set and the final diagnostic results were obtained by the k-nearest neighbor algorithm. …”
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Failure Law of Sandstone and Identification of Premonitory Deterioration Information Based on Digital Image Correlation–Acoustic Emission Multi-Source Information Fusion by Zhaohui Chong, Guanzhong Qiu, Xuehua Li, Qiangling Yao

“…Additionally, by introducing the derivative functions of the multi-source information function for quantitative analysis, a comprehensive evaluation method was proposed based on the multi-source information fusion monitoring to forewarn red sandstone failure by levels during loading. …”
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A new approach of anomaly detection in shopping center surveillance videos for theft prevention based on RLCNN model by Muhammad Sajid, Ali Haider Khan, Kaleem Razzaq Malik, Javed Ali Khan, Ayed Alwadain

“…The amount of video data produced daily by today’s surveillance systems is enormous, making analysis difficult for computer vision specialists. …”
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