TCMHTI: a Transformer-based herb-target interaction prediction model for Qingfu Juanbi Decoction in rheumatoid arthritis by Zhenzhong Liang, Changsong Ding

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Parameters of complete blood count, lipid profile and their ratios in predicting obstructive coronary artery disease in patients with non-ST elevation acute coronary syndrome by M. M. Tsivanyuk, B. I. Geltser, K. I. Shakhgeldyan, A. A. Vishnevskiy, O. I. Shekunova

“…For statistical processing and data analysis, the Mann-Whitney, Fisher, chi-squared tests, univariate logistic regression (LR) were used, while for the creation of predictive models, multivariate LR (MLR) was used. …”
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Impact of China’s new quality agricultural productive forces on carbon emissions from grain production and its mechanism by FAN Zhennan, QIN Zhaohui, DING Zhiguo, TAN Qijia

“…[Results] (1) The new quality agricultural productive forces in China shows a continuous upward trend, and the overall regional differences are characterized by the main grain sales areas>main grain production areas>balanced production and sales areas. (2) There was a significant inhibitory effect of new quality agricultural productive forces on carbon emissions from grain production. (3) Mechanism analysis revealed that new quality agricultural productive forces mainly suppresses carbon emissions from grain production by expanding the scale of farmers’ operations. (4) Heterogeneity analysis showed that all three dimensions of new quality agricultural productive forces can reduce carbon emissions from grain production, and the carbon reduction effect was high for new agricultural workforce, followed by new agricultural means of production, and low for new agricultural objects of work; In terms of grain production functional areas and geographical locations, the carbon reduction effect of new quality agricultural productive forces mainly occurred in the main grain producing areas, production and sales balanced areas, and northern regions. (5) There was a single threshold in the process of new quality agricultural productive forces affecting carbon emissions from grain production. …”
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Application of Post-Occupancy Evaluation in the Design of Collegiatae Educational Space: (Case study: Faculty of Arts and Architecture, Islamic Azad University-Tehran South Branch) by Reza Naghdbishi, Zeinab Gohari

“…Descriptive statistics and structural equation modeling (SEM) in SmartPLS software were employed to analyze the data. This analysis identified the relationship between research variables and evaluated their impact on the design. …”
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Preliminary study of key specific genes involved in tubular ferroptosis in diabetic kidney disease by Ma Li-li, Jiang Lin, Fu Li, Wei Rui, Wang Ting-ting

“…Functional enrichment and protein-protein interaction network （PPI） analyses were conducted. …”
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Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach by Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang, Jiajun Li

“…We analyzed publicly available transcriptomic data from several HCC cohorts and used differential gene expression analysis to identify targets associated with both PFAS exposure and HCC. …”
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Quantitative EEG signatures in patients with and without epilepsy development after a first seizure by Marysol Segovia‐Oropeza, Erik Hans Ulrich Rauf, Ev‐Christin Heide, Niels K. Focke

“…Abstract Objective Diagnosing epilepsy after a first unprovoked seizure in the absence of visible epileptogenic lesions and interictal epileptiform discharges (IED) in the electroencephalogram (EEG) is challenging. Quantitative EEG analysis and functional connectivity (FC) have shown promise in identifying patterns across epilepsy syndromes. …”
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Enhancing road safety of PLEVs by novel vehicle concepts: A comprehensive investigation on regulations, accident statistics, and perception of riders in Europe by Michelangelo-Santo Gulino, Susanna Papini, Giovanni Zonfrillo, Peter Miklis, Thomas Unger, Dario Vangi

“…A review of PLEV-related regulation in European countries, and particularly for electric kick scooters, is initially provided to determine the mandatory equipment for their circulation in the widest possible number of countries. Analysis of accident data for PLEVs in the EU then reveals critical factors contributing to the occurrence of crashes, injuries, and casualties, as well as the type and severity of riders' injuries. …”
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Assessment of upper limb motor control: establishing normative benchmarks for clinical applications by Pablo Martín-Sierra, Cristina Sanchez, Eloy Urendes, Rafael Raya

“…A combination of clinical functional scales with the quantitative metrics presented here is expected to enable better evaluation of motor control. …”
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RESULTS OF RADIOSURGICAL AND DRUG TREATMENT OF PATIENTS WITH BRAIN METASTASES by S. M. Banov, A. V. Golanov, S. R. Ilyalov, E. R. Vetlova, S. A. Maryashev, D. R. Naskhletashvili, I. K. Osinov, V. V. Kostuchenko, A. A. Durgaryan

“…Multifactor analysis has shown that prognostic factors for long-term survival in patients with brain metastases were presence of breast cancer metastases in the brain, limited (4 lesions or less) number of brain metastases, high functional status, and absence of extracranial metastases. …”
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Fatty acid metabolism shapes immune responses in chronic lymphocytic leukemia by Yang Zhang, Jun Ma, Peipei Li, Kang Lu, Yang Han, Xinting Hu, Xiaosheng Fang, Xin Wang, Ya Zhang

“…Methods Bulk RNA sequencing data from CLL patients and healthy controls were analyzed to identify differentially expressed fatty acid metabolic genes. …”
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Self-reported prevalence and associated factors of work related voice disorders among school teachers in Sekota town, Wag Himra zone, North Ethiopia, 2021: a cross-sectional survey by Alemayehu Kibret Belete, Dawit Getachew Yenealem, Jember Azanaw

“…A pretested and self-administered Voice Handicap Index-10 (VHI-10) scale questionnaire was used to obtain information on voice disorder and associated factors. Epi-data 4.6 and SPSS version 25 were used for data entry and analysis respectively. …”
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The Prognostic Significance of Sleep and Circadian Rhythm for Myocardial Infarction Outcomes: Case-Control Study by Wei-Chih Chin, Pao-Hsien Chu, Lung-Sheng Wu, Kuang-Tso Lee, Chen Lin, Chien-Te Ho, Wei-Sheng Yang, I-Hang Chung, Yu-Shu Huang

“…ObjectiveWe aimed to evaluate how sleep patterns and disrupted circadian rhythm affect the prognosis of MI, using actigraphy and heart rate variability (HRV). Nonparametric analysis of actigraphy data was performed to examine the circadian rhythm of patients. …”
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Immune status assessment based on plasma proteomics with meta graph convolutional networks by Min Zhang, Nan Xu, Qi Cheng, Jing Ye, Shiwei Wu, Haoliang Liu, Chengkui Zhao, Lei Yu, Weixing Feng

“…Despite their significance, the link between these proteins and systemic immune function remains unclear. To bridge this gap, researchers developed ProMetaGCN, a model integrating meta-learning, graph convolutional networks, and protein-protein interaction (PPI) data to evaluate immune status via plasma proteomics. …”
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EpCAM-high liver cancer stem cells resist natural killer cell–mediated cytotoxicity by upregulating CEACAM1 by Pil Soo Sung, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang, Dong Jun Park, Jung-Hee Kim, Gil Won Lee, Eun Sun Jung

“…To investigate the functional activity of NK cells against liver CSCs, EpCAMhigh and EpCAMlow Huh-7 cells were sorted by flow cytometry. …”
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A multimodal MRI-based machine learning framework for classifying cognitive impairment in cerebral small vessel disease by Guihan Lin, Weiyue Chen, Yongkang Geng, Bo Peng, Surui Liu, Minjiang Chen, Chunying Pang, Pengjun Chen, Chenying Lu, Zhihan Yan, Shuiwei Xia, Yakang Dai, Jiansong Ji

“…We enrolled 165 CSVD patients, categorized into NCI (n = 81) and MCI (n = 84) groups based on neurocognitive assessments. Multimodal MRI data, including T1-weighted, resting-state functional MRI, and diffusion tensor images, were collected. …”
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INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering by William L Redmond, Yoshinobu Koguchi, Melissa J Kasiewicz, Annah S Rolig, Nisha Holay, Bryan Becklund, Anya Polovina, Sae Jeong Ahn, Brendan P Eckelman, Rashi Yadav, Thi Staebler, Noah D Simons, Yaiza Diaz de Durana

“…In murine models, hexavalent OX40 agonism resulted in significant tumor regression, enhanced survival, and increased CD8+ T-cell effector function. Clinical pharmacodynamic analysis in blood samples from patients treated with INBRX-106 showed heightened T-cell activation and proliferation, particularly in central and effector memory subsets, validating our preclinical findings.Conclusions Our data establish hexavalent INBRX-106 as a differentiated and more potent OX40 agonist, showcasing its ability to overcome the limitations of conventional bivalent therapies by inducing superior receptor clustering and multimeric engagement. …”
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Person-centred care of people living with dementia and its regulation in German-speaking nursing homes: A qualitative focus group study by Anna Louisa Hoffmann-Hoffrichter, Andreas Hohmann, Bernhard Holle, Rebecca Palm, Martina Roes

“…In this substudy, we conducted nine virtual focus group discussions with experts from theory, practice, and regulatory authorities from Germany, Austria and Switzerland about person-centred dementia care. We analysed the data via qualitative content analysis using a deductive-inductive approach. …”
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Uric Acid Correlates with Serum Levels of Mineral Bone Metabolism and Inflammation Biomarkers in Patients with Stage 3a–5 Chronic Kidney Disease by Francisco Mendoza Carrera, Gloria Elizabeth Vázquez Rivera, Caridad A. Leal Cortés, Lourdes del Carmen Rizo De la Torre, Renato Parra Michel, Rosalba Orozco Sandoval, Mariana Pérez Coria

“…In addition, 25 healthy subjects were included in the study with the aim of generating reference data for comparisons. Metabolic parameters including UA serum concentrations, mineral bone metabolism (parathormone (PTH), fibroblast growth factor 23 (FGF23), calcium, and phosphate), and inflammation (interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α)) biomarkers were measured in all of the samples and compared as a function of the estimated glomerular function rate (eGFR) or UA levels. …”
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Genome assembly of an endemic butterfly (Minois aurata) shed light on the genetic mechanisms underlying ecological adaptation to arid valley habitat by Wenqian Hu, Yi Wang, Xiaoxiao Chen, Jialong Huang, Jingge Kuang, Lei Wang, Kangshan Mao, Liang Dou

“…These scaffolds were further clustered and anchored onto 29 chromosomes based on Hi-C data. A total of 16,163 protein-coding genes were predicted, of which 91.83% were functionally annotated. …”
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