Spinal presentations in children with type 1 spinal muscular atrophy on nusinersen treatment across the SMA-REACH UK network: a retrospective national observational study by Francesco Muntoni, Giovanni Baranello, Pinki Munot, Mariacristina Scoto, Adnan Manzur, Marion Main, Evelin Milev, Lianne Abbott, Victoria Selby, Amy Wolfe, Annemarie Rohwer, Catherine Rye, Sarah Gregson, Grainne NicFhirleinn, Rosanna Raab, Heather McMurchie, Angela Topping, Faye Mason, Jennie Sheehan, Felicity Vann, Steph Wadsworth, José Longatto, Lindsey Pallant, Nick Emery, Jenny Moustoukas, Sarah D’Urso, Kay White, Efthymia Panagiotopoulou

“…Survival and improved function mean spinal asymmetry is a new complication with limited data on its prevalence and severity and no current guidelines on management and treatment. …”
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Genomic exploration of foot-and-mouth disease signal molecules in Malnad Gidda and Hallikar breeds of Karnataka: A RNA-seq approach by YAMINI SRI SEKAR, KURALAYANAPALYA P SURESH, SARAVANAN SUBRAMANIAM, SHIJILI MAMBULLY, SWATI RANI, MEHNAJ KHATOON, DHANUSH CHANDRASEKARAN, NAGENDRA N BARMAN, SHARANAGOUDA S PATIL

“…This study utilized RNA-Seq data and gene expression analysis, and unveiled a total of 588 differentially expressed genes (DEGs) in FMD-infected Malnad Gidda and Hallikar breeds. …”
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A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia by Geli Li, Yuchen Ma, Sujie Zhang, Wen Lin, Xinyi Yao, Yating Zhou, Yanyong Zhao, Qi Rao, Yuchen Qu, Yuan Gao, Lianmin Chen, Yu Zhang, Feng Han, Meiling Sun, Chen Zhao

“…Our work is the first that complementarily couples transcriptomic analysis with mechanistic systems-level pathway modeling in the study of BMEC function and endothelium-based therapeutic targets in ischemic stroke.…”
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Estado del Arte en Neurotecnologías para la Asistencia y la Rehabilitación en España: Tecnologías Auxiliares, Trasferencia Tecnológica y Aplicación Clínica by Luis J. Barrios, Jesús Minguillón, Francisco J. Perales, Ricardo Ron-Angevin, Jordi Solé-Casals, Miguel A. Mañanas

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Interplay of PAK1 and CAMKII in Pancreatic Beta Cell Insulin Secretion by Nely Gisela López-Desiderio, Genaro Patiño-López, Citlaltépetl Salinas-Lara, Carlos Sánchez-Garibay, Olga Villamar-Cruz, Alonso Vilches-Flores, José de Jesús Peralta-Romero, Leonel Armas-López, Jazmín García-Machorro, Luis Enrique Arias-Romero, Héctor Iván Saldívar-Cerón

“…Additionally, bioinformatic analysis of publicly available RNA sequencing (RNA-Seq) data from human islets of healthy donors, prediabetic individuals, and T2DM patients provided translational validation. …”
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Incidence of Mortality among Under-Five-Year-Old Children Born to Women Living with HIV and Those Born to Women Not Living with HIV in Botswana: A 5-Year Retrospective Study by Onalethata Lesetedi, Jose Gaby Tshikuka, Shimeles G Hamda, Mgaywa Gilbert Mjungu Damas Magafu, Roy Tapera, Tiny Masupe, Julius Chacha Mwita

“…The incidence rate of UFC death was estimated as a function of the duration from birth to death. Survival functions of UFC born to women living with and not living with HIV were plotted and compared using Kaplan–Meier survival analysis. …”
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Profound downregulation of neural transcription factor Npas4 and Nr4a family in fetal mice neurons infected with Zika virus. by Sergio P Alpuche-Lazcano, James Saliba, Vivian V Costa, Gabriel H Campolina-Silva, Fernanda M Marim, Lucas S Ribeiro, Volker Blank, Andrew J Mouland, Mauro M Teixeira, Anne Gatignol

“…We hypothesized that dysregulation of pathways involved in neurological functions will be identified by RNA profiling of ZIKV-infected fetal neurons. …”
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Study of the toxic effect of trichothecene mycotoxin produced by <i>Fusarium sporotrichioides</i> in an experiment on pigs by I. I. Idiyatov, I. R. Kadikov, V. R. Saitov, G. S. Kashevarov, I. M. Fitsev, A. M. Tremasova, K. V. Perfilova, M. M. Salnikova

“…During the experiment, the clinical condition of animals, feed and water consumption, the dynamics of live weight, analysis of blood parameters, the state of internal organs and tissues and statistical processing of the data obtained by conventional methods were undertaken.Results. …”
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The Etymological Layers of Currency Unit Names in the Mordovian Languages by Sándor Maticsák

“…Among Russian currency names, ruble and kopeck are commonly used in Mordovian, though research indicates that the Mordovian people were also familiar with and to some extent used the names of coins such as groshe, reshet, and treshnik, among others. Lexicographic analysis further reveals that certain words of Mordovian origin have either functioned or previously functioned as currency names. …”
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User-centred design of ChestCare: mHealth app for pulmonary rehabilitation for patients with COPD; a mixed-methods sequential approach by Suad J. Ghaben, Arimi Fitri Mat Ludin, Nazlena Mohamad Ali, Devinder Kaur Ajit Singh

“…Conclusions The development and validation of the ChestCare app resulted from conducting UCD iterative design and sequential MMR, which identified 13 functionalities, including symptom assessment, tracking lung volume, functional capacity test, action plan, intervention program, COPD education, COPD community, monitoring and reminders.…”
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Features of physical therapy of patients after endoprosthetic with the strengthening of capsule-ligamentous structures by S. O. Maslennikov, M. L. Holovakha, E. Yu. Doroshenko, S. M. Malakhova, L. I. Levchenko, S. H. Puzik, A. M. Hurieieva, M. O. Oliinyk

“…Results. Based on the analysis of the results of the study, we note that the quality of life of patients in both groups, the overall subjective condition of the joint, the volume of movements of the operated limb, as well as the evaluation of clinical and functional outcomes of treatment on the Harris Hip Score (HHS) directly correlate with performance preoperative exercises of a therapeutic nature and adherence to the postoperative rehabilitation program of physical therapy. …”
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A novel exploration of treating local skin infections around totally implantable venous access ports: port repositioning technique vs. port re-implantation technique by Qiulian Sun, Ling Tang, Jiefei Cheng, Dongqing Ren, Xinchun Guo

“…Among them, 15 patients in Group A underwent port repositioning surgery, while 20 patients in Group B received port re-implantation surgery. Clinical data of all patients were meticulously collected, including postoperative wound healing status and the functionality of the repositioned or re-implanted TIVAPs. …”
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The 1D Hybrid Material Allylimidazolium Iodoantimonate: A Combined Experimental and Theoretical Study by Hela Ferjani, Rim Bechaieb, Diego M. Gil, Axel Klein

“…UV–Vis diffuse reflectance spectroscopy allowed us to determine the optical band gap to 3.15 eV. Density functional theory (DFT) calculations employing the B3LYP, CAM-B3LYP, and PBE0 functionals were benchmarked against experimental data. …”
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Impact of Nordic walking on health outcomes in older women by E. V. Katamanova, I. V. Kudaeva, L. S. Vasilyeva, A. N. Kudaev, N. V. Verlan

“…With regular NW exercises for 3 months, the functional stability indicators in the sagittal plane are corrected both with open and closed eyes.…”
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Sudoscan in ATTRv Amyloidosis: A Potential Marker of Disease Progression? by Angela Romano, Valeria Guglielmino, Francesca Vitali, Maria Ausilia Sciarrone, Giovanni Siconolfi, Andrea Di Paolantonio, Guido Primiano, Marco Luigetti

“…Sudoscan is a reproducible tool investigating sweat gland function and, indirectly, small nerve fiber impairment. …”
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ZOOTECHNICAL PERFORMANCE EVALUATION OF THE USE OF BIOFLOC TECHNOLOGY IN NILE TILAPIA FINGERLING PRODUCTION AT DIFFERENT DENSITIES by Rafael Bittencourt Vieira, Leopoldo Melo Barreto, Karina Zanoti Fonseca, Mauricio Santana Lordelo, Fabiana Ribeiro de Souza, Norma Suely Evangelista-Barreto

“…Dissolved oxygen, total ammonia nitrogen, pH, and temperature were monitored daily, and nitrite and alkalinity were monitored weekly. The analysis of weight gain data obtained a linear function y = - 0.0017X2 + 3.724X – 87.77, with r2 = 0.864, coefficient of variation = 14.23%, and correlation coefficient = 0.91. …”
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Dyeing of silk with isolated bixin based orange yellow natural dye: Kinetic, thermodynamic and colorimetric aspects by Muhammad Ibrahim, Bisma, Shahid Adeel, Al Mojnun Shamim, Mohammad Khajeh Mehrizi, Muhammad Imran, Muhammad Asif Tahir, Rony Mia

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PAQR5 drives the malignant progression and shapes the immunosuppressive microenvironment of hepatocellular carcinoma by activating the NF-κB signaling by Ruida Yang, Huanhuan Wang, Cong Wu, Yu Shi, Hanqi Li, Xinyue Bao, Yuqian Yang, Shaoshan Han, Xue Yang, Jie Tao, Hao Sun, Shaobo Wu, Liankang Sun

“…Methods This study aimed to elucidate the molecular mechanisms by which PAQR5 facilitates HCC progression and contributes to the immunosuppressive microenvironment through an integrative approach combining multi-omics analysis and experimental validation. Utilizing data from bulk, single-cell, and spatial transcriptomics cohorts, this study systematically assessed the expression patterns, immune landscape, and functional characteristics of PAQR5 across different levels of resolution in HCC. …”
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Effect of oral trehalose supplementation on inflammation and wound healing in patients with peri-trochanteric fractures: study protocol for a randomised clinical trial by Amirhossein Sahebkar, Hoda Zahedi, Mohammad-Reza Jowshan, Reza Zandi, Alireza Tavallaei Zavareh, Amir Mehrvar, Bahareh Nikooyeh, Shahin Talebi

“…Various measurements and assessments will be conducted, including biochemical assays, wound assessments, anthropometric measurements and dietary intake evaluations. Data analysis will be performed using SPSS software, and statistical tests will be used to compare outcomes between the intervention and control groups.Ethics and dissemination The Ethics Committee of Shahid Beheshti University of Medical Sciences (IR.SBMU.RETECH.REC.1403.191).Trial registration number Iranian Registry of Clinical Trials. …”
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Green Synthesis, Optimization, and Characterization of CuO Nanoparticles Using <i>Tithonia diversifolia</i> Leaf Extract by S. S. Millavithanachchi, M. D. K. M. Gunasena, G. D. C. P. Galpaya, H. V. V. Priyadarshana, S. V. A. A. Indupama, D. K. A. Induranga, W. A. C. N. Kariyawasam, D. V. S. Kaluthanthri, K. R. Koswattage

“…FTIR analysis revealed organic functional groups and characteristic metal–oxygen vibrations in the fingerprint region (500–650 cm⁻¹), confirming formation. …”
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