In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome by Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Fernanda Gutierrez-Rodrigues, Massimiliano Bissa, Xingmin Feng, Emma M. Groarke, Haoran Li, Lemlem Alemu, Diego Quinones Raffo, Ivana Darden, Sachiko Kajigaya, Peter C. Grayson, Genoveffa Franchini, Neal S. Young, Bhavisha A. Patel

“…Here, we characterize the immunological landscape of VEXAS syndrome by performing multi-omics single-cell RNA analysis, cytokine multiplex assays, and in vitro functional assays on patients’ peripheral blood. …”
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MODULATION AS A MULTIMODAL TRANSLATION STRATEGY OF GRAPHIC NOVEL PERSEPOLIS BY M. SATRAPI by Anna V. Khodorenko

“…Through the lens of modulation, a descriptive analysis of a historical graphic novel focuses on its pragmatic functions and the dissemination of historical and cultural concepts, examining how shifts in perspective influence meaning adaptation in translation. …”
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SGF29 nuclear condensates reinforce cellular aging by Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, Xiaoyan Sun, Zehua Wang, Xiaoqian Liu, Zunpeng Liu, Hongyu Li, Yingjie Ding, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu

“…Through epigenomic and transcriptomic analysis, our data indicated that both condensate formation and H3K4me3 binding of SGF29 are essential for establishing its precise chromatin location, recruiting transcriptional factors and co-activators to target specific genomic loci, and initiating the expression of genes associated with senescence, such as CDKN1A. …”
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Identification of Tumor-Suppressive <i>miR-30a-3p</i> Controlled Genes: <i>ANLN</i> as a Therapeutic Target in Breast Cancer by Reiko Mitsueda, Ayako Nagata, Hiroko Toda, Yuya Tomioka, Ryutaro Yasudome, Mayuko Kato, Yoshiaki Shinden, Akihiro Nakajo, Naohiko Seki

“…., their proliferation, migration, and invasion abilities. These data indicated that <i>miR-30a-3p</i> acted as a tumor-suppressive miRNA in BC cells. …”
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A novel vasculogenic mimicry-related nomogram predicts prognosis in hepatocellular carcinoma by Yun Zhong, Yun Zhong, Yun Zhong, Yun Zhong, Fadian Ding, Fadian Ding, Fadian Ding, Fadian Ding, Han Zhang, Han Zhang, Han Zhang, Han Zhang, Denghan Zhang, Denghan Zhang, Denghan Zhang, Denghan Zhang, Xiang Zhang, Xiang Zhang, Xiang Zhang, Xiang Zhang, Shangeng Weng, Shangeng Weng, Shangeng Weng, Shangeng Weng

“…Biological process (BP), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and gene set enrichment analysis (GSEA) were applied to analyze the biological function of the hub genes. …”
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Bioinformatics Identification of Lactate‐Associated Genes in Hepatocellular Carcinoma: G6PD's Role in Immune Modulation by Hao‐ran Qu, Chao‐qun Wang, Su‐juan Sun, Wen‐wen Zhang, Cheng‐hao Liu, Xuan‐shuang Du, Yao‐yi‐ao Shu, Xi‐cheng Wang, Qin Pan, Feng‐ling Luo, Hong‐yan Wu, Xiao‐lian Zhang, Min Liu

“…Functional validations, including Western blot, flow cytometry, and molecular docking studies, were performed to confirm the biological impact of these genes. …”
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Preserving the Past to Shape the Future: The Evolution of Office Spaces Through Historic Building Adaptation by Dana Maher Ayoub Abu-Lail, Wafaa Anwar Sulaiman Goriel, Tamás Molnár, Bálint Bachmann, Gabriella Medvegy, Ágnes Borsos, Erzsébet Szeréna Zoltán

“…Through this research study, user preferences and perceptions of the integration of historical features into the modern work environment were examined. Quantitative data were extracted from 60 survey respondents and analyzed in terms of medians, modes and the analysis of key themes, such as historical aesthetics, employee creativity, work satisfaction and environmental factors, including natural light and airflow. …”
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Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Next, an innovative classification system was implemented, classifying 10,905 compounds into a 3-tier hierarchy across 141 classes, based on functional group weighting. Then, data augmentation was performed within each category using simplified molecular input line entry system (SMILES) enumeration combined with structural similarity expansion. …”
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Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy by Jinsen Zhang, Rui Sun, Yingying Lyu, Chaxian Liu, Ying Liu, Yuan Feng, Minjie Fu, Peter Jih Cheng Wong, Zunguo Du, Tianming Qiu, Yi Zhang, Dongxiao Zhuang, Zhiyong Qin, Yu Yao, Wei Zhu, Tiannan Guo, Wei Hua, Hui Yang, Ying Mao

“…In this study, we perform proteomic profiling of gliomas using 343 formalin-fixed and paraffin-embedded tumor samples and 53 normal-appearing brain samples from 188 patients, integrating these data with genomic panel information and clinical outcomes. …”
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Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review by Yan Wang, Juanjuan Wen, Feng Liu, Feng Liu, Xiujuan Peng, Gang Xu, Mingliang Zhang, Zhuangzhuang Huang, Zhuangzhuang Huang

“…The objective of this study is to conduct a comprehensive and systematic review of the botanical characteristics, traditional applications, phytochemical metabolites, pharmacological properties, toxicology, quality control measures, pharmacokinetics, and clinical applications of B. rotunda. A bibliometric analysis of current studies on B. rotunda was also conducted to facilitate further exploration and utilization of B. rotunda in the functional food and pharmaceutical industries. …”
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Evaluation of our care model in patients with fragility hip fracture: Multidisciplinary team and Fracture Liaison Service. A three-year retrospective study by José S. Barreda-Puchades, Joan Andreu-Safont, Sara Linares-Aguayo, Rafael Ortiz-Ramón, Marta Ribelles-Férez, Alberto García-Roig, Pablo Cañete-Sanpastor

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Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment by Chaojuan Huang, Yuyang Zhang, Mingxu Li, Qiuju Gong, Siqi Yu, Zhiwei Li, Mengmeng Ren, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun

“…Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association.MethodsThe publicly available data sources for insulin resistance (fasting insulin, homeostasis model assessment beta-cell function and homeostasis model assessment insulin resistance, proinsulin), brain cortical structure, and cognitive phenotypes (visual memory, reaction time) were obtained from the MAGIC, ENIGMA, and UK Biobank datasets, respectively. …”
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Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System by Bruno Rodrigues, Aline Alves Santana, Aline Boveto Santamarina, Lila Missae Oyama, Érico Chagas Caperuto, Cláudio Teodoro de Souza, Catarina de Andrade Barboza, Leandro Yanase Rocha, Diego Figueroa, Cristiano Mostarda, Maria Cláudia Irigoyen, Fábio Santos Lira

“…After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. …”
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Koopman-based linearization of preparatory EEG dynamics in Parkinson’s disease during galvanic vestibular stimulation by Maryam Kia, Maryam Kia, Maryam S. Mirian, Saeed Soori, Saeed Saedi, Emad Arasteh, Mohamad Hosein Faramarzi, Abhijit Chinchani, Soojin Lee, Artur Luczak, Martin J. McKeown

“…Galvanic Vestibular Stimulation (GVS), a non-invasive neuromodulation technique, shows promise in enhancing motor function in PD, but its underlying neural mechanisms are poorly understood. …”
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Remnant cholesterol is associated with poor prognosis in patients with hepatitis B-related acute-on-chronic liver failure: a Chinese population-based study by Juan Liu, Yuna Wang, Songsong Yuan, Jiwei Fu, Wentao Zhu

“…Results For all 4 regression models, higher RC were associated with worse liver function, coagulation, and HBV-ACLF prognoses. Restricted cubic spline analysis identified a non-linear relationship between RC and HBV-ACLF prognoses, in which the Q3 RC tertile had the lowest 28-day and 90-day HBV-ACLF survival rates; this was further confirmed by Kaplan-Meier analysis. …”
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Association between herbicide exposure and liver enzyme levels in a middle-aged and elderly population by Weiya LI, Zhuoya ZHAO, Xu CHENG, Jun AN, Shiyang ZHANG, Chengyong JIA, Meian HE

“…Additionally, no significant relationships were found between the three serum herbicides and the changes in ALT over 5 years or the risk of liver enzyme abnormalities.ConclusionSerum propham levels in middle-aged and older adults are positively associated with changes in liver enzyme AST, which may have an effect on liver function. More studies are needed to provide scientific evidence for the association between herbicide exposure and liver function.…”
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Distinctive Gait Variations and Neuroimaging Correlates in Alzheimer's Disease and Cerebral Small Vessel Disease by Xia Zhou, Wen‐Wen Yin, Chao‐Juan Huang, Si‐Lu Sun, Zhi‐Wei Li, Ming‐Xu Li, Meng‐Meng Ren, Ya‐Ting Tang, Jia‐Bin Yin, Wen‐Hui Zheng, Chao Zhang, Yu Song, Ke Wan, Yue Sun, Xiao‐Qun Zhu, Zhong‐Wu Sun

“…Voxel‐based morphology analysis assessed grey matter volume (GMV), while cerebral blood flow (CBF) was derived from 3D‐arterial spin labelling data. …”
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Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma by Kai Lei, Kai Lei, Yutong Zhao, Shumin Li, Jiawei Liu, Wenhao Chen, Caihong Zhou, Yi Zhang, Jinmei Tan, Jian Wu, Qi Zhou, Qi Zhou, Jiehui Tan

“…Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics sequencing (ST-seq) data from HCC patients were analyzed to investigate the tumor microenvironment and functional disparities. …”
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Comprehensive circRNA expression profile and hub genes screening during human liver development by Si Ying Li, Shu Ting Liu, Chen Yi Wang, Yu Zuo Bai, Zheng Wei Yuan, Xiao Bing Tang

“…It was found that the activity of circRNAs was boosted remarkably in the hepatoblastic stage. Enrichment analysis found they mainly involved in nervous system regulation of liver function, embryonic organ development and digestive system development. …”
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Two cases of type I sialidosis and a literature review by Yuan Ding, Ming Cheng, Chunxiu Gong

“…A literature review was performed by summarizing data from 31 published articles encompassing 69 genetically confirmed cases of type I sialidosis up to 2023 for comparative analysis. …”
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