Cognitive-behavioral therapy to normalize social learning for patients with major depressive disorders: study protocol for a single-arm clinical trial by Yuening Jin, Si Zu, Pengchong Wang, Fangrui Sheng, Xue Wang, Yun Wang, Qun Chen, Jie Zhong, Fang Yan, Jia Zhou, Zhanjiang Li, Yuan Zhou

“…Data collection of the two groups comprises of demographic information, clinical assessments, psychological assessments, and behavioral experiments (i.e. the Door Game and the Trust Game) in conjuction with task-based function magnetic resonance imaging (fMRI) scanning. …”
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TO JUSTIFY A DIFFERENTIATED APPROACH TO PRESERVATION OF THIRD MOLARS DURING ORTHODONTIC TREATMENT BY DETERMINING THEIR CONDITION AND POSITION IN THE JAW by S.І. Doroshenko, I.S. Kuzmenko, K.V. Storozhenko, S.V. Irkha, Kh.M. Demianchuk

“…Results. The analysis of data showed significant variability in inclination of third molars relative to the jaw base and second molars on both sides of the jaws (on the left and the right). …”
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Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei by Lúcia Mamede, Fanta Fall, Madeline Vast, Kristelle Hughes, Giorgia Martelli, Francesco Caligiore, Bernadette Govaerts, Paul A.M. Michels, Michel Frédérich, Joëlle Quetin-Leclercq

“…In this study, a metabolomics analysis using the data from both LC-HR-MS and 1H-NMR described CTA's effects on Trypanosoma brucei after 3 h exposure under 5 or 10 x EC50. …”
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Development and validation of a machine learning model based on multiple kernel for predicting the recurrence risk of Budd-Chiari syndrome by Weirong Xue, Bing Xu, Hui Wang, Xiaoxiao Zhu, Jiajia Qin, Guangshuang Zhou, Peilin Yu, Shengli Li, Yingliang Jin

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A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice by Qi-Chao Gao, Ge-Liang Liu, Qi Wang, Sheng-Xiao Zhang, Zhi-Lin Ji, Zhao-Jun Wang, Mei-Na Wu, Qi Yu, Pei-Feng He

“…Based on transcriptomic perturbation data of over 40,000 drugs in human cells from the LINCS-L1000 database, our study employed the Jaccard index and hypergeometric distribution test for reverse transcriptional feature matching analysis, identifying Givinostat as a potential treatment for AD. …”
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Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression by Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Fuchun Si

“…Methods Single-cell RNA sequencing data were clustered using a single-cell transcriptome clustering method, and malignant epithelial cells were identified through copy number variation analysis. …”
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Comprehensive Stress-Based De Novo Transcriptome Assembly and Annotation of Guar (Cyamopsis tetragonoloba (L.) Taub.): An Important Industrial and Forage Crop by Fahad Al-Qurainy, Aref Alshameri, Abdel-Rhman Gaafar, Salim Khan, Mohammad Nadeem, Abdulhafed Abdullah Alameri, Mohamed Tarroum, Muhammad Ashraf

“…Trinity was used to achieve a de novo assembly followed by gene annotation, functional classification, metabolic pathway analysis, and identification of SSR markers. …”
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Development and validation of a 14-CpG DNA methylation signature and drug targets for prognostic prediction in breast cancer by Bao-xing Tian, Zhi-xi Yu, Xia Qiu, Li-ping Chen, Yu-lian Zhuang, Qian Chen, Yan-hua Gu, Meng-jie Hou, Yi-fan Gu

“…Kaplan–Meier (KM) survival analysis, receiver operating characteristic (ROC) analysis, and nomogram validation confirmed the clinical value of the signature. …”
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A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients by Mingxuan Gao, Liya Gong, Yanmei Zeng, Dongling Li, Junyan Wen, Ying Guo, Zhujia Li, Jingwen Luo, Chunling Chen, Ge Wen

“…BackgroundAbnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the “gut-brain axis” is involved in a wide range of metabolic regulation through neural and endocrine processes, which has become a key breakthrough in revealing the abnormalities of food intake behaviors in T2DM patients.ObjectiveExploring the mechanism of action of abnormal regulation of ingestive desire in overweight/obese T2DM patients by integrating multimodal MRI techniques with microbiological analysis based on the gut-brain axis.MethodsThirty-one patients with overweight/obese type 2 diabetes mellitus (Group A), 17 patients with simple obesity with abnormal glucose metabolism (Group B), and 14 patients with simple obesity with normal glucose metabolism (Group C) were recruited, and clinical data, MRI, and stool specimens were collected to analyze the correlation between the imaging indicators and the intestinal flora, and clinical data.ResultsCompared with Group C, the abundance of Prevotella and Bifidobacterium in Group A and Group B was significantly reduced, while the abundance of Bacteroides, Fusobacterium, and Phascolarctobacterium was significantly increased. …”
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Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease by Joshua Pillai, Kijung Sung, Linda Shi, Chengbiao Wu

“…Herein, we classified 44 missense variants involved in TREM2 using structural bioinformatic data with AlphaFold2. Using the protocol described in our previous work [1], we determined the structural, stability, and potential functional effects of these variants. …”
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Exome sequencing identifies novel genes associated with cerebellar volume and microstructure by Yuanyuan Liang, Dongrui Ma, Mengjie Li, Zhiyun Wang, Chenwei Hao, Yuemeng Sun, Xiaoyan Hao, Chunyan Zuo, Shuangjie Li, Yanmei Feng, Shasha Qi, Yunpeng Wang, Shilei Sun, Yu-Ming Xu, Ole A. Andreassen, Changhe Shi

“…This study conducts a large-scale exome association analysis using data from approximately 35,000 UK Biobank participants, examining seven cerebellar traits, including total cerebellar volume and white matter microstructure. …”
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Single-nucleus RNA sequencing uncovers metabolic dysregulation in the prefrontal cortex of major depressive disorder patients by Xiang-Yao Li, Yingbo Rao, Guo-Hao Li, Luxi He, Yaohan Wang, Wenli He, Ping Fang, Chenyu Pei, Lun Xi, Haiyan Xie, Yun-Rong Lu

“…In the context of MDD, alterations in synaptic transmission within the prefrontal cortex (PFC) are associated with PFC hypoactivation, a key factor in cognitive function and mood regulation. Given the high energy demands of the central nervous system, these synaptic changes suggest a metabolic imbalance within the PFC of MDD patients. …”
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Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma by Shencheng Ren, Junkan Zhu, Guangyao Shan, Jiaqi Liang, Yunyi Bian, Han Lin, Haochun Shi, Binyang Pan, Guangyin Zhao, Huiqin Yang, Xiaolong Huang, Cheng Zhan, Di Ge, Guoshu Bi

“…To validate this finding, we conducted a retrospective analysis of nearly three thousand LUAD patients’ data from public databases and our institution. …”
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Physical inactivity exacerbates pathologic inflammatory signalling at the single cell level in patients with systemic lupusResearch in context by Sarah L. Patterson, Hoang Van Phan, Chun Jimmie Ye, Cristina Lanata, Sebastián Cruz González, Joonsuk Park, Lindsey A. Criswell, Kamil E. Barbour, Jinoos Yazdany, Maria Dall’Era, Marina Sirota, Patricia Katz, Charles R. Langelier

“…We analyzed peripheral blood mononuclear cell (PBMC) single-cell RNA sequencing (scRNA-seq) data available from the cohort. From the scRNA-seq data, we compared immune cell frequencies, cell-specific gene expression, biological signalling pathways, and upstream cytokine activation states between physically active and inactive patients, adjusting for age, sex and race. …”
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Two rice cultivars recruit different rhizospheric bacteria to promote aboveground regrowth after mechanical defoliation by Changjin Jiang, Fei Wang, Jinling Tian, Wanyuan Zhang, Kabin Xie

“…In field trials, Minghui63 and Nipponbare enriched taxonomically and functionally distinct bacteria in the rhizosphere and root. …”
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UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…The effects of immune cell markers on prognosis were analyzed via univariate Cox regression, least absolute shrinkage and selection operator (LASSO) and gene set variation analysis (GSVA) of bulk sequencing data from The Cancer Genome Atlas (TCGA)-HGSOC cohort. …”
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The Bronchiectasis Severity Index and FACED score for assessment of the severity of bronchiectasis by J.C. Costa, J.N. Machado, C. Ferreira, J. Gama, C. Rodrigues

“…In this regard, two different validated scores are currently used to assess the severity of non-cystic fibrosis bronchiectasis (NCFB): the FACED score and the Bronchiectasis Severity Index (BSI).Objective To describe the etiology of NCFB and compare the results of the assessment of NCFB severity obtained via FACED and BSI scores.Methods Retrospective study of demographic and clinical data of a convenience sample of NCFB patients attending the Functional Breathing Re-adaptation appointment at the Pneumology B Unit, University Hospital Center of Coimbra. …”
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Risk factors for early mortality and impaired quality of life in oral cavity cancer – head and neck cancer register study by Teija Nieminen, Morag Tolvi, Tuija Ylä-Kotola, Lasse Lehtonen, Antti Mäkitie, Taru Ilmarinen

“…Background and purpose: Treatment of locoregionally advanced oral cavity cancer (OCC) is associated with treatment-related complications, functional deficits, and even early mortality. High-quality register data could help in choosing between curative and non-curative intent treatment options. …”
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Genome Selection and Genome-Wide Association Analyses for Litter Size Traits in Large White Pigs by Yifeng Hong, Xiaoyan He, Dan Wu, Jian Ye, Yuxing Zhang, Zhenfang Wu, Cheng Tan

“…Furthermore, a single-step genome-wide association study (ssGWAS) integrated genomic information and pedigree-based relationship matrices to screen for significant SNPs associated with litter size traits across the genome. Functional analysis of key candidate genes was subsequently conducted based on ssGWAS results. (3) Results: Heritabilities for litter traits ranged from 0.01 to 0.06. ssGBLUP improved genomic prediction accuracy by 6.38–13.33% over BLUP. …”
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Comprehensive characterization of lncRNA N6-methyladenosine modification dynamics throughout bovine skeletal muscle development by Cui Mao, Wei You, Yuta Yang, Haijian Cheng, Xin Hu, Xianyong Lan, Enliang Song

“…The first approach employed weighted gene co-expression network analysis (WGCNA) of transcriptomic data to identify correlations between annotated lncRNAs and growth-related traits, resulting in 21 candidate hub lncRNAs. …”
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