Genetic association of lipids and lipid-lowering drug target genes with breast cancer by Tianhua Wang, Yan Yao, Xinhai Gao, Hao Luan, Xue Wang, Lijuan Liu, Changgang Sun

“…We found that HMGCR inhibitors are associated with a reduced risk of breast cancer, and part of their action may be through pathways other than lipid-lowering, including modulation of immune function and reduction of inflammation represented by C-reactive protein levels.…”
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Investigating the mutual effects of autophagy and apoptosis in heart tissue of type 2 diabetic rats in interaction with aerobic exercise training and vitamin D3 injection by Hadi Golpasandi, Mohammad Rahman Rahimi, Slahadin Ahmadi

“…After the completion of aerobic training interventions and vitamin D3 injection and anesthetizing the mice, the heart tissue was extracted and the protein levels of Beclin -1, Bax and Bcl -2 in the left ventricle of the heart tissue were measured by western blot technique. The data were analyzed using one-way analysis of variance (ANOVA).Results: Data analysis showed that type 2 diabetes increased the levels of Beclin-1, Bax and decreased Bcl-2 (P<0.001). …”
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Fungsi Hasil Laboratorium Forensik Sebagai Bukti dalam Tindak Pidana Narkotika by Achmad Miftah Farid, Novi Nur Indahsari

“…This research aims to examine the position of forensic laboratory analysis results within the legal system based on Law Number 35 of 2009 concerning Narcotics, and the function of forensic laboratory results as evidence in narcotics criminal cases at the Sukoharjo Police Resort. …”
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Different Types of Blood Pressure Variability in Hypertensive Patients with Chronic Lower Airway Diseases by M. I. Smirnova, V. M. Gorbunov, A. S. Kurekhyan, Ya. N. Koshelyaevskaya, A. D. Deev

“…ABPM is the most reliable method of BPV assessment in hypertensive patients with CLAD, according to our data. The increase in BPV is associated with irreversible airway obstruction and renal function. …”
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Quantitatively defined stromal B cell aggregates are associated with response to checkpoint inhibitors in unresectable melanoma by James W. Smithy, Xiyu Peng, Fiona D. Ehrich, Andrea P. Moy, Mohammad Yosofvand, Colleen Maher, Nathaniel Aleynick, Rami Vanguri, Mingqiang Zhuang, Jasme Lee, MaryLena Bleile, Yanyun Li, Michael A. Postow, Katherine S. Panageas, Travis J. Hollmann, Margaret K. Callahan, Ronglai Shen

“…Given the complexity of mIF data, the development of automated analysis pipelines is crucial for advancing biomarker discovery. …”
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Assessment of patient-reported outcomes after polytrauma – instruments and methods: a systematic review by Silke Andrich, Michaela Ritschel, Joachim Windolf, Andrea Icks, Maria-Inti Metzendorf, Irmela Gnass, Silke Kuske, Kai Moschinski, Annegret Herrmann-Frank, Sascha Flohé, Johannes Sturm, Sandra Olivia Borgmann, Charlotte Wittgens

“…Systematic reviews and meta-analyses were excluded, but references screened for appropriate studies.Data extraction and synthesis Data extraction, narrative content analysis and a critical appraisal (e.g. …”
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To determine the role of TRIT1 in the diagnosis, prognosis and immunoinvasion of liver hepatocellular carcinoma by Xinyu Niu, Xinyu Niu, Xiaona Pan, Guifang He, Chao Xuan, Qingwu Tian, Yuan Yuan, Jingqiu Chen, Jingqiu Chen, Yaqi Song, Yaqi Song, Yujuan Tang, Yujuan Tang, Tingting Zhou

“…Additionally, TRIT1 expression levels were further examined via reverse transcription quantitative polymerase chain reaction (RT-qPCR). Functional enrichment analysis was performed to elucidate the biological pathways associated with TRIT1. …”
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Transformation of Stock Market Threats into Investment Opportunities: Modelling the Dependence of the Indian and Vietnamese Stock Markets on the US–China Trade War by Iryna Pozovna, Wojciech Duranowski, Olga Pankiv, Iryna Kalenyuk, Serhii Fomenko

“…The article uses ARIMA modelling and correlation-regression analysis to study structural changes in investment policy and development of production capacities in India and Vietnam in the context of the impact of changes caused by the US-China trade war and identifies the functional dependence of the stock market of India and Vietnam in 2014-2014 on the main US and Chinese stock indices. …”
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Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease by Asmita Mishra, Ram Thapa, Kevin Bigam, Martine Extermann, Rawan Faramand, Farhad Khimani, Xuefeng Wang, Vickie Baracos, Joseph A. Pidala

“…Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high‐risk cancer population with mortality risk explained by cGVHD severity, but also informed by baseline comorbidities, functional status before and after HCT, and cumulative toxicity from the procedure and its complications. …”
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Association between dietary patterns and anemia in older adults: the 2015 China adults chronic diseases and nutrition surveillance by Pengfei Wang, Qiya Guo, Xue Cheng, Wen Zhao, Hongyun Fang, Lahong Ju, Xiaoli Xu, Xiaoqi Wei, Weiyi Gong, Lei Hua, Jiaxi Li, Xingxing Wu, Li He

“…Methods The data was obtained from the 2015 Chinese Adults Chronic Diseases and Nutrition Surveillance (2015 CACDNS), dietary information was collected using the food frequency method within the past year, exploratory factor analysis was used to extract dietary patterns, and logistic regression was used to analyze the relationship between dietary patterns and anemia. …”
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Quality of Life, Disability, Well-Being, and Coping Strategies in Patients Undergoing Neurosurgical Procedures: Preoperative Results in an Italian Sample by Silvia Schiavolin, Rui Quintas, Marco Pagani, Stefano Brock, Francesco Acerbi, Sergio Visintini, Alberto Cusin, Marco Schiariti, Morgan Broggi, Paolo Ferroli, Matilde Leonardi

“…The aim of this paper is to present the preliminary results of QoL, well-being, disability, and coping strategies of patients before neurosurgical procedure. Methods. We analysed data on preoperative quality of life (EUROHIS-QoL), disability (WHODAS-II), well-being (PGWB-S), coping strategies (Brief COPE), and functional status (KPS score) of a sample of patients with brain tumours and cerebrovascular and spinal degenerative disease admitted to Neurological Institute Carlo Besta. …”
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Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis by Yanhong Liu, Wenqi Li, Jingxiao Chen, Yi Li, Jieqi Cai, Yongxi Luo, Jiahao Lin, Lu Chen, Aiping Lu, Daogang Guan, Huiyong Xu

“…By constructing a comprehensive pharmacological network, this study seeks to identify key targets and active components associated with periodontitis, providing scientific evidence for the optimization, mechanistic analysis, and clinical application of TCM. Methods Through bioinformatics analysis, periodontitis-associated pathogenic genes were identified from the DisGeNET and GEO databases. …”
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Distinct phenotypes of salivaricin-producing Ligilactobacillus salivarius isolated from the gastrointestinal tract of broiler chickens and laying hens by A.G. Elnar, Y.J. Jang, B.G. Eum, M.H. Kang, G.W. Hwang, D.Y. Kil, G.B. Kim

“…However, two Type B strains (B4311 and B5258) showed inhibitory activity against L. monocytogenes ATCC19114. Multiplex PCR analysis and synteny mapping analysis revealed that B4311 and B5258 strains harbored the lanT gene, highlighting the importance of LanT protein in the cleavage of leader peptide and excretion of mature peptides. …”
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BASE: a web service for providing compound-protein binding affinity prediction datasets with reduced similarity bias by Hyojin Son, Sechan Lee, Jaeuk Kim, Haangik Park, Myeong-Ha Hwang, Gwan-Su Yi

“…This bias arises because most compounds show consistent binding affinities due to high sequence or functional similarity among their target proteins. Our Uniform Manifold Approximation and Projection analysis based on compound fingerprints further revealed that low and high variation compounds do not exhibit significant structural differences. …”
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Identification and validation of key extracellular proteins as the potential biomarkers in diabetic nephropathy by Wei Pan, Qiankun Zhang, Xiaohua Gong, Wenjun Wu, Qi Zhou

“…Functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, were performed on these EP-DEGs. …”
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Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction by Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng

“…Functional enrichment analyses delineated the dysregulation of pathways, while weighted gene co-expression network analysis identified hub genes within ribosome biogenesis-associated modules. …”
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Predicting the efficacy of rehabilitation in patients with type 2 diabetes and diabetic polyneuropathy by T.H. Bakaliuk, N.R. Makarchuk, H.O. Stelmakh, V.I. Pankiv, I.I. Kamyshna

“…Integrating state-of-the-art data analysis methods and molecular-biological approaches into predictive models will contribute to the development of innovative rehabilitation strategies and improve treatment outcomes in this important patient population. …”
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A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Notably, TELscore also served as a robust predictor of immunotherapy response, which was validated in the IMvigor210 cohort. Finally, scRNA analysis highlighted profound cellular and functional divergence between TELscore subgroups. …”
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Genetic Mapping of a QTL Controlling Fruit Size in Melon (<i>Cucumis melo</i> L.) by Fazle Amin, Nasar Ali Khan, Sikandar Amanullah, Shusen Liu, Zhao Liu, Zhengfeng Song, Shi Liu, Xuezheng Wang, Xufeng Fang, Feishi Luan

“…These results provide a better understanding for further fine mapping and functional gene analysis related to melon fruit size.…”
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Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture by Rajendra A. Morey, Yuanchao Zheng, Henry Bayly, Delin Sun, Melanie E. Garrett, Marianna Gasperi, Adam X. Maihofer, C. Lexi Baird, Katrina L. Grasby, Ashley A. Huggins, Courtney C. Haswell, Paul M. Thompson, Sarah Medland, Daniel E. Gustavson, Matthew S. Panizzon, William S. Kremen, Caroline M. Nievergelt, Allison E. Ashley-Koch, Mark W. Logue

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