Adaptive Neural Network Robust Control of FOG with Output Constraints by Shangbo Liu, Baowang Lian, Jiajun Ma, Xiaokun Ding, Haiyan Li

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Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

“…The mouse surrogate anti-TIGIT antibodies were identified and used to extensively investigate the mechanism of action of anti-TIGIT antibodies as monotherapy or in combination with anti-programmed cell death protein-1 (PD-1) antibody in vivo by gene expression profiling and flow cytometry analyses with a mouse syngeneic tumor model.Results Structural analyses with solution NMR and X-ray crystallography revealed that vibostolimab binds the CC’C’’FG loop interface of TIGIT, completely competing for the binding site of CD155 with a larger coverage area than another anti-TIGIT antibody tiragolumab, consistent with surface plasmon resonance analysis, though mouse models with similar antibodies revealed no functional difference in antitumor efficacy. …”
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CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA by Tianyu Jing, Tianyu Jing, Tianyu Jing, Liwen Xu, Liwen Xu, Shutong Sun, Wenyi Yu, Wenyi Yu, Yixi Zheng, Yixi Zheng, Gang Xu, Xinhao Shen, Tieyu Tang, Cheng Chu, Cheng Chu

“…Neurological functional outcomes were reassessed at the end of the follow-up period, and differences between the two groups were analyzed. …”
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Hemoglobin-associated CALR in proximal tubule cells can be used as a biomarker for idiopathic membranous nephropathy by Shuting Pang, Shuting Pang, Qiuyan Tan, Qiuyan Tan, Boji Xie, Boji Xie, Bingmei Feng, Rongbin Zhou, Zige Liu, Zige Liu, Haiyuan Wei, Yian Huang, Mujia Jili, Yuli Xie, Yuli Xie, Shanshan Li, Shanshan Li, Binran Zhao, Binran Zhao, Wei Li, Rirong Yang, Rirong Yang

“…By integrating these data with single-cell RNA sequencing (scRNA-seq) data from IMN and healthy kidney tissues, we performed comprehensive analyses including: Inflammatory index assessment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, Gene Ontology (GO) functional annotation, Gene Set Enrichment Analysis (GSEA) enrichment analysis, Protein-Protein Interaction (PPI) network construction. …”
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Positive Collaboration in Rehabilitation Nursing Enhances Fall Efficacy and Confidence in Elderly Patients with Cerebral Infarction by Luo F, Xu W, Xu Y, Lou L, Xu C

“…Positive collaboration in rehabilitation nursing, which involves coordinated efforts among patients, healthcare providers, and family members, has emerged as a holistic approach to enhance both physical and psychological recovery.Objective: To analyze the effects of positive collaboration concept rehabilitation nursing on elderly patients with cerebral infarction, focusing on fall efficacy and rehabilitation confidence.Methods: A retrospective analysis was conducted on clinical data from 106 elderly patients with cerebral infarction, admitted from October 2022 to April 2024. …”
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Importance of benzoyltransferase GcnE and lysine benzoylation of alcohol dehydrogenase AdhB in pathogenesis and aflatoxin production in Aspergillus flavus by Xuan Chen, Lihan Wu, Yuqi Zhang, Sen Wang, Shihua Wang

“…However, whether Kbz exists in pathogenic fungi and its function remains unknown. Here, we demonstrated for the first time that Kbz is present in Aspergillus flavus and identified 60 benzoylated sites on 46 benzoylated proteins by global benzoylome analysis. …”
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The TGF-β1 Signaling Pathway as an Attractive Target in the Fibrosis Pathogenesis of Sjögren’s Syndrome by Margherita Sisto, Loredana Lorusso, Giuseppe Ingravallo, Roberto Tamma, Domenico Ribatti, Sabrina Lisi

“…Transforming growth factor β1 (TGF-β1) plays a crucial role in the induction of fibrosis, often associated with chronic phases of inflammatory diseases contributing to marked fibrotic changes that compromise normal organ function. The TGF-β1 signal exerts its biological effects via the TGF-β/SMAD/Snail signaling pathway, playing an important pathogenic role in several fibrotic diseases. …”
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Effectiveness and safety of tenofovir amibufenamide and tenofovir alafenamide in treating elderly patients diagnosed with decompensated hepatitis B cirrhosis: a retrospective cohor... by Xinye Qiu, Yue Yin, Shibin Zhang, Wei Liu

“…Compared with the control group, the change of safety dates was also no statistical difference.ConclusionTMF treatment in elderly patients with decompensated hepatitis B cirrhosis had a good antiviral effect, no adverse drug reaction on renal function and blood lipids, and high safety. TMF is not inferior to TAF in antiviral efficacy and safety.…”
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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad

“…Global methylation (5mC) and hydroxymethylation (5hmC) patterns were mapped in the Left ventricular tissue of control and diabetic rats with the help of an enrichment-based (h)MEDIP-sequencing technique by using antibodies specific for 5mC and 5hmC. Sequencing data were validated by performing (h)MEDIP-qPCR analysis at the gene-specific level, and gene expression was analyzed by qPCR. …”
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Monitoring Plasma Concentrations of Intravenously Administered Fosfomycin to Prevent Drug-Related Adverse Events: A Retrospective Observational Study by Kathrin Marx, Nina Malmström, Marie Quast, Annette Glas, Ralph Wendt, Martina Kinzig, Fritz Sörgel, Maike Fedders, Thilo Bertsche, Christoph Lübbert

“…<b>Methods:</b> This retrospective study used routine data from patients receiving intravenous fosfomycin therapy. …”
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Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury by Sun X, Liu Y, Liu Y, Ai S, Luo P

“…Spearman correlation, COX regression analysis and Kaplan-Meier curves were used to evaluate the correlation between serum 5-MTP and renal function and the value of prognosis.Results: The findings revealed that serum 5-MTP levels were significantly elevated in SA-AKI patients compared to both the healthy control and sepsis groups(P&lt; 0.05), and were associated with Scr, BUN, and eGFR levels(P&lt; 0.05). …”
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The relationship of clinical and morphological parameters with the BRAF status of the tumor in patients with stage I skin melanoma by K. S. Titov, M. V. Sorokina, S. S. Lebedev, D. N. Grekov, E. Yu. Neretin, T. A. Yakusheva

“…All patients underwent clinical data analysis, an extended morphological study and a molecular genetic study to determine the BRAF V600E mutation in the primary tumor. …”
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The moderating effect of the psychosocial working conditions (effort/reward/overcommitment) on the association between noise annoyance and cognitive performance among adolescents by Noad-Maria Azzi, Sahar Obeid, Rabih Hallit, Diana Malaeb, Sami El Khatib, Mariam Dabbous, Fouad Sakr, Souheil Hallit, Vanessa Azzi

“…Results The moderation analysis findings revealed that at low levels of effort, higher noise annoyance was significantly associated with worse memory function (Beta = 0.94; p =.002) and mathematics skills (Beta = 0.40; p =.002), whereas at low (Beta = 0.49; p <.001) and moderate (Beta = 0.29; p =.001) levels of effort, it was significantly associated with worse sustained sequential processing. …”
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Symptoms of complex pelvic pain: A survey in three cohorts of women by Cecilie Therese Hagemann, Siri Spetalen, Susan Saga, Ingvild Bratlie, Vilde Dons, Signe Nilssen Stafne

“…Overlap with other pain‐related conditions is frequently reported, and chronic pelvic pain may impact sexual function. Nevertheless, little is known about the symptom burden of chronic pelvic pain and more complex pelvic pain in different groups of women. …”
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Hemiarthroplasties via Posterior Trochanter Osteotomy for Treating Femoral Neck Fractures in Post-Cerebrovascular Disease by Jia YA, Qiao LN, Liu ZB, Xue L, Bi WM, Chen MF, Kang K, Wang F

“…Ying-Ao Jia,1,&amp;ast; Li-Na Qiao,2,&amp;ast; Zhi-Bin Liu,1 Liang Xue,1 Wei-Ming Bi,1 Meng-Fei Chen,1 Kai Kang,1 Fei Wang1 1Department of Orthopaedics, Affiliated Hospital of Yan’an University, Yan’an, 716000, People’s Republic of China; 2Department of Pathology, Affiliated Hospital of Yan’an University, Yan’an, 716000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Fei Wang, Department of Orthopaedics, Affiliated Hospital of Yan’an University, Yan’an, Shaanxi, 716000, People’s Republic of China, Tel +86 18691133000, Email ww_ff@sina.comObjective: The study investigated to examine the clinical outcomes of hemiarthroplasties using posterior femoral trochanter osteotomy for the treatment of femoral neck fractures in patients at the sequelae stage of cerebrovascular disease.Methods: A retrospective analysis was conducted on the data of 53 patients who had been admitted to the Department of Orthopedics at Yan’an University Affiliated Hospital between May 2020 and May 2023. …”
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Molecular cloning, bioinformatics of the duck RIG-1 promoter region, and its differential expression profiles in embryo stages by LUO Jun, LIU Hehe, LIU Junying, ZHANG Tao, WANG Yushi, HAN Chunchun

“…Promoter, as the central element of gene expression regulation, can affect gene function by regulating mRNA transcription. However, there is still no report focusing on avian RIG-1 promoter. …”
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Prehabilitation Exercise Training to Target Improved Muscle Strength in Pretransplant Patients Diagnosed With Multiple Myeloma: Protocol for a Pilot Randomized Controlled Trial by Amber J Normann, Clifton C Mo, Rebekah L Wilson, Michelle Perez, Corey Cutler, Hajime Uno, LaDora V Thompson, Tina L Skinner, Paul G Richardson, Catherine R Marinac, Christina M Dieli-Conwright

“…Trial completion and start of data analysis is expected in July 2025 with expected results to be published in early winter of 2026. …”
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An artificial intelligence approach to palaeogeographic studies: a case study of the Late Ordovician brachiopods of Laurentia by Akbar Sohrabi

“…Discussion of Results & Conclusions  In this study, a neural network model was developed based on palaeogeography and evolutionary analysis of brachiopods in North America, and a back-propagation neural network model was created to estimate the location of the Rhynchotrema and Hiscobeccus specimens, based on a set of nine morphometric data (Nouri-Taleghani et al. 2015; Abdizadeh et al. 2017; Farzi et al. 2017) (Fig. 4). …”
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Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). by Daniele Campa, Anika Hüsing, Angelika Stein, Lucie Dostal, Heiner Boeing, Tobias Pischon, Anne Tjønneland, Nina Roswall, Kim Overvad, Jane Nautrup Østergaard, Laudina Rodríguez, Núria Sala, Maria-José Sánchez, Nerea Larrañaga, José María Huerta, Aurelio Barricarte, Kay-Tee Khaw, Nicholas Wareham, Ruth C Travis, Naomi E Allen, Pagona Lagiou, Antonia Trichopoulou, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Henk van Kranen, H Bas Bueno-de-Mesquita, Göran Hallmans, Mattias Johansson, Isabelle Romieu, Mazda Jenab, David G Cox, Afshan Siddiq, Elio Riboli, Federico Canzian, Rudolf Kaaks

“…We confirmed this in a meta-analysis using as replication set the data from the second phase of our study jointly with the first phase of the Cancer Genetic Markers of Susceptibility (CGEMS) project. …”
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Machine learning-based model for CD4+ conventional T cell genes to predict survival and immune responses in colorectal cancer by Zijing Wang, Zhanyuan Sun, Hengyi Lv, Wenjun Wu, Hai Li, Tao Jiang

“…The immunological responses to cancer heavily rely on the function of CD4Tconv. Despite this critical role, prognostic studies on CRC-related CD4Tconv remain insufficient. …”
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