AlphaMissense Predictions and ClinVar Annotations: A Deep Learning Approach to Uveal Melanoma by David J. Taylor Gonzalez, MD, Mak B. Djulbegovic, MD, MSc, Meghan Sharma, MD, MPH, Michael Antonietti, BS, Colin K. Kim, BS, Vladimir N. Uversky, PhD, DSc, Carol L. Karp, MD, Carol L. Shields, MD, Matthew W. Wilson, MD

“…We explore the use of a novel deep learning tool to assess the functional impact of genetic mutations in UM. Design: A cross-sectional bioinformatics exploratory data analysis of genetic mutations from UM cases. …”
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Integrated frailty and intrinsic capacity care model for community-dwelling older adults in Singapore: a rapid qualitative study of anticipated implementation barriers and enablers... by Mimaika Luluina Ginting, Grace Sum, Sinead Zhen Wang, Yew Yoong Ding, Yew Yoong Ding, Yew Yoong Ding, Laura Tay, Laura Tay

“…We used a rapid qualitative inquiry approach, incorporating a combination of Rapid Research, Evaluation and Appraisal Lab sheet, the Rapid Identification of Themes from Audio recordings, and mind-mapping techniques for data synthesis, analysis, and interpretation. The framework approach was applied to structure and explore the qualitative data for triangulation across FGDs.ResultsFive FGDs were conducted with 22 potential implementers (doctors, nurses, physio/occupational therapists, and community partners) between July and August 2023. …”
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The Effect of Hydraulic Partitioning on Prediction the Rate of Bed Load Transport in Gravel-bed Rivers using Support Vector Machine by Kiyoumars Roushangar, Mohammad Hosseini, Saman Shahnazi

“…The RBF kernel function was used as core tool of support vector machine for all proposed models. …”
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Association between neutrophil-percentage-to-albumin ratio and periodontitis: insights from a population-based study by Ziyang Zheng, Ziyang Zheng, Ziyang Zheng, Xinyu Xie, Xinyu Xie, Xinyu Xie, Lan Wang, Lan Wang, Lan Wang, Mingzhang Xu, Mingzhang Xu, Mingzhang Xu, Jiaqi He, Jiaqi He, Yunyi Deng, Yunyi Deng, Yunyi Deng, Ke Yu, Ke Yu, Ke Yu

“…These findings were further validated by the sensitivity analyses with decreased tooth counts (β = −0.08, p < 0.005) and the lower incidence of functional dentition (OR = 0.96, p = 0.030). Additionally, the replication analysis also enhanced the roundness of the results (OR = 1.07, p < 0.001).ConclusionThis population-based study demonstrated a statistically significant positive relationship between NPAR and the prevalence of periodontitis, NPAR has been recognized as a potential biomarker for periodontal disease. …”
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Study on the age and growth characteristics of Sepia esculenta in the East coast of China based on beak microstructure by Bilin Liu, Bilin Liu, Bilin Liu, Bilin Liu, Yuzhe Ou, Minhua Zhou, Hu Zhang, Yueyue Xiao, Kaiwei Zu, Chaowen Zhu, Haisheng Hu

“…The ML-age relationship fitted a linear growth model, while BW-age relationships followed an exponential model for females and a power function model for males. Growth rate analysis showed varied growth trajectories with age, with the highest absolute growth rate (AGR) of ML observed at 120–150 days for females (1.23 mm/d) and at 60–90 days for males (1.93 mm/d). …”
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Research on Fault Stability in Junggar Basin Based on 3D Geological Modeling by XIONG Yuwei, ZHANG Yan, MA Jinyu, LI Zhe, LEI Cheng, SUN Wentie

“…The Coulomb failure function is used to make mechanical discrimination of five main faults in the study area, and the analysis shows that F1 and F3 faults are in a stable state, while F2, F4 and F5 faults are currently in an unstable state. …”
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Prognostic value of NT-proANP levels on major cardiovascular outcomes in a 31-year follow-up study depends on baseline morbidity by Samuli Sakko, Juha Perkiömäki, Antti Ylitalo, Heikki Huikuri, Olavi Ukkola, Peppi Koivunen, Joona Tapio

“…In subjects with CVDs, the high NT-proANP tertile had decreased kidney function, higher prevalence of CVDs and adverse echocardiographic measures but also the lowest fasting insulin levels, and in longitudinal analysis had an increased risk for HF events and CVD mortality. …”
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ISOdb: A Comprehensive Database of Full-Length Isoforms Generated by Iso-Seq by Shang-Qian Xie, Yue Han, Xiao-Zhou Chen, Tai-Yu Cao, Kai-Kai Ji, Jie Zhu, Peng Ling, Chuan-Le Xiao

“…In addition, ISOdb provides a user interface in the website for uploading sample information to facilitate the collection and analysis of researchers’ datasets. Currently, ISOdb is the first repository that offers comprehensive resources and convenient public access for hosting, analysing, and visualising Iso-Seq data, which is freely available.…”
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Integrated energy low-carbon economic dispatch considering electricity-carbon price correlation and hydrogen energy storage by HUANG Yuehua, LI Chen, CHEN Chen, YANG Churui, GUO Qianting, LIN Chenjie

“…Firstly, considering the fluctuation and interaction between electricity price and carbon price, the Copula function is determined according to the Euclidean distance and the rank correlation coefficient is obtained, and the linear transformation method is used to simulate and sample the relevant electricity and carbon price data. …”
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Effect of Am addition on oxygen potential in (U0.55Pu0.3Am0.15)O2−x by Keisuke Yokoyama, Masashi Watanabe, Akane Usui, Takayuki Seki, Takashi Onishi, Masato Kato

“…The measured oxygen potentials were analyzed by the defect chemistry method. This analysis showed that the oxygen potential of (U0.55Pu0.3Am0.15)O2−x was formulated as a function of O/M ratio and temperature, and that the calculated results were consistent with the measured data. …”
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Effects of acanthoic acid on TNF-α gene expression and haptoglobin synthesis by H-S. Kang, H. K. Song, J-J. Lee, K-H. Pyun, I. Choi

“…When liver cells were treated with acanthoic acid, haptoglobin synthesis was blocked by acanthoic acid. These data confirmed that acanthoic acid inhibited gene expression and biological function of TNF-α.…”
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An Assessment of Provider Payment Mechanisms (PPMs) in Ethiopia: Implications for Redesign of PPMs and Progress Toward Universal Health Coverage by Mideksa Koricho, Tseday Zerayacob, Firehiwot Abebe, Muluken Argaw, Dereje Mengistu, Felegush Birhane, Shewa Negash, Amanuel Haileselassie, Agnes Gatome-Munyua

“…Provider payment, as a function of purchasing, is a tool to use limited health resources better. …”
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Bipolar disorder at mixed states and major depressive disorder with mixed features differ in peripheral biochemical parameters by Xiaohui Wu, Shuo Wang, Zhiang Niu, Yuncheng Zhu, Ping Sun, Wenxi Sun, Jun Chen, Yiru Fang

“…Methods This study included data from 269 BDM patients and 86 MDM patients. Biochemical markers covering immune-inflammatory, liver function, metabolic, and thyroid hormone indices were analyzed. …”
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Effects of total temporomandibular joint replacement with alloplastic prosthesis – a systematic review by Pär Morin, Jani Talvilahti, Mattias Ulmner, Per Alstergren, Eva Nordendahl, Aron Naimi- Akbar

“… Objectives: This paper studies the treatment effect of total joint replacement (TJR) of the temporomandibular joint (TMJ) with alloplastic joint prosthesis regarding function, symptoms and health-related quality of life compared to other surgical and non-surgical treatments in patients with TMJ disorders. …”
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Conducting polymer-based electrochemical sensors: Progress, challenges, and future perspectives by Aashutosh Dube, Shweta J. Malode, Abdullah N. Alodhayb, Kunal Mondal, Nagaraj P. Shetti

“…Conducting polymer-based electrochemical sensors has affectivity in neurochemical and pathogen sensing, which is essential for brain function and mental health.…”
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Improving healthy food recommender systems through heterogeneous hypergraph learning by Jing Wang, Jincheng Zhou, Muammer Aksoy, Nidhi Sharma, Md Arafatur Rahman, Jasni Mohamad Zain, Mohammed J.F. Alenazi, Aliyeh Aminzadeh

“…Unlike previous methods, we convert the heterogeneous hypergraph into a homogeneous space, using a unified loss function to generate recommendations that adapt to individual users’ changing dietary preferences. …”
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Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators by Yang Qiu, Haiyan Zhang, Xiao Yu, Jielu Pan, Dinghong Xiao, Hongyu Miao, Ruiqing Wang, Nan Shen, Peimin Pu, Yinling Zhou, Zhidong Liu, Lin He, Lianjun Xing

“…The robustness of our findings was established through stringent criteria, comprehensive sensitivity analyses, and Bayesian colocalization, followed by functional validation with TCGA data and a transcriptome-wide association study (TWAS). …”
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Transcriptome and DNA methylation analyses provide insight into the heterosis of growth-related traits in hybrid yellow croaker by Dan-Dan Guo, Feng Liu, Qing-Ping Xie, Ting Ye, Fu-Liang Wei, Bao-Long Niu, Bao Lou

“…Functional enrichment analysis revealed that most of the DMEGs were significantly enriched in pathways related to the protein export pathway, proteasome, terpenoid backbone biosynthesis, ubiquitin-mediated proteolysis, autophagy-other pathway. …”
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A plasmid-mediated type III secretion system associated with invasiveness and diarrheagenicity of Providencia rustigianii by Jayedul Hassan, Atsushi Hinenoya, Noritoshi Hatanaka, Sharda Prasad Awasthi, Goutham Belagula Manjunath, Nahid Rahman, Jyoji Yamate, Shota Nakamura, Daisuke Motooka, Akira Nagita, Shah M. Faruque, Shinji Yamasaki

“…The strain was subjected to phenotypic and genetic analyses including whole genome sequencing (WGS) to explore the genetic determinants of the observed invasiveness and diarrheagenic properties. Analysis and annotation of WGS data revealed the presence of two distinct type III secretion systems (T3SS) in strain JH-1, one of which was located on the chromosome designated as cT3SS (3,992,833 bp) and the other on a mega-plasmid designated as pT3SS (168,819 bp). …”
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Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…Changes in CBF across various brain regions were examined using ASL data. The analysis and processing of ASL data were performed using Statistical Parametric Mapping 12 (SPM12) software and the MATLAB platform. …”
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