Frailty as a Predictor of Complications and Transplant-Free Survival after Transarterial Chemoembolization of Hepatocellular Carcinoma by Rana Rabei, Parmede Vakil, Bradley King, R. Peter Lokken, Michael Heller, Nicholas Fidelman, Maureen Kohi

“…Liver function parameters, Barcelona clinic liver cancer tumor stage, and all components of the five-item modified frailty index (mFI-5) were used to determine the patient's frailty status. …”
Get full text

Population Substructures of <i>Castanopsis tribuloides</i> in Northern Thailand Revealed Using Autosomal STR Variations by Patcharawadee Thongkumkoon, Jatupol Kampuansai, Maneesawan Dansawan, Pimonrat Tiansawat, Nuttapol Noirungsee, Kittiyut Punchay, Nuttaluck Khamyong, Prasit Wangpakapattanawong

“…We further examined population history through bottleneck analysis using three models (IAM, SMM, and TPM) and visualized genetic relationships through principal coordinate analysis and cluster analysis. …”
Get full text

Morphology and ultrastructure of external sense organs of Drosophila larvae by Vincent Richter, Anna Rist, Georg Kislinger, Michael Laumann, Andreas Schoofs, Anton Miroschnikow, Michael J Pankratz, Albert Cardona, Andreas S Thum

“…This was achieved by 3D electron microscopic analysis of partial and whole body volumes, which contain high-resolution and complete three-dimensional data of the anatomy of the sensilla and adjacent ganglia. …”
Get full text

Allochrony in Atlantic Lumpfish: Genomic and Otolith Shape Divergence Between Spring and Autumn Spawners by Mathilde Horaud, Núria Raventós, Kim Præbel, Carles Galià‐Camps, Cinta Pegueroles, Carlos Carreras, Marta Pascual, Victor M. Tuset, Shripathi Bhat, Arve Lynghammar

“…Genomic differences between the two groups were concentrated in three chromosomes, with a region of chromosome 1 encompassing the same single nucleotide polymorphisms (SNPs) driving differential season spawning for both localities, suggesting parallel responses. The functional analysis of the SNPs in this region revealed genes associated with responses to environmental stressors, possibly adaptations to seasonal variations at high latitudes. …”
Get full text

Design and verification of a 25 K multiple-SNP liquid-capture chip by target sequencing for dairy goat by Jianqing Zhao, Yaling Wang, Jiayidaer Kamalibieke, Ping Gong, Fuhong Zhang, Huaiping Shi, Wei Wang, Jun Luo

“…Abstract Background In the genetic breeding research of dairy goats, traditional genotyping methods have limitations, and existing goat chips have shortcomings in functional loci and other aspects, which cannot meet the precise genetic analysis needs of dairy goats. …”
Get full text

scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury by Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen

“…Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions. Previous studies have pointed out that patient age is a critical factor influencing SCI prognosis. …”
Get full text

Single cell RNA sequencing reveals the role of local renin-angiotensin system in regulating ovarian physiological cycle and promoting PCOS by Lun Wei, Le Bo, Wangtao Jiang, Ruofan Qi, Chao Luo, Fei Qian, Panjie Ma, Jianping Qiu, Caiping Mao

“…Protein-protein interaction analysis predicted the most closely interacting pathway with RAS, and preliminary evidence of crosstalk between angiotensin II (AngII) and the insulin signaling pathway was identified in the scRNA-seq data. …”
Get full text

The evolving role of PARP inhibitors in advanced ovarian cancer by Levva Sofia, Skolariki Aglaia, Sogka Eleni, Bokas Alexandros, Assi Avraam, Pispirigou Marianna K., Koliou Panagiotis

“…Limited OS data have been published and there is also limited experience regarding long-term safety. …”
Get full text

Thermal freeze-out and collective signatures in $$pp$$ collisions with a non-extensive statistical study on energy and pseudorapidity systematics by Haifa I. Alrebdi, Muhammad Ajaz, Murad Badshah, Muhammad Waqas, Norah A. M. Alsaif, Mohammad Ayaz Ahmad, Jihane Ben Slimane

“…Using a modified Tsallis function incorporating an effective transverse flow velocity, we achieve excellent agreement between the model and experimental data, with consistent fit quality across all $$p_T$$ ranges (validated by Data/Fit panels). …”
Get full text

Altered Metabolism in Knockdown Lines of Two HXXXD/BAHD Acyltransferases During Wound Healing in Potato Tubers by Jessica L. Sinka, Indira Queralta-Castillo, Lorena S. Yeung, Isabel Molina, Sangeeta Dhaubhadel, Mark A. Bernards

“…HXXXD/BAHD acyltransferases occupy a unique place in suberization, as they function to crosslink phenolic and aliphatic monomers during suberin assembly. …”
Get full text

Association between Alzheimer's disease pathologic products and age and a pathologic product-based diagnostic model for Alzheimer's disease by Weizhe Zhen, Yu Wang, Hongjun Zhen, Weihe Zhang, Wen Shao, Yu Sun, Yanan Qiao, Shuhong Jia, Zhi Zhou, Yuye Wang, Leian Chen, Jiali Zhang, Dantao Peng, Dantao Peng

“…Using correlation analysis method like cor function, we analyzed the pathology products (t-Tau, p-Tau, and Aβ proteins), age, gender, and Minimum Mental State Examination (MMSE) scores in the ADNI data. …”
Get full text

Examining the Variability in Planetary Boundary Layer Height over Thailand: Correlations with ENSO and Aerosol Optical Depth by Sirapong Sooktawee, Khwanruthai Renuhom, Siriwan Kaewket, Aduldech Patpai, Pramet Kaewmesri, Thongchai Kanabkaew, Pichnaree Lalitaporn

“…The relationships among the PBLH, ENSO, and AOD were investigated via an empirical orthogonal function (EOF), which decomposes the spatiotemporal data of the PBLH into spatial patterns and corresponding time series. …”
Get full text

Intelligent Approaches to Computer Testing of Perception and Production Skills of Russian EFL Speakers by Marina Kolesnichenko, Vitalii Kapitan

“…Post-test questionnaire assessed usability and perceived learning gains. Data were analysed using descriptive statistics and correlation analysis. …”
Get full text

Clinical and genetic characteristics of type 3 lissencephaly caused by a mutation in the TUBA1A gene (OMIM: 611603) by D. M. Guseva, T. V. Markova, L. A. Bessonova, S. S. Nikitin, E. L. Dadali, O. A. Shchagina

“…Possible effects of new missense mutations in the gene on the function of the protein product of the gene are discussed.Conclusions. …”
Get full text

Examining the Variability in Planetary Boundary Layer Height over Thailand: Correlations with ENSO and Aerosol Optical Depth by Sirapong Sooktawee, Khwanruthai Renuhom, Siriwan Kaewket, Aduldech Patpai, Pramet Kaewmesri, Thongchai Kanabkaew, Pichnaree Lalitaporn

“…The relationships among the PBLH, ENSO, and AOD were investigated via an empirical orthogonal function (EOF), which decomposes the spatiotemporal data of the PBLH into spatial patterns and corresponding time series. …”
Get full text

Causal relationship between mitochondrial proteins and risks of aortic aneurysms and aortic dissection: a Mendelian randomization study by Lei Wang, Yuzuo Lin, Ziyan Lin, Qingtong Wu, Guodong Zhong, Liangwan Chen

“…Methods Large-scale publicly available genome-wide association studies (GWAS) and FinnGen summary data were utilized for MR analysis. The causal relationship between mitochondrial proteins and AA/AD was assessed using inverse-variance weighted (IVW) as the primary method. …”
Get full text

hs-CRP/HDL-C can predict the risk of all cause mortality in cardiovascular-kidney-metabolic syndrome stage 1-4 patients by Fengjiao Han, Haiyang Guo, Hao Zhang, Yang Zheng

“…BackgroundThe precise function of the hs-CRP/HDL-C ratio in forecasting the long-term mortality risk of patients with stages 1-4 of Cardiovascular-Kidney-Metabolic (CKM) syndrome remains inadequately delineated. …”
Get full text

Analyzation of the Peripheral Blood Mononuclear Cells Atlas and Cell Communication of Rheumatoid Arthritis Patients Based on Single-Cell RNA-Seq by Xinqiang Song, Yu Zhang, Lijun Zhao, Jinke Fan, Tao Peng, Ying Ma, Nailiang Guo, Xiaotong Wang, Xudong Liu, Zhe Liu, Lei Wang

“…ScRNA-seq was performed on four RA samples and integrated with single-cell transcriptome data from four healthy control samples downloaded from publicly available databases for analysis. …”
Get full text

Preclinical studies of the falnidamol as a highly potent and specific active ABCB1 transporter inhibitor by Baojie Liu, Yongzheng Lu, Ruihui Lin, Junbao Xu, Zilin Shang, Xinyu Hou, Xulong Shao, Zhifang Pan, Tao Yu, Weiguo Feng

“…The interaction between falnidamol and ABCB1 was evaluated by docking analysis and cellular thermal shift assay. Results Our data showed that falnidamol specifically reversed ABCB1-mediated MDR but not ABCG2-mediated MDR in vitro and in vivo. …”
Get full text

Independent prognostic importance of blood urea nitrogen to albumin ratio in critically ill patients with congestive heart failure by Jingxiang Yang, Jiuyi Wang, Kai Wang

“…The present study analyzed data from the MIMIC-IV (version 2.2) database, targeting patients with congestive heart failure. …”
Get full text