Bioinformatic analyses reveal lysosomal-associated protein transmembrane 5 as a potential therapeutic target in lipotoxicity-induced injury in diabetic kidney disease by Xin Chen, Shenglong Zhu, Ciyou Huang, Jiayi Liu, Jinbang Wang, Siyuan Cui

“…Emerging data have revealed that damage to tubular epithelial cell is a driving force in the progression of diabetic kidney disease (DKD). …”
Get full text

Can Broadening the Kidney Biopsy Criteria Reduce Misleading Diagnoses in Young Patients with End-Stage Renal Diseases? A Survey on the Sicilian Registry of Nephrology, Dialysis, an... by Vincenzo Calabrese, Giovanni Conti, Giulio Geraci, Ligia J. Dominguez, Valeria Cernaro, Maria Teresa Zicarelli, Guido Gembillo, Elisa Longhitano, Domenico Santoro

“…<i>Conclusions:</i> Although Kidney Disease Improving Global Outcomes (KDIGO) did not include hypertension among biopsy indications, our data suggest that performing renal biopsy in young patients with hypertension and worsening renal function could improve kidney diagnosis management.…”
Get full text

Optimal Configuration of ESS in Distribution Network Considering Generation of PV-Load Time Series Scenarios by Xiaolong Xiao, Mingming Shi, Fan Wu, Yukai Wei, Bo Zhao, Fang Zhang

“…The iterative self-organizing data analysis algorithm (ISODATA) is used to optimize clustering of the comprehensive evaluation index scenario to generate PV-Load typical scenarios. …”
Get full text

A review of in vitro approaches as tools for studying rumen fermentation and ecology: effectiveness compared to in vivo outcomes by Federica Scicutella, Giulia Foggi, Matteo Daghio, Federica Mannelli, Carlo Viti, Marcello Mele, Arianna Buccioni

“…In vitro methods offer valuable insights into feed fermentations, composition, and function of ruminal microbiota, providing evaluations under standardised conditions, at lower costs than in vivo trials, minimising the reliance on live animals. …”
Get full text

Clinical Evaluation of the 3nethra Aberro Handheld Autorefractometer by Selvamani Perumal, Surya Venkatramanan, Venkatramanan RJ, Jayanthi T, Jai Adithya, Anjaly Abraham, Henna Cherian

“…When the Bland-Altman's plot analysis was performed, about 98% of data lied within the ± 2 standard deviation variation. …”
Get full text

Overexpression of miR-10b in colorectal cancer patients: Correlation with and E-cadherin expression by Rania Abdelmaksoud-Dammak, Nour Chamtouri, Mouna Triki, Amena Saadallah-Kallel, Wajdi Ayadi, Slim Charfi, Abdelmajid Khabir, Lobna Ayadi, Tahia Sallemi-Boudawara, Raja Mokdad-Gargouri

“…MicroRNAs are emergent players of epigenetics that function as oncogenes or tumor suppressors and that have been implicated in regulating diverse cellular pathways. …”
Get full text

Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC by Tao Zhou, Dan Dan Zhang, Jiejing jin, Jinyang Xie, Jianhua Yu, Chao Zhu, Rong Wan

“…In vitro experiments were conducted with the primary objective of appraising both the expression profile and the precise functional attributes of SMAD3 within the milieu of Liver Hepatocellular Carcinoma (LIHC). …”
Get full text

Stenotrophomonas maltophilia virulence and specific variations in trace elements during acute lung infection: implications in cystic fibrosis. by Arianna Pompilio, Domenico Ciavardelli, Valentina Crocetta, Ada Consalvo, Roberta Zappacosta, Carmine Di Ilio, Giovanni Di Bonaventura

“…Particularly, exposure to CF strain exclusively increased P and K levels, while decreased Fe and Mn ones. Overall, our data clearly indicate that S. maltophilia modulates pulmonary metal balance in a concerted and virulence-dependent manner highlighting the potential role of the element dyshomeostasis during the progression of S. maltophilia infection, probably exacerbating the harmful effects of the loss of CF transmembrane conductance regulator function. …”
Get full text

A new CNN deep learning model for computer-intelligent color matching by He Zhibin, Tan Yanmei, Li Sa

“…However, these intelligent color-matching models still have problems with incomplete color-matching functions and low color-matching accuracy. To solve the above problems, this study optimized the convolutional neural network (CNN) algorithm using the genetic algorithm (GA), extracted data through the GA, and then processed the information using the CNN algorithm. …”
Get full text

VarProDMD: Solving Variable Projection for the Dynamic Mode Decomposition with SciPy’s optimization suite by Gerhard Reinerth, David Messmann, Jean Elsner, Ulrich Walter

“…The optimization procedure uses a complex residual function since the measurements can incorporate complex numbers. …”
Get full text

Ethnonymics as a Historical and Philological Discipline: General and Specific Solutions, Chance and Pattern by Vladimir Vladimirovich Napolskikh

“…The singular nature of ethnonyms, and the apparent lack of opportunity for statistical validation of etymologies — as is more common in toponymy — has led, on the one hand, to a proliferation of speculative and arbitrary explanations, and on the other, to a reliance on the availability of historically verifiable data to support or reject such proposals. Despite widespread acknowledgement of this challenge, the article argues that ethnonymic analysis can function as a methodologically distinct branch of historical and philological research. …”
Get full text

Visualizing sound emission of elephant vocalizations: evidence for two rumble production types. by Angela S Stoeger, Gunnar Heilmann, Matthias Zeppelzauer, André Ganswindt, Sean Hensman, Benjamin D Charlton

“…Recent comparative data reveal that formant frequencies are cues to body size in animals, due to a close relationship between formant frequency spacing, vocal tract length and overall body size. …”
Get full text

The relationships between nomophobia, alexithymia and metacognitive problems in an adolescent population by Mesut Yavuz, Beyza Altan, Büşra Bayrak, Merve Gündüz, Nurullah Bolat

“…It is known that excessive engagement with MPs decreases adolescents` psychological well-being, social and academic functioning. The aim of this study was to investigate the associations of nomophobia with alexithymia which is characterized by difficulties in describing and expressing emotions and using empathy, and with the metacognition characteristics which have the function of controlling the cognitions in an adolescent population. …”
Get full text

Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions. by Xiu-Yuan Li, Ping He, Shaomeng Wang, Yusong Wang, Dingfei Yan, Xiaohui Liu, Haiteng Deng, Zhixing Feng, Juanjuan Wang, Jing-Ren Zhang

“…However, it remains unclear if the fluctuation of NAM O-acetylation has any function. In this study, we show that NAM O-acetylation functions as a potential extracellular signal of cellular metabolism for epigenetic response to nutrient conditions in human pathogen Streptococcus pneumoniae (pneumococcus). …”
Get full text

Performance evaluation of brain state discrimination using near-infrared spectroscopy for brain-computer interface: an exploratory case study by Akira Masuo, Takuto Sakuma, Shohei Kato

“…A new method of environmental control that does not depend on motor functions is eagerly awaited to support independent living for people with severe quadriplegia. …”
Get full text

Internet of Things–based smart home system using a virtualized cloud server and mobile phone app by Guo-Ming Sung, Yen-Shin Shen, Jia-Hong Hsieh, Yu-Kai Chiu

“…Both interlinkage and handler methods are proposed to facilitate a powerful function without delay in displaying information. The proposed system integrates with software and hardware to complete the data analysis and information management quickly and correctly. …”
Get full text

The effects of flight training on flying cadets' brain structure. by Liang Wang, Chengshi Yang, Dongfeng Yan, Lu Ye, Xi Chen, Shan Ma

“…The aim of this study is to investigate the effects of flight training on the brain structure and cognitive functions of flying cadets. The structural magnetic resonance imaging (sMRI) data from 39 flying cadets and 37 general college students underwent analysis using voxel-based morphometry (VBM) and surface-based morphometry (SBM) methods to quantitatively detect and compute multiple indicators, including gray matter volume (GMV), curvature, mean curvature of the white matter surface (MC-WMS), the percentage of surface white matter gray matter (WM-GM percentage), surface Jacobi (S-Jacobi), and Gaussian curvature of white matter surface (GC-WMS). …”
Get full text

Gut Microbiota Composition and Metabolites as the new Determinants of Cardiovascular Pathology Development by O. M. Drapkina, A. N. Kaburova

“…The development of sequencing techniques, together with bioinformatics analysis allowed the scientists to intensively broaden the understanding of the gut microbiota composition and functions of its metabolites in maintaining the health and the development of atherosclerosis, arterial hypertension and heart failure. …”
Get full text

The Yeast F-Box Protein Met30 Regulates Proline Utilization Independently of Transceptor Can1 Under Nutrient-Rich Conditions by Akira Nishimura, Ryoya Tanahashi, Hiroshi Takagi

“…Here, we used the parent strain with the <i>CAN1</i> deletion to derive mutants that can utilize proline even under nutrient-rich conditions. A genomic analysis revealed a mutation in the <i>MET30</i> gene, which encodes an F-box subunit of the SCF ubiquitin ligase complex, that causes reduced Met30 function. …”
Get full text

Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs. by Xiaowen Liang, Xiaowen Liang, Brandon L Garcia, Livia Visai, Sabitha Prabhakaran, Nicola A G Meenan, Jennifer R Potts, Martin J Humphries, Magnus Höök

“…In addition to roles in adhesion, Fn-binding MSCRAMMs exploit physiological Fn functions. For example, several pathogens can invade host cells by a mechanism whereby MSCRAMM-bound Fn bridges interaction with α5β1 integrin. …”
Get full text