Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes by Karla M. O’Neill, Kevin S. Edgar, Shun Hay Pun, David C. Campbell, Tinrui Toh, Xin N. Wong, Bianca Botezatu, Jyoti Kandel, Una McCoy, Jennifer Nicell, Catherine McClintock, Kiran J. McLoughlin, Yuxin Wu, Vinuthna Vani Madishetti, Arya Moez, Mohammed Alsaggaf, Eleanor K. Gill, Rawan A. Abudalo, Christina L. O’Neill, Edoardo Pedrini, Jasenka Guduric-Fuchs, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Chris J. Watson, Reinhold J. Medina, David J. Grieve

“…Methods CB-ECFCs were cultured in high glucose (D-glucose, 25 mmol/L) or control media (5 mmol/L) ± phorbol 12-myristate 13- acetate (PMA, 500 nmol/L) for 72 h with assessment of migratory/tubulogenic capacity and NOX4 mRNA expression (qRT-PCR). Detailed analysis of angiogenic function and signalling (Western blot, RNA sequencing) was performed in CB-ECFCs isolated from donors with gestational diabetes prior to NOX4 plasmid OE to define rescue potential and key mechanistic pathways (network analysis, proteome profiling). …”
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Rehabilitation nursing needs in stroke patients with limb dysfunction: A scoping review (脑卒中肢体功能障碍患者康复护理需求的范围综述) by YANG Dan (杨丹), MENG Meiqi (孟美琪), SHEN Wanting (沈婉婷), LI Xuejing (李学靖), HAO Yufang (郝玉芳), FANG Jiaxin (方嘉欣), WANG Fang (王芳)

“…The subject analysis of the included literatures was conducted based on the framework of the International Classification of Functioning, Disability and Health. …”
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Potential protective regulatory effects on radiation−induced esophageal injury in TUT4−/− mice by Huiwen Ren, Wei Li, Zhigang Fan, Jianlin Wang, Zhiqiang Sun, Renhua Huang, Judong Luo, Bo Gao

“…IntroductionTerminal uridyl transferase 4 (TUT4), a nucleotide transferase that modifies miRNA sequences, plays a critical role in regulating miRNA target interactions and function. However, its involvement in radiation-induced esophageal injury remains poorly understood.MethodsTo investigate this, we performed computational analysis of RNA-seq data from irradiated esophageal tissues of wild-type and TUT4-knockout (TUT4–/–) mice, identifying 53 differentially expressed mRNAs (DEmRNAs), of which 30 were upregulated and 23 downregulated.ResultsGene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that these DEmRNAs were significantly associated with biological processes including lipid metabolism, fatty acid metabolism, proteolysis, and broader metabolic functions. …”
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SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program by Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan

“…Orthotopic and subcutaneous xenograft models were established to verify SLIT3's in vivo function. Cellular bulk RNA-seq analysis was performed with or without SLIT3 recombinant protein treatment to discover the downstream pathways activated by SLIT3, followed by validation with specific pathway inhibitors. …”
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Single-cell transcriptional landscape of peripheral myeloid cells in autoimmune diseases by Frank Qingyun Wang, Xiao Dang, Caicai Zhang, Huidong Su, Yao Lei, Xinxin Chen, Jing Yang, Wanling Yang

“…To address this gap, we analyzed 351,905 myeloid cells from 375 single-cell RNA sequencing samples covering 14 autoimmune diseases, which allowed us to classify myeloid cells into 13 distinct subsets with unique immunological profiles. Through pseudotime analysis, we identified a branching process leading to two intermediary inflammatory subtypes and observed dysregulation in eight co-expression modules crucial for monocyte function across autoimmune conditions. …”
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GATED SPECT IN PATIENTS WITH BIOPSY-NEGATIVE CARDIAC TRANSPLANT REJECTION by E. N. Ostroumov, V. M. Zakharevich, E. D. Kotina, N. N. Mojeiko, A. G. Kupriyanova, E. I. Ryaboshtanova, B. N. Morozov, N. Z. Meboniya, S. V. Mironov, A. Y. Kormer, I. M. Ilynsky, L. V. Beletskaya, E. N. Kazakov

“…The assessment of hemodynamic compromise can provide functional data in transplant patients that is complementary to myocardial biopsies if the biopsy can miss significant rejection. …”
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Extracting speech spectrogram of speech signal based on generalized S-transform. by Li Jiashen, Zhang Xianwu

“…In speech signal processing, time-frequency analysis is commonly employed to extract the spectrogram of speech signals. …”
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Pancreatic atrophy after gastric cancer surgery: influencing factors and effects on BMI and quality of life by Zhaoping Li, Lianlian Cao, Hao Chen, Feng Wang, Liang Tao, Meng Wang

“…Conclusions Clinicians need to monitor pancreatic function, BMI and life quality more carefully in gastric cancer patients with T3 and T4 stages, preoperative low levels of HDL-C and smoking history.…”
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ih-RIDME: a pulse EPR experiment to probe the heterogeneous nuclear environment by S. Kuzin, V. N. Syryamina, M. Qi, M. Fischer, M. Hülsmann, A. Godt, G. Jeschke, M. Yulikov

“…Therefore, the fitted distribution function can further serve as a method for heterogeneity characterization, quantification and structure-based analysis. …”
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Experience in Using ^99mTc-Technephyt Esophageal Transit Scintigraphy for Assessing Pneumatic Dilation Outcome in Patients with Achalasia Cardia by R. A. Bashirov, A. I. Shelepova, L. E. Samoilenko, S. A. Ryzhkin, B. M. Sharafutdinov, A. F. Yusupova, L. F. Ziganshina, B. A. Magomedov, A. I. Kukushkin, V. Yu. Matveev, D. R. Bashirov

“…The disease duration before admission to the hospital ranged from 2 to 17 years (mean 9.2 years).Results. The analysis of ETS results showed a decreased radiopharmaceutical residual activity percentage in cardia for all patients after treatment compared with the initial data. …”
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Beyond Stress Granules: G3BP1 and G3BP2 Redundantly Suppress SARS-CoV-2 Infection by Duo Xu, Mahamaya Biswal, Quanqing Zhang, Christine Light, Yijie Wu, Chenjin Ye, Luis Martínez-Sobrido, Jikui Song, Rong Hai

“…Intriguingly, we observed that the ablation of both G3BP1 and G3BP2 enhanced SARS-CoV-2 replication. Our data collectively supports the notion that G3BP1 and G3BP2 play a critical role in modulating the host–virus interface during SARS-CoV-2 infection, and that their multifaceted function in cellular defense extends beyond the stress granule pathway.…”
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Peculiarities of morphological indicators of quail spleen (Coturnix japonica Temminck et Schlegel, 1849) when using protein-vitamin mineral supplements by O. F. Dunaievska, I. M. Sokulskiy, L. P. Horalskyi, M. L. Radzikhovskyi, B. V. Gutyj

“…The ultrastructural organization of the spleen of quails had peculiarities: the nuclei of leukocytes contain large nucleoli, the endotheliocytes of the central artery of the lymphoid follicle perform a phagocytic function by accumulating autophagosomes in their cytoplasm. …”
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Analyzing Insights of Super-Response in Cardiac Resynchronization Therapy with Fusion Pacing by Alexandra-Iulia Lazăr-Höcher, Simina Crișan, Cristina Văcărescu, Samuel Nistor, Adelina Andreea Faur-Grigori, Andreea Cozgarea, Petru Baneu, Liviu Cirin, Laurențiu Brăescu, Larissa Dăniluc, Dan Gaiță, Constantin-Tudor Luca, Dragoș Constantin Cozma

“…A follow-up protocol was conducted for all patients at 6 months and then annually. Data from the most recent follow-up were used for statistical analysis. …”
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Effectiveness of different physical activity programs in improving older adults’ physical capacities: a randomized controlled trial by Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Víctor Hernández-Beltrán, Orlando Fernandes, Orlando Fernandes, Cláudia Mendes, Cláudia Mendes, Cláudia Mendes, José M. Gamonales, José M. Gamonales, José M. Gamonales, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, José A. Parraca, José A. Parraca

“…In contrast, the Control and Pilates Groups did not exhibit significant improvements in any of the assessed variables. The analysis of the moment*group interaction effect revealed significant differences among the groups, except for the Timed Up and Go (TUG) test.ConclusionIn conclusion, sensorimotor and aquatic training significantly improved physical function, especially balance, strength, and mobility, in older people.…”
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Gene expression in tumor and adjacent normal tissues in lung adenocarcinoma subtypes by Olga Y. Gorlova, Ivan P. Gorlov, R. Taylor Ripley, Chao Cheng, Yafang Li, Bo Peng, Yanhong Liu, Hee-Jin Jang, Sung Wook Kang, Claire Lee, Priyanka Ranchod, Bryan M. Burt, Hyun-Sung Lee, Christopher I. Amos

“…Gene set enrichment analysis identified oxidative phosphorylation as a biological function associated with papillary, and immune response - with solid subtype. …”
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Respiratory Disorders in Complicated Cervical Spine Injury by S. A. Pervukhin, M. N. Lebedeva, A. A. Elistratov, A. V. Palmasph, I. A. Stacenko

“…The severity of patients' status on integral scales, parameters of the respiratory pattern and thoracopulmonary compliance, gas composition, and acidbase status of the blood were assessed. Data on patients who required prolonged mechanical ventilation, duration of mechanical ventilation, incidence of nosocomial pneumonia, duration of stay in the ICU, time of hospital treatment, and mortality were included in the analysis. …”
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Comparison of 3 Aging Metrics in Dual Declines to Capture All-Cause Dementia and Mortality Risk: Cohort Study by Anying Bai, Shan He, Yu Jiang, Weihao Xu, Zhanyi Lin

“…MethodsWe used longitudinal data from waves 10-15 of the Health and Retirement Study. …”
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Relationship between uric acid to high-density lipoprotein cholesterol ratio and sarcopenia in NHANES: exploring the mediating role of bilirubin and association with all-cause mort... by Haiyan Mao, Xiaoying Zhang, Shanshan Huang, Tong Lin, Zhikui Chen

“…BackgroundSarcopenia is a systemic disease characterized by a decline in muscle mass and function. It is associated with adverse health outcomes, and younger patients are at higher risk. …”
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A high-performance extracellular field potential analyzer for iPSC-derived cardiomyocytes by Nidhi Patel, Alex Shen, Yuko Wada, Marcia Blair, Devyn Mitchell, Loren Vanags, Suah Woo, Matthew Ku, Kundivy Dauda, William Morris, Minjoo Yang, Björn C. Knollmann, Joe-Elie Salem, Andrew M. Glazer, Brett M. Kroncke

“…We further analyzed the usability and data replicability of EFPA through an inter-intra observer analysis. …”
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O-GlcNAcylation-related genes mediate tumor microenvironment characteristics and prediction of immunotherapy response in gastric cancer by Wang Wangwen, Lu Xi, Zhu Chengjun, Li Jie, Liu Yue, Yao Zhangchao, Li Xiaolin

“…The transcriptomic and clinical data are obtained from XENA-UCSC and GEO databases. …”
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