Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases by I. Hyun Ruisch, Joanna Widomska, Ward De Witte, Nina R. Mota, Giuseppe Fanelli, Veerle Van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Abel Fóthi, Csaba Barta, Simone Berkel, Kazi A. Alam, Aurora Martinez, Jan Haavik, Aet O’Leary, David Slattery, Mairéad Sullivan, Jeffrey Glennon, Jan K. Buitelaar, Janita Bralten, Barbara Franke, Geert Poelmans

“…., DM2, metabolic syndrome and obesity, to identify genes associated with both AD and SID that could increase our insights into their molecular underpinnings. We then performed functional enrichment analyses of these genes. Subsequently, using (additional) GWAS data, we conducted shared genetic etiology analyses between AD and SID, on the one hand, and blood and cerebrospinal fluid (CSF) metabolite levels on the other hand. …”
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Low Rates of 30-Day Postoperative Complications After Meniscal Allograft Transplantation: A Retrospective Study Using the National Surgical Quality Improvement Program Database by Sarah Whitaker, B.A., Conor O’Neill, M.D., James Satalich, M.D., Omar Protzuk, M.D., Carl Edge, M.D., Eoghan Hurley, M.B., M.Ch., Ph.D., Annunziato Amendola, M.D., Alexander Vap, M.D.

“…Patients were excluded if they did not have sufficient demographic data, namely those without data for age, sex, body mass index, preoperative functional status, American Society of Anesthesiologists classification, operative time, and length of hospital stay. …”
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SAFETY OF CANNED MILK AS AN INTEGRATED CRITERION OF THEIR TECHNOLOGY EFFECTIVENESS. RUSSIAN EXPERIENCE by S. N. Turovskaya, A. G. Galstyan, A. N. Petrov, I. A. Radaeva, E. E. Illarionovа, V. K. Semipyatniy, S. A. Khurshudyan

“…Significant potential lies in the research of thermodynamic characteristics, functional and technological indicators of dairy products and further implementation of the obtained data, as system criteria of the technological operations rationality definition, the validity of production schemes, and the evaluation of product quality. …”
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Cognitive Effect of Levetiracetam in Patients with Alzheimer’s Disease or Mild Cognitive Impairment: A Systematic Review by Mohamad Hosein Mohamadi, MD, Amir Bavafa, PhD, Sahar Salehi, PhD, Mahsa Abedi, MSc, Fahimeh Shahabi, MSc, Sana Jafarlou, MD, Pirhossein Kolivand, PhD, Sajad Sahab-Negah, PhD

“…This study suggests that LEV may exert a beneficial impact on cognitive function in patients with AD or MCI. However, a quantitative comparison or meta-analysis is essential to draw definitive conclusions about the cognitive effects of LEV in AD and MCI.…”
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Impact of disease activity patterns on health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE) by Chiara Tani, Marta Mosca, Chiara Stagnaro, Linda Carli, Elena Elefante, Viola Signorini, Dina Zucchi, Francesco Ferro, Chiara Cardelli, Luca Gualtieri, Davide Schilirò

“…Objective To assess the impact of different disease activity patterns—long quiescent (LQ), chronically active (CA) and relapsing-remitting (RR)—on health-related quality of life (HRQoL) in a cohort of patients with systemic lupus erythematosus (SLE).Methods A retrospective, monocentric analysis of prospectively collected data. Adult SLE outpatients were enrolled between 2017 and 2021.For each year of follow-up, three disease activity patterns were defined: LQ if at each visit clinical Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Activity Index (SELENA-SLEDAI)=0, Physician Global Assessment (PGA)=0; CA if at each visit clinical SELENA-SLEDAI >0, PGA >0; RR if patients presented active disease in at least one visit during the observation period, interspersed with periods of remission. …”
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Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers by James L. Cairns, Johanna Huber, Andrea Lewen, Jessica Jung, Stefan J. Maurer, Tobias Bausbacher, Stefan Schmidt, Pavel A. Levkin, Daniel Sevin, Kerstin Göpfrich, Philipp Koch, Oliver Kann, Carsten Hopf

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Kinesiophobia and associated factors among people with musculoskeletal disorders in Ethiopia: a multicenter cross-sectional study by Yazachew Mekonnen, Moges Gashaw, Yohannes Abich, Mihret Dejen Takele, Samuel Teferi Chanie, Dechasa Imiru Wayessa, Sisay Deme, Alemu Kassaw Kibret

“…Abstract Introduction Kinesiophobia has a major health impact on patients with Musculoskeletal disorders (MSDs) in their functional and physical activities, which leads to poor outcomes, loss of motivation, loss of mobility, and decreased quality of life. …”
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Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor mic... by Wenyang Nie, Wangzheqi Zhang, Zhikai Xiahou, Yuxuan Meng, Yuhang Liu, Jingwen Zhang, Zhen Wang, Yong Wang

“…Immune infiltration and drug sensitivity were evaluated by CIBERSORT, ESTIMATE, xCell, TIDE, and pRRophetic. Functional validation encompassed siRNA knockdown, qRT-PCR, Western blot analysis, and cellular assessment in CRC cell lines.ResultsWe discovered four categories of tumor cells exhibiting variations in cell cycle, stemness, and differentiation. …”
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Features of intra- and extra-cranial blood fl ow in patients with essential hypertension stage II according by V. V. Syvolap, E. A. Poznanskaya, R. P. Nikulina, А. V. Vizir

“…Every year, smoking kills more than 1.2 million people in Europe (of which 450 thousand - due to cardiovascular diseases) and about 650 thousand people of the EU countries (including from cardiovascular problems - 185 thousand). Analysis of the literature suggests paucity and contradictory information about changes in the functional status of the various systems of the body while smoking. …”
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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…Primary outcomes were 28-day mortality, while secondary outcomes included in-hospital mortality, the Barthel Index at discharge, length of hospital stay and laboratory data (albumin, C-reactive protein (CRP), and lymphocyte count) on days 14 and 28.ResultsOf the 17,626 patients enrolled, 15,159 (786 in the IVIG group and 14,373 in the control group) were included in the analysis. …”
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Magnetic resonance tomography capabilities and limitations in managing the efficacy of treatment with biological disease modifying anti-rheumatic drugs in ankylosing spondylitis by P. A. Shesternya, O. D. Gritsenko, P. A. Astanin, A. Yu. Stepanenko, N. V. Popov

“…At the same time, the possibility of its use for follow-up and treatment assessment is actively discussed.Objective: To present comparative analysis of clinical and laboratory data, reflecting the activity of the disease, and analysis of MRI results in patients with ankylosing spondylitis (AS) receiving biological disease modifying anti-rheumatic drugs therapy (bDMARDs).Patients and methods. …”
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Pyoderma in dogs (classification, pathogenesis, main pathogens, treatment) by V. M. Bubnov, Ya. V. Kisera, Yu. V. Martyniv

“…On the basis of the received data, an analysis was carried out and a perspective vector was formed for the further direction of scientific research, which would allow to eliminate the problem of this disease.…”
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Knowledge, attitude, and practice of frailty management among clinical nurses: a cross-sectional study by Xueyan Huang, Haifang Zhou, Ying Feng, Mengchi Li, Rui Wang, Ge Fang, Lumeng Lu, Jian’ao Chen, Wenhui Jiang

“…Data were analyzed by descriptive statistics, univariate analysis, multiple linear regression, and structural equation modeling. …”
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Reduction in Average Ambulance Response Time of Interfacility Transfer for Life-saving Cases (STEMI, STROKE, RTA) in Eastern Health Cluster of Saudi Arabia by Mobarak AlMulhim, Almohannad Edah, Sultan AlAnzi, Muhammad Bilal Maqsood

“…Results: The retrospective data analysis highlighted the average response time for three lifesaving categories was 17 minutes. …”
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The Significance and Diagnostic Potential of CEA and FIB in Colorectal Cancer by Lin Zhu, Jie Feng, Xu Zhang, Xuemei Wei, Cuiling Ming, Yanhong Gao

“…Gene Ontology functional analysis in CRC showed that FGA and related genes were enriched in biological processes including biosynthesis of ribonucleoprotein complex and non‐coding ribonucleic acid metabolic process; in cellular components, they were primarily enriched in pre‐ribosomes; and in molecular functions, they were mainly enriched in binding of unfolded protein. …”
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Predictive outcome of late window ischemic stroke patients following endovascular therapy: a multi-center study by Sijie Zhou, Mohammad Mofatteh, Zhikai Chen, Zhikai Chen, Jinyan Tang, Jicai Ma, Ziqi Ouyang, Jian Wang, Senrong Luo, Yuankang He, Zhenzhang Li, Zhenzhang Li, Yuzheng Lai, Xuxing Liao

“…Multivariate regression analysis found age (p = 0.007), diabetes mellitus (p = 0.022), successful recanalization (mTICI≥2b) (p = 0.006), NIHSS at onset (p = 0.000), and PH1 + PH2 Heidelberg bleeding classification (p = 0.009) as predictors of functional outcome.ConclusionAge, diabetes mellitus history, baseline NIHSS score, successful recanalization, and PH are predictors of 90-day functional outcome of late-window ischemic stroke patients undergoing EVT.…”
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Predicting biomarkers of progressive pulmonary fibrosis: morphological, cytokine profile, and clinical portrait by Nicol Bernardinello, Federica Pezzuto, Lauren D’Sa, Luca Vedovelli, Chiara Giraudo, Anamaria Chelu, Anamaria Chelu, Cecilia de Chellis, Francesca Lunardi, Francesco Fortarezza, Francesca Boscaro, Elisabetta Cocconcelli, Paolo Spagnolo, Elisabetta Balestro, Fiorella Calabrese

“…Clinical, radiological, and functional data were also collected retrospectively and correlated with tissue morphological and molecular cytokine profiles.ResultsFifteen patients were classified as progressors (PPF) and 33 as non-progressors (nPPF) with similar age at diagnosis and gender. …”
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Right atrial strain in Anderson–Fabry disease by Rosa Lillo, Rosa Lillo, Alessio Cianci, Maria Chiara Meucci, Giulia Iannaccone, Giulia Iannaccone, Claudio Di Brango, Filippo Tusa, Mario Marsilia, Gaetano Antonio Lanza, Gaetano Antonio Lanza, Antonella Lombardo, Antonella Lombardo, Francesco Burzotta, Francesco Burzotta, Francesca Graziani

“…BackgroundTo date, only limited data are available on right atrium (RA) morphofunctional remodeling in Fabry disease (FD).PurposeWe aimed to investigate RA structural and functional remodeling in patients with FD vs. healthy controls using 2D speckle tracking echocardiography (STE) and to explore whether any differences exist in FD patients with and without left ventricular hypertrophy (LVH).MethodsWe prospectively enrolled patients with FD and controls matched for age, sex, and cardiovascular risk factors. …”
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Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis by Tingting Zhu, Qixia Shen, Lingling Shen, Yucheng Wang, Bochen Zhu, Lifeng Ma, Shi Feng, Cuili Wang, Sijing Yan, Jingyi Li, Zhimin Chen, Jingyi Zhou, Hongfeng Huang, Bingjue Li, Zhouji Shen, Qian Wang, Jianwei Wang, Wilfried Gwinner, Irina Scheffner, Song Rong, Bing Yang, Junwen Wang, Hermann Haller, Xiaoping Han, Guoji Guo, Zhinan Yin, Jin Jin, Hui-Yao Lan, Jianghua Chen, Hong Jiang

“…In an initial retrospective analysis of clinical data gathered from two major centers in China and Germany, we found a correlation between aging and mitigated rejection outcomes in kidney recipients. …”
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Isobutyrate Confers Resistance to Inflammatory Bowel Disease through Host–Microbiota Interactions in Pigs by Xiuyu Fang, Haiyang Liu, Junling Liu, Yongqing Du, Zihan Chi, Yiqi Bian, Xuan Zhao, Teng Teng, Baoming Shi

“…We established a model of dextran sulfate sodium-induced colitis in pigs, which have gastrointestinal structure and function similar to those of humans; we performed multiomic analysis to investigate the therapeutic effects and potential mechanisms of isobutyrate on IBD at both the animal and cellular levels and validated the results. …”
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