Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells by Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee, Ju-Hee Kang

“…Notably, p21 inhibition also improved differentiation of myoblasts into myotubes, as indicated by increased myosin heavy chain expression and improvements in myotube diameter and fusion index. Conclusions Our data suggest that p21 inhibition selectively eliminates senescent cells while simultaneously enhancing the regenerative capacity of healthy myoblasts, which may combine to improve muscle regeneration and promote myogenesis, ultimately improving muscle health and function in aged individuals. …”
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Prebiotic supplementation in patients with type 1 diabetes: study protocol for a randomised controlled trial in Canada by Shyamchand Mayengbam, Raylene A Reimer, Sonia Butalia, Carol Huang, Elizabeth Rosolowsky, Munier A Nour, Josephine Ho, Weilan Wang, Shannon Pyke, Heidi Virtanen

“…Importantly, the prebiotic group maintained their serum C peptide level (marker of residual beta cell function) while the placebo group saw a drop. Given that preserving endogenous beta cell function in patients with T1D, particularly in the first year of diagnosis, reduces hypoglycaemia and glycaemic variability, we propose to examine the effect of prebiotic supplementation in patients with T1D.Methods and analysis This is a multicentre, randomised, double-blind, placebo-controlled study. …”
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Recent Advancements in Optical Fiber Sensors for Non-Invasive Arterial Pulse Waveform Monitoring Applications: A Review by Jing Wen Chew, Soon Xin Gan, Jingxian Cui, Wen Di Chan, Sai T. Chu, Hwa-Yaw Tam

“…Non-invasive heart rate monitoring devices, in particular, have become some of the most popular tools for health monitoring. However, heart rate data alone are not enough to reflect the health of one’s cardiovascular function or arterial health. …”
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Resolution Improvement Method of Azimuth Gamma Imaging Logging Based on Regularization Constraint by YU Huawei, ZHAO Shuai, YUE Xizhou, LI Guoyu, SHAO Cairui, XIAO Hongbing, CHEN Jinhong

“…Firstly, according to the detector response principle, the response sensitivity function of azimuth gamma logging is obtained by numerical simulation and experiment, and the accuracy of the sensitivity factor is verified. …”
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From NeurODEs to AutoencODEs: A mean-field control framework for width-varying neural networks by Cristina Cipriani, Massimo Fornasier, Alessandro Scagliotti

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Most habitat's and species' assessments in German Natura 2000 sites reflect unfavourable conservation states by Julia S. Ellerbrok, Theresa Spatz, Veronika Braunisch, Michael Strohbach, Dagmar Haase, Kathrin Januschke, Josef Kaiser, Marion Mehring, Thilo Wellmann, Helge Bruelheide, Jori Maylin Marx, Josef Settele, Christian Wirth, Nina Farwig

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Synthesis and investigation of the optical characteristics of RE3+ activated Ca2Li2Si2O7 (Rare earth = Eu, Tb) phosphor for W-LED application by Pragati Tale, Ashok Mistry, Bharti Bawanthade, Ashish Mathur, S.J. Dhoble

“…Fourier transform infrared (FT-IR) spectra were applied for the identification of functional groups, and powder X-ray diffraction (XRD) was used for structural analysis. …”
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MAIT cells protect against sterile lung injury by Xiawei Zhang, Shuailin Li, Wojciech Lason, Maria Greco, Paul Klenerman, Timothy S.C. Hinks

“…Summary: Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. …”
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Impact of pre- and peri-operative risk factors on length of stay and hospital readmission following minimally-invasive partial nephrectomy by Vanessa A. Lukas, Rahul Dutta, Ashok K. Hemal, Matvey Tsivian, Timothy E. Craven, Nicholas A. Deebel, David D. Thiel, Ram Anil Pathak

“…Univariate and multivariable analysis exhibited similar results. For LOS greater than 3 days, undergoing non-elective surgery (OR=5.247), transfusion of greater than four units within 72 h prior to surgery (OR=5.072), pre-operative renal failure or dialysis (OR=2.941), and poor pre-operative functional status (OR=2.540) exhibited the strongest statistically significant associations. …”
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Public awareness, attitudes, behavior and norms building green hospitals' power by Ari Nurfikri, Deni Danial Kesa, Mingchang Wu, Elsa Roselina, Abas Hidayat

“…The respondents of this research were 400 green hospital users from Indonesia and Taiwan. The data analysis method includes tests for normality, linearity, and heteroscedasticity. …”
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The Socio-Economic Role of Small Agribusiness in the Development of Modern Ukraine and Poland by Oleksandr Shpykuliak, Ivan Balaniuk, Diana Shelenko, Sergiy Balaniuk, Alona Sukhovii

“…Factors influencing the formation of the socio-economic role of small agribusiness, directions for establishing the institutional and organizational-economic structure of small-scale enterprises in the agricultural sector of Ukraine and Poland are singled out. An analysis of the activities of small agribusiness entities was carried out using statistical data from GUS (Central Statistical Office of Poland) and the State Statistics Service of Ukraine for the period from 2010 to 2020. …”
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Stroop task and practice effects demonstrate cognitive dysfunction in long COVID and myalgic encephalomyelitis / chronic fatigue syndrome by James N Baraniuk, Kiran Thapaliya, Maira Inderyas, Zack Y Shan, Leighton R Barnden

“…Abstract Background: The Stroop task was used to investigate differences in cognitive function between Long COVID (LC), Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and healthy control subjects. …”
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Application of the Weibull Model to Statins for Triglyceride Management in Patients With Hyperlipidaemia by Natsuki Nakayama, Kuniharu Imai, Shiori Niwa, Yoshimi Moriwaki, Chika Oshima, Nozomi Furukawa, Makoto Hirai

“…Notably, compared with No‐STG patients, STG patients presented lower hazard functions for TG concentrations up to 170 mg/dL. However, above 170 mg/dL, the hazard function for STG was equal to or slightly greater than that for No‐STG. …”
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Unveiling the tissue-specific landscape of nuclear-encoded mitochondrial genes involved in amino acid  metabolism in buffalo by E. M. Sadeesh, Madhuri S. Lahamge

“…Abstract Mitochondria play a pivotal role in energy production, metabolism, and cellular signaling, serving as key regulators of cellular functions, including differentiation and tissue-specific adaptation. …”
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Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation. by Malgorzata Milewska, David Romano, Ana Herrero, Maria Luisa Guerriero, Marc Birtwistle, Franz Quehenberger, Stefan Hatzl, Boris N Kholodenko, Oreste Segatto, Walter Kolch, Armin Zebisch

“…Importantly, we also observed a more aggressive disease phenotype when BRAF V600E coexisted with low MIG-6 expression. Finally, analysis of methylation data was performed and revealed that higher methylation of MIG-6 correlated to its decreased expression. …”
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Multi-objective particle swarm algorithm based on angular segmentation archive and dynamic update tactics by Yi Luo, Yanmin Liu, Jianjie Chen, Jie Yang, Jiang Yu

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Real-Time, Risk-Based Clinical Trial Quality Management in China: Development of a Digital Monitoring Platform by Min Jiang, Shuhua Zhao, Yun Mei, Zhiying Fu, Yannan Yuan, Jie Ai, Yuan Sheng, Ying Gong, Jingjing Chen

“…MethodsLeveraging the risk-based quality management mindset, we built a digital dynamic monitoring platform by using big data analysis and automatic quantitative technology. …”
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Exploratory GABAa-informed control network modulates hyperarousal brain dynamics in chronic insomnia by Liyong Yu, Liang Gong, Xiaoqin Chen, Yuqi He, Rong Li, Xiaojuan Hong, Qi Zhang, Siyi Yu

“…This study demonstrates that hyperarousal in chronic insomnia is characterized by more frequent and unpredictable transitions between brain states compared to healthy controls, as revealed by hidden Markov modeling of resting-state functional MRI data. By conducting an exploratory integration of DTI-based structural connectivity and regional GABAa receptor distribution within a network control theory framework, we find that chronic insomnia is associated with a flattened energy landscape reflecting hyperarousal, indicating that less energy is required for the brain to transition between states. …”
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Programmed Cell Death Protein 10 (PDCD10) Regulates Vesicle Trafficking and Contributes to the Progression of Clear Cell Renal Cell Carcinoma by Rui Wang, Tianyu Lin, Yi Liu, Hao Wang, Xinyu Liu, Yihan Dong, Jiaxin Li, Huamao Jiang, Ruibing Chen, Yong Wang, Dan Yue

“…Here, we performed a comprehensive transcriptomic and proteomic analysis on 50 clear cell renal cell carcinoma (ccRCC) tumour samples, and the data systematically depicted the alterations in the molecular landscape. …”
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Exploring effects of Souvenaid on cerebral glucose metabolism in Alzheimer's disease by Nienke M.E. Scheltens, Casper T. Briels, Maqsood Yaqub, Frederik Barkhof, Ronald Boellaard, Wiesje M. van derFlier, Lothar A. Schwarte, Charlotte E. Teunissen, Amos Attali, Laus M. Broersen, Bart N.M. vanBerckel, Philip Scheltens

“…Souvenaid, containing the specific nutrient combination Fortasyn Connect, was designed to improve synapse formation and function. The NL‐ENIGMA study explored the effect of Souvenaid on synapse function in early AD by assessing cerebral glucose metabolism (CMRglc) with 18F‐fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET). …”
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