Validation of the inadequate delivery of oxygen index in an adult cardiovascular intensive care unitCentral MessagePerspective by Heather Holman, BS, Dimitar Baronov, PhD, Jeff McMurray, MD, Arman Kilic, MD, Marc Katz, MD, Sanford Zeigler, MD

“…Three simulated monitoring situations were constructed by downsampling the physiologic data set to exclude all SvO2 sources (scenario A); all PAC data but allowing for SvO2 values (scenario B); and all PAC data, including SvO2 and cardiac index (CI) (scenario C). …”
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Understanding Patient and Physiotherapist Requirements for a Personalized Automated Smartphone Telemonitored App for Posttotal Knee Arthroplasty Rehabilitation: Qualitative Study by Eleanor Shuxian Chew, Aileen Eugenia Scully, Samanth Shi-Man Koh, Ee-Lin Woon, Juanita Krysten Miao-Shi Low, Yu-Heng Kwan, John Wei-Ming Tan, Yong-Hao Pua, Celia Ia-Choo Tan, Luke Jonathan Haseler

“…Two reviewers (ESC and SSK) independently analyzed the data using thematic analysis, with data triangulation achieved through cross-checking of data sources by 3 reviewers (ESC, SSK, and AES). …”
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An Internet of Things infrastructure for gait characterization in assisted living environments and its application in the discovery of associations between frailty and cognition by Iván González, Fco Javier Navarro, Jesús Fontecha, Luis Cabañero-Gómez, Ramón Hervás

“…The latter, in combination with other characteristics that are commonly used to assess the state of frail elders and which come from anthropometric, biological, nutritional, functional, and mobility domains, allows us to perform a cross-sectional cohort study and a subsequent multiple logistic regression to evaluate their impact on cognitive functioning. …”
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Evaluation of Psychomotor Development in Children Treated with Therapeutic Hypothermia by Aneta Kubisa, Anna Rozensztrauch, Dariusz Janczak, Małgorzata Paprocka-Borowicz

“…The study was carried out on a group of 27 children treated with therapeutic hypothermia. The data involved an analysis of medical records and the results of psychomotor development evaluation using the Munich Functional Development Diagnostics scale. …”
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The role of microRNAs in learning and long-term memory by L. N. Grinkevich

“…A large number of studies are currently being conducted to investigate the role of microRNAs in the brain functioning. A number of microRNAs have been shown to be involved in the process of synaptic plasticity, as well as in the long-term memory formation. …”
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Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization by Chloé Dias, Nissrine Ballout, Guillaume Morla, Katia Alileche, Christophe Santiago, Ida Chiara Guerrera, Adeline Chaubet, Jerome Ausseil, Stephanie Trudel

“…Results Functional enrichment analysis for both proteomics and RNA sequencing data from sfGAGs-EVs revealed a specific content involved in neuroinflammation and neurodevelopment pathways. …”
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Novel Tl2GeX6 (X=Cl,Br) double perovskites for solar cell, optoelectronic, and thermoelectric applications: A DFT investigation by Redi Kristian Pingak, Amine Harbi, Soukaina Bouhmaidi, Albert Z. Johannes, Nikodemus U.J. Hauwali, Wahidullah Khan, Fidelis Nitti, David Tambaru, M. Moutaabbid, Larbi Setti

“…The calculated elastic parameters and elastic moduli data also demonstrated that the new double perovskites exhibit mechanical stability while the calculated electronic band structure and the density of states using the PBE functional indicated that the materials are semiconductors with energy gap values of 0.3 eV for Tl2GeBr6 and 1.72 eV for Tl2GeCl6, respectively. …”
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Impacts of Plu kaow (<i>Houttuynia cordata</i> Thunb.) Ethanolic Extract on Diabetes and Dyslipidemia in STZ Induced Diabetic Rats: Phytochemical Profiling, Cheminformatics Analyse... by Shaikh Shahinur Rahman, Anuwatchakij Klamrak, Napapuch Nopkuesuk, Jaran Nabnueangsap, Piyapon Janpan, Kiattawee Choowongkomon, Jureerut Daduang, Sakda Daduang

“…PK also improved the tested liver, kidney, and heart function biomarkers and reversed damage to normal pancreatic, liver, kidney, and heart cells in histological analysis. …”
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LINC01559 drives osimertinib resistance in NSCLC through a ceRNA network regulating miR-320a/IGF2BP3 axis by Leidi Xu, Yibo Zhang, Liangliang Xing, Ying Zhou, Ning Chang, Hangtian Xi, Xiangrui Xu, Jian Zhang, Jian Zhang

“…Functional validation employed in vitro assays (proliferation, migration, invasion, drug sensitivity) and xenograft models. …”
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Identification of SMYD2 as a candidate diagnostic and prognostic biomarker for gastric cancer by Sichao Wang, Chuanxi Zhao, Dongmei Li, Qingzhi Liu, Cuiping Mao, Shanshan Ding, Shujun Zhang, Wenjing Shang

“…SMYD2 expression in GC tissues was analyzed using TCGA and GEO data and validated by immunohistochemistry (IHC). …”
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Balloon-based exposed payload designed for astrobiological research in Earth’s near space by YanQiu Wang, JianXun Shen, Chao Wang, WeiNing Li, GaoHong Wang, Wei Lin, YuanDa Jiang

“…Here, we describe the versatile Biological Samples Exposure Payload (BIOSEP) loaded on the CAS-BAP with respect to its structure and function. The primary function of BIOSEP is to expose appropriate biological specimens to the harsh conditions of near space and subsequently return the exposed samples to laboratories for further analysis. …”
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Integrated proteomic and metabolomic profiling identifies distinct molecular signatures and metabolic pathways associated with obesity and potential targets for anti-obesity therap... by Yi Li, Yi Li, Huawu Yang, Xinpeng Zhang, Xingyu He, Anke Liuli, Rui Li, Xingyu Han, Yongmei Li, Pan Gao

“…Integrated protein-metabolite network analysis identified OSBPL10, CUL2, and PRTN3 as potential regulators of lipid metabolism and insulin resistance, offering insights into obesity-associated metabolic dysfunction.ConclusionsThis study integrated proteomic and metabolomic data from visceral adipose tissue obtained through sleeve gastrectomy, identifying obesity-related functional pathways and molecular signatures linked to metabolic phenotypes, highlighting the value of multi-omics in understanding adipose tissue remodeling and postoperative metabolic improvement.…”
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Investigating imaging network markers of cognitive dysfunction and pharmacoresistance in newly diagnosed epilepsy: a protocol for an observational cohort study in the UK by Anthony Guy Marson, Marta García-Fiñana, Christophe de Bézenac, Gus Baker, Perry Moore, Nicola Leek, Rajiv Mohanraj, Leonardo Bonilha, Mark Richardson, Simon Keller

“…Baseline assessments will include neuropsychological evaluation, structural and functional Magnetic Resonance Imaging (MRI), Electroencephalography (EEG), and a blood and saliva sample. …”
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Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study&amp;mdash;Rational and Design by Li W, Lei J, Li B, Tang X, Peng Y, Huang K, Yang T

“…By setting a narrower range of lung function thresholds to define pre- and mild-COPD, this study will effectively observe the early disease progression of COPD patients in a shorter period of time. …”
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Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep by Xue Li, Buying Han, Dehui Liu, Song Wang, Lei Wang, Quanbang Pei, Zian Zhang, Jincai Zhao, Bin Huang, Fuqiang Zhang, Kai Zhao, Dehong Tian

“…Finally, comprehensive analysis of selective sweep and transcriptome data suggested that Tibetan sheep breeds inhabiting different altitudes on the Qinghai–Tibet Plateau adapt by enhancing cardiopulmonary function, regulating body fluid balance through renal reabsorption, and modifying nutrient digestion and absorption pathways. …”
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RETRACTED: Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure by Chiara Verra, Shireen Mohammad, Gustavo Ferreira Alves, Elisa Porchietto, Sina Maren Coldewey, Sina Maren Coldewey, Massimo Collino, Christoph Thiemermann

“…The potential mechanism underlying both the cardiac dysfunction and the effect of baricitinib was analyzed by western blot analysis in the heart. Trauma and subsequent sepsis significantly depressed the cardiac function and induced multiple-organ failure, associated with an increase in the activation of JAK2/STAT3, NLRP3 inflammasome and NF- κβ pathways in the heart of both male and female animals. …”
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Macrostructural and microstructural alterations of hippocampal subregions in T2DM: NODDI provides added value to DTI and volumetric analyses by Xuan Huang, Ziyu Diao, Die Shen, Jianyu Li, Jiahe Wang, Kun Wang, Shijun Qiu

“…Neuropsychological and clinical data were further analyzed to explore correlations with cognitive function. …”
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Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Ju Huang, Jing Li, Jing Li, Zhijun Geng, Zhijun Geng, Lixia Yin, Lixia Yin, Minzhu Niu, Qingqing Li, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Xue Song, Yueyue Wang, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu, Jianguo Hu

“…Combining network pharmacology prediction analysis with our validation data from animal models and colonic organoids, we demonstrated that Cyn significantly inhibits IEC apoptosis, as indicated by a decrease in the proportion of TUNEL-positive cells and changes in apoptosis-related protein levels. …”
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Screening and validation of key microRNAs regulating muscle development in Hanper sheep. by Yunxia Zhi, Boxin Hu, Shujun Tian, Ying Bai, Xiaoyong Chen

“…Transcriptome sequencing was conducted to identify miRNAs, and bioinformatics tools were applied to predict their target genes. GO and KEGG functional annotations were used to analyze the biological functions of these target genes. …”
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Self-directed arm-crank exercise to improve volitional control of the trunk in patients with subacute spinal cord injury: a multicentre, parallel-group, randomised controlled trial... by Tom E Nightingale, Joan L Duda, Shin-Yi Chiou, Eduardo Martinez-Valdes, Zubair Ahmed, Maria del Rocio Hidalgo Mas, Joshua Kearney, Vicki Middleton, Chuang-Yuan Chiu

“…Thematic analysis will be conducted on qualitative data obtained from focus groups in which the feasibility, enablers and challenges of ACET for individuals with subacute SCI will be discussed.Ethics and dissemination This study was approved by The Health Research Authority and Health and Care Research Wales (22/NS/0054). …”
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