Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor by Yuyan Liu, Rongjie Wei, Yong Tang, Shuo Sun, Wei Zhang, Yu Zhou, Zhenhua Pan, Quanhong Han, Xiujuan Zhao, Yanhua Chu

“…Additionally, peptide center analysis was performed on the proteomic data to identify key differentially expressed proteins based on screening results. …”
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Exploration of biomarkers associated with histone lactylation modification in spinal cord injury by Yisong Sun, Jie Gao, Juehua Jing

“…Gene set enrichment analysis (GSEA) was performed to assess the functional roles of these biomarkers. …”
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Metabolic profiling of glioblastoma and identification of G0S2 as a metabolic target by Jianlei Kang, Yujie Xu, Qitai Zhao, Ying Wang, Zhenyan He, Xin Xu

“…The predictive model showed robust performance in forecasting the survival of glioma patients. Functional analysis identified G0S2 as a key metabolic regulator highly expressed in gliomas. …”
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Integration of AI with artificial sensory systems for multidimensional intelligent augmentation by Changyu Tian, Youngwook Cho, Youngho Song, Seongcheol Park, Inho Kim, Soo-Yeon Cho

“…However, no studies have systematically categorized the output functions of these systems or analyzed the associated AI algorithms and data processing methods. …”
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Joint resting state and structural networks characterize pediatric bipolar patients compared to healthy controls: a multimodal fusion approach by Xiaoping Yi, Mingzhao Ma, Xueying Wang, Jinfan Zhang, Feifei Wu, Haimiao Huang, Qian Xiao, An Xie, Peng Liu, Alessandro Grecucci

“…In this study, Resting state Regional Homogeneity (ReHo) and grey matter concentration (GMC) data of 58 PBD patients, and 21 healthy controls matched for age, gender, education and IQ, were analyzed in a data fusion unsupervised machine learning approach known as transposed Independent Vector Analysis. …”
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Liquidity and Leverage Impact on Islamic Bank Value: A Test on Multigroup Moderated Mediation Effect by Yusuf Falaqi Ahmad, Vivin Maharani Ekowati, Meldona

“…A quantitative research approach is employed, utilizing Moderated Regression Analysis (MRA) and Path Analysis. The sample comprises financial statement data from Islamic Commercial Banks in the three countries. …”
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FORCETRACKER: A versatile tool for standardized assessment of tissue contractile properties in 3D Heart-on-Chip platforms. by José M Rivera-Arbeláez, Milica Dostanić, Laura M Windt, Jeroen M Stein, Carla Cofiño-Fabres, Tom Boonen, Maury Wiendels, Albert van den Berg, Loes I Segerink, Christine L Mummery, Pasqualina M Sarro, Berend J van Meer, Marcelo C Ribeiro, Massimo Mastrangeli, Robert Passier

“…ForceTracker is coded in Python and uses a multi-threading approach for time-efficient analysis of large data sets in multiple formats. The software efficiency to analyze circular and rectangular pillar shapes is successfully tested by analyzing different format videos from two EHT platforms, developed by different research groups. …”
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CRISPR-Cas9 and Its Bioinformatics Tools: A Systematic Review by Alicja Jasieniecka, Inês Domingues

“…CRISPR-Cas9 has revolutionized genetic research with bioinformatics tools essential for tasks like guide RNA design, off-target prediction, and data analysis. This systematic review summarizes the functionality and key features of such tools. …”
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Identification of CT based radiomic biomarkers for progression free survival in head and neck squamous cell carcinoma by Xiao Ling, Soha Bazyar, Matthew Ferris, Jason Molitoris, Erin Allor, Hannah Thomas, Danielle Arons, Lisa Schumaker, Rebecca Krc, William Silva Mendes, Phuoc T. Tran, Amit Sawant, Ranee Mehra, Daria A. Gaykalova, Lei Ren

“…An ensemble feature selection involving correlation analysis, univariate survival analysis, best-subset selection, and the LASSO-Cox algorithm was used to select functional features, which were then used to build final Cox Proportional Hazards models (CPH). …”
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Corona or hydrochloric acid modulates embryonic diapause in silkworms by activating different signaling pathways by Yuli Zhang, Guizheng Zhang, Mangui Jiang, Pingyang Wang, Xia Wang, Qiuying Cui, Quan Sun

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Methods for processing and analyzing images of vascularized micro-organ and tumor systems by Stephanie J. Hachey, Christopher J. Hatch, Daniela Gaebler, Alexander G. Forsythe, Makena L. Ewald, Alexander L. Chopra, Zhangying Chen, Kapil Thapa, Melvin Hodanu, Jennifer S. Fang, Jennifer S. Fang, Jennifer S. Fang, Christopher C. W. Hughes, Christopher C. W. Hughes, Christopher C. W. Hughes

“…To manage the extensive imaging data generated, we created standardized, high-throughput workflows for image analysis. …”
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Assessment of the attractiveness of a region for coffee production: the case of Karo Regency by Syahbudin Hasibuan, Zulkarnain Lubis, Sri Ariani Safitri, Zahraturrahmi Zahraturrahmi, Marizha Nurcahyani

“…Sampling techniques included purposive, simple random, stratified, and snowball sampling. Data analysis involved descriptive statistics, gross margin analysis, and SWOT analysis using IFAS and EFAS matrices to formulate strategic recommendations. …”
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Germline genetic scores associated with cancer gene expression and immune responses across multiple cancer types by Soojin Cha, Injeong Shim, Sang-Hyuk Jung, Beomsu Kim, Soyeon Kim, Mi-So Park, Hyunbin Cho, Yonghyun Nam, Woong-Yang Park, Dokyoon Kim, Hong-Hee Won

“…Methods We conducted a large-scale analysis of UK Biobank data, including 61,249 cancer cases and 254,203 controls of European ancestry across 16 cancer types. …”
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Androgen Receptor Localizes to Plasma Membrane by Binding to Caveolin-1 in Mouse Sertoli Cells by Qiong Deng, Yong Wu, Zeng Zhang, Yue Wang, Minghua Li, Hui Liang, Yaoting Gui

“…The nonclassical androgen signaling pathway translates signals into alterations in cellular function within minutes, and this action is proposed to be mediated by an androgen receptor (AR) localized to the plasma membrane. …”
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Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisResearch in context by Wen Tian, Shan-Shan Dong, Feng Jiang, Jun-Qi Zhang, Chen Wang, Chang-Yi He, Shou-Ye Hu, Ruo-Han Hao, Hui-Miao Song, Hui-Wu Gao, Ke An, Dong-Li Zhu, Zhi Yang, Yan Guo, Tie-Lin Yang

“…Methods: We performed cis-eQTL analysis using genomics and cartilage transcriptomics data from 204 patients with OA (largest sample size to date). …”
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Epigenetic Changes Regulating Epithelial–Mesenchymal Plasticity in Human Trophoblast Differentiation by William E. Ackerman IV, Mauricio M. Rigo, Sonia C. DaSilva-Arnold, Catherine Do, Mariam Tariq, Martha Salas, Angelica Castano, Stacy Zamudio, Benjamin Tycko, Nicholas P. Illsley

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Causal relationships between immune cell subtypes and risk of Pneumocystis pneumonia and lung cancer: a Mendelian randomization study by Zhongqiu Tian, Wenfang Tang, Long Wen, Zhixiong He, Yanyan Fang, Yubin Fan, Yan Peng, Linyan Xu, Bin Li, Xuelian Chen

“…Survival differences between risk groups were assessed with Kaplan-Meier analysis. We characterized gene functions using GO analysis, evaluated immune cell infiltration with CIBERSORT/ESTIMATE, and performed weighted gene co-expression network analysis to identify functional gene modules associated with phenotypic traits. …”
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Interplay of lung microbiome and epigenetics in former smokers: A machine learning and fuzzy logic approach on COPD progression by Hamidreza Taherkhani, Azadeh Kavianfar, Hossein Lanjanian, Nazanin Hosseinkhan, Mahdieh Salimi, Sajjad Nematzadeh, Mohammad Mehdi Naghizadeh, Sadegh Azimzadeh, Ali Masoudi-Nejad

“…Discriminative features related to mortality and the distinction between current smokers and former smokers were successfully identified using features obtained from a fuzzy logic-based model built on the extracted data. A comprehensive microbiome analysis revealed a total of 1781 OTUs, with 13 showing significant differences in abundance and relevance to COPD across 5 phyla. …”
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NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles. by Shucheng Chen, Mark Harris

“…We further showed that the assembly phenotype of C142A and E191A was restored by ablation of interferon regulatory factor-1 (IRF1), a downstream effector of PKR. These data suggest a novel interaction between NS5A DI and PKR that functions to evade an antiviral pathway that blocks virus assembly through IRF1.…”
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Computational studies reveal structural characterization and novel families of Puccinia striiformis f. sp. tritici effectors. by Raheel Asghar, Nan Wu, Noman Ali, Yulei Wang, Mahinur Akkaya

“…In our study, one of the comparative structural analyses revealed a new structure family with a core structure of four helices, including Pst27791, PstGSRE4, and PstSIE1, which target key wheat immune pathway proteins, impacting the host immune functions. Further comparative structural analysis showed similarities between Pst effectors and effectors from other pathogens, such as AvrSr35, AvrSr50, Zt-KP4-1, and MoHrip2, highlighting a possibility of convergent evolutionary strategies, yet to be supported by further data encompassing on some evolutionarily distant species. …”
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