Development and validation of a novel endoplasmic reticulum stress-related lncRNA signature in laryngeal squamous cell carcinoma by Xiazhi Pan, Qin Che, Duanshali Liu, Yingli Xie, Beicheng Li, Shanshan Zhang, Tian Li, Gege Li, Xiaohan Li, Qiuchen Zheng, Kai Zhao, Mingbo Liu

“…Our research aimed to find an ERS signature to forecast the prognosis of laryngeal squamous cell carcinoma and to investigate its potential biological functions. LSCC sample data obtained from The Cancer Genome Atlas (TCGA) database were co-expressed with ERS- related genes, and then a prognostic signature on the basis of endoplasmic reticulum stress- related lncRNAs (ERS-related lncRNAs) was constructed by differential analysis and Cox regression analysis. …”
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LincRNA-MSTRG.673.2 Promotes Chicken Intramuscular Adipocyte Differentiation by Sponging miR-128-3p by Binbin Zhang, Shuaipeng Zhu, Yuehua He, Wenjie Liang, Tingqi Zhu, Ruili Han, Donghua Li, Yanbin Wang, Yadong Tian, Guoxi Li, Xiangtao Kang, Wenting Li, Guirong Sun

“…Functional enrichment analysis revealed that DELincRNAs from the overexpression group (M group) and interference group (SI group) were involved in the negative regulation of metabolic processes, response to steroid hormones, and regulation of actin cytoskeleton. …”
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ALDOA contributes to colorectal tumorigenesis and metastasis by targeting YAP by Liang Sun, Ting Lu, Linhua Jiang, Huihui Yao, Qixuan Xu, Jie Sun, Xiaoqin Yang, Songbing He, Xinguo Zhu

“…In addition, loss of function and gain of function experiments showed that ALDOA promoted CRC cell proliferation and migration in vitro and in vivo. …”
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Reconstruction options in pediatric population with hemi or total mandibulectomy defects: A systematic review by Adity Bansal, Shakil Ahmed Nagori, Ashi Chug, Ashutosh Dixit, Rebecca Chowdhry, Srinivas Gosla Reddy

“…The main aim is to provide optimum esthetics and function. Materials and methods: PubMed, Cochrane CENTRAL, Embase, MEDLINE and Scopus databases were searched for articles published only in English language up to May 2021, involving reconstruction of hemi or total mandibulectomy defects in patients with the age of 8 years or less, associated with benign or malignant pathology. …”
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Hippocampal vascular supply and its mediating role in systemic physiological influences on hippocampal volume by Tae Kim, Tae Kim, Javier Rasero, Anna L. Marsland, Mark R. Scudder, Tamer S. Ibrahim, Tamer S. Ibrahim, Peter J. Gianaros

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Hidden cause of paralysis: tight filum terminale in spinal cord injury without radiographic abnormality by Yi Yuan, Yi Yuan, Zong Jian An, Fei Gao, Zhi Hui Li, Wei Li Xu, Yong Sun

“…ObjectiveTo explore the clinical characteristics and surgical treatment outcomes of spinal cord injury without radiographic abnormality (SCIWORA) in children.MethodsA retrospective analysis was conducted on the clinical data of four children diagnosed with SCIWORA who were admitted to the Neurosurgery Department of Qingdao Women and Children's Hospital from November 2022 to June 2024. …”
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mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage by Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero

“…Results Cultured rat cardiomyocytes treated with rapamycin for 6–24 h showed a significant reduction in phosphorylation of p70S6K, indicative of sustained inhibition of mTOR. Structural and functional analysis revealed increased mitochondrial fragmentation and impaired bioenergetics characterized by decreases in ROS production, oxygen consumption, and cellular ATP. …”
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The relationship between remote diffusion-weighted imaging lesions and the triglyceride-glucose index and clinical outcomes in patients with intracerebral hemorrhage by Lu Wang, Yu Gu, Guoliang Jiang, Chunyan Lei, Potao Zhang, Wen Jiang, Xinglong Yang, Ansong Jin, Qionghua Deng

“…ObjectiveThis study aimed to observe the relationship between the presence of distal diffusion-weighted imaging (DWI) lesions and triglyceride-glucose (TyG) index and clinical outcome after intracerebral hemorrhage (ICH), and identify the risk factors for DWI lesions in ICH patients.MethodsICH patients at the First Affiliated Hospital of Kunming Medical University were retrospectively collected. Demographic data, laboratory examination, and imaging data of the patients were collected. …”
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Whole-cell patch clamp and extracellular electrophysiology recordings in mouse brain slices by Huimin Chen, Xiangyi Shi, Fuzheng Guo

“…We detail procedures for solution preparation, data acquisition, and analysis, with troubleshooting strategies to ensure experimental reliability and reproducibility.For complete details on the use and execution of this protocol, please refer to Wang et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Structural Disorder by Octahedral Tilting in Inorganic Halide Perovskites: New Insight with Bayesian Optimization by Jingrui Li, Fang Pan, Guo‐Xu Zhang, Zenghui Liu, Hua Dong, Dawei Wang, Zhuangde Jiang, Wei Ren, Zuo‐Guang Ye, Milica Todorović, Patrick Rinke

“…The subsequent variations in energetics and properties are described by 3D potential‐energy surfaces (PESs) and property landscapes, delivered by Bayesian optimization as implemented in the Bayesian optimization structure search code sampling density functional theory (DFT) calculations. The rapid convergence of the PES with about 200 DFT data points in 3D searches demonstrates the power of active learning and strategic sampling with Bayesian optimization. …”
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Left ventricular flow dynamics by cardiac imaging techniques in heart failure patients: state of the art by Donato Mele, Lorenzo Serio, Riccardo Beccari, Antonella Cecchetto, Stefano Nistri, Gianni Pedrizzetti

“…Abstract Background The evaluation of left ventricular (LV) flow dynamics is a novel approach to assessing LV function that goes beyond traditional metrics. This approach has been applied to patients with heart failure (HF), providing valuable insights that are discussed in this review, with the aim of enhancing our understanding of LV function in the context of the HF syndrome. …”
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A stele‐enriched gene regulatory network in the Arabidopsis root by Siobhan M Brady, Lifang Zhang, Molly Megraw, Natalia J Martinez, Eric Jiang, Charles S Yi, Weilin Liu, Anna Zeng, Mallorie Taylor‐Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J M Walhout, Philip N Benfey

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THE PERFORMANCE OF A LONG-TERM ANTIBACTERIAL THERAPY IN CHILDREN WITH CYSTIC FIBROSIS DURING PRIMARY PLATING OF PSEUDOMONAS AERUGINOSA by О. I. Simonova, Yu. V. Gorinova, А. V. Lazareva, N. I. Burkina

“…Methods: In a retrospective continuous study it was analyzed the results of inhalation use of the colistimethate sodium in a dose of 2 million IU/day in children with moderate cystic fibrosis with newly diagnosed P. aeruginosa. Results: The analysis included data of 25 children at the age of 2–10 years, 17 of them were treated with colistimethate sodium for 6 months, 8 — for 12 months. …”
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Induction of intestinal barrier dysfunction in dairy heifers: Evaluation of new serum inflammatory markers and method for quantifying intestinal hyperpermeability by K.E. Vagnoni, E. Lopez-Cruz, M. Carranza, D.B. Vagnoni

“…., ruminal acidosis, heat stress, weaning) can impair intestinal barrier function, this is an important phenomenon to study. …”
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SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. by Wan-Shan Yang, Mel Campbell, Pei-Ching Chang

“…These finding suggest that SUMO-2/3 modification plays an essential role in the epigenetic regulatory function of JMJD2A. Consistently, hierarchical clustering analysis of RNA-seq data showed that a SUMO-deficient mutant of JMJD2A was more closely related to JMJD2A knockdown than to wild-type. …”
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Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study. by Roberto Lorbeer, Holger Hetterich, Ralf Strobl, Anina Schafnitzel, Hannah Patscheider, Andreas Schindler, Katharina Müller-Peltzer, Wieland Sommer, Annette Peters, Christa Meisinger, Margit Heier, Wolfgang Rathmann, Fabian Bamberg, Eva Grill

“…MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. …”
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Interannual variability in thermal state of the upper mixed layer in the Bering Sea in winter by V. A. Luchin

“…Series of annual mean fields of the mixed layer temperature in December-March were decomposed by applying the empirical orthogonal function (EOF); dynamics of the first two components of decomposition (described in sum 50.4 % of the initial fields variability) are analyzed. …”
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A predictive framework using advanced machine learning approaches for measuring and analyzing the impact of synthetic agrochemicals on human health by Sahezpreet Singh, Puneet Kaur, Inderdeep Kaur, Gurpreet Singh, Satinder Kaur, Parminder Kaur

“…Data sourced from credible organizations, including WHO, CDC, EPA, NHANES, and USDA, underwent extensive preprocessing and analysis. …”
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The illness management and recovery program: a contribution to recovery-oriented secondary mental health services by Kristin B. Ørjasæter, Tone Winnem, Kristin Heiervang, Ottar Ness, Kim T. Mueser

“…Altogether, 36 practitioners from five mental health hospitals and district psychiatric centers in Norway participated. Reflexive thematic analysis was used to analyze the data. Results The results show that IMR (a) actively facilitates the alignment of coping mechanisms with patients’ lives, and (b) emphasizes a recovery-oriented approach in the delivery of services. …”
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Pre-transplant residual diuresis and oxalic acid concentration influence kidney graft survival. by Gideon Post Hospers, Mirjam Laging, Wesley J Visser, Pedro Miranda Afonso, Jeroen Ghp Verhoeven, Ingrid Ram Mertens Zur Borg, Dennis A Hesselink, Anneke M E de Mik-van Egmond, Michiel G H Betjes, Madelon van Agteren, David Severs, Jacqueline van de Wetering, Robert Zietse, Michel J Vos, Ido P Kema, Marcia M L Kho, Marlies E J Reinders, Joke I Roodnat

“…<h4>Background and hypothesis</h4>Oxalic acid, a toxic metabolic end product, accumulates when kidney function deteriorates. Apart from its direct tubulotoxicity, it crystallizes at concentrations above 30-40 µmol/L. …”
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