Quantification of Lower Limb Kinematics During Swimming in Individuals with Spinal Cord Injury by Melina Giagiozis, Sabrina Imhof, Sibylle Achermann, Catherine R. Jutzeler, László Demkó, Björn Zörner

“…Spinal cord injuries (SCI) often result in impaired motor functions. To quantify these impairments, swimming patterns were analyzed in individuals with SCI. …”
Get full text

Identification and Classification Features of Patient Portal, A Systematic Review by Reyhane Norouzi Aval, Houshang Rafatpanah, Masoumeh Sarbaz, Seyyedeh Fatemeh Mousavi Baigi, Khalil Kimiafar

“…The checklist was used for data extraction, and finally, started to identify the functional features of patient portals based on the review of retrieved articles. …”
Get full text

Biomarker Research in ADHD: the Impact of Nutrition (BRAIN) - study protocol of an open-label trial to investigate the mechanisms underlying the effects of a few-foods diet on ADHD... by Esther Aarts, Tim Stobernack, Stefan P W de Vries, Rob Rodrigues Pereira, Lidy M Pelsser, Cajo J F ter Braak, Peter van Baarlen, Michiel Kleerebezem, Klaas Frankena, Saartje Hontelez

“…We hypothesise that an FFD affects brain function, and that the nutritional impact on ADHD is effectuated by a complex interplay between the microbiota, gut and brain, that is, the microbiota–gut–brain axis.Methods and analysis The Biomarker Research in ADHD: the Impact of Nutrition (BRAIN) study is an open-label trial with researchers blinded to changes in ADHD symptoms during sample processing and initial data analyses.Ethics and dissemination The Medical Research and Ethics Committee of Wageningen University has approved this study (NL63851.081.17, application 17/24). …”
Get full text

Integrated single-cell and transcriptome sequencing to construct a prognostic model of M2 macrophage-related genes in prostate cancer by TANG Kairan, FENG Chengling, HAN Bangmin

“…Differential genes in scRNA-seq data were identified using the FindMarkers function, and immune cell subtypes were characterized. …”
Get full text

Multivariate Spatial Autoregressive Model with Latent Variables: Application to Economic Growth Modeling by Anik Anekawati, Purhadi, Mohammad Rofik

“…Research involving causal relationships among latent variables that generally use structural equation modeling (SEM) analysis and spatial data simultaneously has an unavoidable impact on using spatial SEM analysis. …”
Get full text

CLINICAL AND DIAGNOSTIC VALUE OF YKL-40 AND NGAL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE by Valeriy Kuznetsov, Yana Kozlova, Alexey Sobolev, Ekaterina Frolova, Alexandra Uchevatkina, Olga Secretareva, Natalya Vasilieva

“…Clinical and anamnestic data, indices of external respiratory function were evaluated. …”
Get full text

A Dual-Source Deep Learning Model for Mapping Wet Anabranches in Braided Rivers on the Tibetan Plateau by Xiaolu Liu, Xiaoyi Ma, Shuai Qin, Tang Liu, Chenghu Zhou

“…Additionally, a multicomposite loss function was designed to enhance the model's performance. …”
Get full text

Blurring the lines: an empirical examination of the interrelationships among acceptability, appropriateness, and feasibility by Zoe Fehlberg, Zornitza Stark, Marlena Klaic, Stephanie Best

“…Five interrelationships were categorized from analysis of interview data (n = 14) and explain how clinicians’ perceptions of the intervention, positive or negative, were determined by interrelating factors of acceptability, appropriateness, and feasibility and that in different scenarios, the function and emphasis of importance among outcomes switched. …”
Get full text

Psychological and pedagogical readiness of a guide to work with disabled people by O. V. Zaslavskaya, A. S. Malafiy

“…Primary data obtained during the survey, as well as secondary data from open sources and databases were used. …”
Get full text

The use of bone autoplasty for false joints of the humerus diaphysis by K. I. Khorak, P. G. Kogan, D. G. Parfeev, A. I. Avdeev, A. M. Morozov, M. E. Piskareva

“…Over the last decades, clinical practice has changed many approaches to the tactics and choice of therapeutic means to restore bone integrity, as well as to restore the supporting and motor functions of the traumatized limb. Analysis of the data obtained from the literature has shown that the best results in the treatment of false joints of the humerus diaphysis were demonstrated by the techniques combining the use of bone autoplasty and additional metal structures.…”
Get full text

Obstructive Sleep Apnea in Overweight and Obese Children: Factors Influencing Quality of Life by Montaha Al‐Iede, Rahaf Rahal, Sondos Al‐Mashaqbeh, Mohannad Alajmi, Hadeel Al‐Rawi, Mohammed Alshrouf, Fareed Khdair Ahmad, Abeer Alassaf, Rasha Odeh, Iyad Almofleh, Nihad Almasri

“…ABSTRACT Introduction There is a paucity of data regarding biological sex influence and the impact of obstructive sleep apnea (OSA) on the quality of life (QoL) of obese children with OSA. …”
Get full text

Cognitive considerations for adults with sickle cell disease completing the brief pain inventory by Julia A. O'Brien, Jermon A. Drake, Donald J. Bearden, Kim E. Ono, Soumitri Sil, Lindsey L. Cohen, Alana Karras, Enrico M. Novelli, Charles R. Jonassaint

“…To examine patterns in how patients completed the BPI-SF and determine whether incorrectly completing the BPI-SF was related to cognitive functioning or education. Methods:. A secondary analysis was completed using data from a study examining brain aging and cognitive impairment in SCD. …”
Get full text

WNK2 variants associated with familial osteoarthritis alter the chondrocyte response to hyperosmotic stress by Chris Stubben, Gregory J Stoddard, Michael J Jurynec, Matthew Honeggar, Shivakumar R Veerabhadraiah, Nikolas H Kazmers, David J Grunwald, Derek J Matheson, Collin Aslor, Antonio C Zelada

“…Wild type (WT) and variant WNK2 functions were analysed by overexpression effects in immortalised and primary human chondrocytes; loss-of-function effects were analysed in WNK2 mutant cells. …”
Get full text

Genome-wide association study −Driven drug repositioning for the treatment of insomnia by Rahmat Dani Satria, Wirawan Adikusuma, Usi Sukorini, Devy Eka Avitasari, Indra Sari Kusuma Harahap, Mohammad Hendra Setia Lesmana, Lalu Muhammad Irham, Nur Imma Fatimah Harahap, Pranindya Rinastiti, Donytra Arby Wardhana, Richardus Wisnandito Prabasaktya, Chiou-Feng Lin, Aprilia Paramitasari, Andrian Fajar Kusumadewi

“…This study aimed to identify potential therapeutic targets for insomnia by integrating gene network analysis, genomic data, and bioinformatics-driven drug repurposing strategies, aligning with the United Nations’ Sustainable Development Goal (SDG) 3: Good Health and Well-being. …”
Get full text

Investigation into the monitoring and control of mechanical dynamics in inclined mining equipment utilizing digital twin technology by Panshi XIE, Hang YANG, Yongping WU, Baofa HUANG, Weidian LIN, Leilei YI

“…The system's mapping between virtual and real domains is achieved through detailed analysis and processing of the gathered data. Ultimately, the feasibility and efficacy of this system are corroborated through a multi-functional, variable-angle large-scale "support-surrounding rock" system physical simulation platform. …”
Get full text

Current status and prognostic factors of paediatric arterial ischaemic stroke in China: a study protocol for Chinese Paediatric Ischaemic Stroke Registry (CPISR) by Wei Li, Bin Zhu, Wen Sun, Fan Wu, Pan Zhang, Lulu Xiao, Huiping Wang, Gang Cai, Yingjie Xu, Wanqiu Zhang, Cuirong Duan, Mingyang Niu, Qiankun Li, Zhiwen Su

“…Introduction The treatment of paediatric AIS is particularly challenging due to its rarity, limited clinical awareness and absence of targeted treatment protocols and evidence-based data. This study aims to address these gaps by investigating the epidemiology, risk factors, aetiology and treatment of stroke in children in China and to observe the short-term and long-term functional outcomes of paediatric stroke and explore the factors that influence outcomes.Method and analysis The Chinese Paediatric Ischaemic Stroke Registry (CPISR) is a multicentre, prospective observational study that plans to consecutively recruit patients at 85 centres across 20 provinces in China. …”
Get full text

Development and application of a cGPS 20K liquid-phase SNP microarray in Jiaji ducks by Tieshan Xu, Zixin Xu, Dingping Bai, Fanghu Wu, Yuanyuan Shang, Mao Li, Guang Rong, Lihong Gu

“…The microarray was used to genotype a population of 236 Jiaji ducks, and the genotyping data were then used for population structure analysis and genome-wide association studies (GWAS) of plumage color phenotypes. …”
Get full text

FN3K expression in COPD: a potential comorbidity factor for cardiovascular disease by Irfan Rahman, Emma H Baker, Gaetano Caramori, Alberto Papi, Amr Alderawi, Andrew William Hitchings, Christos Rossios, Ian Adcock, Victor E Ortega, Jeffrey L Curtis, Simon Dunmore, Paul Kirkham, Paolo Casolari

“…The top five nominal FN3K polymorphisms with possible association to decreased cardiorespiratory function (p<0.008–0.02), all failed to reach the threshold (p<0.0028) to be considered highly significant following multi-comparison analysis. …”
Get full text

“Surviving and Thriving”: evidence for cortical GABA stabilization in cognitively-intact oldest-old adults by Mark K. Britton, Greg Jensen, Richard AE Edden, Nicolaas AJ Puts, Sara A. Nolin, Stacy Suzanne Merritt, Roxanne F. Rezaei, Megan Forbes, Keyanni Joy Johnson, Pradyumna K. Bharadwaj, Mary Kathryn Franchetti, David A. Raichlen, Cortney J. Jessup, G. Alex Hishaw, Emily J. Van Etten, Aaron T. Gudmundson, Saipavitra Murali-Manohar, Hannah Cowart, Theodore P. Trouard, David S. Geldmacher, Virginia G. Wadley, Noam Alperin, Bonnie E. Levin, Tatjana Rundek, Kristina M. Visscher, Adam J. Woods, Gene E. Alexander, Ronald A. Cohen, Eric C. Porges

“…We extend our previously-reported Individual Participant Data Meta-Analysis of GABA levels across the lifespan, integrating four large cross-sectional datasets sampling cognitively-intact oldest-old adults. …”
Get full text

Explainable AI-driven assessment of hydro climatic interactions shaping river discharge dynamics in a monsoonal basin by Prashant Parasar, Akhouri Pramod Krishna

“…The main findings of this study are (1) KAN demonstrated high predictive performance with root mean squared error (RMSE) values ranging from 42.7 to 58.3 m3/s, Nash–Sutcliffe efficiency (NSE) between 0.80 and 0.87, mean absolute error (MAE) between 28.9 to 52.7 and R2 values between 0.84 and 0.90 across stations. (2) SHAP based feature contribution analysis identified Relative humidity (hurs), specific humidity (huss), and temperature (tas) as key predictors, while (pr) showed limited contribution due to spatial inherent inconsistencies in GCM precipitation data. (3) The bootstrapped SHAP distributions highlighted substantial variability in feature importance, particularly for humidity variables, revealing station specific uncertainty patterns in model interpretation. (4) The KAN framework results indicate strong temporal alignment and physical realism, confirming KAN’s robustness in capturing seasonal discharge dynamics and extreme flow events under monsoon influence environments. (5) In this study KAN with SHAP (SHapley additive exPlanations) is implemented for hydrological modeling under monsoon-influenced and data-limited regions such as SRB, offering improved accuracy, functional precision and efficiency compared to traditional models. …”
Get full text