Scalable Precision Psychiatry With an Objective Measure of Psychological Stress: Prospective Real-World Study by Helena Wang, Norman Farb, Bechara Saab

“…The recommendation algorithm selected increasingly efficacious therapy sessions as a function of training data when trained with either ∆OSL (F1,16=5.37, P=.03) or ∆SRM data (F1,16=3.69, P<.05). …”
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Quality of life in pregnant women with subclinical hypothyroidism: clinical management gaps by Zahra Panahi, Marziye Sadeghi Gogheri, Mohadese Dashtkoohi, Mohammadamin Noorafrooz, Nasim Eshraghi, Marjan Ghaemi, Fahimeh Ghotbizadeh Vahdani, Razieh Akbari, Mohammad Sadeq Najafi, Mohammadamin Parsaei, Alireza Imani Porshokouh, Bahram Salmanian, Sedigheh Hantoushzadeh

“…This decline affected all areas assessed, including general and mental health, physical function, bodily pain, and social functioning. TSH levels emerged as a significant predictor of overall HRQoL using regression analysis (B coefficient − 1.30,95% CI: -2.08 to -0.52; p = 0.001). …”
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Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…The results of Mendelian randomization analysis further confirm that PTEN is an important therapeutic target for improving cognitive function. …”
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اختبار العلاقة بين العدالة التنظيمية والاحتراق الوظيفي - (دراسة تطبيقية في المعهد التقني / كوفة by سناء جاسم الذبحاوي, دجلة جاسم الذبحاوي

“…Standing at the level of both organizational justice and functional combustion. Hence it becomes clear to us its importance. …”
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Short- and mid-term outcomes after redo surgical valve replacement by Pardis Sadeghi, Ali Hosseinsabet, Reza Mohseni-Badalabadi, Arash Jalali, Ahmad Vakili-Basir, Mina Pashang, Negar Omidi, Jamshid Bagheri, Mohammadjavad Mehrabanian

“…Hypertension and baseline functional class were independent predictors of MAE occurrence. …”
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Recording dan Pencarian Silsilah Kambing Perah Menggunakan Algoritme Depth First Search by Rizki Wahyudi, Muhammad Iqbal, Lussy Dwi Oktaviana

“…The results of black-box recording system testing and pedigree search of goat data show the functional system went as expected. …”
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Infographics as a tool for presentation of an organisation in the media space by V. V. Zotov, O. I. Molchanova

“…The purpose of the article is to consider infographics as a media format for self-presentation of an organisation, as a tool for managing its image. The conducted analysis allows us to show a classification of the infographics according to the following criteria: display method, data type, purpose, presentation format, presence of interactivity, and time perspective. …”
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Identification of critical transition signal (CTS) to characterize regulated stochasticity during ABA-induced growth-to-defense transition by Rasmieh Hamid, Bahman Panahi, Feba Jacob, Amir Ghaffar Shahriari

“…Gene Ontology (GO) enrichment analysis revealed a significant overrepresentation of defense-related biological processes, while STRING network analysis revealed strong functional interactions between DNB genes and differentially expressed genes (DEGs) and highlighted key regulatory hubs. …”
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Exploring the hepatic-ophthalmic axis through immune modulation and cellular dynamics in diabetic retinopathy and non-alcoholic fatty liver disease by Shuyan Zhang, Jiajun Wu, Leilei Wang, Cheng Zhang, Yinjian Zhang, Yibin Feng

“…Additionally, gene set enrichment and variation analyses (GSEA and GSVA) were performed to uncover key functional enrichments. Results Our comparative analysis of the two datasets focused on T cells, macrophages and endothelial cells, revealing SYNE2 as a notable DEG. …”
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Multiomics genetic insights into potential molecular targets for intracranial aneurysm by Shuo Wang, Xiaolin Chen, Yi Yang, Yitong Jia, Runting Li, Fa Lin

“…Key molecules linked to aSAH and uIA were identified through MR (SMR) and colocalisation analysis. Functional research and drug development relied on postanalysis approaches, including single-cell analysis, enrichment studies and molecular docking.Results Nine genes and one protein associated with aSAH, along with two genes and one protein for uIA, were identified. …”
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Gender difference in ASAS HI among patients with ankylosing spondylitis. by Hsin-Hua Chen, Yi-Ming Chen, Kuo-Lung Lai, Tsu-Yi Hsieh, Wei-Ting Hung, Ching-Tsai Lin, Chih-Wei Tseng, Kuo-Tung Tang, Yin-Yi Chou, Yi-Da Wu, Chin-Yin Huang, Chia-Wei Hsieh, Wen-Nan Huang, Yi-Hsing Chen

“…After adjusting for disease activity (ASDAS-erythrocyte sedimentation rate [ESR], ASDAS- C-reactive protein [CRP], BASDAI+ESR or BASDAI+CRP), mSASSS and other potential confounders including medications, comorbidities, and laboratory data, any associations between gender and the sum score of ASDAS HI were assessed using multiple linear regression analysis, as well as any associations between gender and an ASAS HI score >5 using multivariable logistic regression analysis.…”
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Unveiling the Mechanism of Retinoic Acid Therapy for Cutaneous Warts: Insights from Multi-Omics Integration by Dong ZY, He MJ, Hu Y, Wang F, Ran DL, Fu DS, He Q, Yang RP, Zhang JA

“…Furthermore, the genetic susceptibility and molecular basis of viral warts are not yet fully understood.Methods: We utilized a multi-omics integration approach, encompassing genome-wide association study (GWAS) meta-analysis, summary data-based Mendelian randomization (SMR) analysis, and transcriptomic validation using the GSE136347 dataset. …”
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Patients’ Expectations for App-Based Therapy in Knee Osteoarthritis: User-Centered Design Approach by Pika Krištof Mirt, Karmen Erjavec, Sabina Krsnik, Petra Kotnik, Hussein Mohsen

“…MethodsA mixed methods approach was used, integrating quantitative data from a structured questionnaire and qualitative data from in-depth interviews. …”
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CCDC138 overexpression predicts poor prognosis and highlights ciliopathy-linked mechanisms in uterine corpus endometrial carcinoma by Aiping Wang, Fang Yang, Chunhua Zhang, Shi Li, Han Fu

“…Bioinformatics approaches, including weighted gene co-expression network analysis (WGCNA), singlesample gene set enrichment analysis (ssGSEA), machine learning, and survival analysis, were employed to assess CCDC138 expression and its functional relevance in UCEC. …”
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Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity by Amy C. Sims, Alexandra Schäfer, Kenichi Okuda, Sarah R. Leist, Jacob F. Kocher, Adam S. Cockrell, Padraig E. Hawkins, Minako Furusho, Kara L. Jensen, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Kelly G. Stratton, Natalie C. Lamar, Carrie D. Niccora, Karl K. Weitz, Richard D. Smith, Thomas O. Metz, Katrina M. Waters, Richard C. Boucher, Stephanie A. Montgomery, Ralph S. Baric, Timothy P. Sheahan

“…Infection of mice lacking functional T and B cells showed that adaptive immunity was important in controlling viral replication but also increased pathogenesis. …”
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Etodolac Single Dose Metabolic Profile Elucidation: Pharmacokinetics and Adverse Events in Healthy Volunteers by Karen Sánchez-Luquez, Anne Michelli Reis Silveira, Salvador Sánchez-Vinces, Alex Ap. Rosini Silva, Joyce Barreto, Rhubia Bethania Socorro Lemos de Brito, Caroline de Moura Garcia, Ana Lais Vieira, Marcia Ap. Antonio, Patrícia de Oliveira Carvalho

“…Network analysis was employed to interpret the data. Results: Correlations were observed between metabolomic profiles and pharmacokinetic parameters as well as clinical characteristics. …”
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Genomic and algorithm-based predictive risk assessment models for benzene exposure by Minyun Jiang, Minyun Jiang, Na Cai, Na Cai, Juan Hu, Lei Han, Lei Han, Fanwei Xu, Baoli Zhu, Baoli Zhu, Baoli Zhu, Baoli Zhu, Boshen Wang

“…We then conducted a functional prediction analysis on these genes using four machine learning models, complemented by GSVA enrichment analysis.ResultsOut of the data, 40 DEGs were identified, primarily linked to cytokine signaling, lipopolysaccharide response, and chemokine pathways. …”
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Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapy by Li Zhang, Sergio Rutella, Jongbok Lee, Ismat Khatri, Yoosu Na, Enoch Tin, Karen Fang, Michele Nawata, Juan Arteaga, Mark D Minden

“…Collectively, this hinders our ability to bolster DNT functionalities in cancer therapy. Here, we performed single-cell RNA sequencing with in vitro and in vivo functional analysis on DNTs. …”
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Experience with artificial intelligence algorithms for the diagnosis of vertebral compression fractures based on computed tomography: from testing to practical evaluation by Zlata R. Artyukova, Alexey V. Petraikin, Nikita D. Kudryavtsev, Fedor A. Petryaykin, Dmitry S. Semenov, Daria E. Sharova, Zhanna E. Belaya, Anton V. Vladzimirskyy, Yuriy A. Vasilev

“…The expert group of radiologists assessed the diagnostic accuracy and functional capacity of the AI algorithms at all stages. …”
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A novel Tc17 population recruited by tumor cells promotes tumor progression in gastric cancer by Yichao Wang, Yichao Wang, Hao Yuan, Yayun Tan, Li Wu, Li Wu, Xinchen Zhao, Xinchen Zhao, Zeyuan Yang, Zeyuan Yang, Shaoxing Dai, Shaoxing Dai, Naixue Yang, Naixue Yang

“…We found that tumor cells can recruit Tc17 cells via the CXCL16-CXCR6 axis, this finding was validated on spatial transcriptome data. And in turn, Tc17 cells may promote tumor progression by secreting IL-17A and IL-26, as functionally corroborated by CCK-8 Assay, wound healing, and transwell assay in vitro.ConclusionsThese findings reveal the immunosuppressive role of Tc17 cells in gastric cancer, provide a new perspective for understanding the immunosuppressive mechanism of the gastric cancer tumor microenvironment, and provide a potential target for the development of targeted therapeutic strategies…”
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