MicroRNA: sex steroids, hormonal carcinogenesis, hormonal sensitivity of tumor tissue by A. V. Malek, L. M. Bershtein

“…As a result, the effect of many microRNA is converging on the single mRNA, results in suppression of corresponding protein function and, in the end, leads to inhibition of regulatory cascade downstream of sex steroids.Finally, the analysis of the fundamental aspects of sex hormones – microRNA interplay is supplemented by brief overview of clinically significant problems. …”
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THE INFLUENCE OF ANATOMICAL AND PHYSIOLOGICAL FEATURES OF THE TONGUE ON THE DISTURBANCE OF ARTICULATIVE AND ORAL KINETIC PRAXIS IN THE PRESENCE OF DENTOFACIAL ANOMALIES by L.I. Voloshina, V.M. Dvornyk, M.G. Skikevych, P.I. Tkachenko, S.O. Bilokon, D.S. Avetikov

“…The aim of the study was to conduct a comparative analysis of data on tongue topography based on ultrasound and clinical assessment at rest. …”
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Does peatland rewetting mitigate flooding from extreme rainfall events? by S. Karimi, V. Mosquera, E. Maher Hasselquist, J. Järveoja, H. Laudon

“…To date, however, empirical data showing that rewetting of drained peatlands actually restores their hydrological function similar to pristine peatlands are largely lacking, particularly for boreal fens. …”
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Contribution of cognitive performance and cognitive decline to associations between socioeconomic factors and dementia: A cohort study. by Jennifer Rusmaully, Aline Dugravot, Jean-Paul Moatti, Michael G Marmot, Alexis Elbaz, Mika Kivimaki, Séverine Sabia, Archana Singh-Manoux

“…<h4>Methods and findings</h4>Data are drawn from the Whitehall II study (N = 10,308 at study recruitment in 1985), with cognitive function assessed at 4 waves (1997, 2002, 2007, and 2012). …”
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Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals. by Suzanne Pickering, Stephane Hué, Eun-Young Kim, Susheel Reddy, Steven M Wolinsky, Stuart J D Neil

“…These data affirm the importance of Vpu functions for in vivo persistence of HIV-1 within infected individuals, not simply for transmission, and highlight its potential as a target for antiviral therapy.…”
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The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma by Xi Zhang, Xi Zhang, Yan Liu, Yan Liu, Bai-Zhao Peng, Xing-hong Zhou, Yan-ting You, Ying Yang, Shuai Ji, Tian-yu Zhong, Xiao-hu Chen, Yan-yan Liu, Xiao-shan Zhao

“…First, we explored prognostic data and predicted the function of TSHZ3 in lung cancer through bioinformatics analysis. …”
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Mapping Small Extracellular Vesicle Secretion Potential in Healthy Human Gingiva Using Spatial Transcriptomics by Blanka Maria Borowiec, Małgorzata Blatkiewicz, Marta Dyszkiewicz-Konwińska, Dorota Bukowska, Bartosz Kempisty, Marcin Ruciński, Michał Nowicki, Joanna Budna-Tukan

“…Our study is the first to perform a meta-analysis of available gingival transcriptomic data in the specific context of sEVs biogenesis. …”
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Predicting survival in bladder cancer with a novel apoptotic gene-related prognostic model by Ding-ming Song, Kun Feng, Wen-fei Luo, Dong-shan Lv, Li-po Zhou, Yi-bo He, Yanyang Jin

“…CIBERSORT and Single-Sample Gene Set Enrichment Analysis (ssGSEA) were used to calculate the type of immune cell infiltration and immune functions. …”
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Remimazolam induced cytotoxicity mediated through multiple stress pathways and acted synergistically with tyrosine kinase inhibitors in hepatocellular carcinoma by Hsiu-Lung Fan, Jia-Lin Chen, Shu-Ting Liu, Jia-Tong Lee, Shih-Ming Huang, Zhi-Fu Wu, Hou-Chuan Lai

“…It is important to understand the mechanisms of cytotoxicity for HCC in detail.Methods: We performed cell viability analysis, western blotting analysis, reverse transcription–polymerase chain reaction analysis, and flow cytometry analysis in two HCC cell lines, HepG2 and Hep3B cells.Results: Our data demonstrated that remimazolam induced cytotoxicity by suppressing cell proliferation, inhibiting G1 phase progression, and affecting mitochondrial reactive oxygen species (ROS) levels, leading to apoptosis, DNA damage, cytosolic ROS elevation, lipid peroxidation, autophagy, mitochondrial depolarization, and endoplasmic reticulum stress. …”
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Integrated transcriptomic and immune profiling reveals crucial molecular pathways and hub genes associated with postoperative delirium in elderly patients by Zi-han Gou, Nan Su, Xiao-chuan Li, Da-peng Ren, Shan-shan Ren, Lin Wang, Yao Wang

“…Analysis of functional enrichment revealed that DEGs were enriched in activities like neuron projection development, axonogenesis, and synapse organization, with KEGG pathway analysis identifying neuroactive ligand-receptor interaction and neurodegeneration pathways. …”
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Analisis Dampak Perubahan Iklim Dan Urban Sprawl Kota Palembang Pada Tata Ruang Perkotaan Di Kawasan Perbatasan Kabupaten Banyuasin by Kgs M Benyamin Azhary

“…Kata kunci: Tata Ruang, Perubahan Iklim, Urban Sprawl ABSTRACT The urban development planning system tends to still assess the climate element as a static element, where so far it has been considered that there is no reciprocal interaction between climate and changes in land use or spatial allocation. Climate data is more often used as supporting data for land suitability statements for the development of the function of an area only, especially for agricultural and fishery areas. …”
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FORECASTING NUMBER OF INTERNATIONAL TOURIST ARRIVALS USING MULTI INPUT INTERVENTION ARIMA MODEL by Hidayatul Khusna, Muhammad Mashuri, Muhammad Ahsan, Wibawati Wibawati, Diaz Fitra Aksioma, Novri Suhermi

“…The type of intervention variable chosen is a step function because both inputs give permanent effect to the international tourist arrivals. …”
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Relationship between serum ECP and TIgE levels and the risk of postoperative recurrence in patients with chronic rhinosinusitis with nasal polyps by Qing Zhang, Hui Li, Di Xie, SiJian Fan

“…The CRSwNP patients were assigned into recurrence and non-recurrence groups based on the absence/presence of disease recurrence after a 2-year follow-up. An analysis was conducted on the correlation between the patients' clinical data and their serum ECP and TIgE levels. …”
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CellFM: a large-scale foundation model pre-trained on transcriptomics of 100 million human cells by Yuansong Zeng, Jiancong Xie, Ningyuan Shangguan, Zhuoyi Wei, Wenbing Li, Yun Su, Shuangyu Yang, Chengyang Zhang, Jinbo Zhang, Nan Fang, Hongyu Zhang, Yutong Lu, Huiying Zhao, Jue Fan, Weijiang Yu, Yuedong Yang

“…Yet, current single cell data analysis suffers from the inherent data noises, batch effects, and sparsity, highlighting the requirement of a unified model to represent cellular states. …”
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Thyroid Hormone Levels in Patients with Head and Neck Cancer Undergoing Radiochemotherapy: A Retrospective Study by Nidhi Rohan Purandare, Meenakshi, Shilpa Jain, Neeti Patel, Sarita A Shinde

“…The present study investigates how RCT impacts thyroid function in patients with HNC. Aim: To determine the effect of RCT on Thyroid Stimulating Hormone, (TSH) triiodothyronine and thyroxine. …”
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Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration by Qiang Liu, Hua Zhang, Heng Xiao, Ao Ren, Ying Cai, Rui Liao, Huarong Yu, Zhongjun Wu, Zuotian Huang

“…Disease Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis enrichment analyses were performed to explore differential gene functions and disease pathways. …”
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Risk factors and outcomes of thyroid immune-related adverse events following PD-1/PD-L1 inhibitors treatment in a large tertiary Chinese center by Wenwen Gong, Erhan Zheng, Minchao Liu, Yaliang Han, Zhaohui Lyu, Qinghua Guo

“…Methods We retrospectively analyzed the clinical data of 1151 patients with malignant solid tumors who received PD-1 or PD-L1 inhibitors treatment and underwent thyroid function evaluation in a large 3 A hospital of Beijing from September 2019 to December 2023. …”
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Generative design recommendations for the historical Mardiṅ High School and Gaziṗaşa Primary School buildings, Turkey by Mizgin Gökçe Salık, Fatma Demet Aykal

“…This study focuses on a key issue in re-functionalizing buildings, where facade elements designed without sustainability concerns become problematic. …”
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Software for developing digital twins of agricultural machinery working bodies by D. A. Mironov, D.  V. Popov, R. K. Rasulov, A. K. Lamm

“…In the agricultural sector, their role is particularly crucial, since digital twins facilitate not only the analysis of soil, climate, yield, and plant data but also the forecast of changes in these parameters. …”
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SAPA 129 as a Government Strategy for Protecting Women from Violence in Aceh Province by Adella Utami, Bintarsih Sekarningrum, R. Nunung Nurwati

“…Employing a qualitative case study approach, data were collected through in-depth interviews, participant observation, and document analysis. …”
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