Impact of intermediate-dose tertiary prophylaxis on quality of life and psychological aspects of adult patients with severe/moderate hemophilia A by Hua Gao, Jia Liu, Shiqiu Zhou, Jing Gao, Jing Tan, Rong Chen

“…This research aims to explore the impact of intermediate-dose tertiary prophylaxis with recombinant human FVIII (rhFVIII) on quality of life, anxiety and depression in such individuals transitioned from on-demand treatment.Methods This retrospective analysis collected data from July 2019 to July 2022. …”
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Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron diseaseResearch in context by Cory J. Holdom, Rakesh Pilkar, Christine C. Guo, Ruben P.A van Eijk, Nadia Sethi, Robert D. Henderson, Shyuan T. Ngo, Frederik J. Steyn

“…Methods: This longitudinal study included 95 patients with MND who wore an ActiGraph GT9X Link device on their non-dominant wrist for 8 days, with follow-up every 3–4 months. Accelerometer data were processed using ActiLife and GGIR. Joint models were used to simultaneously investigate the longitudinal change in ALS Functional Rating Scale-Revised (ALSFRS-R) scores and accelerometer-derived outcomes alongside their relationship with overall survival. …”
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A simple scalable extracellular vesicle isolation method using polyethylenimine polymers for use in cellular delivery by Marie Ange Djeungoue Petga, Catherine Taylor, Alexander Macpherson, Surendar Reddy Dhadi, Thomas Rollin, Jeremy W. Roy, Anirban Ghosh, Stephen M. Lewis, Rodney J. Ouellette

“…Furthermore, once eluted from the polymers, the isolated EVs were able to deliver functional protein cargo to recipient cells. Overall, our data support PEI-based isolation of EVs as a simple, rapid method for the recovery of functional EVs.…”
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A high-precision edge detection technique for magnetic anomaly signals based on a self-attention mechanism by Ju Haihua, Wang Li, Yang Jie, Liu Gaochuan, Xia Zhong, Jiao Jian, Zhang Le, Dai Bo

“…This poses a challenge for high-precision magnetic data boundary detection. Additionally, traditional loss functions fail to guide the network in effectively extracting boundary information, limiting the accuracy of boundary detection. …”
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CARI Guideline: Evidence-Based Recommendations for Balanced Electrolyte Solutions to Improve Kidney Transplant Outcomes by Colm O’Reilly, David Tunnicliffe, Allan Blackley, Michael Collins, Emmy O’Neill, Siah Kim, Karthik Venkataraman, Emily See, Ross Francis

“…This guideline seeks to synthesize the available evidence and make recommendations for the Australian and New Zealand care by a multidisciplinary working group, including consumers with lived experience of kidney transplantation.A recently published systematic review and meta-analysis of randomized controlled trials (RCTs), including data from the BEST Fluids trial, evaluating balanced electrolyte solutions versus normal saline in kidney transplants was identified and absolute effects were determined using baseline risks of SONG Transplant Core outcomes from either national registries or event rates in the control arms of the included trials. …”
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SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer by Jingming Zhuang, Yang Wang, Xinyong Wu, Zijing Peng, Zhengnan Huang, Chao Zhao, Bing Shen

“…The Gene Ontology (GO) and GSEA were employed for biological process enrichment analysis. The biological role of SIGMAR1 in BC was investigated through functional experiments and subcutaneous tumour-bearing experiments in nude mice. …”
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High resolution profiling of cell cycle-dependent protein and phosphorylation abundance changes in non-transformed cells by Camilla Rega, Ifigenia Tsitsa, Theodoros I. Roumeliotis, Izabella Krystkowiak, Maria Portillo, Lu Yu, Julia Vorhauser, Jonathon Pines, Jörg Mansfeld, Jyoti Choudhary, Norman E. Davey

“…Integrated with complementary resources, our data link cycle-dependent abundance dynamics to functional changes and are accessible through the Cell Cycle database (CCdb), an interactive web-based resource for the cell cycle community.…”
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DMYTRО DONTSOV’S TEXTS IN THE ASPECT OF CORPUS LINGUISTICS AND LEXICOGRAPHY by Oksana R. Mykytyuk, Liliia V. Kharchuk

“…Through the use of large-scale empirical data and advanced computer technologies to reach objective insights into language function, linguistic corpora have quickly become invaluable resources. …”
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Designing a Business Model in the Tourism Industry of Iran by Amirhossein Samadian, Saeid Ehdaie, kamyar Raissifar

“…In this research, according to the snowball method, the interviews will continue until the data reaches saturation. The method of data analysis is qualitative content analysis and open coding method is used to extract primary codes and then categories. …”
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Investigating Antecedents to Older Adults’ Uptake of Health Information Systems: A Quantitative Case Study of Electronic Personal Health Records by Reza Torkman, Amir Hossein Ghapanchi, Reza Ghanbarzadeh

“…Findings: the data analysis of the participants’ responses uncovered that seniors’ usage intention toward PHRs is a function of the PHR’s perceived usefulness (<i>p</i> < 0.01, OR = 2.5, 95% CI 1.5–4.1), perceived barriers (<i>p</i> < 0.05, OR = 1.3, 95% CI 0.8–2.1), perceived confidence (<i>p</i> < 0.05, OR = 1.6, 95% CI 1.0–2.5), and cues to action (<i>p</i> < 0.05, OR = 1.8, 95% CI 1.1–2.9). …”
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Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine. by Jacques C Mbongue, Dequina A Nicholas, Kangling Zhang, Nan-Sun Kim, Brittany N Hamilton, Marco Larios, Guangyu Zhang, Kazuo Umezawa, Anthony F Firek, William H R Langridge

“…Heat map analysis of the proteomic data revealed an overall down-regulation of vaccinated DC functions, suggesting vaccine suppression of DC maturation. …”
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Multi-omics joint screening of biomarkers related to M2 macrophages in gastric cancer by Xilong Wang, Ying Zhang

“…The results of gene function enrichment analysis suggested that it may affect the occurrence and development of GC through DNA replication and cell cycle. …”
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Rosaceae phylogenomic studies provide insights into the evolution of new genes by Lan Jiang, Xiaoxu Li, Kun Lyu, Han Wang, Zhiyuan Li, Wang Qi, Lin Zhang, Yunpeng Cao

“…Here, Type-I genes are found to have more relaxed selection pressure and lower Ks values than Type-II, indicating that these newly evolved Type-I genes may play important roles in driving phenotypic evolution. Functional analysis exhibited that newly formed fusion genes can regulate the phenotype traits of plant growth and development, suggesting the functional significance of these genes. …”
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Application of Levi’s Muscle Index in frailty assessment: comparison of bioimpedance measures among older adults by Kworweinski Lafontant, Kworweinski Lafontant, David H. Fukuda, Estefania Zamarripa, Estefania Zamarripa, Abigail L. Tice, Jethro Raphael M. Suarez, Jethro Raphael M. Suarez, Chitra Banarjee, Chitra Banarjee, Dahee Kim, Jeffrey R. Stout, Jeffrey R. Stout, Joon-Hyuk Park, Joon-Hyuk Park, Rui Xie, Rui Xie, Rui Xie, Ladda Thiamwong, Ladda Thiamwong

“…IntroductionFrailty is prevalent among older adults and is characterized by reductions in physical function and muscle quality. Despite the emerging clinical utility of bioelectrical impedance analysis (BIA) and phase angle (PhA) as a bioimpedance index, little is known about how bioimpedance indices such as Levi’s Muscle Index (LMI), reactance/height (Xc/Height), and resistance/height (R/Height), relate to physical function and frailty.MethodsThis cross-sectional study examined 208 community-dwelling older adults (female, n = 183; age = 74.2 ± 6.9 years; BMI = 30.4 ± 6.4 kg/m2) to compare physical function measures and bioimpedance indices across frailty categories determined by the FRAIL questionnaire. …”
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NOX4 serves as a pan-cancer prognostic biomarker and therapeutic target in tumorigenesis by Jiting Sun, Zhiyuan Gong, Lijie Zheng, Zhixian Ding, Lusheng Wang, Yu Tang, Shizhan Deng, Yonggan Dong, Heng Tang

“…In vitro assays, including Wound healing, Transwell, and CCK-8 assays, were conducted to validate the biological functions of NOX4 in breast cancer cells. Pan-cancer analysis revealed that NOX4 is significantly upregulated in various cancers, including breast cancer. …”
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Toxicities Associated with Systemic Administration of Interleukin-6 in Wistar Albino Rats by Nabisubi P, Mugasa CM, Matovu E, Ssekatawa K, Uwituze V, Ssentamu G, Namayanja M, Kato CD

“…On day 22 post-treatment, rats were euthanized, and blood and body organs were collected for analysis. Blood was used to determine liver and renal function, and hematology parameters, while liver and kidney tissue sections were used for histopathological analysis.Results: The results revealed that systemic administration of interleukin-6 for 21 days significantly decreased levels of serum creatinine (p&lt; 0.00) and serum urea (p&lt; 0.01). …”
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PERSUASIVE COMPONENT OF THE METAPHORICAL MODEL “NATURE IS ART” IN ECOLOGICAL DISCOURSE: PRAGMA-COGNITIVE ASPECT by Ksenia A. Pavlova

“…The article focuses on the issue of persuasive functioning of a metaphorical model ‘Nature is Art’ in ecological discourse. …”
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LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue by Linpei Jia, Rufu Jia, Yinping Li, Xiaoxia Li, Qiang Jia, Hongliang Zhang

“…Then, Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were done to explore the biological functions and potential important pathways of DEGs. …”
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Homologs of the rolC gene of naturally transgenic toadflaxes Linaria vulgaris and Linaria creticola are expressed in vitro by T. V. Matveeva, O. D. Bogomaz, L. A. Golovanova, Yu. S. Li, D. Dimitrov

“…Until the last moment, the expression of cT-DNA genes in Linaria has not been documented. However, the analysis of the nucleotide sequence indicates the functionality of rolC gene in L. vulgaris Mill., L. acutiloba Fisch. ex Rchb., L. genistifolia (L.) …”
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Preparing and Analyzing Expressed Sequence Tags (ESTs) Library for the Mammary Tissue of Local Turkish Kivircik Sheep by Nehir Ozdemir Ozgenturk, Zehra Omeroglu Ulu, Salih Ulu, Cemal Un, Kemal Ozdem Oztabak, Kemal Altunatmaz

“…Putative functions of all unique sequences and statistical analysis were determined by Geneious software. …”
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