Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

“…Finally, molecular docking studies suggested that RA could directly interact with GRP78, PERK, and IRE1, but not with MANF.Conclusion: RA plays a protective role in improving cognitive function against endotoxemia-associated encephalopathy in mice via inhibiting the GRP78/PERK/MANF pathway.Keywords: Rosmarinic acid, endotoxin, neuronal damage, GRP78/PERK/MANF pathway…”
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Metabolite differences and molecular mechanism between dehiscent and indehiscent capsule of mature sesame by Yinping Zhang, Ruirui Chen, Yujun Liu, Shuwen Xu, Shuguang Gao, Haiyang Zhang, Hongmei Miao, Lingling Qin, Xiangyu Zhou, Kiran Thakur, Cheng Li, Juan Li, Pengcheng Wei, Zhao-Jun Wei

“…Apart from its function in cell signaling, the latter may contribute to the glycosylation of lignin monomers, while the former may provide ATP for cellular microtubule movement. …”
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Comparison of orthofix external fixator combined with vascularized fibula graft versus single segmental femoral lengthening for treating femoral defects ≥ 6 cm: a retrospective stu... by Yiliyaer Wumaierjiang, Yimurang Hamiti, Ainizier Yalikun, Aihemaitijiang Yusufu

“…Methods The follow - up data of 72 patients with femoral defects, who received treatment from January 2009 to May 2019, were collected for retrospective analysis. …”
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The association of vitamin deficiency with depression risk in late-life depression: a review by Yao Gao, Yao Gao, Xiao-Na Song, Zhong-Ping Wen, Jian-Zhen Hu, Jian-Zhen Hu, Xin-Zhe Du, Xin-Zhe Du, Ji-Hui Zhang, Sha Liu, Sha Liu

“…By integrating mechanistic insights with clinical data, this analysis aims to guide evidence-based vitamin supplementation protocols for LLD within geriatric care frameworks.…”
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RNAi of Neuropeptide CCHamide-1 and Its Receptor Indicates Role in Feeding Behavior in the Pea Aphid, <i>Acyrthosiphon pisum</i> by Sohaib Shahid, Muhammad Bilal Amir, Tian-Bo Ding, Tong-Xian Liu, Guy Smagghe, Yan Shi

“…The docking analysis revealed that the <i>CCHa1</i> peptide binds to its receptor <i>CCHa1R</i> through specific amino acid residues, which are critical for maintaining the structural and functional integrity of the peptide–receptor complex. …”
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Effectiveness of using autologous platelet cryolysate after knee arthroscopy by S.I. Gerasymenko, M.V. Poluliah, A.M. Babko, A.S. Gerasymenko, D.M. Poluliah, R.M. Ostpchuk, D.S. Yarosh, O.M. Lushchii, N.Y. Marchenko

“…A comprehensive, multifactorial analysis assessed clinical indicators, including pain level on the visual analogue scale (VAS), joint functionality on the Lysholm scale, quality of life on the EQ-5D scale, recovery duration, and complication rates across different treatment groups. …”
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JUSTIFICATION OF DIRECTIONS FOR IMPROVING THE ORGANIZATION OF MEDICAL CARE FOR PATIENTS WITH COVID-19 AND METABOLIC DISORDERS by Tetiana S. Gruzieva, Olena Ya. Antonyuk

“…Data analysis was conducted using R (EZR) software. …”
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RET/GFRα signals are dispensable for thymic T cell development in vivo. by Afonso Rocha Martins Almeida, Sílvia Arroz-Madeira, Diogo Fonseca-Pereira, Hélder Ribeiro, Reena Lasrado, Vassilis Pachnis, Henrique Veiga-Fernandes

“…Furthermore, analysis of RET gain of function and Ret conditional knockout mice showed that RET is also unnecessary for adult thymopoiesis. …”
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Effector Pt31812 from Puccinia triticina acts as avirulence factor for Lr42-mediated resistance in wheat by Jianyuan Li, Jianyuan Li, Jiali Li, Jie Wei, Jie Wei, Lin Li, Yue Qi, Yue Qi, Yue Zhang, Yue Zhang, Wenxiang Yang, Qian-Hua Shen

“…Subcellular localization of Pt31812 was analyzed using transient expression on Nicotiana Benthamiana. Further functional analysis was conducted using transient expression and host-induced gene silencing (HIGS). …”
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An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell by Erkang Yi, Haiqing Li, Yu Liu, Qingyang Li, Chengshu Xie, Ruining Sun, Fan Wu, Zhishan Deng, Kunning Zhou, Hairong Wang, Xinru Ran, Yumin Zhou, Pixin Ran

“…Gene expression in specific cell types was analyzed, and Mendelian randomization was used to confirm associations between candidate genes and lung function/COPD. Preliminary in vitro functional validation was performed on prioritized core candidate genes. …”
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A Transcriptomic Signature of Depressive Symptoms in Late Life by Stuart Matan-Lithwick, Melissa C. Misztal, Mu Yang, Thomas DeLong, Shreejoy Tripathy, Jeffrey T. Dunn, David A. Bennett, Philip L. De Jager, Yanling Wang, Daniel W. Fisher, Hongxin Dong, Daniel Felsky

“…Methods: Differential expression analysis was performed on bulk-tissue RNA sequencing data generated from dorsolateral prefrontal cortex samples of elderly participants in ROS/MAP (Religious Orders Study and Memory and Aging Project; N = 998, mean age at death = 89.7 years). …”
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Gut health predictive indices linking gut microbiota dysbiosis with healthy state, mild gut discomfort, and inflammatory bowel disease phenotypes using gut microbiome profiling by Joann Phan, Suneer Jain, Jurgen F. Nijkamp, Rajkumar Sasidharan, Ashish Agarwal, Julia K. Bird, Anneleen Spooren, Jonas Wittwer Schegg, Emiel Ver Loren van Themaat, Tim N. Mak

“…Two systems in use are the metagenomic aerotolerant predominance index (MAPI) and keystone scores. The aim of this analysis was to compare different gut microbiome scores, specifically MAPI and a keystone species score, on two cross-sectional data sets and to investigate correlations of these scores with self-reported gut discomfort and gastrointestinal disease. …”
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Extracellular vesicles from bronchoalveolar lavage fluid provide insights into the inhaled corticosteroids treatment response in COPD by Jiahua Fang, Justina C. Wolters, Karim Rafie, Changshuo Wang, Sabine Bartel, Maarten van den Berge, Machteld N. Hylkema

“…Weighted gene co-expression network analysis was applied to identify EV protein modules associated with lung function (n = 24) at baseline. …”
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Spatio-Temporal Variations of Indonesian Rainfall and Their Links to Indo-Pacific Modes by Melly Ariska, Suhadi, Supari, Muhammad Irfan, Iskhaq Iskandar

“…The analysis of rainfall patterns in the Indonesian region utilized the Empirical Orthogonal Function (EOF) method to identify spatial and temporal variations. …”
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A study of heart–brain information flow across sleep stages using transfer entropy by Shumei Zhu, Jingyi Yu, Yuman Luo, Jun Wang

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ADMET evaluation in drug discovery: 21. Application and industrial validation of machine learning algorithms for Caco-2 permeability prediction by Dong Wang, Jieyu Jin, Guqin Shi, Jingxiao Bao, Zheng Wang, Shimeng Li, Peichen Pan, Dan Li, Yu Kang, Tingjun Hou

“…Our findings, based on the Shanghai Qilu’s in-house dataset, showed that the boosting models retained a degree of predictive efficacy when applied to industry data. Furthermore, Y-randomization test and applicability domain analysis were employed to assess the robustness and generalizability of these models. …”
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Generalized Propensity Score Matching with Multilevel Treatment Options by Onur Baser

“…Results are compared with multivariate regression analysis, where the generalized linear model is used with gamma family and log link function…”
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Inventory woes and logistic bottlenecks: operational challenges in the SCM of the Indian defense sector by Sandeep Sharma, Ravi Chaurasiya, Rohit Mohite, Sandesh Akre

“…This study undertakes a qualitative analysis based solely on secondary data sources to examine key dimensions of defense logistics operations. …”
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A linear tessellation model for the identification of "food desert": A case study of Shanghai, China. by Lu Wang, Yakun He, Zhonghai Yu, Hongrui Wang, Wenjuan Ye, Xin Li, Yingping Liu, Junxiao Zhang

“…Secondly, the "food desert" phenomenon in Shanghai are identified combing with the results of the network K-function. Finally, the resident income conditions in different modes are fitted based on the housing price data and the spatial distribution of four "food desert" patterns are detected by the overlay analysis of food accessibility and resident income conditions. …”
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Knowledge and attitude of dental undergraduates, graduates, and postgraduates on dental implants for children – A cross-sectional study by Ramya Ramanathan, Paul Chalakkal, Ridhima Gaunkar, Vidya Baliga

“…Statistical Analysis: The data obtained was compiled into a Microsoft Excel document and the analysis was done using IBM SPSS for Windows version 24.0 (IBM Corp., Armonk, USA). …”
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