Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy by Alessandro Bruschi, Eric Staals, Andrea Sambri, Luca Cevolani, Marco Gambarotti, Alberto Righi, Michele Fiore, Eleonora Villari, Stefano Pasini, Maria Giulia Pirini, Massimiliano De Paolis, Davide Maria Donati

“…Open anterior synovectomy effectively improves knee function, pain, swelling in patients with anterior knee D-TGCT, although functional recovery may take up to 6–12 months.…”
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Younger severe asthma patients with interleukin 4 (CC variant) and dupilumab treatment are more likely to achieve clinical remission by Mona Al-Ahmad, Asmaa Ali, Wafaa Talat

“…CR was defined as the absence of exacerbations and oral corticosteroids (OCS) use, an Asthma Control Test (ACT) score of ≥ 20, Asthma Control Questionnaire (ACQ-6) score of ≤ 0.75 and forced expiratory volume in one second (FEV1) ≥ 80% predicted. Data were collected on demographics, clinical, and functional parameters; including biomarkers such as blood eosinophils count (BEC), total immunoglobulin E (IgE), and fractional exhaled nitric oxide (FeNO), as well as the polymorphism patterns of the interleukin-4 (IL-4) and tumor necrosis factor-alpha (TNF-α) genes. …”
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Factors Associated With Patient Experience From 2 Tertiary Care Hospitals—A Cross-Sectional Study From Karachi, Pakistan by Aqsa Amjad MBBS, Zaibun Nisa MBBS, FCPS, Sana Javed Khan MBBS, Sania Sabir Sethi BS, Asmara Ghafoor MBBS, Anoosha Iqbal MBBS, Farheen Shahzad MBBS, Mehmood Riaz MBBS, FCPS, Uzma Ghori MBBS, FCPS, Aysha Almas MBBs, FCPS, PhD

“…Healthcare systems are rapidly transitioning toward patient-centered models, however, there is limited data regarding this from low- and medium-income countries. …”
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PI3K/AKT signaling pathway plays an important role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease by Cuiping Shao, Youqing Xu

“…Differentially expressed genes (DEGs) were identified via the limma package in R (|logFC|> 1, adjusted p value < 0.05). Functional enrichment analysis was conducted via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and gene set enrichment analysis (GSEA). …”
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Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis. by Lucia De Franceschi, Giovanni Scardoni, Carlo Tomelleri, Adrian Danek, Ruth H Walker, Hans H Jung, Benedikt Bader, Sara Mazzucco, Maria Teresa Dotti, Angela Siciliano, Antonella Pantaleo, Carlo Laudanna

“…The experimentally determined phosphoproteomic data-sets allowed us to relate the subsequent network analysis to the pathogenetic background. …”
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A network of conserved damage survival pathways revealed by a genomic RNAi screen. by Dashnamoorthy Ravi, Amy M Wiles, Selvaraj Bhavani, Jianhua Ruan, Philip Leder, Alexander J R Bishop

“…A biologically intuitive, highly interconnected MMS survival network was revealed after we incorporated pathway data in our interactome analysis.…”
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Digital brand image management based on feedback loops by N. I. Ivashkova, G. S. Timokhina, I. P. Shirochenskaya

“…Methods: collection, processing, and analysis of secondary data were carried out on the basis of desk research, synthesis methods, contentanalysis, and systemic, structural and functional data evaluation using an interdisciplinary approach.   …”
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Cutting Fluid Effectiveness in the High-Speed Finish Machining of Inconel 718 Using a Whisker-Reinforced Ceramic Tool by Walid Jomaa, Monzer Daoud, Hamid Javadi, Philippe Bocher

“…It addresses this topic by providing a comprehensive understanding of the machinability of Inconel 718 under both dry and wet conditions through analytical friction modeling and a detailed analysis of the chip formation process. Two new indexes, named the Area Function (<i data-eusoft-scrollable-element="1">AF</i>) and the Shape Function (<i data-eusoft-scrollable-element="1">SF</i>), were derived to assess the serration intensity of the chips. …”
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Ardisia japonica (Thunb.) Blume and Lespedeza cuneata G. Don may treat chronic obstructive pulmonary disease by targeting HK2 and PTAFR by Xian Luo, Zheng Hang Ge, Shan Luo, Bo Li, Xun Zhou, Yi Yang, Yong Jiang, Tao Tan, Ke Lin Wang

“…Additionally, functional analysis, immune factor profiling, molecular docking, and reverse transcription-polymerase chain reaction (RT-qPCR) were performed.ResultsHK2 and PTAFR emerged as critical genes for COPD treatment, exhibiting significantly elevated expression in COPD samples. …”
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Real-World Safety and Efficacy of Targeted Therapies in Rheumatoid Arthritis: A 5-Year, 5130-Case Follow-Up from FIRST Registry by Koshiro Sonomoto, Shingo Nakayamada, Hiroaki Tanaka, Atsushi Nagayasu, Yoshiya Tanaka

“…TNFi had high remission rates but low retention, whereas CTLA4-Ig and IL-6Ri had lower remission rates and higher retention. Changes in functional improvement were modest overall, and in patients aged 75 years and older, functional gains remained limited. …”
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Dynamic Monitoring of Goaf Stress Field and Rock Deformation Driven by Optical Diber Sensing Technology by Jing Chai, Zhe Yan, Yibo Ouyang, Dingding Zhang, Jianfeng Yang, Gaoyi Yang, Chenyang Ma

“…Addressing the critical technological needs for the real-time monitoring of stress distribution in mining areas, a new method for inverting goaf pressure using distributed optical fiber monitoring data is proposed. By coupling the key stratum fracture mechanics model with the subsidence trajectory function model, a theoretical model is established to accurately describe spatial stress evolution during coal mining. …”
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Prediction of Time Diversity Gain for Earth-to-Satellite Microwave Link Design Based on Real Time Rain Intensity Measurement by Md. Moktarul Alam, Md. Rafiqul Islam, Mohsen Koohestani, Elfatih A. A. Elsheikh

“…However, time diversity analysis demands measured rain attenuation data, where the latter is unavailable at most of the places to be able to design future high frequency links. …”
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Ethnomathematics: Modelling the volume of solid of revolution at Buginese and Makassarese traditional foods by Zulfiqar Busrah, Hikmawati Pathuddin

“…Data Analysis Techniques consist of the domain analysis to obtain an overview of Buginese and Makassarese traditional foods and the taxonomic analysis to categorize mathematical concepts obtained from the modeling and simulation. …”
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DNA methylation patterns associated with prior tuberculosis infection in people with HIV by Joseph Baruch Baluku, Sharon Namiiro, Daphine Kigongo Zawedde, Brenda Namanda, Hakiimu Kawalya, Irene Najjingo, Waiswa Geoffrey, Nixon Niyonzima, Naghib Bogere, Edwin Nuwagira, Joshua Rhein, Nick Jones, Christian Kraef, Megan Shaughnessy, Arohi Chauhan, Immaculate Nankya, Sayoki Mfinanga, Stanton Gerson, Bruce Kirenga

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Chinese Massage (Tuina) Attenuates Knee Osteoarthritis by Modulating Autophagy-Related Cytokines: A Multidisciplinary Methodological Investigation by Wang Z, Zhao C, Li M, Zhang L, Diao J, Wu Y, Yang T, Shi M, Lei Y, Wang Y, Li M, Bian Y, Zhou Y, Xu H

“…Zhen Wang,1,&amp;ast; Chi Zhao,1,2,&amp;ast; Mengmeng Li,1,2,&amp;ast; Lili Zhang,1,&amp;ast; Jieyao Diao,1 Yiming Wu,2 Tao Yang,2 Mingwei Shi,2 Yang Lei,2 Yu Wang,3 Miaoxiu Li,4 Yanqin Bian,5 Yunfeng Zhou,1 Hui Xu1,2 1College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Acupuncture and Massage Department, The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3College of Computer Science, Xidian University, Xian, People’s Republic of China; 4College of Acupuncture and Massage, Shanghai University of Chinese Medicine, Shanghai, People’s Republic of China; 5Orthopaedic Research Laboratory, University of California, Davis, CA, USA&amp;ast;These authors contributed equally to this workCorrespondence: Hui Xu, Email 15036065036@163.comBackground: Tuina therapy has demonstrated its potential in modulating autophagy-related factors in knee osteoarthritis (KOA); however, its core therapeutic targets and specific mechanisms require systematic elucidation through interdisciplinary research.Objective: This study investigated the mechanism by which Tuina alleviates KOA progression using multidimensional approaches, including Mendelian randomization (MR), in vivo experiments, and machine learning.Methods: Genetic data from genome-wide association studies of 60 cytokines and KOA were analyzed using MR analysis to identify autophagy-related factors significantly associated with KOA. …”
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Common bean pan-genome reveals abundant variation patterns and relationships of stress response genes and pathways by Xu Wang, Ming Yan, Shanshan Cui, Fang Li, Qingqing Zhao, Qingnan Wang, Bin Jiang, Yixin Huang, Yang Sun, Xiangdong Kong

“…Pan-genome construction is an effective way to overcome this problem. Resequencing data from 683 common bean landraces and breeding lines provided a pan-genome construction data resource. …”
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The mechanism of settling tax on goods and services in the relationship between the investor – main contractor (buyer of construction services) and another contractor in the light... by Mateusz Niemiec

“…The study is devoted to the examination of the function of the so called reverse charge mechanism in the field of construction works. …”
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In vivo SPECT reporter gene imaging of regulatory T cells. by Ehsan Sharif-Paghaleh, Kavitha Sunassee, Richard Tavaré, Kulachelvy Ratnasothy, Alexander Koers, Niwa Ali, Rowa Alhabbab, Philip J Blower, Robert I Lechler, Lesley A Smyth, Gregory E Mullen, Giovanna Lombardi

“…After 24 hours NIS expressing Tregs were observed in the spleen and their localisation was further confirmed by organ biodistribution studies and flow cytometry analysis. The data presented here suggests that SPECT/CT imaging can be utilised in preclinical imaging studies of adoptively transferred Tregs without affecting Treg function and viability thereby allowing longitudinal studies within disease models.…”
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Right ventricular dysfunction assessed by cardiovascular magnetic resonance is associated with poor outcome in patients undergoing transcatheter mitral valve repair. by Maximilian Spieker, Jonathan Marpert, Shazia Afzal, Athanasios Karathanos, Daniel Scheiber, Florian Bönner, Patrick Horn, Malte Kelm, Ralf Westenfeld

“…<h4>Background</h4>In patients undergoing TMVR, only limited data exist regarding the role of RV function. Previous studies assessed the impact of pre-procedural RV dysfunction stating that RV failure may be associated with increased cardiovascular mortality after the procedure.…”
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Model-Free Adaptive Fast Integral Terminal Sliding Mode Control for Permanent Magnet Synchronous Motor with Position Error Constraint by Xingyu Qu, Shuang Zhang, Chengkun Peng

“…Meanwhile, an improved prescribed performance function and error transformation function are designed, and a fast integral terminal sliding surface is constructed along with a discrete approach law that adaptively adjusts the switching gain. …”
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