Differential relationships among homocysteine levels, cognitive deficits, and low-frequency fluctuation in brain activity in bipolar disorder with suicidal ideation by Yuanyuan Huang, Sumiao Zhou, Shixuan Feng, Hehua Li, Ziyun Zhang, Chenyu Liu, Junhao Li, Wei Han, Kai Wu, Xingbing Huang, Fengchun Wu

“…We then calculated the amplitude of low-frequency fluctuation (ALFF) from resting-state functional magnetic resonance imaging data. Mediated-effects analysis was conducted to explore the association among these three variables. …”
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Evolution of the umbilical cord blood proteome across gestational development by Leena B. Mithal, Nicola Lancki, Ted Ling-Hu, Young Ah Goo, Sebastian Otero, Nathaniel J. Rhodes, Byoung-Kyu Cho, William A. Grobman, Judd F. Hultquist, Denise Scholtens, Karen K. Mestan, Patrick C. Seed

“…In this study, we comprehensively characterized the cord blood proteome of infants born between 25 to 42 weeks using untargeted mass spectrometry and functional enrichment analysis. We determined that the cord blood proteome at birth varies significantly across gestational development. …”
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PTPRO represses breast cancer lung metastasis by inhibiting the JAK2-YAP axis by Xiao Xiong, Jingfang Liu, Xiaotong Wu, Zhimeng Yao, Yuhua Meng, Shuang Liu, Yexi Chen, Hongzheng Ren, Shegan Gao, Xiaofu Qiu, Hao Zhang

“…Analysis of catalytic-dead PTPRO mutant breast cancer cells confirmed that functional PTPRO is a determinant of the activation of the JAK2–YAP pathway and the suppression of breast cancer metastasis. …”
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Imaging Bone–Cartilage Interactions in Osteoarthritis Using [F]-NaF PET-MRI by Dragana Savic MSc, Valentina Pedoia PhD, Youngho Seo PhD, Jaewon Yang PhD, Matt Bucknor MD, Benjamin L. Franc MD, Sharmila Majumdar PhD

“…Regions of interest were identified, and kinetic analysis of dynamic PET data provided the rate of uptake ( K i ) and the normalized uptake (standardized uptake value) of [ 18 F]-NaF in the bone. …”
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Mechanistic insights into promotion of non-small cell lung cancer by BAG5 using integrative multi-omics approaches by Jing-Shan Huang, Jing-Shan Huang, Jing-Shan Huang, Jia-Mei Wang, Ye Yuan, Ting Zhang, Bai-Qiang Li, Fu-Ying Zhao, Liang Hao, Zhan-Wu Yu, Hua-Qin Wang

“…IntroductionWith the continuous emergence of new technologies in omics, the integrative analysis of multi-omics data has become a new direction to explore life mechanisms. …”
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A Case Control Study Examining the Patterns and Predictors of Referral to Cancer Rehabilitation at Canada's Largest Comprehensive Cancer Centre by Jennifer M. Jones, Rogih Andrawes, Michelle A. Weller, Adrienne Lam, Gilla K. Shapiro, Madeline Li, Danielle Rodin, Lisa Avery

“…A retrospective secondary analysis of data extracted from the Princess Margaret (PM) Cancer Registry, electronic patient records, and patient‐reported outcome data (PROMs) (including ESAS‐r and ECOG status) was performed. …”
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Single cell spatial transcriptomics links Wnt signaling disruption to extracellular matrix development in a cleft palate model by Jeremie Oliver Piña, Resmi Raju, Evan Stipano, Aye Chan Myo, Ziyi Wang, Mitsuaki Ono, Parna Chattaraj, Masae Furukawa, Rena N. D’Souza

“…Functional enrichment analysis revealed a palate cell-specific perturbation in Wnt signaling effector function in tandem with disrupted expression of extracellular matrix genes in developing mesenchyme. …”
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Effect of an Online Mobility Self-Management Program on Walking Speed in Older Adults With Preclinical Mobility Limitation: Protocol for a Randomized Controlled Trial by Julie Richardson, Ayse Kuspinar, Susanne Sinclair, Marla Beauchamp, Sinead Dufour, Ada Tang, Joy MacDermid, Evelyne Durocher, Lehana Thabane, Feng Xie, Andrew Costa

“…Data analysis will begin in November 2025 and results will be published in the Summer of 2026. …”
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The efficacy and tolerability of leflunomide (Arava®) in therapy for psoriatic arthritis by Vladimir Vasilyevich Badokin

“…When performing the therapy, account must be taken of the presence and magnitude of the major manifestations of this disease: the pattern of arthritis and spondylosis, the number of inflamed entheses, the number of swollen fingers or toes, the pattern of psoriasis in terms of its extent and stage, the presence and magnitude of systemic manifestations and the functional state of involved organs. There are data on the biological activity of leflunomide, its effect on the main manifestations of PsA with an analysis of its efficacy and tolerability, as well as the results of a comparative investigation of disease-modifying anti-rheumatic drugs used for the therapy of this disease.…”
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Limb apraxia in multiple sclerosis by Rapaić Dragan, Medenica Veselin, Kozomora Ružica, Ivanović Lidija

“…For research purposes, we used the following instruments: Questionnaire for Collecting Demographic Data, Kurtzke Functional Systems Scores, Waterloo-Sunnybrook Apraxia Battery (WatAB). …”
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Two casting methods compared in patients with Colles' fracture: A pragmatic, randomized controlled trial. by Lauri Raittio, Antti P Launonen, Teemu Hevonkorpi, Toni Luokkala, Juha Kukkonen, Aleksi Reito, Minna K Laitinen, Ville M Mattila

“…Of these, 88% were female and the mean age was 73.5 (range 65-94) years. In the primary analysis, the mean difference in patient-rated wrist evaluation measure between groups was -4.9 (95% CI: -13.1.- 3.4., p = .24) in favor of the functional cast position. …”
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Self-rated health and its association with the individual’s activities of daily living: A cross-sectional study among elderly residing in an urban settlement by Sahoo Priyaranjan, Mohapatra Ipsa, C Acharya Geeta

“…A semi-structured questionnaire having sections on socio-demographic factors, self-rated health and validated Activities of daily living (ADL) and Instrumental Activities of Daily Living (IADL) instruments were used to collect data. Statistical Analysis Used: Continuous variables were presented as mean ± SD; categorical variables as frequency and percentage., Chi-square test as a test of association. …”
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The role of the cast index in predicting clinical outcomes in elderly patients with distal radius fractures by Cumhur Deni̇z Davulcu, Muhammed Yusuf Afacan

“…This study investigates the relationship between the cast index and clinical, radiographic, and functional outcomes in patients aged 65 and older with distal radius fractures treated with closed reduction and casting. …”
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Time-dependent consolidation mechanisms of durable memory in spaced learning by Yifeixue Yang, Ziyi Huang, Yun Yang, Mingxia Fan, Dazhi Yin

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The evaluation of surgical treatment outcomes of low and high-energy pelvic fractures using ilio-iliac plate fixation by Wojciech Iluk, Daniel Kotrych

“…The preoperative and postoperative blood hemoglobin levels and the changes in these values were evaluated. The data was processed, and a statistical analysis was performed. …”
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Beneficial Effects of the Novel Digital Incentive Spirometer Device and Incentive Spirometer in Patients Undergoing Open-Heart Surgery: Randomized Controlled Trial by Kornanong Yuenyongchaiwat, Somrudee Harnmanop, Lucksanaporn Mahawong, Nattapoomin Ruangphet, Kannika Jeangubon, Chaopraya Nenmanee, Chitima Kulchanarat, Opas Satdhabudha

“…We developed a digital incentive spirometer (DIS) that displays the relevant data. ObjectiveIn this study, we aimed to explore the beneficial effects of a DIS on respiratory function in patients who underwent OHS. …”
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An Accurate FFPA-PSR Estimator Algorithm and Tool for Software Effort Estimation by Senthil Kumar Murugesan, Chidhambara Rajan Balasubramanian

“…Secondly, the function point analysis is extended by the security and reliability factors in the calculation. …”
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Gamma-glutamyl transpeptidase is a promising biological marker of heart failure by A. M. Alieva, I. E.  Baykova, K.  V. Voronkova, N. V. Teplova, L.  M.  Shnakhova, R.  K.  Valiev, D. A. Elmurzaeva, A. M. Rakhaev, M. R.  Kalova, I.  G. Nikitin

“…The localization of this enzyme in tissues with a transport function has led to the assumption that it is involved in the transport of amino acids through the γ-glutamyl cycle.Conclusion. …”
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The Klebsiella pneumoniae tellurium resistance gene terC contributes to both tellurite and zinc resistance by Ruixiang Yang, Shuang Han, Yanshuang Yu, Hongru Li, John D. Helmann, Katharina Schaufler, Michael D. L. Johnson, Qiu E. Yang, Christopher Rensing

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A novel mechanism of sperm midpiece epididymal maturation and the role of CCDC112 in sperm midpiece formation and establishing an optimal flagella waveform by Maddison L. Graffeo, Joseph Nguyen, Farin Yazdan Parast, Jessica E. M. Dunleavy, Denis Korneev, Hongyi Yang, Hidenobu Okuda, Anne E. O’Connor, Donald F. Conrad, Reza Nosrati, Brendan J. Houston, Moira K. O’Bryan

“…Abstract Background The mitochondrial sheath is a defining feature of mammalian sperm with proposed functions in structural support and energy production for flagella movement. …”
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