Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. by Erin N Smith, Daniel L Koller, Corrie Panganiban, Szabolcs Szelinger, Peng Zhang, Judith A Badner, Thomas B Barrett, Wade H Berrettini, Cinnamon S Bloss, William Byerley, William Coryell, Howard J Edenberg, Tatiana Foroud, Elliot S Gershon, Tiffany A Greenwood, Yiran Guo, Maria Hipolito, Brendan J Keating, William B Lawson, Chunyu Liu, Pamela B Mahon, Melvin G McInnis, Francis J McMahon, Rebecca McKinney, Sarah S Murray, Caroline M Nievergelt, John I Nurnberger, Evaristus A Nwulia, James B Potash, John Rice, Thomas G Schulze, William A Scheftner, Paul D Shilling, Peter P Zandi, Sebastian Zöllner, David W Craig, Nicholas J Schork, John R Kelsoe

“…To demonstrate that this result is not likely to be a false positive, we analyze replication rates in a large meta-analysis of height and show that, in a large enough study, associations replicate as a function of power, approaching a linear relationship. …”
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Population differences in transcript-regulator expression quantitative trait loci. by Pierre R Bushel, Ray McGovern, Liwen Liu, Oliver Hofmann, Ahsan Huda, Jun Lu, Winston Hide, Xihong Lin

“…The structure of the biological process subtree and a gene interaction network of the TReQTL revealed that tumor necrosis factor, NF-kappaB and variants in G-protein coupled receptors signaling may play a central role as communicators in Foxp3 functional regulation. The potential pleiotropic effect of the Foxp3 TReQTLs was gleaned from integrating mRNA-Seq data and SNP-set enrichment into the analysis.…”
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Combined Transplantation of Mesenchymal Progenitor and Neural Stem Cells to Repair Cervical Spinal Cord Injury by Seok Voon White, Yee Hang Ethan Ma, Christine D. Plant, Alan R. Harvey, Giles W. Plant

“…In combination, these transplants will provide better anatomical and functional outcomes. The intravenous MSCs would provide cell protection and reduce inflammation. …”
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Unlocking the Shopper’s Mind: How Emerging Technologies Like Artificial Intelligence Is Shaping the Future of Retail by Florina-Gabriela MITU, Marius BOTA, Emil Emanuel SAVAN

“…This paper will attempt to contribute, by exploratory research and secondary data analysis, to a better understanding of how these new trends adapts to the digitization of retail due to technological development and ethical concerns raised by its increased use. …”
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Single-cell sequencing reveals dysregulated cell type perturbations and critical mediator communication remodelling in colorectal cancer by Chengyuan Xu, Chengyuan Xu, Siqi Zhang, Zhouyu Zhang, Luoqiu Zhang, Bin Sun, Zicheng Yu, Hailong Liu

“…Understanding the cellular composition and dynamic changes is essential for uncovering mechanisms of tumour progression.MethodsTo investigate the cellular heterogeneity and immune microenvironment of CRC, identifying critical subpopulations, functional pathways, and prognostic biomarkers, single-cell transcriptomic data from 41 CRC samples across four datasets were integrated. …”
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RNAi screening of uncharacterized genes identifies promising druggable targets in Schistosoma japonicum. by Yuxiang Xie, Xiaoling Wang, Shaoyun Cheng, Wanling Liu, Cun Yi, Yanmin You, Wei Zhang, Yuepeng Wang, Enlu Tang, Jipeng Wang, Wei Hu

“…For Sjc_0002003, we further characterize the underlying molecular cause of the observed phenotype. Through RNA-seq analysis and functional studies, we revealed that silencing Sjc_0002003 reduces the expression of a series of intestinal genes, including Sjc_0007312 (hypothetical protein), Sjc_0008276 (vha-17), Sjc_0002942 (PLA2G15), and Sjc_0003646 (SJCHGC09134 protein), leading to gut dilation. …”
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c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress. by Rebecca M Corrigan, James C Abbott, Heike Burhenne, Volkhard Kaever, Angelika Gründling

“…Taken together, these data suggest a function for this novel secondary messenger in controlling cell size of S. aureus and in helping bacteria to cope with extreme membrane and cell wall stress.…”
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EFNB1 drives glioma progression and shapes the immune microenvironment: a potential prognostic biomarker by Yungui Zheng, Jiasong Shi

“…A retrospective RNA-seq analysis was conducted by utilizing the data from glioma patients in the TCGA and CGGA databases. …”
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Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. by Charles R Farber, Brian J Bennett, Luz Orozco, Wei Zou, Ana Lira, Emrah Kostem, Hyun Min Kang, Nicholas Furlotte, Ani Berberyan, Anatole Ghazalpour, Jaijam Suwanwela, Thomas A Drake, Eleazar Eskin, Q Tian Wang, Steven L Teitelbaum, Aldons J Lusis

“…In the current study, genome-wide association (GWA) and co-expression network analysis were used in the recently described Hybrid Mouse Diversity Panel (HMDP) to identify and functionally characterize novel BMD genes. …”
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Effect of hypoalbuminemia on mortality in cirrhotic patients with spontaneous bacterial peritonitis by Tsung-Hsing Hung, Ping-Hung Ko, Chih-Ying Wang, Chih-Chun Tsai, Hsing-Feng Lee

“…Objectives: The impact of hypoalbuminemia on the short-term and long-term mortality of cirrhotic patients with spontaneous bacterial peritonitis (SBP), both with and without renal function impairment, remains insufficiently elucidated based on population-based data. …”
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Optimization of Management Mode of Small- and Medium-Sized Enterprises Based on Decision Tree Model by Yuzhu Diao, Qing Zhang

“…The C4.5 algorithm is one of the decision tree algorithms, which has the advantages of easy to understand and high accuracy, and the concept of information gain rate is added compared with its predecessor ID3 algorithm. After theoretical analysis, C4.5 algorithm is chosen to analyze the performance appraisal results, and the decision tree for performance appraisal is generated by collecting data, data preprocessing, calculating information gain rate, determining splitting attributes, and postpruning. …”
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STRUKTUR FRASA NOMINAL ATRIBUTIF DALAM BAHASA SASAK by Dian Mahendra, Daru Winarti

“…The results of data analysis show that the structure of attributive nominal phrases in Sasak is divided into six types. …”
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New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease by Ting Fang, Qiaoyan Liu, Xinxin Huangfu, Hongkai Zhu, Hongwen Sun, Liming Chen

“…Additionally, the study explored the targets of action for TPHP and DPHP using network toxicity analysis, conducted protein interaction analysis, and explored the functional aspects of action through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. …”
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Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…Subsequently, the function enrichment analysis and protein–protein interaction of the DEGs were conducted. …”
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Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…Riparian land use types (built area, wetland, trees, crop, water, bare ground, and rangeland) within four buffer zones (0.5 km, 1 km, 2 km, 5 km) were extracted from ESRI’s global 10-m resolution land cover data. Statistical analyses included: Analysis of Variance (ANOVA) and Permutational Multivariate Analysis of Variance (PERMANOVA) to test interannual differences; Non-metric Multidimensional Scaling (NMDS) to visualize community structure; Pearson correlation analysis to examine relationships among diversity indices; and Multiple Linear Regression (MLR) models to quantify the driving effects of riparian land use on fish diversity. …”
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Development of a bioinformatics tool for identifying members of the Apis mellifera gut microbiome by R. Makovei, N. Shemedyuk, Kh. Malysheva, I. Dvylyuk, M. Chokhan

“…Available free software typically has significant functional limitations, preventing comprehensive analysis. …”
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Development of a specialized product “Baikal Energy”: Protein-carbohydrate by Kotova Tatyana, Khanturgaev Andrey, Khanturgaeva Natalia, Tsytsykov Vladimir

“…The technology was tested at NPF BaikalBiotechnology LLC production facilities in Ulan-Ude and introduced into production. The data obtained can be used to create other specialized functional food products that help improve health and detoxify the body.…”
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Unveiling the cultural tapestry: exploring gender dynamics in embracing digital technology brands among the Y Generation in Saudi Arabia: a social structure theory and luxury value... by Aliyu Alhaji Abubakar

“…The study tested twelve hypotheses to assess the impact of financial, functional, individual, and social dimensions on digital technology brand adoption. …”
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The versatility of botox use in strabismology by G. V. Gladysheva, I. L. Plisov, N. G. Antsiferova, V. B. Pushchina, D. R. Mamulat

“…The generalized modern data on the functional features of the onset of various pathologies in strabismology help assess the potentials of optimizing strabismus treatment with type A botulinum toxin. …”
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Drilling dynamics measurement of drilling motors and its application in recognition of motor operation states through machine learning by Fei Li, Haolan Song, Yifan Wang

“…The solutions were validated by deploying the recorder in drilling field runs and analyzing recorded data using the associated design software, yielding a functional data collection, automatic data statistical analysis, and operation state recognition accuracy of 95%. …”
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