Cigarette Smoke Exposure Inhibits Bacterial Killing via TFEB-Mediated Autophagy Impairment and Resulting Phagocytosis Defect by Garrett Pehote, Manish Bodas, Kathryn Brucia, Neeraj Vij

“…Briefly, RAW cells were treated with cigarette smoke extract (CSE), chloroquine (autophagy inhibitor), TFEB-shRNA, CFTR(inh)-172, and/or fisetin prior to bacterial infection for functional analysis. Results. Bacterial clearance of PA01-GFP was significantly impaired while its survival was promoted by CSE (p<0.01), autophagy inhibition (p<0.05; p<0.01), TFEB knockdown (p<0.01; p<0.001), and inhibition of CFTR function (p<0.001; p<0.01) in comparison to the control group(s) that was significantly recovered by autophagy-inducing antioxidant drug, fisetin, treatment (p<0.05; p<0.01; and p<0.001). …”
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Vision of multidisciplinary team on the role of physiotherapy in a public home care program by Bibiana Melher Pereira, Cristiane Fernanda Gessinger

“…The population served is predominantly old people and have chronic diseases, and are cared mostly by family caregivers, most of them old. After analysis, the objectives found for home physical therapy were: functionality, improved posture, vestibular rehabilitation, respiratory focus, prevention, guidelines and adhesion to family care. …”
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LC–MS/MS-guided discovery of japonamides C and D, two new cyclohexadepsipeptides, from the Nicotiana tabacum-derived endophytic fungus Aspergillus japonicus TE-739D by Haisu Wang, Xianwei Hao, Chen Dong, Xiaolong Yuan, Peng Zhang, Gan Gu

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Artificial intelligence for the understanding of electrolyte chemistry and electrode interface in lithium battery by Chen Yawei, Liu Yue, He Zixu, Xu Liang, Yu Peiping, Sun Qintao, Li Wanxia, Jie Yulin, Cao Ruiguo, Cheng Tao, Jiao Shuhong

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Evaluate the Probability of Failure in Rainfall-Induced Landslides Using a Fuzzy Point Estimate Method by Ya-Sin Yang, Hsin-Fu Yeh

“…Nonetheless, when the observation data are not sufficient for determining the probability distribution function, the fuzzy theory can be an alternative method for the analysis. …”
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Semi-Automated Dataset Generation for Residential Buildings Using Graph-Based Topological Modelling by Angelo Massafra, Dania H. Al-Harasis, Lorenzo Stefanini, Wassim Jabi

“…The method was tested on 98 buildings in Bologna, Italy, yielding an 89.8% success rate and demonstrating its effectiveness in data-limited contexts. The resulting dataset facilitates the analysis of floor spatial configurations and the extraction of geometric attributes, laying the foundation for future analyses that will integrate machine learning techniques for functional detection and typological clustering.…”
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Automatic Grading for Complex Multifile Programs by Tiantian Wang, Djoko Budi Santoso, Kechao Wang, Xiaohong Su

“…Next, standardization process is performed for problematic code removal, unused function removal, and function sequence ordering based on function call. …”
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The Relationship Between Grip Strength and Cognitive Impairment: Evidence From NHANES 2011–2014 by Wenyi Nie, Jingqing Hu

“…In the three cognitive function scoring tests, interaction was only observed in the racial subgroup. …”
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Early warning and stratification of the elderly cardiopulmonary dysfunction-related diseases: multicentre prospective study protocol by Ping Wang, Min Zhou, Li Fan, Yi Xia, Ziwei Zhang, Zhiping Guo, Zaiyi Liu, Yang Hou, Xiuxiu Zhou, Qianxi Jin, Yu Guan, Chuanchang Li, Yongping Bai, Wei-Hua Liao, Hongyu Lin, Shiyuan Liu

“…By leveraging artificial intelligence technology, multimodal data will be integrated to establish reference ranges for cardiopulmonary function in the elderly population, as well as to develop early-warning models and severity grading standard models.Ethics and dissemination The study has been approved by the local ethics committee of Shanghai Changzheng Hospital (approval number: 2022SL069A). …”
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EBV-miR-BART5-5p regulates RORA to promote proliferation and migration of gastric cancer cells. by Changqi Du, Shuang Liang, Xia Wang, Yujiao Qi, Shangdong Li, Hongling Li

“…This study aims to explore the function and underlying mechanisms of EBV-miR-BART5-5p in gastric cancer, providing a basis for the identification of more effective biomarkers for EBVaGC.…”
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A novel bivariate regression model derived from the clayton copula and the Odd Dagum-G family and its application by Julius Kwaku Adu-Ntim, Akoto Yaw Omari-Sasu, Maxwell Akwasi Boateng, Isaac Adjei Mensah

“…These results highlight its flexibility and potential to improve statistical analysis, especially for complex dependencies in real-world data.…”
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Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients. by Jennifer C Miller, Jennifer Shepherd, Derek Rinderknecht, Andrew L Cheng, Niema M Pahlevan

“…This study 1) studies whether the Vivio can capture carotid arterial pulse waveform data in children ages 0-19 years old; 2) tests the performance of two sensor head geometries, one larger and smaller than the standard size used in adults, designed for the pediatric population; 3) compares the IFs between pediatric age groups and adults with normal function. …”
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Rehabilitation impact indices and their independent predictors: a systematic review by Amardeep Thind, Gerald Choon-Huat Koh, Robert Petrella, Cynthia Huijun Chen

“…Then, various names of the same formula were used to identify studies, limited to articles in English and up to 31 December 2011, including case–control and cohort studies, and controlled interventional trials where RIIs were outcome variable and matching or multivariate analysis was performed.Results The five RIIs identified were (1) absolute functional gain (AFG)/absolute efficacy/total gain, (2) rehabilitation effectiveness (REs)/Montebello Rehabilitation Factor Score (MRFS)/relative functional gain (RFG), (3) rehabilitation efficiency (REy)/length of stay-efficiency (LOS-EFF)/efficiency, (4) relative functional efficiency (RFE)/MRFS efficiency and (5) revised MRFS (MRFS-R). …”
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The Relationship between Optimism and Mindfulness with Cognitive Performance in Older Adults by Sanaz Ghannadi, Morteza Tarkhan

“…The research instruments included the Revised Life Orientation Test (LOT-R) for optimism, the Five Facet Mindfulness Questionnaire (FFMQ) for mindfulness, and the Cognitive Performance Evaluation Questionnaire (CPEQ) for cognitive function. Data were analyzed using Pearson's correlation coefficient and multiple regression analysis (simultaneous method) at a significance level of 0.05.Results: The results showed a significant positive relationship between optimism and mindfulness with cognitive function, meaning that the more optimistic and mindful older adults were, the better their cognitive function. …”
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Diagnostic Value of SMARCE1 and CRISP3 Combined with Tumor Markers in Cervical Cancer by Lijie He, Jing Wang, Heping Zhang

“…The female sexual function index (FSFI) and the functional assessment of cancer therapy-general (FACT-G) score were used to evaluate female sexual function and quality of life. …”
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Proximal lateral entry technique for the treatment of supracondylar humeral fractures in children and intraoperative nerve protection: a novel technique by Bufeng Zheng, Wenyu Feng, Lei Geng, Kun Jiang

“…Methods This retrospective analysis involved data from pediatric patients with supracondylar humeral fractures who were admitted to the Department of Pediatric Surgery at Binzhou Medical University Hospital between September 2017 and November 2023. …”
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Quantitative micro-CT-derived biomarkers elucidate age-related lung fibrosis in elder mice by Davide Buseghin, Andrea Grandi, Erica Ferrini, Gino Villetti, Roberta Ciccimarra, Nicola Sverzellati, Andrea Aliverti, Francesca Pennati, Franco Fabio Stellari

“…After fibrosis induction, animals received Nintedanib once-daily for two weeks and longitudinally monitored by micro-CT, which provided structural and functional biomarkers, followed by post-mortem histological analysis as terminal endpoint. …”
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Effects of Three Sessions of Diaphragmatic Myofascial Release on Pain, Balance, and Quality of Life in Patients with Chronic Nonspecific Low Back Pain (A Regional Interdependence M... by soheil hejazi yekta, kazem malmir, Sara Fereydounnia, Khadijeh Otadi, Fatemeh Ehteshami

“…Results: Repeated measures ANOVA will be used for data analysis after collection. Conclusion: This trial will examine the effects of diaphragm myofascial release compared with sham diaphragm myofascial release on pain, balance, chest expansion, lumbopelvic mobility, and disability in individuals with chronic nonspecific LBP. …”
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TET dioxygenases localize at splicing speckles and promote RNA splicing by Florian D. Hastert, Jasmin Weber, Christina Bauer, Andreas Zhadan, Deepanshu N. D. Singh, Thomas C. Dix, Roland Arnold, Sergey Bessonov, Matthias Soller, Heinrich Leonhardt, M. Cristina Cardoso, Maria Arroyo

“…This study explores the relationship between RNA splicing and the TET dioxygenase activity, shedding light on the role of hm5C (RNA 5-hydroxymethylcytosine), and TET proteins in RNA metabolism. Integrating data from mass spectrometry, AlphaFold structural modeling, microscopic analysis, and different functional assays, including in vitro splicing, TET proteins were found to regulate splicing. …”
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The significance of kinesiotaping in the rehabilitation of patients after orthognathic surgery by R. I. Slabkovsky, N. S. Drobysheva, A. B. Slabkovskay

“…Orthognathic surgery aims to restore the anatomical shape, spatial position of the mandible, and normalize its functions, thereby improving facial aesthetics and patients’ quality of life. …”
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