Matrix metalloproteinases as diagnostic and prognostic biomarkers in skin cutaneous melanoma and squamous cell carcinoma by Jingya Hei, Xiaohui Bai, Jing Wang

“…Matrix metalloproteinases MMP7, MMP11, and MMP14 were significantly upregulated in SCC and showed elevated expression in primary SKCM tumors, confirmed by RT-qPCR analysis. Functional enrichment revealed dysregulation of ECM–receptor interaction and IL-17 signaling pathways. …”
Get full text

TEOREMA FUNGSI INVERS DAN APLIKASINYA DALAM ESTIMASI VOLATILITAS MODEL STOKASTIK by NILMA SARI, FAIHATUZ ZUHAIROH

“…The Inverse Function Theorem plays a fundamental role in various areas of applied mathematics, particularly in stochastic analysis and financial modeling. …”
Get full text

Tertiary cancer center results of sterilized auto-graft prosthetic osteo-articular complex reconstruction following bone tumor resection by Himanshu Rohela, Anupam Lahiri, Irfan Ahmed, Kundan Singh Chufal, Kripa Mishra, Rajan Arora

“…Background: Bone tumor resections necessitate complex reconstruction methods to maintain limb function and structural integrity. Various approaches, including tumor prostheses and biological reconstructions, offer distinct advantages and disadvantages. …”
Get full text

Learning Multi-Attribute Differential Graphs With Non-Convex Penalties by Jitendra K. Tugnait

“…Two proximal gradient descent methods are presented to optimize the objective function. Theoretical analysis establishing sufficient conditions for consistency in support recovery, convexity and estimation in high-dimensional settings is provided. …”
Get full text

Impact of physical activity on maternal and neonatal outcomes among women with vaginal births—single center prospective cohort study by Anna Weronika Szablewska, Bartosz Zaja̧c

“…Participants were recruited from antenatal outpatient clinics and classified based on their physical activity levels before and during pregnancy according to WHO as well as Canadian and the American College of Obstetricians and Gynecologists’ guidelines. Data collection occurred in two stages: first, through a questionnaire including socio-demographic data and the Polish version of the Get Active Questionnaire for Pregnancy, and second, by analyzing biomedical data routinely collected during childbirth. …”
Get full text

Assessment of <i>CRB1</i>-Associated Retinopathies Using the S-MAIA Fast Protocol and Spectral-Domain Optical Coherence Tomography by Bethany E. Higgins, Ana Catalina Rodriguez-Martinez, Giovanni Montesano, Vijay K. Tailor-Hamblin, Samantha Malka, Robert H. Henderson, Mariya Moosajee

“…<b>Results:</b> Microperimetry and SD-OCT data were obtained from 14 and 18 patients, respectively, but eccentric fixation hindered structure-function analysis. …”
Get full text

Enhancing PQQ production in Acinetobacter calcoaceticus through uniform design and support vector regression by Yu-han Li, Yu-han Li, Su-hang Yao, Su-hang Yao, Yan Zhou, Xiu-lan He, Xiu-lan He, Zhe-ming Yuan, Zhe-ming Yuan, Qiu-long Hu, Cheng-wen Shen, Xin Li, Xin Li, Yuan Chen

Get full text

THE LIMITS OF THE APPLICABILITY OF ARTIFICIAL INTELLIGENCE TECHNOLOGIES IN THE ADMINISTRATION OF CRIMINAL JUSTICE by RUDENKO D.A.

“…The author, concluding that adjudication cannot be delegated to artificial intelligence, justifies the allocation of five acceptable areas of its use within the judicial stage of criminal proceedings: solving repetitive tasks by intelligent analysis of an array of data (optimization function), monitoring compliance by the court with formal requirements and rules (control function), prompt establishment of legally significant circumstances during the judicial review of criminal cases (auxiliary function), support for the judge’s decision-making (the function of assistance in decision-making), assistance to the court in the statistical field (statistical function).…”
Get full text

An improved elastic net clustering algorithm with dynamic parameter strategy by Junyan Yi, Maoming Wang, Changsheng Zhou

“…First, we design a novel energy function according to the aim of clustering, which can help the network well distinguish the probability distribution of the data points affiliated with a specific cluster and obtain better clustering solutions, especially for high-dimensional and large-scale problems. …”
Get full text

Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma by Yuhang Chen, Fenglin Zhang, Suoyi Dai, Jiangang Zhao, Wenxun Cai, Ke Zhang, Xinghe Liao, Lianyu Chen

“…Functional enrichment and gene set enrichment analysis (GSEA) analyses were conducted to explore pathways. …”
Get full text

Transoral Laser Microsurgery and Transoral Robotic Surgery in Aging Patients: A State-of-The-Art Review by Lechien JR

“…Critical literature analysis was carried out considering the last advancement in TOLS and TORS, and their related surgical, functional, and survival outcomes.Findings: The mean age of patients with supraglottic LSCCs has progressively increased in the past decades. …”
Get full text

Effects of Psychotropic Medications Taken by Pregnant Women on Newborn Medical Condition and Lactation Method by Yuta Yoshino, Toru Yagi, Koichi Tsubouchi, Yusuke Takaishi, Yuki Ozaki, Jun‐ichi Iga, Keiichi Matsubara, Yuko Matsubara, Yuka Uchikura, Takashi Sugiyama, Shu‐ichi Ueno

Get full text

Extracting interpretable signatures of whole-brain dynamics through systematic comparison. by Annie G Bryant, Kevin Aquino, Linden Parkes, Alex Fornito, Ben D Fulcher

“…Here, we address this limitation by systematically comparing diverse, interpretable features of both intra-regional activity and inter-regional functional coupling from resting-state functional magnetic resonance imaging (rs-fMRI) data, demonstrating our method using case-control comparisons of four neuropsychiatric disorders. …”
Get full text

Association between gut microbiota in HIV-infected patients and immune reconstitution following antiretroviral therapy (ART) by Yuru Shi, Miaomiao Hu, Jing Wu, Ting Liu, Yingjie Qi, Ang Li

“…Based on the observed immune function reconstruction, we further categorized the ART(+) group into a responder group (n = 30) and a non-responder group (n = 20). …”
Get full text

Preferences of People of Advanced and Gerontic Age in Diet Formation by Ruban N., Reznichenko I.

“…Therefore, gerodietetic foods are a factor of healthy lifestyle and active longevity. Functional food products should be based on age-related issues and consumer preferences. …”
Get full text

Neural Changes after Vision Therapy in Convergence Insufficiency: A Systematic Review by Laura Barberán-Bernardos, Natalia Jiménez, David P. Piñero

“…Some neural changes have been reported after VT in CI with the use of functional magnetic resonance imaging (fMRI). Specifically, a modification of the functional activity of some brain areas (especially front fields, oculomotor vermis, and cerebellum) was found. …”
Get full text

The prognostic significance and Immunomodulatory role of SCGB3A1 expression in stage I lung adenocarcinoma by Xin Zhang, ShiNing Li, Yujin Lv, XinYu Liu, Yong Ao, LeQi Zhong, Yi Hu

“…We investigated the relationship between SCGB3A1 expression and patient clinical-pathological data and prognosis. Furthermore, through GO, KEGG, and GSEA enrichment analyses, we explored the functional roles of SCGB3A1 and its association with immune cell infiltration and immune checkpoint genes. …”
Get full text

Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets by Carol Dangelmaier, Hymavathi Reddy Vari, Dhruv N Vajipayajula, Manal Elzoheiry, Monica Wright, Ashvin Iyer, Alexander Y Tsygankov, Satya P Kunapuli

“…Although there was potentiation of platelet functional responses, there was no difference in tail bleeding times. …”
Get full text

A distributed brain response predicting the facial expression of acute nociceptive pain by Marie-Eve Picard, Miriam Kunz, Jen-I Chen, Michel-Pierre Coll, Etienne Vachon-Presseau, Tor D Wager, Pierre Rainville

“…We then applied a multivariate pattern analysis to the fMRI data to predict the facial expression of pain. …”
Get full text

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation by Kevin B Myant, Patrizia Cammareri, Michael C Hodder, Jimi Wills, Alex Von Kriegsheim, Balázs Győrffy, Mamun Rashid, Simona Polo, Elena Maspero, Lynsey Vaughan, Basanta Gurung, Evan Barry, Angeliki Malliri, Fernando Camargo, David J Adams, Antonio Iavarone, Anna Lasorella, Owen J Sansom

“…However, due to the large size of this gene and a lack of functional analysis of identified mutations, their significance to carcinogenesis is unclear. …”
Get full text