SPINK1 facilitates tumor progression via the EGFR/JAK/STAT3 axis in oral squamous cell carcinoma: insights from single-cell RNA sequencing by Mingyan Bao, Zhangui Tang

“…ObjectiveThis study aimed to elucidate the functional role and molecular mechanisms of Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) in oral squamous cell carcinoma (OSCC) through integrative analysis of single-cell RNA sequencing (scRNA-seq) data.Materials and methodsCellular subpopulations within OSCC were stratified using transcriptomic datasets from the GEO database. …”
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RELIABILITY EVALUATION OF MULTIPLE PERFORMANCE AEROENGINES BASED ON Gamma PROCESS AND MIXED DISTRIBUTION UNDER COMPETITIVE FAILURE

“…In order to solve the reliability evaluation under the competitive failure of multiple performance aero-engines,multiple performance data was fused into an overall degradation data by the matrix similarity,and a nonlinear Gamma process with random effects was used to fit the overall degradation data to obtain the reliability function under multivariate degradation.Assume that multiple performance of the aero-engines have sudden failures,the optimal sudden failure distribution was selected by Anderson-Darling(AD)distribution test,the reliability function under sudden failures was obtained by the mixed distribution.Assume that degradation failure and sudden failure were independent,the reliability evaluation of the multiple performance aeroengines under competitive failure was realized.Finally,the effectiveness and accuracy of the model were verified by the case analysis.…”
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Research on a Dynamic Evaluation of Financial Risks of Intellectual Property Pledge Financing of High-Tech Enterprises by Xiangyu Ge, Ying Jin, Qing Li, Xiaofang Yao, Shican Liu

“…This article first outlines the information entropy method, functionalizing indicator data and weight data, and applies the combination of the weight function and indicator function in dynamic evaluation function, to get the final evaluation result. …”
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Dynamic metabolomic and transcriptomic profiling reveals yellow flower development in Camellia perpetua, a rare continuously flowering golden Camellia species by Xianliang Zhu, Haidu Jiang, Xinfeng Pan, Jiaxin Fu, Lihui Peng, Jin Zhang, Jianmin Tang, Rong Zou, Bo Zhao, Xiao Wei, Shengfeng Chai

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Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C by Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers

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Analyzing Cost Efficiency and Project Scope in Post-Disaster Housing: Reconstruction Cases of TOKI in Türkiye by Özlem Geylani

“…Specifically, a quantitative analysis is conducted on 434 disaster housing projects for which detailed financial data are available. …”
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Lignans-rich extract of Schisandra chinensis prevent alcohol-associated liver disease by regulating the gut microbiota and tryptophan metabolism by Yan-Yu Chi, Jun-Yan Xiang, Hui-Min Li, Hao-Yu Shi, Ke Ning, Hongyu Xiang, Qiuhong Xie

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Leveraging Whole-Genome Resequencing to Uncover Genetic Diversity and Promote Conservation Strategies for Ruminants in Asia by Qinqian Wang, Ying Lu, Mengfei Li, Zhendong Gao, Dongfang Li, Yuyang Gao, Weidong Deng, Jiao Wu

“…It not only reveals the intricate structure of ruminant genomes but also provides essential data for deciphering gene function, variation patterns, and evolutionary processes, thereby advancing the exploration of ruminant genetic mechanisms. …”
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Systematic screening of metabolic pathways to identify two breast cancer subtypes with divergent immune characteristics by Xiangshu Cheng, Shuhao Zhang, Xin Meng, Rui Chen, Hao Tang, Jiacheng Wang, Yongshuai Jiang, Ruijie Zhang

“…To characterize BCMS, we applied an analytical framework encompassing functional enrichment (GSEA), immune infiltration (Mcpcounter), clinical correlation, drug sensitivity (oncoPredict) on bulk transcriptome data, cell-cell communication analysis (CellChat) on single-cell RNA sequencing (scRNA-seq) data, and spatial co-localization analysis (CellTrek) on spatial RNA sequencing (spRNA-seq) data. …”
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Exponentiated Odd Lomax Exponential distribution with application to COVID-19 death cases of Nepal. by Govinda Prasad Dhungana, Vijay Kumar

“…Therefore, the intended model is an alternative model for survival data and lifetime data analysis.…”
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From Biomarker Discovery to Clinical Applications of Metabolomics in Glioblastoma by Neja Šamec, Gloria Krapež, Cene Skubic, Ivana Jovčevska, Alja Videtič Paska

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and as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma by Xin Zhang, Jin-Xiang Wan, Zun-Ping Ke, Feng Wang, Hai-Xia Chai, Jia-Qiang Liu

“…Driver genes influencing the prognosis of this disease were determined using clustering analysis. Functional analysis of driver genes was performed by literature search and Gene Set Enrichment Analysis. …”
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Changes in EEG Microstate Dynamics and Cognition Post‐Chemotherapy in People With Breast Cancer by S. Damji, S. Sattari, K. Zadravec, K. L. Campbell, J. Brunet, N. Virji‐Babul

“…ABSTRACT Objective Chemotherapy‐related cognitive changes following breast cancer are commonly reported; however, changes in brain dynamics of large‐scale neural networks remain unclear. Using data from the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial, we conducted exploratory analyses to compare self‐reported and objective measures of cognition and applied microstate analysis to resting state (RS) electroencephalography (EEG) data of women with breast cancer before and following chemotherapy treatment. …”
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On Software Defect Prediction Using Machine Learning by Jinsheng Ren, Ke Qin, Ying Ma, Guangchun Luo

“…This is achieved by applying kernel function to the asymmetric partial least squares classifier and asymmetric principal component analysis classifier, respectively. …”
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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. by Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe

“…However, making functional sense of genomic data relies on the ability to infer binding phenotype from var gene sequence. …”
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Effects of Symptom Burden on Quality of Life in Patients with Lung Cancer by Ling-Jan Chiou, Yun-Yen Lin, Hui-Chu Lang

“…The multiple regression analysis showed that appetite loss was the most frequently associated factor for global QOL (β = −0.32; adjusted R²: 27%) and cognitive function (β = −0.15; adjusted R²: 11%), while fatigue was associated with role function (β = −0.35; adjusted R²: 43%), emotional function (β = −0.26; adjusted R²: 9%), and social function (β = −0.26; adjusted R²: 27%). …”
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Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis by Lin-Lin Zhang, Xiao-Xiao Wu, Xu-Fan Wang, Dong-Sheng Di, Qian Huang, Rui-Shan Liu, Zong-Wen Shuai, Dong-Qing Ye, Rui-Xue Leng

“…The epigenetic annotation and cytokine assay were used for exploring potential variant function.Results The extracted genetic association data from three previous GWASs showed that the allele T of functional SNP rs2431697 increased RA susceptibility. …”
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Individualised physical exercise training and enhanced protein intake in older citizens during municipality-based rehabilitation: protocol for a randomised controlled trial by Karen Søgaard, Lars Holm, Sanel Teljigovic, Louise Fleng Sandal, Tina Dalager, Nina Odgaard Nielsen, Gisela Sjøgaard

“…The Short Musculoskeletal Function Assessment questionnaire is the primary outcome.Ethics and dissemination Approvals from The Ethics Committee in Region Zealand, Denmark (SJ-758), and the General Data Protection Regulation at the University of Southern Denmark, Odense (10.330) have been obtained.Trial registration number NCT04091308…”
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The trypanosome Rab-related proteins RabX1 and RabX2 play no role in intracellular trafficking but may be involved in fly infectivity. by Senthil Kumar A Natesan, Lori Peacock, Ka Fai Leung, Keith R Matthews, Wendy Gibson, Mark C Field

“…<h4>Conclusions/significance</h4>RabX1 and RabX2, two members of the trypanosome Rab subfamily, were shown to have no major detectable role in intracellular transport, despite the localization of each gene product to highly specific endomembrane compartments. These data extend the functional scope of Rab proteins in trypanosomes to include non-canonical roles in differentiation-associated processes in protozoa.…”
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B-Lines in the Assessment of Interstitial Lung Disease Associated with Scleroderma: The Role of Handheld Devices by Codrina Ancuța, Cristina Pomirleanu, Ecaterina Gănceanu, Milena Adina Man, Eugen Ancuta, Paraschiva Postolache

“…<b>Objective</b>: to explore the usefulness of an ultraportable ultrasound device for the management of SSc-related ILD and to compare it with clinical and instrumental data. <b>Methods</b>: A total of 19 consecutive SSc patients underwent a comprehensive pulmonary evaluation: clinical, pulmonary function tests (PFTs) (spirometry, DLCO), lung CT (1.5 mm slice thickness reconstruction; HRCT), and lung ultrasound (LUS). …”
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