Genome-Wide Association Integrating a Transcriptomic Meta-Analysis Suggests That Genes Related to Fat Deposition and Muscle Development Are Closely Associated with Growth in Huaxi... by Cheng-Li Liu, Tao Ren, Peng-Cheng Ruan, Yong-Fu Huang, Simone Ceccobelli, De-Jun Huang, Lu-Pei Zhang, Guang-Xin E

“…Additionally, publicly available RNA-seq data from the longissimus dorsi muscle of both young and adult cattle were analyzed to identify key genes and genetic markers associated with growth in Huaxi cattle. …”
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Leveraging the enrichment analysis from a genome-wide association study against epilepsy—focusing on the role of tryptophan catabolites pathway in patients with drug-resistant epil... by Alice Y. W. Chang, Alice Y. W. Chang, Chin-Wei Huang, Ping-Lin Tsai, Chun-An Liang, Chun-An Liang, Wei Chen Liao, Tzu-Fun Fu, Tzu-Fun Fu, Hui Hua Chang, Hui Hua Chang, Hui Hua Chang, Hui Hua Chang

“…Moreover, we investigated the potential role of molecular signature profiles, as exemplified by tryptophan catabolites (TRYCATs), in DRE patients.MethodsWe used data from the Taiwan Biobank to perform a GWAS and identified enrichment pathways through the functional database Reactome. …”
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Electronic Nose System Based on Metal Oxide Semiconductor Sensors for the Analysis of Volatile Organic Compounds in Exhaled Breath for the Discrimination of Liver Cirrhosis Patient... by Makhtar War, Benachir Bouchikhi, Omar Zaim, Naoual Lagdali, Fatima Zohra Ajana, Nezha El Bari

“…This study included 55 participants: 27 LC patients and 28 HCs. Sensor’s measurement data were analyzed using machine learning techniques, such as principal component analysis (PCA), discriminant function analysis (DFA), and support vector machines (SVMs) that were utilized to uncover meaningful patterns and facilitate accurate classification of sensor-derived information. …”
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Relationship between blood urea nitrogen and 28-day all-cause mortality in patients with acute pulmonary edema: a retrospective analysis of the MIMIC-IV database by Guang Tu, Yuwen Liu, Xiaomi Huang, Yanfang Zeng, Zhonglan Cai, Chunyan Wang

“…Blood Urea Nitrogen (BUN) levels, which indicate renal function and metabolic state, may have prognostic value in critically ill patients. …”
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A Fourfold Bi-Filter and Permuted Bi-Quad-Wrapper Feature Selection Method for Finding Optimal Moments of Multi-Trajectory Transient Records in Transient Analysis by Seyed Alireza Bashiri Mosavi, Omid Khalaf Beigi

“…Fast and accurate transient analysis (TA) requires a meticulously explored nonlinear transient excursion space (NTES). …”
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Network pharmacological approach combined with weighted gene co-expression network analysis identifies CDKN2A as the keg target of Changweiqing against colorectal cancer by Ma Zushuai, Ji Yanrong, Zhao Chengdu, Zhu Xu, Ding Qianshan

“…Core targets were further analyzed using Gene Expression Profiling Interactive Analysis platform, Human Protein Atlas database, University of ALabama at Birmingham CANcer data analysis Portal (UALCAN) and GeneMANIA database. …”
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Effectiveness of advance care planning programmes in improving end-of-life outcomes for individuals with dementia and their caregivers in nursing homes: protocol for a systematic r... by Chih-Cheng Lai, Yu-Tai Lo, Yi-Jhen Chen, Jheng-Yan Wu

“…Sensitivity and subgroup analyses will be conducted to address heterogeneity.Ethics and dissemination Ethics approval was not required for this systematic review and meta-analysis, as it involves the synthesis of existing literature without direct data collection or patient participation. …”
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Remote Sensing-Based Analysis of the Coupled Impacts of Climate and Land Use Changes on Future Ecosystem Resilience: A Case Study of the Beijing–Tianjin–Hebei Region by Jingyuan Ni, Fang Xu

“…Our findings highlight the role of climate and land use in reshaping ecological structure, function, and services. This study offers scientific support for assessing and managing regional ecosystem resilience and informs adaptive urban governance in the face of future climate and land use uncertainty, promotes the sustainable development of ecosystems, and expands the applicability of remote sensing in dynamic ecological monitoring and predictive analysis.…”
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Machine Learning and Experimental Validation Reveal MYH11 as a Novel Prognostic Biomarker and Therapeutic Target in Bladder Cancer by Tan Z, Chen X, Fu S, Huang Y, Li H, Gong C, Lv D, Yang C, Wang J, Ding M, Wang H

“…This study aimed to explore the potential molecular mechanisms of BCa using multi-omics and single-cell analysis.Methods: First, differential analysis of transcriptome data related to BCa from public databases was performed, and a risk model was then developed using 101 different machine learning algorithms to determine prognostic genes, followed by independent prognostic analysis to construct a nomogram. …”
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Autonomous International Classification of Diseases Coding Using Pretrained Language Models and Advanced Prompt Learning Techniques: Evaluation of an Automated Analysis System Usin... by Yan Zhuang, Junyan Zhang, Xiuxing Li, Chao Liu, Yue Yu, Wei Dong, Kunlun He

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Multifaceted Role of Specialized Neuropeptide-Intensive Neurons on the Selective Vulnerability to Alzheimer’s Disease in the Human Brain by Manci Li, Nicole Flack, Peter A. Larsen

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Dynamic role of gastric stem cells and chief cells in precancerous lesions of gastric cancer: global knowledge mapping and emerging trends based on bibliometric analysis from 2004... by Chen Wang, Lijie Zhou, Yangang Wang, Yangang Wang

“…This study aimed to elucidate the roles of GSCs and chief cells in maintaining gastric epithelial integrity, their contributions to the development of precancerous lesions, and the molecular mechanisms that regulate their behavior during disease progression.MethodsThe study integrated bibliometric analysis, pathfinding, and data visualization using tools such as CiteSpace, VOSviewer, and R software. …”
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Simulation of endothelium-dependent vasodilation in young male persons based on the parameters of body weight components by O. P. Kentesh, M. I. Nemesh, O. S. Palamarchuk, Yu. M. Savka, Ya. I. Slyvka, V. P. Feketa

“…To determine the endothelial vasoregulatory function on the basis of correlation-regression analysis, models were constructed with coefficients of determination R2 of 0.277 (BMI), 0.126 (TFP), 0.189 (VFC) and 0.146 (FFM). …”
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Integrated care programmes for sport and work participation, performance of physical activities and quality of life among orthopaedic surgery patients: a systematic review with met... by Maurits W van Tulder, Pieter Coenen, Gino M Kerkhoffs, Gerben Hulsegge, Joost G Daams, Rutger C van Geenen, Judith A Huirne, Johannes R Anema, P Paul Kuijer

“…We aimed to assess the effectiveness of integrated care among orthopaedic surgery patients.Design Systematic review with meta-analysis.Data source Medline, EMBASE and CINAHL (until 17 June 2019).Eligibility for selecting studies We searched for controlled studies on integrated care interventions consisting of active referral to case managers, rehabilitation with participation-based goals and/or e/mHealth, with outcomes of sports and work participation, performance of physical activities and/or QoL. …”
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Identification of the disulfidptosis-related key gene CD2AP as a potential biomarker and new therapeutic target for LUAD patients by comprehensive multi-omics analysis by Zhiwu Lin, Jing Lv, Chuanqiang Dai, Yuanwei Zhai, Jiudong Jiang, Yang Gao, Rulin Li, Jiangang Fan, Yang Yu, Liang Wu, Yanchun Yang

“…This study aimed to explore CD2AP’s function in LUAD and its potential as a biomarker and therapeutic target through multi-omics analysis. …”
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Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

“…Objective To evaluate the impact of the ‘Getting it Right First Time’ (GIRFT) national improvement programme in orthopaedics, which started in 2012.Design Mixed-methods study comprising statistical analysis of linked national datasets (National Joint Registry; Hospital Episode Statistics; Patient-Reported Outcomes); economic analysis and qualitative case studies in six National Health Service (NHS) Trusts.Setting NHS elective orthopaedic surgery in England.Participants 736 088 patients who underwent primary hip or knee replacement at 126 NHS Trusts between 1 April 2009 and 31 March 2018, plus 50 NHS staff.Intervention Improvement bundle including ‘deep dive’ visits by senior clinician to NHS Trusts, informed by bespoke set of routine performance data, to discuss how improvements could be made locally.Main outcome measures Number of procedures conducted by low volume surgeons; use of uncemented hip implants in patients >65; arthroscopy in year prior to knee replacement; hospital length of stay; emergency readmissions within 30 days; revision surgery within 1 year; health-related quality of life and functional status.Results National trends demonstrated substantial improvements beginning prior to GIRFT. …”
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Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smoo... by Smriti Bohara, Atefeh Bagheri, Elif G. Ertugral, Igor Radzikh, Yana Sandlers, Peng Jiang, Chandrasekhar R. Kothapalli

“…Despite extensive epidemiological data, the molecular mechanisms relating hyperglycemia to CVD remain incompletely understood. …”
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Metabolomics and network pharmacology–guided analysis of TNF-α expression by Argemone mexicana (Linn) targeting NF-kB the signalling pathway in cancer cell lines by Sunanda Kulshrestha, Anjana Goel, Subhadip Banerjee, Rohit Sharma, Mohammad Rashid Khan, Kow-Tong Chen, Kow-Tong Chen

“…Network pharmacology analysis used Binding DB, STRING, DAVID, and KEGG for data mining to evaluate predicted compounds using functional annotation analysis. …”
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Exploring SLC30A6 as a potential prognostic, immunomodulatory, and therapeutic biomarker in various cancers with a focus on pancreatic cancer: a pan-cancer analysis by Fatemeh Maghool, Parisa Kadkhodaei Elyaderani, Samaneh Mohammadzadeh, Amir Hosseini, Aida Heidari, Pouria Samadi

“…Methods We conducted a comprehensive analysis of SLC30A6 using data from 33 different cancer types, and all data were analyzed in silico. …”
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Clinical and genetic analysis of ERCC8-Related cockayne syndrome: hepatic dysfunction as a biomarker, anhidrosis as a rare feature, and rehabilitation outcomes for ankle contractur... by Jing Chen, Wei Su, Dan Gao, Fangfang Liu, Shuang Chen, Wenhan Zhang, Min Peng, Tao Lei, Hongmin Zhu

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