Integrated Genome-Wide Analysis of Gene Expression and DNA Copy Number Variations Highlights Stem Cell-Related Pathways in Small Cell Esophageal Carcinoma by Di Liu, Xinyan Xu, Junmiao Wen, Liyi Xie, Junhua Zhang, Yuxin Shen, Guoliang Jiang, Jiayan Chen, Min Fan

“…These overlapped genes were subjected to the functional annotation using DAVID 6.8. In order to elucidate the effect of CNV on mRNA expression, we integrated the genome-wide copy number data and gene expression in 3 paired samples. …”
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Cyanidin-3-glucoside protects the photooxidative damage of retinal pigment epithelium cells by regulating sphingolipid signaling and inhibiting MAPK pathway by Tingting Liu, Wentao Qi, Wenting Peng, Jianan Zhang, Yong Wang

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PO48 | Thrombotic risk evaluation and thrombophilia testing in beta-thalassemia patients: a retrospective cohort analysis from a reference regional center

“…Nineteen had complete screening (including both functional and genetic testing), while 18/65 and 28/65 patients had partial genetic and functional screening, respectively (Table 1). …”
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Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis by Yuxin Lin, Xiaoping Zhong, Zhengyuan Chi, Hui Li, Rui Han, Hao Li, Shukai Zheng, Shijie Tang, Jiasheng Chen

“…Gene Set Variation Analysis of transcriptome sequencing data identified significant downregulation of platelet-derived growth factor binding and glycosaminoglycan (GAG) degradation, which are closely related to the protein functions involved in 3-PG metabolism. …”
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Genome-Wide Identification and Expression Profiling Analysis of the Mitochondrial Calcium Uniporter Gene Family Under Abiotic Stresses in <i>Medicago sativa</i> by Wanhong Li, Bowei Jia, Jiaxun Sheng, Yang Shen, Jun Jin, Xiaoli Sun, Xiangping Liu, Mingzhe Sun

“…These results provide detailed knowledge of alfalfa <i>MCU</i> genes and suggest their potential functions in abiotic stress response.…”
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Understanding the political economy of reforming global health initiatives – insights from global and country levels by Sophie Witter, Natasha Palmer, Rosemary Jouhaud, Shehla Zaidi, Severine Carillon, Rene English, Giulia Loffreda, Emilie Venables, Shifa Salman Habib, Jeff Tan, Fatouma Hane, Maria Paola Bertone, Seyed-Moeen Hosseinalipour, Valery Ridde, Asad Shoaib, Adama Faye, Lilian Dudley, Karen Daniels, Karl Blanchet

“…The study adopted a cross-sectional, mixed-methods approach, drawing from a range of data sources and data collection methods, including a global and regional level analysis as well as three embedded country case studies in Pakistan, South Africa and Senegal. …”
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The Genesis of the Scientific School of Accounting of Nizhny Novgorod State University Named After N. I. Lobachevsky in the System of Development of Economic Knowledge by I. E. Mizikovskii

“…In the course of the research, methods of historicism, structural-functional and systemic types of analysis were used; formalization, interpretation, evaluation and systematization of scientific data; a causal approach was applied. …”
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The role and importance of libraries in the modern information space by R. I. Mamina, E. V. Pirainen

“…The article objective is to show the library role and importance in shaping the information space. The analysis has shown that: · information space of the library fully reflects the basic properties and intrinsic characteristics of the information space, its specifics is defined by peculiarities of the library activity; · introduction of innovative technologies in the library activity has significantly diversified the scope of its servi-ces and increased its relevance in the community, at present the library is a multi-functional cultural-social institution; · libraries mission both on the level of social memory and the educational level is constantly growing. …”
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Longitudinal impact of cross-clamp duration on postoperative sleep disturbance and quality of life in elderly cardiac surgery patients: a secondary analysis of the MINDDS trial by Grace E. Namirembe, Jamie Sparling, Alexis Novak, Ariel Mueller, Julia Bertsch, Kwame Wiredu, Jason Z. Qu, M. Brandon Westover, Timothy T. Houle, Oluwaseun Akeju

“…ObjectivesThis study aimed to assess the enduring impact of cross-clamp duration on postoperative sleep disturbance and functional outcomes (up to 180 days) in cardiac surgery patients.DesignThis is a secondary analysis of data from a randomized, double-blind trial comparing dexmedetomidine to placebo for delirium prevention (Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep).SettingData from patients recruited at a tertiary medical center in Boston, Massachusetts, between March 2017 and February 2022 were analyzed in January 2024.ParticipantsThe study included 394 patients aged ≥60 who underwent cardiac surgery with cardiopulmonary bypass.InterventionsThe primary exposure was cross-clamp time, while secondary exposures included surgical type [isolated coronary artery bypass graft (CABG) or not] and dexmedetomidine randomization.Measurements and main resultsThe primary outcome was sleep quality, assessed using the PROMIS Sleep Disturbance questionnaire at 30, 90, and 180 days postoperatively. …”
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Effect of repetitive transcranial magnetic stimulation with different stimulation parameters on post-stroke dysphagia: a systematic review and meta-analysis of randomized controlle... by Xu-Miao Peng, Xu-Miao Peng, Cheng Gong, Mei-Xia Xiao, Liang-Sheng Chen, Liang-Sheng Chen, Yi Li, Yi Li, Jie Chen, Mao-Yuan Wang, Mao-Yuan Wang, Mao-Yuan Wang, Yun Luo, Yun Luo, Yun Luo

“…Meta-analyses demonstrated that both cerebral and cerebellar rTMS treatments significantly improved the swallowing function of PSD patients (p &lt; 0.05). Subgroup analysis of cerebral rTMS showed that high-frequency rTMS (HF-rTMS) could effectively improve the swallowing function of PSD patients (p &lt; 0.05), while low-frequency rTMS (LF-rTMS) failed to improve the swallowing function of PSD patients compared with the control group (p &gt; 0.05). …”
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Effects of traditional fitness qigong exercise on frailty status and overall well-being in frail or pre-frail patients: a systematic review and meta-analysis by Weijing Sun, Weijing Sun, Lingling Li, Zhenzhen Zhang, Xiuli Duan, Juanjuan Wei, Kim Lam Soh

“…Two reviewers independently selected and screened the papers, extracted the data, and assessed the bias risk. We used Review Manager 5.4 for data analysis, pooling the mean difference (MD) or standardized mean difference (SMD) through either random-effects or fixed-effects meta-analysis, depending on the level of heterogeneity.ResultsEighteen randomised controlled trials were included. …”
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Impact of shift work and obesity on risk of hyperuricemia in coal miners: A cross-sectional design based dose-response relationships and interaction analysis by Zeyuan ZHANG, Yingjun CHEN, Yingtong CHEN, Mengtian XIONG, Zichao PANG, Gaisheng LIU, Hongxia ZHAO, Liuquan JIANG, Qingsong CHEN

“…Restricted cubic spline functions were used to analyze the dose-response relationship between years of shift work, daily shift work hours, and HUA. …”
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Human Health Risk Prediction Method of Regional Atmospheric Environmental Pollution Sources Based on PMF and PCA Analysis under Artificial Intelligence Cloud Model by Shihui Zhang, Xinghua Sun, Naidi Liu, Jing Mi

“…This method takes the 75-day measured environmental receptor data of an area under the artificial intelligence cloud model as the basic data, uses the normrnd () function to expand the receptor data, and uses the positive definite matrix factor analysis (PMF) and principal component analysis (PCA) models to verify the rationality of the data expansion. …”
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Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials by Filippo Migliorini, Nicola Maffulli, Luise Schäfer, Joshua Kubach, Marcel Betsch, Mario Pasurka

“…No difference was observed in VAS at rest (<i>p</i> = 0.4), VAS at exercise (<i>p</i> = 0.1), and subscale function (<i>p</i> = 0.4) of the WOMAC score. Studies which reported data from five to eight weeks of follow-up evidenced lower VAS at rest in favour of the HA group (<i>p</i> = 0.01). …”
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Radiographic Evaluation of The Bone Density Around Tooth-Anchored One-Piece Immediate-Loading Dental Implant by Bangen Mohammed Karam, Bahar Jaafar Selivany, Huda Jameel Qasim, Rafah Hussein Mohammed

“…This study evaluates the impact of immediate functional loading on bone density changes using radiographic grayscale and texture analysis over one year. …”
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Unveiling the role of coagulation-related genes in acute myeloid leukemia prognosis and immune microenvironment through machine learning by Liyun Ji, Yanxia Yang, Siyue Ma

“…Functional enrichment analysis indicated that DEGs were mainly associated with leukocyte migration and cytokine signaling pathways. …”
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Study on the Response of Cotton Leaf Color to Plant Water Content Changes and Optimal Irrigation Thresholds by Binbin Mao, Lulu Wang, Junhui Cheng, Bing Chen, Jiandong Wang, Kai Zhang, Xiaowei Liu

“…In 2023, leaf color data from the top five functional leaves were measured at five time points daily throughout the irrigation cycle. …”
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A novel computational approach for the mining of signature pathways using species co-occurrence networks in gut microbiomes by Suyeon Kim, Ishwor Thapa, Hesham Ali

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A Flexible Truncated (<i>u</i>,<i>v</i>)-Half-Normal Distribution: Properties, Estimation and Applications by Maher Kachour, Hassan S. Bakouch, Mustapha Muhammad, Badamasi Abba, Lamia Alyami, Sadiah M. A. Aljeddani

“…Some key properties of the proposed model, including its cumulative distribution function, probability density function, survival function, hazard rate, and moments, are derived and analyzed. …”
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The clinical efficacy of percutaneous endoscopic lumbar discectomy combined with platelet-rich plasma injection for lumbar disc herniation: a systematic review and meta-analysis by Hua Song, Ying Zhang

“…Data were extracted and analyzed to evaluate recurrence rates, pain relief, functional outcomes, and intervertebral disc health status.ResultsA total of 4 eligible studies were identified in this research, comprising 421 patients, of whom 212 received the combined treatment of PRP and PELD, while 209 underwent PELD alone. …”
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