Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion by Hong Li, Hong Li, Yixin Zhou, Wenya Xue, Pan Yin, Luyu Liu, Shaobo Wu, Yahao Zhao, Qi An, Yang Sun

“…Dgat2 was significantly elevated in ischemia-reperfusion mouse models, confirmed by RT-PCR and Western blot. Functional enrichment indicated that Dgat2 may be involved in biological oxidation and lipid metabolism. …”
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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…CNMA was conducted only for  BMI outcomes due to the availability of extensive data. Our analysis showed that none of the individual components could produce a statistically significant change in BMI when compared to TAU. …”
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Drying kinetics and thermodynamic analysis; enhancing quinoa (Chenopodium quinoa Willd.) quality profile via pre-treatments assisted germination and processing by Jabir Khan, Palwasha Gul, Qingyun Li, Kunlun Liu

“…The intensity of functional groups decreased in the infrared spectra, although the transmission of signals was greater in pretreated samples than in control. …”
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Analysis of confounders of the image quality of a high-resolution isotropic three-dimensional Dixon water-fat late gadolinium enhancement technique by Johanna Kuhnt, Edyta Blaszczyk, Leo Dyke Krüger, Leonhard Grassow, Claudia Prieto, René Botnar, Karl Philipp Kunze, Michaela Schmidt, Darian Steven Viezzer, Thomas Hadler, Maxmilian Fenski, Jeanette Schulz-Menger

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Transcriptional Sequencing and Gene Expression Analysis of Various Genes in Fruit Development of Three Different Black Pepper (Piper nigrum L.) Varieties by Choy Yuen Khew, Jennifer Ann Harikrishna, Wei Yee Wee, Ee Tiing Lau, Siaw San Hwang

“…These results indicate several candidate genes related to the development of flower and fruit in black pepper and provide a resource for future functional analysis and potentially for future crop improvement.…”
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Multimodal neuroimaging investigation of post-stroke fatigue in middle-aged and older adults: combining resting-state fMRI and DTI-ALPS analysis by Jingjing Sun, Yanlin Tang, Wenni Wang, Yong Zhang, Hengshan Ji, Peng Wang

“…DTI-ALPS analysis revealed a negative correlation between DTI-ALPS index and fatigue severity (R2 = 0.40, p < 0.001) in the PSF group, suggesting an association between impaired glymphatic clearance and fatigue symptoms in middle-aged and older stroke survivors.ConclusionThis multimodal neuroimaging study highlights altered brain functional connectivity and glymphatic dysfunction as potential neural correlates of PSF in middle-aged and older adults. …”
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Enhanced analysis of MHD radiative hybrid nanofluid flow over a spinning disc with hall currents via advanced computational techniques by Muhammad Jebran Khan, Mohsin Ali, Maher Ali Rusho, Juan Carlos Cayán Martínez, Eduardo Francisco García Cabezas, Diego Ramiro Ñacato Estrella, Angel Geovanny Guamán Lozano, Noormal Samandari

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Association between Chinese visceral adiposity index and sarcopenia: a China health and retirement longitudinal study (CHARLS)-based longitudinal analysis by Changbo Sun, Honggang Jiang, Hongmei Zhu, Chengkai Shao, Zhen Luo, Bin Zhang, Xudong Zhang, Shiyi Wang

“…Abstract Objectives Sarcopenia, characterized by a progressive decline in muscle mass and function, is increasingly associated with metabolic dysregulation. …”
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Benefits and Harms of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. by Heidi Storgaard, Lise L Gluud, Cathy Bennett, Magnus F Grøndahl, Mikkel B Christensen, Filip K Knop, Tina Vilsbøll

“…<h4>Design</h4>Systematic review and meta-analysis.<h4>Data sources and study selection</h4>We included double-blinded, randomised controlled trials (RCTs) evaluating SGLT2-i administered in the highest approved therapeutic doses (canagliflozin 300 mg/day, dapagliflozin 10 mg/day, and empagliflozin 25 mg/day) for ≥12 weeks. …”
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Spatiotemporal analysis of rainfall and temperature variability and trends for a mixed crop-livestock production system: its implications for developing adaptation strategies by Sintayehu Alemayehu, Daniel Olago, Opere Alfred, Tadesse Terefe Zeleke, Sintayehu W. Dejene

“…This comprehensive approach integrates statistical analysis with environmental and agricultural data to provide a detailed understanding of climate dynamics and their practical implications. …”
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Wild wisdom meets cultivation: comparative rhizomicrobiome analysis unveils the key role of Paraburkholderia in growth promotion and disease suppression in Coptis chinensis by Xianhe Cao, Qingjun Yuan, Chengcheng Hu, Hanxing Zhang, Xianyun Sun, Binbin Yan, Xiaojing Ma, Long Zhang, Luqi Huang, Shaojie Li, Zhenying Zhang

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Leukocyte-Rich Platelet-Rich Plasma’s Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials by Peiyuan Tang, Meihui Huang, Wenfeng Xiao, Ting Wen, Pavel Volotovsky, Mikhail Gerasimenko, Shiyao Chu, Shuguang Liu, Kai Zhang, Yusheng Li

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Effectiveness of high-intensity laser therapy in the treatment of shoulder impingement syndrome: a systematic review and meta-analysis of randomised clinical trials by Hernán Andrés de la Barra Ortiz, Antonia Cortés, Fernando Pizarro, Nicolás Sabaj, Esteban Sainz

“…RCTs reported a reduction in pain and an improvement in functionality in the meta-analysis. VAS MD = –1.56 cm (95% CI: –2.1,1.0); CMS MD = 4.0% (95% CI: 1.7, 6.2). …”
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A Comparative Analysis of Genetic and Epigenetic Factors in METH Addiction: A Focus on SLC (SLC6A4) and COMT Genes by Haider K. Hussain, Yolanda Loarce Tejada, Anna Barbaro

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Efficacy of virtual reality balance training on rehabilitation outcomes following anterior cruciate ligament reconstruction: A systematic review and meta-analysis. by Chao Du, Nei-Meng Gu, Tian-Ci Guo, Ai-Feng Liu

“…<h4>Methods</h4>This meta-analysis was registered in PROSPERO with the registration number CRD42024520383. …”
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Evaluation of the Effects of Photobiomodulation on Bone Density After Placing Dental Implants: A Pilot Study Using Cone Beam CT Analysis by Ruxandra-Elena Luca, Alessandro Del Vecchio, Ioana-Roxana Munteanu, Mădălin-Marius Margan, Carmen Darinca Todea

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Urinary Extracellular Vesicle Analysis Reveals Early Signs of Kidney Inflammation and Damage in Single Ventricle Paediatric Patients After Fontan Operation by Grange C, Deorsola L, Degiovanni B, Tomanin D, Prudente D, Peruzzi L, Pace Napoleone C, Bussolati B

“…Moreover, we analysed the levels of markers of kidney regeneration, such as CD133 and CD24, and of inflammation using a bead-based cytofluorimetric multiplex analysis. The markers’ levels were correlated with patients’ demographical, clinical and surgical data.Results: uEVs from children with single ventricle defects showed reduced levels of Klotho and CD133, compared with the ones of healthy subjects. …”
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Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis. by Miriam S Udler, Jaegil Kim, Marcin von Grotthuss, Sílvia Bonàs-Guarch, Joanne B Cole, Joshua Chiou, Christopher D. Anderson on behalf of METASTROKE and the ISGC, Michael Boehnke, Markku Laakso, Gil Atzmon, Benjamin Glaser, Josep M Mercader, Kyle Gaulton, Jason Flannick, Gad Getz, Jose C Florez

“…We identified five robust clusters of T2D loci and traits, each with distinct tissue-specific enhancer enrichment based on analysis of epigenomic data from 28 cell types. Two clusters contained variant-trait associations indicative of reduced beta cell function, differing from each other by high versus low proinsulin levels. …”
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Clinical and Immunological Analysis of Retinal Pigment Epithelium Transplantation Derived from Induced Pluripotent Stem Cells under Pharmacological Immunosuppression in Rabbits by N. V. Neroeva, N. V. Balatskaya, A. G. Brilliantova, L. A. Katargina, A. E. Kharitonov, M. A. Lagarkova, A. N. Bogomazova

“…When testing biomedical cellular products, special requirements are placed on the animal model, which should simulate pathological changes, such as in humans, and have sufficient immunological tolerance to xenogenic human cells, enabling them to function fully. For this purpose, lines of immuno-modified or immunodeficiency animals are used, usually small rodents (rats and mice), but the small size and structure of their eyes do not allow manipulation in vitreoretinal interventions in humans. …”
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Reinforcing gut integrity: A systematic review and meta-analysis of clinical trials assessing probiotics, synbiotics, and prebiotics on intestinal permeability markers by Zeinab Ghorbani, Nargeskhatoon Shoaibinobarian, Morvarid Noormohammadi, Kate Taylor, Asma Kazemi, Ali Bonyad, Sara Khoshdooz, Ulrike Löber, Sofia K. Forslund-Startceva

“…Background: Given the magnitude and variety of chronic metabolic disease linked to increased intestinal permeability, appropriate strategies to reinforce gut barrier function are urgently needed. Methods: This systematic review and meta-analysis explores the effects of pro- and synbiotic, or prebiotic administration, on various intestinal permeability markers. …”
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