Integrated genomic analysis of the stemness index signature of mRNA expression predicts lung adenocarcinoma prognosis and immune landscape by Xingzhao Lu, Wei Du, Jianping Zhou, Weiyang Li, Zhimin Fu, Zhibin Ye, Guobiao Chen, Xian Huang, Yuliang Guo, Jingsheng Liao

Get full text

Global, regional and national burdens of bipolar disorders in adolescents and young adults: a trend analysis from 1990 to 2019 by Yifan Chen, Long Sun, Meiqi Wang, Yunxi Zhong, Xiaoying Su, Qixiu Li, Ziming Shao

Get full text

Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL by Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang, Arsenij Ustjanzew, Nadine Lehmann, Khalifa El Malki, Arthur Wingerter, Alexandra Russo, Olaf Beck, Sebastian Attig, Lea Roth, Julian König, Claudia Paret, Jörg Faber

“…Our data suggest that loss of RBP functionality by mutations altering their binding motifs or by deregulated expression might harbor the potential for the disease-associated accumulation of therapy-resistant CD19 isoforms.…”
Get full text

Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus by Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li

“…Gene Ontology term enrichment analysis revealed that the candidate gene data sets were enriched in gene categories associated with mRNA splicing via spliceosome in the biological process, integral component of membrane in the cellular component, and protein binding in the molecular function. …”
Get full text

MiRNA-mRNA integration analysis of three continuous embryonic stages of Chinese horseshoe crab Tachypleus tridentatus by Yunfan Huang, Ying Qiao, Shengping Zhong, Xingzhi Zhang, Menghong Hu, Kityue Kwan, Theerakamol Pengsakul, Jiasen Guo, Xuyang Chen, Xiaowan Ma, Qiongzhen Li

“…To better understand the complex developmental gene regulatory networks in T. tridentatus, the time-course gene expression data analysis is the first step. Our results provide a valuable resource for analyzing the functions of gene repertoires in embryonic developmental stages （Stage 18 to Stage 20）of horseshoe crab.…”
Get full text

Outcomes of Active Treatment for Localised Prostate Cancer After Holmium Laser Enucleation of the Prostate: A Systematic Review and Meta-analysis by Alberto Artiles Medina, Ana Tagalos Muñoz, Ana Domínguez Gutiérrez, Alfonso Muriel García, José Daniel Subiela, Noelia Álvarez Díaz, Guillermo Fernández Conejo, Victoria Gómez Dos Santos, Almudena Coloma del Peso, Francisco Javier Burgos Revilla

“…Comparative and noncomparative studies providing data on patients who underwent HoLEP and subsequent treatment modalities for PCa were included if these reported post- or intraoperative complications, pathological findings, and oncological or functional outcomes. …”
Get full text

Sensitivity Analysis of Soil Hydraulic Parameters for Improved Flow Predictions in an Atlantic Forest Watershed Using the MOHID-Land Platform by Dhiego da Silva Sales, Jader Lugon Junior, David de Andrade Costa, Renata Silva Barreto Sales, Ramiro Joaquim Neves, Antonio José da Silva Neto

“…The hydraulic soil parameters of VGM are dependent on soil type and are typically estimated from experimental data; however, they are often obtained using pedotransfer functions, which carry significant uncertainty. …”
Get full text

Experimental analysis on residual ultimate bearing capacity of thin plate with internal explosion dent damage under biaxial compression by Lei AO, Zhizhong SHI, Lei ZHANG, Ziqi DING, Zhiyong PEI, Weiguo WU

“…This damage not only compromises the ship's structural integrity but also affects its overall functionality and safety. To accurately assess a ship's ability to withstand such damage and make informed battlefield decisions, it is crucial to evaluate the residual load-bearing capacity of damaged structures under complex sea conditions. …”
Get full text

Safety Profile and Suicidality Associated with the Use of Esketamine in the Treatment of Major Depressive Disorder in European Countries: An EudraVigilance Database Analysis by Ilaria Ammendolia, Carmen Mannucci, Emanuela Esposito, Gioacchino Calapai, Mariaconcetta Currò, Paola Midiri, Cristina Mondello, Luigi Cardia, Fabrizio Calapai

Get full text

A competing risk analysis of predictors of time to lost to follow-up among adults with TB/HIV coinfection in Bahir Dar by Robel Demelash, Getachew Hailu, Taye Abuhay, Zemenu Addis, Ayenew Tega, Degarege Nibret, Yitagesu Habtu

“…The LTFUs from ART and anti-TB treatment were events of interest and competing events, respectively, and others were censored. The data were entered into Epi data and then exported to Stata and Rstudio. …”
Get full text

Modelling geographical accessibility to support disaster response and rehabilitation of a healthcare system: an impact analysis of Cyclones Idai and Kenneth in Mozambique by Nicolas Ray, Fleur Hierink, Nelson Rodrigues, Maria Muñiz, Rocco Panciera

Get full text

Integrative bioinformatics and immunohistochemical analysis unravel the prognostic significance and immunological implication of LIMCH1 in breast cancer: a retrospective study by Xin Yu, Bei Li, Wenge Li, Jingping Yuan, Shengrong Sun, Juanjuan Li

“…This study employed an integrative approach combining bioinformatics analysis of The Cancer Genome Atlas (TCGA) cohort and clinical immunohistochemistry (IHC) cohort data. …”
Get full text

Diagnosing urban traffic anomalies by integrating geographic knowledge and tensor theory by Zilong Zhao, Luliang Tang, Chang Ren, Xue Yang, Zihan Kan, Qingquan Li

“…The framework is divided into three parts: road traffic status acquisition, traffic anomaly detection, and urban anomaly analysis. First, we perform filtering and map matching on the trajectory data to obtain the traffic states of urban roads and construct them into a tensor. …”
Get full text

Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma by Peng-Lei Zhai, Peng-Lei Zhai, Meng-Min Chen, Meng-Min Chen, Meng-Min Chen, Qi Wang, Jing-Jun Zhao, Xiao-Mei Tang, Cui-Ni Lu, Jia Liu, Qin-Xin Yang, Ming-Liang Xiang, Qing-Hai Tang, Biao Gu, Shu-Ping Zhang, Si-Ping Tang, Da Fu, Da Fu

“…We confirmed notable differences among these subtypes in terms of prognosis, functional enrichment, genomic alterations, TIME patterns, and responses to immunotherapy. …”
Get full text

Effectiveness of care coordination interventions delivered to stroke survivors in low and middle-income countries: Systematic review and meta-analysis protocol. by Stephanopoulos Kofi Junior Osei, Anthony Danso-Appiah

“…It will assess whether these interventions improve clinical outcomes such as motor and cognitive functioning, mental wellbeing, mortality, and disability-adjusted life years (DALYs) of stroke survivors. …”
Get full text

Condition-Specific Molecular Network Analysis Revealed That Flagellar Proteins Are Involved in Electron Transfer Processes of Shewanella piezotolerans WP3 by Dewu Ding, Meineng Wang, Meili Wu, Chengzhi Gan, Pu Wu

“…Functional module analysis showed that different flagellar assembly modules appeared under these conditions and suggested that flagellar proteins are important for these conditions. …”
Get full text

Efficacy of ginkgo biloba extract in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis of randomized controlled trials by Xuxin Sun, Ling Peng, Wenchao Xiao, Keying Li, Sheng Chen

“…ObjectiveThis systematic review and meta-analysis aims to assess the efficacy of GBE in the treatment of IPF by evaluating its impact on total effective rate, blood gas analysis, pulmonary function tests, and markers of inflammation and fibrosis.MethodsWe conducted a comprehensive search across seven databases, including PubMed, EMBASE, Web of Science, CNKI, Wanfang DATA, VIP, and CBM, without restrictions on publication date. …”
Get full text

Inspection of temperature alteration and it’s prediction possibility in Ardebil province using statistical analysis and adaptive neuro -fuzzy inference system

Get full text

Consumer Perceptions of Cultural Sustainability in Neo-Chinese Furniture: A Text Mining Analysis of Online Reviews from JD and Tmall by Yiming Chen, Yongmei Chen, Xinyou Liu

“…The data revealed that Tmall reviews were 23% more likely to mention aesthetic attributes (viz., style, elegance), while JD reviews contained 35% more references to functional features and material credibility (viz., “solid wood,” “durability”). …”
Get full text

Comparative analysis of the efficacy of oblique lateral interbody fusion versus transforaminal lumbar interbody fusion in the treatment of lumbar disc herniation by Daodong Chen, Tao Liu, Kunyang Du, Zhenjun Zhu

“…A retrospective study was conducted on 133 patients who underwent either OLIF (n = 68) or TLIF (n = 65) between January 2020 and December 2022. Data on patient demographics, pain and functional outcomes (measured by Visual Analogue Scale [VAS] and Oswestry Disability Index [ODI]), radiological outcomes (sagittal and coronal Cobb angles, apical vertebra deviation), fusion and collapse rates, and postoperative recovery (ambulation time and hospitalization duration) were collected. …”
Get full text