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Suggested Topics within your search.
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7781
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7782
Identifying Inhibitor-SARS-CoV2-3CL<sup>pro</sup> Binding Mechanism Through Molecular Docking, GaMD Simulations, Correlation Network Analysis and MM-GBSA Calculations
Published 2025-02-01“…Our findings indicate that a CNA-identified node in domain II of 3CL<sup>pro</sup> acts as a conduit, transferring conformational changes from the catalytic regions in domains I and II, triggered by the binding of inhibitors (7YY, 7XB, and Y6G), to domain III, thereby modulating 3CL<sup>pro</sup>’s activity. Normal mode analysis (NMA) and principal component analysis (PCA) revealed that inhibitor binding affects the structural flexibility and collective movements of the catalytic sites and domain III, influencing 3CL<sup>pro</sup>’s function. …”
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7783
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7784
Multi-Omics Analysis Combined with Machine Learning Identified FABP4 in Smooth Muscle Cells as a Pathogenic Factor in Atherosclerosis
Published 2025-07-01“…Differential expression analysis identified 20 genes highly expressed in both scRNA-seq and array data. …”
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7785
Effectiveness of interventions for middle-aged and ageing population with neck pain: a systematic review and network meta-analysis protocol
Published 2022-06-01“…Descriptive data and ROB will be summarised and tabulated. Traditional pairwise meta-analysis using random-effect model will be performed for all direct comparisons, and NMA using a frequentist random-effect model then performed based on NP classification where possible. …”
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7786
Spatial database applications for network analysis: Case study of bicycle accessibility of forested areas in the Poznań Metropolitan Area, Poland
Published 2024-12-01“…The implemented functionalities consist of solutions for finding the equidistance or isochrone area for any selected point location. …”
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7787
Prevalence and contributing factors of depression among women with infertility in low-resource settings: a systematic review and meta-analysis
Published 2025-02-01“…The data were analyzed with STATA version 14, and a meta-analysis was conducted using a random-effects model. …”
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7788
Beyond the SAFE strategy: Systematic review and meta-analysis of prevalence and associated factors of active trachoma among children in Ethiopia.
Published 2025-01-01“…<h4>Method</h4>The literature search was performed from PubMed, Google Scholar, EMBASE, HINARI, Scopus, and Web of Sciences from January 1-30, 2024. Data were extracted by using a pre-tested and standardized data extraction format and analyzed using STATA 17 statistical software. …”
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7789
A comprehensive analysis of gene expression and the immune landscape in gastric cancer through single-cell and multi-omics approaches
Published 2024-11-01“…We conducted temporal and clustering analyses with single-cell sequencing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses to clarify their functions. Using machine learning, we identified relevant genes to create highly accurate prediction models. …”
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Transcriptome-Wide Analysis of N6-Methyladenosine-Modified Long Noncoding RNAs in Particulate Matter-Induced Lung Injury
Published 2025-01-01“…Three key m<sup>6</sup>A-modified lncRNAs (lncRNA NR_003508, lncRNA uc008scb.1, and lncRNA ENSMUST00000159072) are identified through a joint analysis of the MeRIP-seq and lncRNA-seq data, and their validation is carried out using MeRIP-PCR and qRT-PCR. …”
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7793
Criteria Analysis for the Selection of a Generative Artificial Intelligence Tool for Academic Research Based on an Improved Group DEMATEL Method
Published 2025-05-01“…Using this method, a comprehensive set of criteria—including functionality, ease of use, cost, data security, and community support—is systematically analyzed. …”
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7794
Barriers to Mental Health Support in Cyberbullying: A Thematic Analysis of What Mental Health Professionals and Cyber Experts Think
Published 2025-07-01“…Ten specialists were interviewed, including mental health professionals and cyber experts who work with children and adolescents. The data were analyzed using thematic analysis. Results: Seven major themes emerged from the study as follows: (a) knowledge of cyberbullying, (b) negative impact of cyberbullying, (c) attributed factors for cyberbullying, (d) barriers for help-seeking, (e) child-centric intervention, (f) parental intervention, and (g) whole-school approach to cyberbullying. …”
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Wood Species Recognition Based on Visible and Near-Infrared Spectral Analysis Using Fuzzy Reasoning and Decision-Level Fusion
Published 2021-01-01“…First, the wood spectral curve—with spectral bands of 376.64–779.84 nm and 950–1650 nm—was processed using the principal component analysis (PCA) dimension reduction algorithm. The wood spectral data were divided into two datasets, namely, training and testing sets. …”
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Clinical Outcome After Surgical Treatment of Traumatic Peroneal Nerve Injury: An Analysis of Risk Factors After Different Surgical Approaches
Published 2025-01-01“…Conclusions: According to the present data, a significant number of patients achieved functional improvement following surgical treatment, indicating that this procedure should be considered an important treatment option in selected cases.…”
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A genome-wide SNP-SNP interaction analysis exploring novel interacting loci associated with the risk of recurrence in colorectal cancer.
Published 2025-01-01“…The PLINK epistasis function was utilized to examine pairwise SNP interactions. …”
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Analysis of the high order ADL(<i>p, q</i>) models used to describe connections between time series
Published 2020-04-01“…In the previous papers it was also shown that the ARIMA(p, d, q) automatical fitting functions in popular packages use limitations on the p, q orders of the time series process: q ≤ 5, p ≤ 5. …”
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