Nomogram prediction of molecular characteristics in WHO grade 3–4 diffuse gliomas based on fractal analysis and VASARI features by Changyou Long, Dan Xu, Wenbo Sun, Weiqiang Liang, Jie Zhou, Shen Gui, Huan Li, Haibo Xu

Get full text

A Resource-Efficient, High-Dose, Gamified Neurorehabilitation Program for Chronic Stroke at Home: Retrospective Real-World Analysis by Spencer A Arbuckle, Anna Sophie Knill, Michelle H Chan-Cortés, Gabriela Rozanski, Anastasia Elena Ford, Louis T Derungs, John W Krakauer, Naveed Ejaz, David Putrino, Jenna Tosto-Mancuso, Meret Branscheidt

“…Patient recovery was evaluated with standardized impairment and functional clinical measures and patient self-reported outcome measures. …”
Get full text

Comparative analysis of bacterial communities and environmental interactions in seawater and saline-alkali aquaculture ponds for Scylla paramamosain in northern China by Dongping Zhou, Dongping Zhou, Yuanyuan Fu, Lei Liu, Weichuan Lin, Zhibin Lu, Yangfang Ye, Minglei Zhang

“…These findings are crucial for optimizing the growth environment of S. paramamosain, providing essential data for improving aquaculture conditions and promoting the development of northern S. paramamosain farming.…”
Get full text

Comparative Meta-Analysis of Clinical Outcomes in Chronic Achilles Ruptures: Isolated FHL Transfer, Hamstring Transfer, and Turndown Flaps by Bedri Karaismailoglu MD, FEBOT, Samir Ghandour MD, Joris R.H. Hendriks MS, Mani Eftekhari, Ehab Eltouny MD, Gregory R. Waryasz MD, Daniel Guss MD, MBA, John Y. Kwon MD, Soheil Ashkani-Esfahani MD, Lorena Bejarano-Pineda MD, Christopher W. DiGiovanni MD

Get full text

Analysis of capacity load and nutritional status of peritoneal dialysis patients with diabetic kidney disease and non diabetic kidney disease by BAI Tian-li, YU Qing, ZHU Bing-bing, WANG Yun-man, WANG Hao

“…Objective To analyze the changes of capacity load and nutritional status of diabetic kidney disease(DKD) and non diabetic kidney disease(NDKD) patients within one year of peritoneal dialysis,so as to provide theoretical basis for better clinical intervention.Methods The general data of 116 patients(42 in DKD group and 74 in NDKD group) who received peritoneal dialysis(PD) in our hospital from January 2010 to August 2019 were collected by retrospective analysis.The indexes of laboratory tests such as liver function and brain natriuretic peptide were measured at baseline and 1,3,6,12 months after PD;and clinical evaluation indexes such as peritoneal dialysis mode,dialysate concentration and dosage,24-hour ultrafiltration volume,24-hour urine volume,blood pressure,edema,and types of antihypertensive drugs were compared within a group and between groups by statistical tools,so as to clarify PD efficacy and the efficacy difference between the two groups.Results The dosage of peritoneal dialysis in the DKD group was higher than that in NDKD group(P<0.05) at various time points one month after dialysis.There was no significant difference in 24-hour peritoneal ultrafiltration volume(P>0.05),but 24-hour urine volume in the DKD group was less than that in the NDKD group(P<0.05),the incidence of edemat was higher than that of NDKD group(P<0.05) after 12 months of dialysis,but there was no significant difference in blood pressure level and types of antihypertensive drugs taken(P>0.05).After treatment,serum albumin(Alb) in the study population was lower than that at baseline(P<0.05),and Alb in the DKD group was lower than that in the NDKD group(P<0.05) from baseline to six months after dialysis.There was no significant difference between the two groups after six months(P>0.05).Conclusions The nutritional status in the DKD group is worse than that in the NDKD group at the early stage of dialysis.After 12 months of dialysis,the patients in the DKD group are in a higher capacity load condition than those in the NDKD group.After 1 month of dialysis,the DKD group needs a bigger peritoneal dialysis dosage than the NDKD group.This suggests that clinicians should make a reasonable peritoneal dialysis plan according to their body fluid retention,blood pressure and other factors to maintain an appropriate blood volume and protect residual renal functions.…”
Get full text

Optimized enrichment of murine blood–brain barrier vessels with a critical focus on network hierarchy in post-collection analysis by Hanaa Abdelazim, Audra Barnes, James Stupin, Ranah Hasson, Carmen Muñoz-Ballester, Kenneth L. Young, Stefanie Robel, James W. Smyth, Samy Lamouille, John C. Chappell

“…This vital role in neurological health and function has garnered significant attention from the scientific community and inspired methodology for enriching BBB capillaries. …”
Get full text

A Predictive Model of the Photosynthetic Rate of Chili Peppers Using Support Vector Regression and Environmental Multi-Factor Analysis by Bin Li, Bo Qiao, Qianyu Zhao, Dan Yang, Rongcheng Zhu, Zhexuan Wang, Yujie Yang

Get full text

Efficacy of traditional Chinese medicine injections for treating idiopathic pulmonary fibrosis: A systematic review and network meta-analysis. by Shuai-Yang Huang, Hong-Sheng Cui, Ming-Sheng Lyu, Gui-Rui Huang, Dan Hou, Ming-Xia Yu

“…RevMan 5.4 software and Stata software (version 16.0) were used for the data analysis. NMA were carried out for calculating the odd ratios (ORs) with 95% confidence intervals (CI), the surface under cumulative ranking curve (SUCRA) and the probabilities of being the best.…”
Get full text

Unraveling shared diagnostic genes and cellular microenvironmental changes in endometriosis and recurrent implantation failure through multi-omics analysis by Dongxu Qin, Yongquan Zheng, Libo Wang, Zhenyi Lin, Yao Yao, Weidong Fei, Caihong Zheng

“…Additionally, gene set enrichment analysis (GSEA) and competing endogenous RNA (ceRNA) network analysis were employed to further elucidate the biological functions and regulatory mechanisms of these genes. …”
Get full text

Effect of restrictive fluid resuscitation on severe acute kidney injury in septic shock: a systematic review and meta-analysis by Jing-Yuan Xu, Xin-Er Cai, Wan-Ting Ling, Xiao-Tian Cai, Ming-Kun Yan, Yan-Jie Zhang

“…A new restrictive fluid resuscitation therapy has been applied, and its influence on patients’ renal function remains unclear. The purpose of this study is to evaluate the influence of restrictive fluid resuscitation on incidence of severe acute kidney injury (AKI) in adult patients with sepsis hypotension and shock compared with usual care.Design Systematic review and meta-analysis using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach.Data sources PubMed, Embase, Web of Science and Cochrane Library were searched through 1 November 2024.Eligibility criteria We included randomised controlled trials that compared restrictive fluid resuscitation with liberal fluid therapy on patients with sepsis-associated hypotension and shock, to find out their effect on the incidence of severe AKI. …”
Get full text

Analysis of risk factors of low cardiac output syndrome after pericardiectomy for tuberculous constrictive pericarditis: A retrospective study by Shuangshuang Yan, Jing Guo, Shuzhen Wang, Lijuan Zhang, Li Zhang, Qiuyu Xiao, Qian Li, Zhengkai Zhao, Lijian Cheng, Feng Xiong

“…The personal and clinical data of these patients with LCOS and without LCOS were collected and compared. …”
Get full text

Hepatic arterial infusion chemotherapy versus systemic chemotherapy for advanced intrahepatic cholangiocarcinoma: a meta-analysis of survival outcomes by Di Zeng, Di Zeng, Zhimeng Cheng, Zhimeng Cheng, Geng Liu, Geng Liu, Jiong Lu, Jiong Lu, Bei Li, Bei Li

“…Data on overall survival (OS), progression-free survival (PFS), and key prognostic factors were extracted. …”
Get full text

Efficacy of mesenchymal stem cells and platelet-rich plasma therapies on wound healing: A Systematic Review and meta-analysis by Yunqing Sun, Ming Zhu, Lianmei Qiu

“…Background: Wound healing is a complex physiological process essential for maintaining tissue integrity and function. This meta-analysis aims to evaluate the efficacy of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP), and their combination in enhancing wound healing. …”
Get full text

Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease by Lisa Budzinski, Gi-Ung Kang, René Riedel, Toni Sempert, Leonie Lietz, René Maier, Janine Büttner, Bettina Bochow, Marcell T. Tordai, Aayushi Shah, Amro Abbas, Tanisha Momtaz, Jannike L. Krause, Robin Kempkens, Katrin Lehman, Gitta A. Heinz, Anne E. Benken, Stefanie Bartsch, Kathleen Necke, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen, Tilmann Kallinich, Tobias Alexander, Bosse Jessen, Carl Weidinger, Britta Siegmund, Andreas Radbruch, Anja Schirbel, Benjamin Moser, Hyun-Dong Chang

“…The data were analyzed by machine-learning to assess disease-specific marker patterns in the microbiota phenotype. mMFC captured detailed characteristics of CD microbiota and identified patterns to classify CD patients. …”
Get full text

Epidemiological evidence relating risk factors to chronic obstructive pulmonary disease in China: A systematic review and meta-analysis. by Hong Chen, Xiang Liu, Xiang Gao, Yipeng Lv, Liang Zhou, Jianwei Shi, Wei Wei, Jiaoling Huang, Lijia Deng, Zhaoxin Wang, Ying Jin, Wenya Yu

“…Stata 11.0 was used for meta-analysis. After merging the data, the pooled effect and 95% confidence intervals (CIs) were calculated to assess the association between risk factors and COPD. …”
Get full text

Adherence to the planetary health diet is associated with slower cognitive decline: a prospective cohort analysis of Chinese older adults by Lulu Tang, Xiaoli Yu, Changcui Qiu, Yu Lu, Yunlan Wang, Fei Liu, Xiaoping Zhu

Get full text

Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis by Rui Chu, Mingming Li, Yeshou Xie, Yinuo Du, Tao Ni

“…ObjectiveInsulin-like growth factor-1 (IGF-1) is thought to play an important role in regulating skeletal muscle mass and function, with its decline potentially linked to age-related frailty and sarcopenia. …”
Get full text

Analysis of the Consumption of Medicinal Products Associated with a High Risk of Drug-Induced Liver Injury in Patients with COVID-19 by V. I. Petrov, A. Yu. Ryazanova, N. S. Tokareva

“…However, a growing number of studies have shown an association between liver function impairment and combinations of medicinal products used to treat COVID-19.AIM. …”
Get full text

Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials. by Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari

Get full text

Association of different inflammatory indices with risk of early natural menopause: a cross-sectional analysis of the NHANES 2013–2018 by Mengyu Zheng, Mengyu Zheng, Junying Li, Junying Li, Yushan Cao, Yushan Cao, Zhuo Bao, Zhuo Bao, Xing Dong, Xing Dong, Pei Zhang, Pei Zhang, Jinxiang Yan, Jinxiang Yan, Yixuan Liu, Yixuan Liu, Yongzhen Guo, Yongzhen Guo, Xianxu Zeng, Xianxu Zeng

“…BackgroundEarly natural menopause, characterized by the cessation of ovarian function before the age of 45, has been a subject of prior research indicating that inflammation may predict the onset of menopause. …”
Get full text