Analysis of related deaths in patients with systemic sclerosis combined with renal failure in the United States from 1999 to 2020 by Rongxiu Huo, Yanting Yang, Chengcheng Wei, Danli Meng, Xiaocong Huo, Yang Yang, Bangqin Wang, Yijia Huang, Rongjun Huang, Jinying Lin, Xinxiang Huang

“…Annual death toll and ASMR data from 1999 to 2020 were obtained from the death database of the US CDC. …”
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A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population by Lora Khatib, Se Jin Song, Amanda H. Dilmore, Jon G. Sanders, Caitriona Brennan, Alejandra Rios Hernandez, Tyler Myers, Renee Oles, Sawyer Farmer, Charles Cowart, Amanda Birmingham, Edgar A. Diaz, Oliver Nizet, Kat Gilbert, Nicole Litwin, Promi Das, Brent Nowinski, Mackenzie Bryant, Caitlin Tribelhorn, Karenina Sanders-Bodai, Soline Chaumont, Jan Knol, Guus Roeselers, Manolo Laiola, Sudarshan A. Shetty, Patrick Veiga, Julien Tap, Muriel Derrien, Hana Koutnikova, Aurélie Cotillard, Christophe Lay, Armando R. Tovar, Nimbe Torres, Liliana Arteaga, Antonio González, Daniel McDonald, Andrew Bartko, Rob Knight

“…These results highlight the growing importance of building metagenomic data sets that are standardized, comprehensive, and representative of diverse populations to increase our ability to tease apart the complex relationship between diet and the microbiome.IMPORTANCEAn analysis of fecal microbiome data from individuals in the United States, United Kingdom, and Mexico shows that associations with dietary components vary both by country and by level of resolution (i.e., genus and strain). …”
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Analysis of coagulation alteration and its correlation with β2-microglobulin in 371 patients with newly diagnosed multiple myeloma by Miao Hu, Yanfen Ma, Keli Jia, SaSa Liu, Huarong Jing, Ruicheng Li

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Cloning and Analysis of the Expansin Gene BdEXP1 from Migration Plant parasitic Nematode (Bursaphelenchus doui) by Kaiyang GUO, Shifeng LIN, Rengang WANG, Li LI, Jie ZHANG, Shizhou YU, Zili WANG, Guoqin LIU

“…【Objective】An expansin gene BdEXP1 was cloned from Bursaphelenchus doui, and its expression characteristics were investigated in order to provide reference for the in-depth study of the function of BdEXP1 gene in the interactions between B. doui and hosts.…”
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Mediation Mendelian randomization analysis of immune cell phenotypes and glioma risk: unveiling the regulation of cerebrospinal fluid metabolites by Siyuan Zhao, Jinghao Jiang, Jianwu Zhang, Xiaoqing Jin

“…The potential mediating effects of cerebrospinal fluid metabolites were investigated to explore the underlying mechanisms linking immune cell function and glioma. The GWAS data for immune cells, cerebrospinal fluid metabolites, and glioma used in this study were sourced from public databases. …”
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Integrated proteomics and metabolomics network analysis across different delivery modes in human pregnancy: a pilot study by Yun Huang, Yanyan Ni, Yu Meng, Xiaojing Zeng, Xiaoqing He, Lin Zhang, Jun Zhang

“…KEGG enrichment analyses were performed to investigate the biological function of the identified modules. Integrative multiomics analysis was employed to examine the biological interplay between proteomic and metabolic interactions. …”
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Surgical treatment versus conservative management for acute Achilles tendon rupture: a systematic review and meta-analysis by Zhitao Yang, Zhaogang Ge, Jiang Zheng, Liang Zhang, Zhen Yang

“…Regardless of surgical or conservative treatment, PRP did not yield superior clinical or functional outcomes.…”
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Genome-wide analysis of AP2/ERF transcription Factors in Cymbidium sinense reveals their impact on orchid diversity by Yong-Lu Wei, Jian-Peng Jin, Jian-Peng Jin, Jie Li, Qi Xie, Chu-Qiao Lu, Jie Gao, Gen-Fa Zhu, Feng-Xi Yang

“…GO enrichment and KEGG pathway analysis further elucidated these patterns. To validate transcriptome-based predictions, qRT-PCR analysis was performed on ten key CsAP2/ERF genes, showing high consistency with RNA-seq data. …”
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Bioinformatic Analysis of Apoptosis-Related Genes in Preeclampsia Using Public Transcriptomic and Single-Cell RNA Sequencing Datasets by Liu L, Li X, Yang H, Xu F, Dong X

“…Lingyan Liu,1– 3,* Xiuling Li,2,3,* Hongfen Yang,2,3 Fei Xu,3,4 Xudong Dong2,3 1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People’s Republic of China; 2Department of Obstetrics, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, People’s Republic of China; 3Medical School, Kunming University of Science and Technology, Kunming, 650500, People’s Republic of China; 4Department of Pain Management, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Xu, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Xishan District, Kunming, 650500, People’s Republic of China, Tel +861871-63638625, Email 494428530@qq.com Xudong Dong, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Xishan District, Kunming, 650500, People’s Republic of China, Tel +861871-63638625, Email xudong52@outlook.comPurpose: Apoptosis, which is crucial in preeclampsia (PE), affects trophoblast survival and placental function. We used transcriptomics and single-cell RNA sequencing (scRNA-seq) to explore apoptosis-related genes (ARGs) and their cellular mechanisms as potential PE biomarkers.Patients and Methods: All the data included in this study were sourced from public databases. …”
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Molecular analysis highlights TREM2 as a discriminating biomarker for patients suffering from pancreatic ductal adenocarcinoma by Dimitrios Papakonstantinou, Haiding Wang, Mohamed-Amine Bani, Kevin Mulder, Garett Dunsmore, Alice Boilève, Gérôme Jules-Clément, Leonardo Panunzi, Leslie Robert de Sousa, Carlos de la Calle Fabregat, Marc Deloger, Nicolas Signolle, Grégoire Gessain, Sergey I Nikolaev, Michel Ducreux, Antoine Hollebecque, Florent Ginhoux, Camille Blériot

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Adjuvant endocrine treatment strategies for non-metastatic breast cancer: a network meta-analysisResearch in context by Andri Papakonstantinou, Guillermo Villacampa, Victor Navarro, Mafalda Oliveira, Antonios Valachis, Tomas Pascual, Alexios Matikas

“…In addition, an extracted individual patient data meta-analysis was conducted to estimate the absolute differences between treatments. …”
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Comprehensive analysis of potential biomarkers for the diagnosis and prognosis of Cervical squamous cell carcinoma - based on GEO and TCGA databases by Yufen Chen, Qinghua Deng, Tengyue Fu, Yuxiang Huang, Houlin Li, Jingmu Xie, Feng Liao, Feimiao Zeng, Xinyi Fang, Ruiman Li, Zhuming Chen

“…Prognostic models were constructed and validated, with additional analyses exploring immune cell infiltration and gene function via GSEA and clinical correlation. Finally, key genes were validated via qRT-PCR in CESC tissues.ResultsA total of 112 differentially expressed genes (DEGs) were identified through differential analysis of the GEO and TCGA datasets. …”
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The natural evolution of untreated deep endometriosis and the effect of hormonal suppression: A systematic literature review and meta‐analysis by Veronica Bandini, Francesca Giola, Deborah Ambruoso, Sonia Cipriani, Francesca Chiaffarino, Paolo Vercellini

“…Therefore, we conducted a systematic review and meta‐analysis to investigate whether and how frequently deep endometriosis progresses over time without or with ovarian suppression. …”
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Sarcopenia defined by multidimensional factors and its prognostic role in heart failure: a systematic review and meta-analysis by Jinmei Lu, Yi Gao, Lingbo Zhou, Xinhui Peng, Haiming Feng, Zaixing Zheng

“…ObjectiveTo perform a systematic review and meta-analysis evaluating the impact of sarcopenia—defined by reductions in muscle mass, strength, and/or function—on clinical outcomes in patients with heart failure (HF), thereby informing more effective management strategies.MethodsA comprehensive literature search was conducted through 14 February 2025, using PubMed, Embase, Cochrane Library, and CNKI to identify prospective and retrospective cohort studies involving HF patients diagnosed with sarcopenia based on Asian Working Group for Sarcopenia (AWGS), European Working Group on Sarcopenia in Older People (EWGSOP2), or Ishii criteria. …”
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Heritability and Genetics of Type 2 Diabetes Mellitus in Sub-Saharan Africa: A Systematic Review and Meta-Analysis by Evans Adu Asamoah, Christian Obirikorang, Emmanuel Acheampong, Max Efui Annani-Akollor, Edwin Ferguson Laing, Eddie-Williams Owiredu, Enoch Odame Anto

“…We conducted a systematic review and meta-analysis on the heritability and genetic risk of T2DM in SSA. …”
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Healing Heels: A Meta-analysis of Platelet-rich Plasma vs Corticosteroid Injections in Plantar Fasciitis Treatment by Clevio Desouza, Vijay Shetty

“…Materials and methods: This systematic review and meta-analysis adhered to Cochrane and PRISMA guidelines. …”
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Characterization of 2,500 Patients with Heart Failure and Analysis of Their Optimal Medical Therapy: Insights from the AMERICCAASS Registry by Alex David Sotomayor-Julio, Sebastián Seni-Molina, Juliana María Gutiérrez-Posso, Juan Andrés Muñoz-Ordoñez, Valeria Azcárate-Rodríguez, Hoover O. León-Giraldo, Eduardo R. Perna, Víctor Rossel, Daniel Quesada-Chaves, Mario Speranza, Mark H. Drazner, Walter Alarco, Alexander Romero-Guerra, Gabriel Frago, Daniela García Brasca, Álvaro Mauricio Quintero-Ossa, Javier Galeano Figueredo, Milton Lubeck Herrera, Antonella A. Ferrer, Ruddy Miguel García Safadit, Freddy Pow-Chon-Long, Felix Nunura Arrese, Kwame van der Hilst, Silvia Carolina Lazo-Majano, Elisabeth Ashley Hardin, Orlando David Fernández-Flores, Gabriela Ormaechea-Gorricho, Luis Felipe Anhuaman-Atoche, Annia María Carrero-Vásquez, Andrés Ulate Retana, Pablo Hurtado Nuñez, Emilio Samael Peralta-López, Juan Esteban Gómez-Mesa, On Behalf of AMERICCAASS Research Group

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Meta-analysis of the effects of calcium phosphate bone tissue engineering scaffolds on orthodontic bone augmentation and tooth movement by Jiawen Zhao, Jiawen Zhao, Xuefei Liu, Xuefei Liu, Qi Zhang, Qi Zhang, Yinan Jin, Yinan Jin, Gang Zhao, Gang Zhao

“…ObjectiveIn oral clinical treatment, adequate alveolar bone volume is a crucial prerequisite for expanding the indications of orthodontic treatment and achieving functional and aesthetic reproduction during the tooth movement process. …”
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Impact of Hypoalbuminemia on Outcomes Following Hepatic Resection: A NSQIP Retrospective Cohort Analysis of 26,394 Patients by Dunavan Morris-Janzen, Sukhdeep Jatana, Kevin Verhoeff, A. M. James Shapiro, David L. Bigam, Khaled Dajani, Blaire Anderson

“…<b>Background/Objectives:</b> Efforts to preoperatively risk stratify and optimize patients before liver resection allow for improvements in postoperative outcomes, with hypoalbuminemia being increasingly researched as a surrogate for nutrition, overall health and functional status. Given the paucity of studies examining the relationship between hypoalbuminemia and liver resection, this study aims to determine the impact of hypoalbuminemia on outcomes following liver resections using a large multicenter database. …”
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Analysis of Academic Information System Using Information System Success Model and System Quality Model Case Study of Institut Teknologi Nasional Malang by Kurnia Dwi setyowati, Totok Chamidy, Muhammad Faisal

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