Real-world safety of carboplatin in non-small cell lung cancer: a retrospective signal detection and subgroup analysis based on the FAERS database by Lei Wang, Kunpeng Yang, Kunpeng Yang, Hui Zhao, Peiyun Lv, Chenglun Cai, Zhe Wang, Bao Wang, Bao Wang, Bao Wang

“…This study aims to systematically assess carboplatin-related AEs and explore demographic factors that may influence risk.MethodsA retrospective analysis was performed using data from the FDA Adverse Event Reporting System (FAERS) spanning the first quarter of 2004 to the third quarter of 2024. …”
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clonevdjseq: A workflow and bioinformatics management system for sequencing, archiving, and analysis of VDJ sequences from clonal libraries by Keith Mitchell, Samuel Hunter, Lutz Froenicke, Karl Murray, Matthew Settles, James S. Trimmer

“…Abstract Background Advances in next-generation sequencing technologies have facilitated extensive analysis of B cell and T cell receptor (BCR/TCR, respectively) sequences from monoclonal hybridoma libraries, single B cells, and single T cells, generating vast amounts of important data pertaining to antigen recognition. …”
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Network insights into childhood obesity: unveiling methylated-differentially expressed genes and pathways through integrative bioinformatics analysis by Felipe Mateus Pellenz, Guilherme Coutinho Kullmann Duarte, Giovanna Câmara Giudicelli, Thayne Woycinck Kowalski, Taís Silveira Assmann, Daisy Crispim

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Establishing an objective decision criterion for intraocular lens exchange due to homogeneous calcification: a prospective clinical analysis by Timur M. Yildirim, Grzegorz Łabuz, Nikola Henningsen, Hyeck-Soo Son, Victor A. Augustin, Leoni Britz, Lizaveta Chychko, Ramin Khoramnia, Gerd U. Auffarth

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Single-cell Analysis Highlights Anti-apoptotic Subpopulation Promoting Malignant Progression and Predicting Prognosis in Bladder Cancer by Linhuan Chen, Yangyang Hao, Tianzhang Zhai, Fan Yang, Shuqiu Chen, Xue Lin, Jian Li

“…Gene set enrichment analysis (GSEA), cell trajectory analysis, cell cycle analysis, and single-cell regulatory network inference and clustering (SCENIC) analysis explored the functional heterogeneity between malignant epithelial cell subpopulations. …”
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Identification of human genes potentially involved in the pathogenesis of viral hepatitis C based on multi-network bioinformatics analysis by Ekaterina V. Anufrieva, Yulia V. Ostankova, Vladimir S. Davydenko, Alexandr N. Schemelev, Areg A. Totolian

“…The following genes were used as basic genes: CD81, CLDN1, LDLR, OCLN, SCARB1, the products of which are involved in interaction with viral glycoproteins E1 and E2 at the stage of HCV attachment and penetration into the cell. Data analysis was performed, including a two-stage scoring ranking of the identified candidate genes based on their interaction with basic genes and their presence in the results of network analysis of different web resources. …”
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Unraveling Racial Disparities in Papillary Thyroid Cancer: A Comparative Bulk RNA-Sequencing Gene Expression Analysis by Luiza Barseghyan, Samuel Chan, Celina R. Yamauchi, Andrea Shields, Mia C. Perez, Alfred A. Simental, Salma Khan

“…Significant differences were confirmed in some of the genes in TCGA data analysis. This study identifies genetic factors contributing to racial disparities in PTC, emphasizing the need for further validation in larger cohorts and functional studies. …”
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Accuracy of clinical diagnosis of behavioural variant frontotemporal dementia: a protocol for a systematic review and meta-analysis by Giancarlo Logroscino, Stefania Mondello, Daniele Urso, Stefano Giannoni-Luza

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Impact of Chemotherapy on Vaccine Immunogenicity and Revaccination Response of Acute Lymphoblastic Leukemia—A Systematic Review and Meta-Analysis by Yuyuan Zeng, Chuanyu Yang, Xihan Li, Qi An, Bo Zhou, Wenquan Niu, Yu Tian, Yifei Cheng, Lin Wang

“…R 4.4.2 was employed for data analysis. Results: A total of 29 relevant studies were identified, with 8 undergoing meta-analysis. …”
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Unveiling molecular mechanisms of pigment synthesis in gardenia (Gardenia jasminoides) fruits through integrative transcriptomics and metabolomics analysis by Kangqin Li, Lixin Yu, Liqin Gao, lingzhi Zhu, Xiaotao Feng, Shaoyong Deng

“…The transcriptomics data produced high-quality clean data amounting to 46.98 gigabytes, exhibiting a mapping ratio of 86.36% to 91.43%. …”
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Impact of preoperative complement-dependent cytotoxicity crossmatch on postoperative outcomes in kidney transplant recipients: A retrospective analysis by Chonghe Xu, Siqi Xie, Meiyi Lu, Wei Xu, Mei Zhu

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Analysis of Vicious Circle of Poverty, the Social Role of Micro Waqf Bank, and Permissiveness of Street Vendors in Rural Indonesia by Rahmat Dahlan, Aselina Endang Trihastuti, Raden Ali Pangestu, Ita Sitasari, Emmy Hamidiyah Syaiin, Muhamad Fauzi

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Chronic obstructive pulmonary disease as a risk factor for cognitive impairment: a systematic review and meta-analysis by Yang Zhao, Shu Li, Xia Chen, Zhenjie Yu

“…Previous studies revealed the association between COPD and cognitive impairment, but the conclusions remain controversial.Objectives The current systematic review aimed to investigate whether COPD is an independent risk factor for cognitive impairment.Study design A systematic review and meta-analysis.Data sources PubMed, Cochrane Library, MEDLINE, Embase, Web of Science, China Knowledge Resource Integrated Database, Wanfang Database, Chinese Biomedical Database and Weipu Database were searched from inception to 1 December 2022.Eligibility criteria The inclusion criteria involved studies that reported cognitive impairment in COPD. …”
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Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. by Karl Markus Roupé, Srinivas Veerla, Joshua Olson, Erica L Stone, Ole E Sørensen, Stephen M Hedrick, Victor Nizet

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Transcriptomic analysis reveals molecular phenological changes during the flower-to-fruit transition in Vanilla planifolia Andrews (Orchidaceae) by Olga Andrea Hernández-Miranda, Jorge E. Campos, Estela Sandoval-Zapotitla, Ulises Rosas, María Teresa Ortiz-Melo, Victor Manuel Salazar-Rojas

“…Conclusions This study characterizes the molecular and phenological changes occurring during the flower-to-fruit transition in V. planifolia by integrating transcriptomic analysis with anatomical data on post-pollination syndrome. …”
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Differential gene expression analysis identified determinants of cell fate plasticity during radiation-induced regeneration in Drosophila. by Michelle Ledru, Caitlin A Clark, Jeremy Brown, Shilpi Verghese, Sarah Ferrara, Andrew Goodspeed, Tin Tin Su

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Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries. by Li-Jun Tan, Hu Zhu, Hao He, Ke-Hao Wu, Jian Li, Xiang-Ding Chen, Ji-Gang Zhang, Hui Shen, Qing Tian, Marie Krousel-Wood, Christopher J Papasian, Claude Bouchard, Louis Pérusse, Hong-Wen Deng

“…The aim of this study was to verify the extent to which 6 confirmed obesity genes (FTO, CTNNBL1, ADRB2, LEPR, PPARG and UCP2 genes) could be replicated in 8 different samples (n = 11,161) and to explore whether the same genes contribute to obesity-susceptibility in populations of different ancestries (five Caucasian, one Chinese, one African-American and one Hispanic population). GWAS-based data sets with 1000 G imputed variants were tested for association with obesity phenotypes individually in each population, and subsequently combined in a meta-analysis. …”
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Analysis of the short-term effect of three different level pedicle screws in the treatment of thoracolumbar type A fractures by Alimujiang Yusufu, Abudula Abulaiti, Abuduwupuer Haibier, Junyi Ma, Yuan Ma

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Quantitative Proteomic Analysis of BHK-21 Cells Infected with Foot-and-Mouth Disease Virus Serotype Asia 1. by Hui-Chen Guo, Ye Jin, Shi-Chong Han, Shi-Qi Sun, Yan-Quan Wei, Xian-Ji Liu, Xia Feng, Ding Xiang Liu, Xiang-Tao Liu

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Efficacy of electrical stimulation for post-stroke motor dysfunction: A protocol for systematic review and network meta-analysis. by Yihao Zhou, Hongyan Zhang, Hong Huo, Siyu Yang, Ying Zhang, Shaojie Cai, Xu Dong, Dongyan Wang

“…Two reviewers will evaluation the risk of bias in all included studies with the version 2 of the Cochrane risk-of-bias assessment tool. Data synthesis will be performed using a random-effects model of network meta-analysis to compare the efficacy and safety of different electrical stimulation therapies. …”
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