BRD4 as the key lactylation related gene in heart failure identified through bioinformatics analysis by Kaiyuan Li, Lingyu Han, Xiaowen Wang, Zhipeng Zheng, Min Sha, Jun Ye, Li Zhu

“…Key LRGs implicated in HF were selected using the Least Absolute Shrinkage and Selection Operator (LASSO) and Weighted Gene Co-Expression Network Analysis (WGCNA). The diagnostic efficacy and biological significance of these genes were evaluated through receiver operating characteristic (ROC) curve analysis, Gene Set Enrichment Analysis, and immune cell infiltration analysis. …”
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Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system by Shikha Vashisht, Costantino Parisi, Cecilia L. Winata

“…Subsequently, these CHD-SNPs were annotated and categorized into noncoding and coding regions based on their location. To study the functional implications of noncoding CHD-SNPs, we cross-validated them with enhancer-specific histone modification marks from developing human heart across 9 Carnegie stages and identified potential cardiac enhancers. …”
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Research trends of protein palmitoylation in cancer from 2004 to 2024: a bibliometric and visualization analysis by Yufeng Peng, Kewei Peng, Yi Wang, Luyao Li, Yuefei Lu

“…Palmitoylation involves the covalent attachment of palmitic acid (C16) to cysteine residues, altering the protein’s hydrophobicity and thereby affecting its membrane localization, stability, and functional activity. Recently, palmitoylation has been closely associated with the development and progression of various cancers, making it a key factor in cancer biology research.MethodsThis study conducted a systematic bibliometric analysis using the Web of Science Core Collection (WoSCC) as the data source. …”
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Host Immune Response to Clinical Hypervirulent Klebsiella pneumoniae Pulmonary Infections via Transcriptome Analysis by Langhuan Lei, Xiaoli Zhang, Rui Yang, Haiming Jing, Yue Yuan, Zhifu Chen, Qiang Gou, Zhuo Zhao, Jinyong Zhang, Xingyong Wang

“…Studies on individual immune cells or cytokines have partially revealed the function of the host immune defense against K. pneumoniae pulmonary infection. …”
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Covariation Between Microbiome Composition and Host Transcriptome in the Gut of Wild Drosophila melanogaster: A Re‐Analysis by Frances Llanwarne, Adam J. Dobson

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Comparative genome analysis of patulin-producing Penicillium paneum OM1 isolated from pears by Wencai Zhao, Sung-Yong Hong, Ae-Son Om

“…Results The genome of P. paneum OM1 was estimated to be approximately 27.16 Mb with four chromosomes. Gene Ontology analysis using 7,098 functionally annotated proteins showed that genes involved in fungal defense mechanisms, such as SM biosynthesis, are enriched in the genome of P. paneum OM1. …”
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Circulating Asprosin and Neuregulin-4 in metabolic dysfunction-associated steatotic liver disease (MASLD): A systematic review and meta-analysis by Roshan Kumar Mahat, Vedika Rathore

“…Background: Adipokines, such as asprosin and neuregulin 4 (Nrg4), are implicated in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) and may function as potential diagnostic biomarkers and therapeutic targets. …”
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Causal role of endothelial dysfunction in ischemic stroke and its subtypes: A two-stage analysis by Qian Wu, Jiabo Cui, Yao Jiang, Xiaoxin Li, Chongge You

“…Methods: A two-stage study was conducted combining systematic meta-analysis and Mendelian randomization (MR). The meta-analysis integrated data from 29 observational studies to assess associations between endothelial dysfunction proteins (vWF, sE-selectin, sP-selectin, ICAM-1, VCAM-1, sLOX-1, VEGF, ET-1, SDF-1) and IS. …”
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Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. by J R Managbanag, Tarynn M Witten, Danail Bonchev, Lindsay A Fox, Mitsuhiro Tsuchiya, Brian K Kennedy, Matt Kaeberlein

“…Here we report that the single-gene deletion strains identified by our shortest-path longevity analysis are significantly enriched for mutations conferring either increased or decreased replicative life span, relative to a randomly selected set of 564 single-gene deletion strains or to the current data set available for the entire haploid deletion collection. …”
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A newly identified pathology of episodic angioedema with hypereosinophilia (Gleich syndrome) revealed by multiomics analysis by Tatsuya Koreeda, MS, Hirokazu Muraoka, MD, PhD, MPH, Yasunori Sato, PhD

“…The analysis included WGS and RNA-seq of blood samples. …”
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Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis by Mahyaar Omouri-Kharashtomi, Seyedeh Yasaman Alemohammad, Negin Moazed, Inas Afzali Nezhad, Hamed Ghoshouni

“…This systematic review and meta-analysis aims to assess the prognostic value of the novel hepatic function assessment measure known as albumin-bilirubin (ALBI) grade in patients with CCA. …”
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Growth Mindset Profiles Among Senior High School Students: Academic Achievement and Stress Analysis by Stephen Jay Co, Mary Grace Dela Cruz

“…This research utilized person-centered methodology to examine distinct configurations of growth mindset beliefs among Filipino senior high school students and examine their relationship with academic outcomes across different specializations, moving beyond traditional fixed-growth dichotomies. K-means clustering analysis was conducted with data from 1,043 Filipino senior high school students across four academic strands (STEM, ABM, HUMSS, GAS). …”
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Effects of drought and salt stress on the root phenotype of wheat seedlings and underlying gene expression analysis by Kaiyue Tang, Chuanjing An, Chuanjing An, Lixia Li, Tao Sun, Jiancheng Song, Jiqiang Zhao

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Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma by Can Xu, Jin Yang, Huan Xiong, Xiaoteng Cui, Yuhao Zhang, Mingjun Gao, Lei He, Qiuyue Fang, Changxi Han, Wei Liu, Yangyang Wang, Jin Zhang, Ying Yuan, Zhaomu Zeng, Ruxiang Xu

“…Consensus cluster analysis was followed by Gene Set Enrichment Analysis, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses of DEGs to determine the biological functions and pathways regulated by PMTRGs. …”
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Characterization and kinetic analysis of Vc1509, a NAD+ dependent deacetylase from Vibrio cholerae by Arindam Jana, Pragyan Mishra, Ritu Ghosh, Ajit Kumar Dhal, Shibangini Beura, Amrita Mishra, Rahul Modak

“…In this study, we present the first comprehensive functional and kinetic analysis of Vc1509. We established a scalable expression system for high-yield production of recombinant Vc1509 required for detailed characterization. …”
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Comprehensive analysis of regulatory B Cell related genes in prognosis and therapeutic response in lung adenocarcinoma by Liangyu Zhang, Liangyu Zhang, Jianshen Zeng, Jianshen Zeng, Xun Zhang, Xun Zhang, Menglong Zhang, Menglong Zhang, Yilin Lin, Yilin Lin, Fancai Lai, Fancai Lai

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Orthodontic Management of Class II Malocclusion with Clear Aligners: Mandibular Advancement vs. Class II Elastics by Elisabetta Cretella Lombardo, Letizia Lugli, Roberta Lione, Patrizio Bollero, Paola Cozza, Chiara Pavoni

“…<b>Background</b>: This cephalometric study aimed to evaluate the effects of clear aligner therapy in growing individuals with Class II malocclusion, comparing two functional approaches: the use of Class II elastics or the Mandibular Advancement (MA). …”
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The effects of preoperative glenohumeral osteoarthritis on rotator cuff repair: A systematic review and meta-analysis. by Sen Fang, Junwen Liang, Xudong Yang, Cairang Daoji, Zhixuan Nian, Mingchun Li, Jin Jiang, Xiangdong Yun

“…The postoperative functional scores: the VAS score (MD: 0.14; 95% CI -0.19-0.47; P = 0.41)、ASES score (MD: -0.33; 95% CI -1.64-0.99)were similar between the two groups. …”
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Population-specific DPYD variants and fluoropyrimidine toxicity risk: an analysis using public genomic databases by Suvam Banerjee, Souvik Sengupta

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Mapping evolution and trends of cell membrane-coated nanoparticles: A bibliometric analysis and scoping review by Li Chong, Hu Jing, He Jing, He Chengqi

“…Despite the growing body of literature, comprehensive bibliometric analysis in this field is still lacking. This study conducted a bibliometric analysis of CMNP-related publications sourced from the Web of Science Core Collection database, covering the period from January 1, 2011, to December 31, 2023. …”
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