Identification and analysis of individuals who deviate from their genetically-predicted phenotype. by Gareth Hawkes, Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N Beaumont, GIANT Consortium, Jessica Tyrrell, Michael N Weedon, Joel Hirschhorn, Timothy M Frayling, Andrew R Wood

“…We show that these individuals are enriched for self-reporting being shorter or taller than average at age 10, diagnosed congenital malformations, and rare loss-of-function variants in genes previously catalogued as causal for growth disorders. …”
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Identification of Potential Core Genes in Parkinson’s Disease Using Bioinformatics Analysis by Wei Quan, Jia Li, Xiya Jin, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen

“…Differentially expressed genes (DEGs) were identified, followed by functional enrichment analysis and protein-protein interaction (PPI) network construction. …”
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Analysis of the interaction between N-acetylneuraminic acid and disaccharides on silica surface by L. M. Ushakova, E. M. Demianenko, M. I. Terets, V. V. Lobanov, M. T. Kartel

“…The results of quantum chemical modeling confirm the obtained experimental data. …”
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Assessment of meniscal extrusion with ultrasonography: a systematic review and meta-analysis by Khalis Boksh, Duncan E. T. Shepherd, Daniel M. Espino, Jenna Shepherd, Arijit Ghosh, Randeep Aujla, Tarek Boutefnouchet

“…Pooled data were analyzed by random or fixed-effects models. …”
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Genotype clinical phenotype analysis of 35 cases of hereditary spherocytosis in children by Huang Duowen, Huang Duowen, Guo Xia, Guo Xia, Gao Ju, Gao Ju

“…Grouping according to different mutated genes/mutation types, and statistical analysis of blood routine and liver function indicators between different groups; Mann Whitney test analysis was used for inter group data processing, and significant differences were considered when both sides were p < 0.05.ResultsCompared with the SPTB group, the ANK1 group had significantly lower RBC (p = 0.021) and HGB (p < 0.01), but the differences in other indicators were not statistically significant (p > 0.05).ConclusionsAfter excluding potential influencing factors such as splenectomy, the anemia symptoms in ANK1-HS patients were more severe than those in SPTB-HS patients. …”
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Progress and Frontiers of Research on Dexmedetomidine in Perioperative Medicine: A Bibliometric Analysis by Zheng T, Pei Z, Huang X

“…VOSviewer and Citespace software were used for bibliometric analysis and data visualization.Results: A total of 1652 suitable publications were extracted from the database for analysis, including 1,497 articles and 155 reviews. …”
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Comparative transcriptome analysis of PBMCs in cats diagnosed with and recovered from FIPV by Ju Young Lee, Hyeong Ryeol Cho, Hong-Geun Oh, Jeong Ho Hwang

“…We identified 677 (FIPD/Normal) and 431 (FIPR/FIPD) differentially expressed genes with statistical significance. These data were input into the bioinformatics program. …”
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Effectiveness and pharmacoeconomic analysis of the treatment of severe asthma with omalizumab in clinical practice by Eva Martínez-Moragón, María Climent, Eusebi Chiner, Cleofé Fernández-Aracil, Fernando Sánchez-Toril, Inmaculada Lluch-Tortajada

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Clustering Electrophysiological Predisposition to Binge Drinking: An Unsupervised Machine Learning Analysis by Marcos Uceta, Alberto del Cerro‐León, Danylyna Shpakivska‐Bilán, Luis M. García‐Moreno, Fernando Maestú, Luis Fernando Antón‐Toro

“…We used hierarchical agglomerative UML techniques based on Ward's minimum variance criterion to clusterize relations between power spectrum and functional connectivity and alcohol consumption, based on similarity in their correlations, in frequency bands from theta to gamma. …”
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Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma by Zhencong Chen, Ming Li, Ke Ma, Guoguo Shang, Jiaqi Liang, Jiacheng Yin, Jizhuang Luo, Cheng Zhan, Yu Shi, Qun Wang

“…Methods Pure mucinous adenocarcinoma patient information collected from the Surveillance, Epidemiology, and End Results (SEER) database, the Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (FDZSH), and the Cancer Genome Atlas (TCGA) were extracted, evaluated, and compared with other lung adenocarcinomas (LUAD) patient data. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to explore the functional importance of underlying molecular changes. …”
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The nephrotoxicity of contrasts in coronary artery intervention treatment:a Meta analysis by XU Xiao, HUANG Min, DU Li-guo, LI Xiao-ning

“…Objective To assess the nephrotoxicity of isotonic contrast media compared with low-osmolar contrast media in percutaneous coronary interventioa Methods Randomized controlled trials(RCTs) of isotonic contrast medium or low osmolar nonionic contrast medium in percutaneous coronary intervention were searched in the database of CENTRAL,EMbase,PubMed,CNKI,Wanfang,VIP,CBM from their start year to January 2014.The literature references were searched by hand at the same time.Screening and information extraction were done by two researchers independently according to the inclusion and exclusion criteria.Review Manager(version 5.2) of the Cochrane collaboration was used in data analysis.Results Seven RCTs were identified for analysis of aggregated summary data on 2 677 patients.In 6 studies the increased serum creatinine more than 25%of the baseline levels was used as diagnostic criteria of CIN,and there was significant difference in the CIN incidence between the isotonic contrast medium and low osmolar nonionic contrast medium[RR = 0.57,95% CI(0.38~0.84),P = 0.005].In 7 studies the increased serum creatinine more than 44 μmol/L(0.5 mg/dl) was used as diagnostic criteria,and the incidence of CIN showed significant difference between the isotonic contrast medium and low osmolar nonionic contrast medium[RR = 0.65,95% CI(0.43—0.98),P = 0.04].There was no significant difference in the incidence of CIN among 5 trials in patients with the average age ≥65 years old[RR = 0.66,95% CI(0.40~1.09),P = 0.10].To those patients with the average 60~65 years old,there was no significant difference in the incidence of CIN between the isotonic contrast medium and low osmolar nonionic contrast medium[RR = 0.61,95% CI(0.28~1.32),P = 0.21].In 3 articles including the patients with increased baseline of serum,there was significant difference in the incidence of CIN between the isotonic contrast medium and low osmolar nonionic contrast medium[RR = 0.40,95%CI(0.21 ~0.76),P = 0.006].In 2 studies including the patients with normal serum creatinine,the incidence of CIN between the isotonic contrast medium and low osmolar nonionic contrast medium had no significant difference[RR= 1.14,95% CI(0.39~3.37),P = 0.81].If the dosage of contrast medium was <200 ml,there was no significant difference between the two contrast media[RR = 0.85,95% CI(0.51 ~ 1.43),P = 0.55],but if the dosage was≥200 ml,isotonic contrast medium had lower incidence of CIN than low osmolar nonionic contrast medium[RR= 0.38,95% CI(0.18—0.80),P = 0.01].Conclusions The current evidence indicated that the incidence of CIN caused by isotonic contrast medium is lower than that by low osmolar nonionic contrast medium in coronary artery intervention.However,the osmotic pressure may not be the only determinant mechanism of CIN,especially in old patients.It may be associated with the basic renal function,age,etc.Isotonic contrast agents and lower dosage are recommended for the coronary artery intervention,in order to reduce the incidence of the CIN.…”
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Analysis of the Critical Discourse of the Mediatization of Religion in Murals from the Constitutional Era by Samaneh Seraj, Khashayar Ghazizadeh

“…The research concentrates on 20 religious-themed murals from the Constitutional Era, selected through purposive sampling based on their relevance. Data analysis adheres to Fairclough’s three-dimensional framework for critical discourse analysis, highlighting historical, social, and cultural contexts. …”
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An Integrative Genomics Approach for the Discovery of Potential Clinically Actionable Diagnostic and Prognostic Biomarkers in Colorectal Cancer by Mark Fertel, Duaa Mohammad Alawad, Chindo Hicks

“…Significantly differentially expressed genes were evaluated for the presence of somatic mutations and subjected to functional enrichment analysis to discover molecular networks and signaling pathways enriched for somatic mutations. …”
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Risk Analysis of Groundwater Contaminant in Rural Areas Using Spatial Distribution by Herawati Herawati, Maria Kanan, Anwar Mallongi, Ramli Bidullah, Sandy N. Sakati, Dwi Wahyu Balebu

“…Background: Water is a very important material for the life of creatures in nature and its function for life cannot be replaced by other compounds. …”
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Technical Efficiency of Sweet Potato Production: A Stochastic Frontier Analysis by Godfrey C. Onuwa, Solomon T. Folorunsho, Ganiyu Binuyo, Mercy Emefiene, Onyekwere P. Ifenkwe

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Body Weight Measurement in Critically Ill Patients: A Bibliometric Analysis by Refonda Rias Anggiri, Suhartini Ismail, Retnaningsih Retnaningsih, Sumardi Sumardi

“…The potential topics related to this study were issues, such as “hemorrhage,” “ground glass opacity,” “artificial feeding,” “mathematical analysis,” “blood urea nitrogen,” “net ultrafiltration,” “kidney function test,” “cross infection,” and “virus load.” …”
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Analysis of Renal Pathology Predictors in Tender-Age Infants: Cohort Study by Elena V. Safina, Inga A. Plotnikova, Vera L. Zelentsova, Olga I. Myshinskaya

“…The early onset of nephropathies creates certain risk of early chronic kidney disease development with loss of function (especially in children with unfavorable intrauterine period), renal tissue dysplasia, congenital malformations and/or urodynamic disorders.Objective. …”
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Analysis of clinical and genetic characteristics of 18 pediatric patients with Barth syndrome by ZHAN Tianliu, YAN Zihang, WU Jinjin, CHEN Hao, CHEN Lijun, CHEN Yiwei, FU Lijun

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Valuing the Recreational Uses of Pakistan’s Wetlands: An Application of the Travel Cost Method by Iftikhar Hussain Adil, Ali Dehlavi

“…The strongest argument in favour of revising data collection and processing strategies in this regard is perhaps the finding that shared and rented transportation is common in developing countries, while cost coefficients tend to figure prominently in welfare measurement irrespective of the functional form. …”
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Comparative Analysis of Anterolateral Ligament Reconstruction versus Lateral Extra-articular Tenodesis in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Systemati... by Sung Huang Laurent Tsai, Chen Huan Hsu, Wei-Cheng Chen, Cheng-Pang Yang, Hao-Che Tang, Chien-Hao Chen, Chih-Hao Chiu, Alvin Chao-Yu Chen, Kuo-Yao Hsu, Yi-Sheng Chan

“…Conclusions: The conclusion of our network meta-analysis suggests that ACLR, in combination with additional augmentation techniques, such as ALLR or LET, may result in superior functional outcomes compared to ACLR alone. …”
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