Specific immune-inflammatory profiles and neurocognitive deficits predict illness trajectories in people with type 2 diabetes mellitus or psychiatric disorders by Joan Vicent Sánchez-Ortí, Patricia Correa-Ghisays, Vicent Balanzá-Martínez, Gabriel Selva-Vera, Víctor M. Victor, Constanza San Martin Valenzuela, Pau Soldevila-Matías, Fabián Robledo-Yagüe, María Flores-Rodero, Jon Sánchez-Valle, Jaume Forés-Martos, Diego Macías Saint-Gerons, Inmaculada Fuentes-Durá, Rafael Tabarés-Seisdedos

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deep-Sep: a deep learning-based method for fast and accurate prediction of selenoprotein genes in bacteria by Yao Xiao, Yan Zhang

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Salivary lactoferrin levels in Down Syndrome: a case-control study by Desireé Antequera, Lucía Sande, Eliane García Mato, Deborah Romualdi, Laura Carrero, Cristina Municio, Pedro Diz, Eva Carro

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Enhancing Attention Network Spatiotemporal Dynamics for Motor Rehabilitation in Parkinson’s Disease by Guangying Pei, Mengxuan Hu, Jian Ouyang, Zhaohui Jin, Kexin Wang, Detao Meng, Yixuan Wang, Keke Chen, Li Wang, Li-Zhi Cao, Shintaro Funahashi, Tianyi Yan, Boyan Fang

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Moonlighting activity of threonine synthase in cyanobacterial cell death by Wonjae Kim, Yongjun Son, Yerim Park, Minkyung Kim, Reagan Lee, Keu Eun San Kim, Sung Jae Shin, Woojun Park

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Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics by Xiaojun Wu, Yuanming Ye, Mubai Sun, Yongfeng Mei, Bowen Ji, Ming Wang, Enming Song

“…Results will inspire continuing advancements in functions and benign interfaces to biological systems, thus yielding therapy and diagnostics for human healthcare.…”
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Early postnatal exposure to bicuculline modulates E/I balance and induces ASD-like behavioral phenotypes in mice by Dongpil Shin, Eunbi Cho, Kwanghoon Park, ChiHye Chung, Dong Hyun Kim, Se Jin Jeon, Chan Young Shin

“…DEG analysis of the PFC in bicuculline-treated mice unveiled aberrant gene profiles related to the regulation of synaptic function. Clinical significance and underlying mechanisms of abnormal brain activity, neurodevelopment, and ASD-related behaviors prompted by neonatal bicuculline treatment require further investigation. …”
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Computing with electromagnetic fields rather than binary digits: a route towards artificial general intelligence and conscious AI by Johnjoe McFadden

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The Virtual Parkinsonian patient by Marianna Angiolelli, Damien Depannemaecker, Hasnae Agouram, Jean Régis, Romain Carron, Marmaduke Woodman, Letizia Chiodo, Paul Triebkorn, Abolfazl Ziaeemehr, Meysam Hashemi, Alexandre Eusebio, Viktor Jirsa, Pierpaolo Sorrentino

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The antioxidant role of aromatic plant extracts in managing neurodegenerative diseases: A comprehensive review by Youyang Zhu, Miao Tian, Shiyu Lu, Yuliang Qin, Ting Zhao, Hongling Shi, Zhaofu Li, Dongdong Qin

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Association of neurodegeneration, cognitive impairment, and short stature in Down syndrome; Could proinflammatory cytokines be the common factor? by Ghazaleh Sadeghi, Mohammad Hadi Farjoo

“…The group of GnRH neurons responsible for cognitive functions is also impaired in DS, and treatment with GnRH agonists has demonstrated improvements in cognition. …”
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Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease by Benjamin Siciliano, Nicholas D. Henkel, William G. Ryan V, Ali Sajid Imami, John M. Vergis, Chongchong Xu, Taylen O. Arvay, Smita Sahay, Priyanka Pulvender, Abdul-rizaq Hamoud, Chadwick Hales, Robert E. McCullumsmith, Zhexing Wen

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Bindarit attenuates neuroinflammation after subarachnoid hemorrhage by regulating the CCL2/CCR2/NF-κB pathway by Yanting Yao, Qiaowei Wu, Kaikun Yuan, Pei Wu, Chao Xu, Zhiyong Ji, Weishi Xu, Hongli Yu, Anyu Xu, Yanchen Liu, Huaizhang Shi

“…Bindarit improved neurological functions and reduced neuroinflammation by regulating the CCL2/CCR2/NF-κB pathway in early brain injury after SAH.…”
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Rapid neurogenesis through transcriptional activation in human stem cells by Volker Busskamp, Nathan E Lewis, Patrick Guye, Alex HM Ng, Seth L Shipman, Susan M Byrne, Neville E Sanjana, Jernej Murn, Yinqing Li, Shangzhong Li, Michael Stadler, Ron Weiss, George M Church

“…The resulting cells exhibited transcriptional, morphological and functional signatures of differentiated neurons, with greatest transcriptional similarity to prenatal human brain samples. …”
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Neuroimmune axis: Linking environmental factors to pancreatic β-cell dysfunction in Diabetes by Luz Andreone

“…Pancreatic islets are a highly innervated tissue whose function can be influenced by the brain, either directly through the autonomic nervous system or indirectly via neuroendocrine mechanisms. …”
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Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease by Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Mann

“…Abstract Neurodegenerative diseases are a growing burden, and there is an urgent need for better biomarkers for diagnosis, prognosis, and treatment efficacy. Structural and functional brain alterations are reflected in the protein composition of cerebrospinal fluid (CSF). …”
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Dysregulated neural coding in the vagus nerve during long sepsis by Joshua J. Strohl, Tomás S. Huerta, Sergio Robbiati, Patricio T. Huerta

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Analog Sequential Hippocampal Memory Model for Trajectory Learning and Recalling: A Robustness Analysis Overview by Daniel Casanueva‐Morato, Alvaro Ayuso‐Martinez, Giacomo Indiveri, Juan P. Dominguez‐Morales, Gabriel Jimenez‐Moreno

“…Through extensive experimentation together with an extensive analysis of the model's behavior in the presence of external noise sources, its correct functioning is demonstrated, proving the robustness and consistency of the proposed neuromorphic sequential memory system.…”
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The effect of dual inflammation on the acute phase clinical outcomes of schizophrenia patients with comorbid COVID-19 by Jiahui Zhu, Jiamin Shao, Peng Wang, Yuan Liu, Gangming Cheng, Qi Zhou, Zhuoran Li, Jiayi Li, Mingqia Wang, Zhuokai Zhang, Xuan Dong, Chuan Shi

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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

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